Carl A Pinkert

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseases
    Carl A Pinkert
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Methods Cell Biol 80:549-69. 2007
  2. ncbi request reprint Production of transmitochondrial mice
    Carl A Pinkert
    Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8645, USA
    Methods 26:348-57. 2002
  3. ncbi request reprint Muscle growth after postdevelopmental myostatin gene knockout
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Am J Physiol Endocrinol Metab 292:E985-91. 2007
  4. ncbi request reprint Myofibrillar protein synthesis in myostatin-deficient mice
    Stephen Welle
    Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E409-15. 2006
  5. ncbi request reprint Mouse embryo yield and viability after euthanasia by CO2 inhalation or cervical dislocation
    Robert L Howell
    University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, and the University of Rochester Transgenic Facility, Rochester, New York 14642 8645, USA
    Comp Med 53:510-3. 2003
  6. ncbi request reprint Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation system
    Faith M Young
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Biol 271:77-90. 2004
  7. pmc In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine
    Sergiy M Nadtochiy
    Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14620, USA
    J Mol Cell Cardiol 46:960-8. 2009
  8. ncbi request reprint Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain
    Yu Ching Lai
    University of Rochester School of Medicine and Dentistry, Rochester, New York
    Arthritis Rheum 54:1184-97. 2006
  9. ncbi request reprint Foundation Review: Transgenic animals and their impact on the drug discovery industry
    David A Dunn
    Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, NY, USA
    Drug Discov Today 10:757-67. 2005
  10. pmc NDUFS4: creation of a mouse model mimicking a Complex I disorder
    Christopher A Ingraham
    Department of Biomedical Genetics, Univ of Rochester Medical Center, Rochester, NY, USA
    Mitochondrion 9:204-10. 2009

Collaborators

  • Paul S Brookes
  • Ian A Trounce
  • Shey Shing Sheu
  • Rabi Tawil
  • Lili Wang
  • Kumiko Takeda
  • Matthew McKenzie
  • S Welle
  • John Olschowka
  • S Kyrkanides
  • Christopher A Ingraham
  • David A Dunn
  • Robert L Howell
  • Lindsay S Burwell
  • Sergiy M Nadtochiy
  • Hong Ming Shen
  • Wendy K Pogozelski
  • Yu Ching Lai
  • Faith M Young
  • Ada Elgavish
  • Jolanta Skalska
  • Cody M Spencer
  • Alan E Friedman
  • Leah D Fletcher
  • Carolyn A Cassar
  • Grazyna Bozek
  • Ursula Storb
  • Kevin McBride
  • Amy Kenter
  • Solomon S Shaftel
  • Jen nie H Miller
  • M Kerry O'Banion
  • J Edward Puzas
  • Ian M Dickerson
  • Ross H Tallents
  • Yoon Chang
  • David L Kooyman
  • Samuel E Scroggins
  • Andrea Bottaro
  • Philip A Wood
  • Todd Cartee
  • Roycelynn Mentor-Marcel
  • John Wilbanks
  • Liqun Tian
  • Isam Eldin Eltoum
  • Catherine L Donegan

Detail Information

Publications18

  1. ncbi request reprint Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseases
    Carl A Pinkert
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Methods Cell Biol 80:549-69. 2007
  2. ncbi request reprint Production of transmitochondrial mice
    Carl A Pinkert
    Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8645, USA
    Methods 26:348-57. 2002
    ....
  3. ncbi request reprint Muscle growth after postdevelopmental myostatin gene knockout
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Am J Physiol Endocrinol Metab 292:E985-91. 2007
    ..We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass...
  4. ncbi request reprint Myofibrillar protein synthesis in myostatin-deficient mice
    Stephen Welle
    Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E409-15. 2006
    ..Thus the increased protein synthesis and RNA content per muscle in myostatin-deficient mice cannot be explained entirely by an increased number of myonuclei...
  5. ncbi request reprint Mouse embryo yield and viability after euthanasia by CO2 inhalation or cervical dislocation
    Robert L Howell
    University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, and the University of Rochester Transgenic Facility, Rochester, New York 14642 8645, USA
    Comp Med 53:510-3. 2003
    ..534). Decisions regarding the method of euthanasia can be made on the basis of criteria other than those associated with embryo yield and viability...
  6. ncbi request reprint Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation system
    Faith M Young
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Biol 271:77-90. 2004
    ..In this review, we discuss the technical aspects of the procedure, as well as its advantages and drawbacks compared to alternative approaches, and our practical experience in establishing the system at the University of Rochester...
  7. pmc In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine
    Sergiy M Nadtochiy
    Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14620, USA
    J Mol Cell Cardiol 46:960-8. 2009
    ..Overall, these results are consistent with a role for mitochondrial S-nitrosation and complex I inhibition in the cardioprotective mechanism of IPC and SNO-MPG in vivo...
  8. ncbi request reprint Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain
    Yu Ching Lai
    University of Rochester School of Medicine and Dentistry, Rochester, New York
    Arthritis Rheum 54:1184-97. 2006
    ..To examine the effects of intraarticular induction of interleukin-1beta (IL-1beta) expression in adult mice...
  9. ncbi request reprint Foundation Review: Transgenic animals and their impact on the drug discovery industry
    David A Dunn
    Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, NY, USA
    Drug Discov Today 10:757-67. 2005
    ....
  10. pmc NDUFS4: creation of a mouse model mimicking a Complex I disorder
    Christopher A Ingraham
    Department of Biomedical Genetics, Univ of Rochester Medical Center, Rochester, NY, USA
    Mitochondrion 9:204-10. 2009
    ..Decreased Complex I activity with unaltered Complex II activity, along with an accumulation of lactate, were consistent with Complex I disorders in this mouse model...
  11. ncbi request reprint Transgenic mouse with human mutant p53 expression in the prostate epithelium
    Ada Elgavish
    Department of Genetics, Kaul Building 624, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Prostate 61:26-34. 2004
    ..To test this possibility in future studies, the objective of the present study was to generate a transgenic mouse model expressing mutant p53 in the prostate (PR)...
  12. ncbi request reprint Mitochondrial activity in response to serum starvation in bovine (Bos taurus) cell culture
    Kumiko Takeda
    Department of Animal Breeding and Reproduction, National Institute of Livestock and Grassland Science, National Agricultural Research Organization, Ibaraki, Japan
    Cloning Stem Cells 4:223-9. 2002
    ..Future research should reveal whether specific cell culture parameters represent one of the factors for the varying incidence of heteroplasmy identified in cloned animals...
  13. ncbi request reprint Cybrid models of mtDNA disease and transmission, from cells to mice
    Ian A Trounce
    Center for Neuroscience, University of Melbourne, Victoria 3010, Australia
    Curr Top Dev Biol 77:157-83. 2007
    ..When breakthrough technology for mtDNA transformation arrives, cybrids will remain valuable for allowing exchange of engineered mtDNAs between cells...
  14. ncbi request reprint Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex III
    Matthew McKenzie
    Genomic Disorders Research Centre, University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, Australia
    Mol Biol Evol 20:1117-24. 2003
    ..The greater sensitivity of complex III to xenocybrid dysfunction may result from the encoding of redox center apoproteins in both nuclear and mitochondrial genomes, a unique feature of this RC complex...
  15. pmc Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney
    Hong Ming Shen
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Mol Immunol 45:1883-92. 2008
    ..Despite this modification, known to enhance AID activity, resting B cells did not undergo SHM. Apparently, the large amounts of AID in resting B cells are not targeted to Ig genes in vivo, in contrast to findings in vitro...
  16. pmc The mitochondrial genome sequence of Mus terricolor: comparison with Mus musculus domesticus and implications for xenomitochondrial mouse modeling
    Wendy K Pogozelski
    Department of Chemistry, State University of New York at Geneseo, Geneseo, NY 14454, USA
    Gene 418:27-33. 2008
    ....
  17. pmc Production of homoplasmic xenomitochondrial mice
    Matthew McKenzie
    Genomic Disorders Research Centre, Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Victoria 3065, Australia
    Proc Natl Acad Sci U S A 101:1685-90. 2004
    ..These xenocybrid models represent the first viable transmitochondrial mice with homoplasmic replacement of endogenous mtDNA and confirm the feasibility of producing mitochondrial defects in mice by using a xenomitochondrial approach...
  18. ncbi request reprint Microinjection of cytoplasm or mitochondria derived from somatic cells affects parthenogenetic development of murine oocytes
    Kumiko Takeda
    Department of Animal Breeding and Reproduction, National Institute of Livestock and Grassland Science, National Agricultural and Bio Oriented Research Organization, Tsukuba, Ibaraki, 305 0901, Japan
    Biol Reprod 72:1397-404. 2005
    ..These results have further implications for in vitro fertilization protocols employing ooplasmic transfer where primary oocyte failure is not confirmed...