Carl A Pinkert
Affiliation: University of Rochester
- Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseasesCarl A Pinkert
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Methods Cell Biol 80:549-69. 2007
- Production of transmitochondrial miceCarl A Pinkert
Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8645, USA
Methods 26:348-57. 2002....
- Muscle growth after postdevelopmental myostatin gene knockoutStephen Welle
Department of Medicine, University of Rochester, Rochester, NY, USA
Am J Physiol Endocrinol Metab 292:E985-91. 2007..We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass...
- Myofibrillar protein synthesis in myostatin-deficient miceStephen Welle
Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 290:E409-15. 2006..Thus the increased protein synthesis and RNA content per muscle in myostatin-deficient mice cannot be explained entirely by an increased number of myonuclei...
- Mouse embryo yield and viability after euthanasia by CO2 inhalation or cervical dislocationRobert L Howell
University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, and the University of Rochester Transgenic Facility, Rochester, New York 14642 8645, USA
Comp Med 53:510-3. 2003..534). Decisions regarding the method of euthanasia can be made on the basis of criteria other than those associated with embryo yield and viability...
- Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation systemFaith M Young
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Methods Mol Biol 271:77-90. 2004..In this review, we discuss the technical aspects of the procedure, as well as its advantages and drawbacks compared to alternative approaches, and our practical experience in establishing the system at the University of Rochester...
- In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycineSergiy M Nadtochiy
Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14620, USA
J Mol Cell Cardiol 46:960-8. 2009..Overall, these results are consistent with a role for mitochondrial S-nitrosation and complex I inhibition in the cardioprotective mechanism of IPC and SNO-MPG in vivo...
- Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and painYu Ching Lai
University of Rochester School of Medicine and Dentistry, Rochester, New York
Arthritis Rheum 54:1184-97. 2006..To examine the effects of intraarticular induction of interleukin-1beta (IL-1beta) expression in adult mice...
- Foundation Review: Transgenic animals and their impact on the drug discovery industryDavid A Dunn
Department of Pathology and Laboratory Medicine, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, NY, USA
Drug Discov Today 10:757-67. 2005....
- NDUFS4: creation of a mouse model mimicking a Complex I disorderChristopher A Ingraham
Department of Biomedical Genetics, Univ of Rochester Medical Center, Rochester, NY, USA
Mitochondrion 9:204-10. 2009..Decreased Complex I activity with unaltered Complex II activity, along with an accumulation of lactate, were consistent with Complex I disorders in this mouse model...
- Transgenic mouse with human mutant p53 expression in the prostate epitheliumAda Elgavish
Department of Genetics, Kaul Building 624, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Prostate 61:26-34. 2004..To test this possibility in future studies, the objective of the present study was to generate a transgenic mouse model expressing mutant p53 in the prostate (PR)...
- Mitochondrial activity in response to serum starvation in bovine (Bos taurus) cell cultureKumiko Takeda
Department of Animal Breeding and Reproduction, National Institute of Livestock and Grassland Science, National Agricultural Research Organization, Ibaraki, Japan
Cloning Stem Cells 4:223-9. 2002..Future research should reveal whether specific cell culture parameters represent one of the factors for the varying incidence of heteroplasmy identified in cloned animals...
- Cybrid models of mtDNA disease and transmission, from cells to miceIan A Trounce
Center for Neuroscience, University of Melbourne, Victoria 3010, Australia
Curr Top Dev Biol 77:157-83. 2007..When breakthrough technology for mtDNA transformation arrives, cybrids will remain valuable for allowing exchange of engineered mtDNAs between cells...
- Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex IIIMatthew McKenzie
Genomic Disorders Research Centre, University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, Australia
Mol Biol Evol 20:1117-24. 2003..The greater sensitivity of complex III to xenocybrid dysfunction may result from the encoding of redox center apoproteins in both nuclear and mitochondrial genomes, a unique feature of this RC complex...
- Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidneyHong Ming Shen
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
Mol Immunol 45:1883-92. 2008..Despite this modification, known to enhance AID activity, resting B cells did not undergo SHM. Apparently, the large amounts of AID in resting B cells are not targeted to Ig genes in vivo, in contrast to findings in vitro...
- The mitochondrial genome sequence of Mus terricolor: comparison with Mus musculus domesticus and implications for xenomitochondrial mouse modelingWendy K Pogozelski
Department of Chemistry, State University of New York at Geneseo, Geneseo, NY 14454, USA
Gene 418:27-33. 2008....
- Production of homoplasmic xenomitochondrial miceMatthew McKenzie
Genomic Disorders Research Centre, Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Victoria 3065, Australia
Proc Natl Acad Sci U S A 101:1685-90. 2004..These xenocybrid models represent the first viable transmitochondrial mice with homoplasmic replacement of endogenous mtDNA and confirm the feasibility of producing mitochondrial defects in mice by using a xenomitochondrial approach...
- Microinjection of cytoplasm or mitochondria derived from somatic cells affects parthenogenetic development of murine oocytesKumiko Takeda
Department of Animal Breeding and Reproduction, National Institute of Livestock and Grassland Science, National Agricultural and Bio Oriented Research Organization, Tsukuba, Ibaraki, 305 0901, Japan
Biol Reprod 72:1397-404. 2005..These results have further implications for in vitro fertilization protocols employing ooplasmic transfer where primary oocyte failure is not confirmed...