Joseph M Pilewski

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Gene therapy for airway diseases: continued progress toward identifying and overcoming barriers to efficiency
    Joseph M Pilewski
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 27:117-21. 2002
  2. pmc Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity
    Dimitra Mitsani
    Divisions of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:2371-7. 2012
  3. doi request reprint Donor smoking history and age in lung transplantation: a revisit
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 95:513-8. 2013
  4. pmc Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
    Yvonne R Chan
    Division of Pulmonary, Allergy and Critical Care Medicine, The Eye and Ear Institute, University of Pittsburgh, and the Richard King Mellon Foundation Institute for Pediatric Research, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 131:1117-29, 1129.e1-5. 2013
  5. doi request reprint Intrapulmonary disposition of amphotericin B after aerosolized delivery of amphotericin B lipid complex (Abelcet; ABLC) in lung transplant recipients
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 90:1215-9. 2010
  6. doi request reprint A polymorphism linked to elevated levels of interferon-γ is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center
    Dimitra Mitsani
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Heart Lung Transplant 30:523-9. 2011
  7. doi request reprint Staphylococcus aureus infections in the early period after lung transplantation: epidemiology, risk factors, and outcomes
    Ryan K Shields
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Heart Lung Transplant 31:1199-206. 2012
  8. doi request reprint Early major neurologic complications after lung transplantation: incidence, risk factors, and outcome
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 95:866-71. 2013
  9. pmc Elevated CXCL10 (IP-10) in bronchoalveolar lavage fluid is associated with acute cellular rejection after human lung transplantation
    Shahid Husain
    1 Division of Infectious Diseases, Department of Medicine, Multi Organ Transplant Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada 2 Division of Infectious Diseases, Department of Medicine, Toronto General Research Institute, McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada 3 The Toronto Lung Transplant Program, McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada 4 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 5 Division of Respirology, Department of Medicine, The Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada 6 Department of Cardiothoracic Surgery, Cleveland Clinic, Cleveland, OH 7 Departments of Pediatrics and Immunology, University of Pittsburgh, Pittsburgh, PA 8 Department of Medicine, University of Washington, Seattle, WA 9 Address correspondence to Shahid Husain, M D, M S, Division of Infectious Diseases, Department of Medicine, NC 27710
    Transplantation 97:90-7. 2014
  10. doi request reprint Lung transplantation after lung volume reduction surgery
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Transplantation 96:421-5. 2013

Detail Information

Publications74

  1. ncbi request reprint Gene therapy for airway diseases: continued progress toward identifying and overcoming barriers to efficiency
    Joseph M Pilewski
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 27:117-21. 2002
  2. pmc Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity
    Dimitra Mitsani
    Divisions of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:2371-7. 2012
    ..Voriconazole prophylaxis was most effective at troughs of >1.5 μg/ml. A cutoff for toxicity was not identified, but troughs of >4 μg/ml were rare. The data support a target range of >1.5 to 4 μg/ml...
  3. doi request reprint Donor smoking history and age in lung transplantation: a revisit
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 95:513-8. 2013
    ..Because we experienced unexpected adverse outcomes after transplant of lungs from teenaged donors with no smoking history, this study revisited the effects of donor smoking history in relation to age on transplant outcomes...
  4. pmc Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
    Yvonne R Chan
    Division of Pulmonary, Allergy and Critical Care Medicine, The Eye and Ear Institute, University of Pittsburgh, and the Richard King Mellon Foundation Institute for Pediatric Research, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 131:1117-29, 1129.e1-5. 2013
    ..This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized...
  5. doi request reprint Intrapulmonary disposition of amphotericin B after aerosolized delivery of amphotericin B lipid complex (Abelcet; ABLC) in lung transplant recipients
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 90:1215-9. 2010
    ..However, no published data exist regarding the pharmacokinetic profile of amphotericin B lipid complex in lung transplant recipients...
  6. doi request reprint A polymorphism linked to elevated levels of interferon-γ is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center
    Dimitra Mitsani
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Heart Lung Transplant 30:523-9. 2011
    ..Single-nucleotide polymorphisms (SNPs) associated with active cytomegalovirus (CMV) infections after lung transplantation have not been identified...
  7. doi request reprint Staphylococcus aureus infections in the early period after lung transplantation: epidemiology, risk factors, and outcomes
    Ryan K Shields
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Heart Lung Transplant 31:1199-206. 2012
    ..Staphylococcus aureus infections among lung transplant recipients are poorly studied...
  8. doi request reprint Early major neurologic complications after lung transplantation: incidence, risk factors, and outcome
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 95:866-71. 2013
    ....
  9. pmc Elevated CXCL10 (IP-10) in bronchoalveolar lavage fluid is associated with acute cellular rejection after human lung transplantation
    Shahid Husain
    1 Division of Infectious Diseases, Department of Medicine, Multi Organ Transplant Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada 2 Division of Infectious Diseases, Department of Medicine, Toronto General Research Institute, McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada 3 The Toronto Lung Transplant Program, McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada 4 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 5 Division of Respirology, Department of Medicine, The Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada 6 Department of Cardiothoracic Surgery, Cleveland Clinic, Cleveland, OH 7 Departments of Pediatrics and Immunology, University of Pittsburgh, Pittsburgh, PA 8 Department of Medicine, University of Washington, Seattle, WA 9 Address correspondence to Shahid Husain, M D, M S, Division of Infectious Diseases, Department of Medicine, NC 27710
    Transplantation 97:90-7. 2014
    ....
  10. doi request reprint Lung transplantation after lung volume reduction surgery
    Norihisa Shigemura
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Transplantation 96:421-5. 2013
    ..The risk-benefit tradeoffs of the combined procedure have not been thoroughly examined, although substantial information regarding LVRS has emerged...
  11. doi request reprint Extracorporeal membrane oxygenation as a bridge to lung transplant: midterm outcomes
    Christian A Bermudez
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Thorac Surg 92:1226-31; discussion 1231-2. 2011
    ..The impact on mid-term survival is unknown. We analyzed outcomes after lung transplant over a 19-year period in patients who received ECMO support...
  12. pmc Imaging the postdeposition dispersion of an inhaled surfactant aerosol
    Timothy E Corcoran
    Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Aerosol Med Pulm Drug Deliv 25:290-6. 2012
    ..To test this, we performed a pilot scintigraphy study of surfactant and saline deposition and postdeposition dispersion...
  13. pmc Ganciclovir-resistant cytomegalovirus infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens
    Lucio R Minces
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 58:128-35. 2014
    ..Foscarnet-based regimens often eradicated viremia rapidly but were ineffective in the long term and limited by toxicity. ..
  14. pmc Five-year outcomes with alemtuzumab induction after lung transplantation
    Susan Shyu
    Department of Medicine, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 30:743-54. 2011
    ....
  15. pmc AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells
    MICHAEL M MYERBURG
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, S976 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Respir Cell Mol Biol 42:676-84. 2010
    ....
  16. doi request reprint Lung transplantation with lungs from older donors: recipient and surgical factors affect outcomes
    Norihisa Shigemura
    1 Department of Cardiothoracic Surgery and 2 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 3 Address correspondence to Norihisa Shigemura, M D, Ph D, UPMC Presbyterian, Suite C 900, 200 Lothrop Street, Pittsburgh, PA 15213
    Transplantation 98:903-8. 2014
    ..A shortage of donors has compelled the use of extended-criteria donor organs in lung transplantation. The purpose of this study was to evaluate the impact of using older donors on outcomes after lung transplantation using current protocols...
  17. pmc Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking
    MICHAEL M MYERBURG
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Montefiore University Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 43:712-9. 2010
    ..These findings demonstrate that Na(+) absorption in the airway is acutely modulated by the coordinated trafficking of channels to the luminal surface and by the proteolytic activation of ENaC in response to ASL volume expansion...
  18. pmc SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
    Carol A Bertrand
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Gen Physiol 133:421-38. 2009
    ....
  19. doi request reprint Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung
    Landon W Locke
    Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Eur Respir J 47:1392-401. 2016
    ..Depressed MCC in cystic fibrosis is associated with P. aeruginosa infection. ABS is consistently increased in cystic fibrosis. ..
  20. doi request reprint Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation
    Christian A Bermudez
    Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Ann Thorac Surg 98:1936-42; discussion 1942-3. 2014
    ..We compared early and midterm outcomes of these 2 support methods...
  21. pmc Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers
    JESSICA BON
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e105066. 2014
    ..Emphysema and osteoporosis are epidemiologically associated diseases of cigarette smokers. The causal mechanism(s) linking these illnesses is unknown. We hypothesized autoimmune responses may be involved in both disorders...
  22. doi request reprint De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation
    Matthew R Morrell
    Division of Pulmonary Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    J Heart Lung Transplant 33:1288-94. 2014
    ..However, the role of donor-specific HLA antibody (DSA) responses as a risk factor for poor outcomes remains controversial...
  23. doi request reprint Lobar lung transplantation: a relevant surgical option in the current era of lung allocation score
    Norihisa Shigemura
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Ann Thorac Surg 96:451-6. 2013
    ..Here, we review our experience using cadaveric lobar lung transplantation as a surgical option in an attempt to decrease mortality while waiting...
  24. pmc Nature and correlates of post-traumatic stress symptomatology in lung transplant recipients
    Cynthia J Gries
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Heart Lung Transplant 32:525-32. 2013
    ..The burden of post-traumatic stress disorder (PTSD) symptoms may be associated with worse outcomes after transplantation. Little is known about the prevalence and correlates of PTSD symptoms in lung transplant recipients...
  25. pmc Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients
    Jianmin Xue
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 191:2089-95. 2013
    ..These findings have implications regarding IPF pathogenesis and illuminate the potential for novel treatment regimens that specifically target B cells in patients with this lung disease. ..
  26. pmc Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3
    Monique Brissett
    University of Pittsburgh, Department of Medicine, Pittsburgh, Pennsylvania 15231, USA
    Arthritis Rheum 64:272-80. 2012
    ....
  27. pmc Plasma inflammatory mediators associated with bone metabolism in COPD
    Jessica M Bon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 7:186-91. 2010
    ..Furthermore, they may be useful in monitoring disease activity, and serve as targets for biological therapy...
  28. pmc A physiologically-motivated compartment-based model of the effect of inhaled hypertonic saline on mucociliary clearance and liquid transport in cystic fibrosis
    Matthew R Markovetz
    Department of Chemical and Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America
    PLoS ONE 9:e111972. 2014
    ..Herein, we present a compartment-based mathematical model of the airway that extends the resolution of functional imaging data...
  29. ncbi request reprint Surgical Strategy for Lung Transplantation in Adults With Small Chests: Lobar Transplant Versus a Pediatric Donor
    Balakrishnan Mahesh
    1 Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 2 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
    Transplantation 100:2693-2698. 2016
    ..Here, we review our experience using LLT and standard lung transplantation using a pediatric donor (PDLT) for adults with small chests...
  30. pmc Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy
    Ryan K Shields
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 55:1308-11. 2011
    ..5 μg/ml were more likely to have successful outcome (P = 0.055). Age ≥ 65 years, oral administration, and absence of proton pump inhibitors were associated with higher levels of posaconazole (P = 0.006, 0.006, and 0.001, respectively)...
  31. doi request reprint Cystic fibrosis pulmonary guidelines: pulmonary complications: hemoptysis and pneumothorax
    Patrick A Flume
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 182:298-306. 2010
    ..There may be intermittent pulmonary exacerbations or acute worsening of infection and obstruction, which require more intensive therapies. Hemoptysis and pneumothorax are complications commonly reported in patients with cystic fibrosis...
  32. pmc Psychiatric Predictors of Long-term Transplant-Related Outcomes in Lung Transplant Recipients
    Emily M Rosenberger
    1 Department of Medicine, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 2 Departments of Psychiatry and Surgery, University of Pittsburgh, Pittsburgh, PA 3 Department of Acute and Tertiary Care Nursing, School of Nursing, University of Pittsburgh, Pittsburgh, PA 4 Department of Surgery, University of Pittsburgh, Pittsburgh, PA 5 Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 6 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 7 Department of Surgery, Temple University, Philadelphia, PA 8 Departments of Psychiatry, Psychology, Epidemiology, Biostatistics, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA
    Transplantation 100:239-47. 2016
    ....
  33. doi request reprint High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment
    Ryan K Shields
    University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 70:246-52. 2011
    ..Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens...
  34. doi request reprint Prolonged Use of the Hemolung Respiratory Assist System as a Bridge to Redo Lung Transplantation
    Christian A Bermudez
    Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Ann Thorac Surg 100:2330-3. 2015
    ..Hemolung support improved the patient's clinical status and allowed redo lung transplantation. ..
  35. pmc Clinical trials of health information technology interventions intended for patient use: unique issues and considerations
    Annette DeVito Dabbs
    aSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Trials 10:896-906. 2013
    ..Despite the proliferation of health information technology (IT) interventions, descriptions of the unique considerations for conducting randomized trials of health IT interventions intended for patient use are lacking...
  36. pmc Liquid hyper-absorption as a cause of increased DTPA clearance in the cystic fibrosis airway
    Timothy E Corcoran
    Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, UPMC MUH NW628, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    EJNMMI Res 3:14. 2013
    ..Here we consider whether the clearance of radiolabeled diethylene triamine pentaacetic acid (DTPA) might be used to detect changes in airway liquid absorption...
  37. pmc Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis
    Ximena D Ruiz
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e43049. 2012
    ..This is the first report describing elevated levels of SDC2 in fibrosis. Increased SDC2 expression is due, at least in part, to the activity of two pro-fibrotic factors, TGFβ and IGFBP-3...
  38. pmc Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study
    Ann Marie Egloff
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Respir Res 13:9. 2012
    ..We sought to define the contribution of GRPR expression in bronchial epithelia to lung cancer risk in a larger case-control study where adjustments could be made for tobacco exposure and sex...
  39. pmc CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema
    Jennifer G McComb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Pathol 173:949-61. 2008
    ..We suggest that one function of the CX3CR1-CX3CL1 pathway is to recruit and sustain divergent immune cell populations implicated in the pathogenesis of cigarette smoke-induced emphysema...
  40. pmc Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    James L Kreindler
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 120:3242-54. 2010
    ..These data provide rationale for a therapeutic trial of vitamin D to prevent or treat ABPA in patients with CF...
  41. pmc Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension
    Eileen Hsu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 63:783-94. 2011
    ....
  42. doi request reprint Experience with immune monitoring in lung transplant recipients: correlation of low immune function with infection
    Shahid Husain
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 87:1852-7. 2009
    ..We report the correlation between Cylex ImmuKnow (ng/mL ATP) values and various infectious syndromes in a large prospective cohort of lung transplant recipients...
  43. doi request reprint Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: long-term survival
    Christian A Bermudez
    Division of Cardiothoracic Surgery, Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 87:854-60. 2009
    ..We analyzed outcomes after ECMO use for PGD after lung transplantation at a single center over a 15-year period and assessed long-term survival...
  44. pmc Vitamin D supplementation decreases Aspergillus fumigatus specific Th2 responses in CF patients with aspergillus sensitization: a phase one open-label study
    Nikki Lynn Hue Nguyen
    Division of Infectious Diseases, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA Richard King Mellon Foundation Institute for Pediatric Research, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Asthma Res Pract 1:. 2015
    ..This Phase I clinical trial investigated the safety and effectiveness of daily vitamin D3 supplementation in CF patients with ABPA to reduce allergic responses and ABPA symptoms, and increase serum vitamin D levels...
  45. pmc Quantitative imaging of airway liquid absorption in cystic fibrosis
    Landon W Locke
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Eur Respir J 44:675-84. 2014
    ..However, mucus effects become negligible in the presence of an osmotic stimulus. Functional imaging of DTPA absorption provides a quantifiable marker of immediate response to treatments that promote airway surface liquid hydration...
  46. pmc Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation
    Kong Chen
    Richard King Mellon Foundation Institute for Pediatric Research, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center UPMC, Pittsburgh, Pennsylvania, USA
    JCI Insight 1:. 2016
    ..In an acute P. aeruginosa lung infection murine model, BET inhibition decreased inflammation, without exacerbating infection, suggesting that BET inhibition may be a potential therapeutic target in patients with CF...
  47. pmc Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses
    Rehan A Kahloon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:768-75. 2013
    ..Diverse autoantibodies are present in most patients with idiopathic pulmonary fibrosis (IPF). We hypothesized that specific autoantibodies may associate with IPF manifestations...
  48. pmc Role of insulin-like growth factor binding protein-3 in allergic airway remodeling
    Kristen L Veraldi
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 180:611-7. 2009
    ....
  49. pmc Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia
    Fei Sun
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 22:3255-63. 2008
    ..Thus, PTD-mediated DeltaFRD fragment delivery may provide a therapy for CF...
  50. doi request reprint Postdeposition dispersion of aerosol medications using surfactant carriers
    Amy L Marcinkowski
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Aerosol Med Pulm Drug Deliv 21:361-70. 2008
    ..3, 1.9-fold increases; p = 0.03, 0.003). Surfactant carriers enhanced dispersion after aerosol deposition onto model airway surfaces, and may improve the efficacy of inhaled preparations such as inhaled antibiotics for cystic fibrosis...
  51. doi request reprint Lung Transplantation for Cystic Fibrosis
    Matthew R Morrell
    Lung Transplant Program, University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Clin Chest Med 37:127-38. 2016
    ....
  52. doi request reprint Post-transplant colonization with non-Aspergillus molds and risk of development of invasive fungal disease in lung transplant recipients
    Fernanda P Silveira
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15237, USA
    J Heart Lung Transplant 27:850-5. 2008
    ..The clinical significance and risk of progression to invasive disease of the non-Aspergillus molds from the bronchoalveolar lavage (BAL) of lung transplant (LTx) recipients are not known...
  53. pmc Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1
    Philip M Bauer
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cardiovasc Res 93:682-93. 2012
    ..In this study, we investigated the role activated CD47 plays in promoting PAH...
  54. pmc The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis
    Jianmin Xue
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e14715. 2011
    ..We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be present in IPF patients...
  55. pmc Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis
    Mike M Myerburg
    Division of Pulmonary, Allergy, and Critical Care Medicine, Univ of Pittsburgh Medical Center, 628 NW Montefiore Univ Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 294:L932-41. 2008
    ....
  56. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  57. pmc IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    Shean J Aujla
    Children s Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:275-81. 2008
    ..These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites...
  58. ncbi request reprint Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation
    Kenneth R Hallows
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Biol Chem 281:4231-41. 2006
    ..We propose that therapies to activate AMPK in the CF airway may be beneficial in reducing excessive airway inflammation, a major cause of CF morbidity...
  59. ncbi request reprint Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis
    Mike M Myerburg
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:27942-9. 2006
    ....
  60. ncbi request reprint Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin
    Kashif Raza
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 26:862-4. 2007
    ..We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diagnosed by polymerase chain reaction, and treated with intravenous ribavirin with a successful outcome...
  61. pmc Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
    Joseph M Pilewski
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Montefiore 628 NW, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Pathol 166:399-407. 2005
    ..Taken together, our results suggest that IGFBPs play an important role in the development of fibrosis in IPF...
  62. ncbi request reprint Finally, mice with CF lung disease
    Raymond A Frizzell
    Nat Med 10:452-4. 2004
  63. ncbi request reprint Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model
    Shruti M Phadke
    Division of Pediatric Pulmonology, The Children s Hospital of Pittsburgh, 3705 Fifth Avenue, 15213, Pittsburgh, PA, USA
    Peptides 24:1099-107. 2003
    ..Overall, eLLPs are selectively toxic to bacteria and may be useful against CF airway infections...
  64. pmc Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
    Wen Ning
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 101:14895-900. 2004
    ..Our study represents the first comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers and reveals previously unreported candidate genes that may serve as potential molecular targets in COPD...
  65. ncbi request reprint Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD
    Wen Ning
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Montefiore NW 628, 3459 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:466. 2006
  66. pmc Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration
    Hidekata Yasuoka
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Pathol 169:1633-42. 2006
    ..Thus, the IGFBP-5-induced fibrotic phenotype in vivo may represent a novel model to better understand the pathogenesis of fibrosis...
  67. ncbi request reprint Molecular and functional properties of lung SP cells
    Susan D Reynolds
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, USA
    Am J Physiol Lung Cell Mol Physiol 292:L972-83. 2007
    ..We conclude that the SP phenotype is common to clonogenic cells at multiple airway locations and suggest that Hoechst efflux is a property of cells expressing a wound-repair phenotype...
  68. ncbi request reprint Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
    James B Bruns
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 282:6153-60. 2007
    ..Our results suggest that multiple proteases cleave ENaC gamma subunits to fully activate the channel...
  69. ncbi request reprint Hepatocyte growth factor and other fibroblast secretions modulate the phenotype of human bronchial epithelial cells
    Mike M Myerburg
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1352-60. 2007
    ..These results provide a model to study fibroblast modulation of epithelial phenotype and indicate that HGF secreted by subepithelial fibroblasts contributes to HBE cell differentiation...
  70. ncbi request reprint Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 179:2592-9. 2007
    ..Recognition that an autoreactive immune process is present in IPF can productively focus efforts toward identifying the responsible Ag, and implementing more effective therapies...
  71. pmc Autoantibodies in patients with chronic obstructive pulmonary disease
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:156-63. 2008
    ..Adaptive immune responses are present in patients with chronic obstructive pulmonary disease (COPD), and it has been postulated that these processes could be autoreactive...
  72. ncbi request reprint Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel
    Marcelo D Carattino
    Renal Electrolyte Division, University of Pittsburgh, S931 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 294:F47-52. 2008
    ..Our findings suggest that this eight-residue tract is a key conserved inhibitory domain that provides epithelial cells with a reserve of inactive channels that can be activated as required by proteases...
  73. ncbi request reprint Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5
    Robert W Walters
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 277:23709-13. 2002
    ..Thus, O-linked carbohydrates of mucin are potent inhibitors of AAV4. Furthermore, whereas mucin plays an important role in innate host defense, its activity is specific; some vectors or pathogens are more resistant to its effects...
  74. pmc Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
    Florencia McAllister
    Lung Immunology and Host Defense Laboratory, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:404-12. 2005
    ..aeruginosa. IL-23 and the downstream cytokines IL-17A and IL-17F are critical molecules for proinflammatory gene expression in HBE cells and are likely involved in the proinflammatory cytokine network involved with CF pathogenesis...