JAY PETTEGREW

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Molecular insights into neurodevelopmental and neurodegenerative diseases
    J W Pettegrew
    Department of Psychiatry, School of Medicine, Neurophysics Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res Bull 53:455-69. 2000
  2. ncbi request reprint Brain metabolic effects of acute nicotine
    J W Pettegrew
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Neurochem Res 26:181-5. 2001
  3. ncbi request reprint Effects of chronic lithium administration on rat brain phosphatidylinositol cycle constituents, membrane phospholipids and amino acids
    J W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 3:189-201. 2001
  4. ncbi request reprint Brain membrane phospholipid alterations in Alzheimer's disease
    J W Pettegrew
    Department of Psychiatry School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Neurochem Res 26:771-82. 2001
  5. ncbi request reprint 31P-MRS study of acetyl-L-carnitine treatment in geriatric depression: preliminary results
    Jay W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 4:61-6. 2002
  6. ncbi request reprint Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B 28, 4201 St Antoine Street, Detroit, MI 48201, USA
    Psychiatry Res 148:217-21. 2006
  7. ncbi request reprint Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies
    Pravat K Mandal
    Neurophysics Laboratory, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neurochem Res 29:2267-72. 2004
  8. ncbi request reprint Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats
    Joseph Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 8:65-74. 2005
  9. ncbi request reprint Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment
    Pravat K Mandal
    Laboratory of Neurophysics, Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA
    Neurochem Res 29:447-53. 2004
  10. ncbi request reprint Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Biol Psychiatry 52:823-30. 2002

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Molecular insights into neurodevelopmental and neurodegenerative diseases
    J W Pettegrew
    Department of Psychiatry, School of Medicine, Neurophysics Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res Bull 53:455-69. 2000
    ....
  2. ncbi request reprint Brain metabolic effects of acute nicotine
    J W Pettegrew
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Neurochem Res 26:181-5. 2001
    ..These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects...
  3. ncbi request reprint Effects of chronic lithium administration on rat brain phosphatidylinositol cycle constituents, membrane phospholipids and amino acids
    J W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 3:189-201. 2001
    ..This study examines lithium effects on rat brain metabolites associated with the above systems and their reversal by myo-inositol...
  4. ncbi request reprint Brain membrane phospholipid alterations in Alzheimer's disease
    J W Pettegrew
    Department of Psychiatry School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Neurochem Res 26:771-82. 2001
    ..The present findings could possibly contribute to an abnormal membrane repair in AD brains which ultimately results in synaptic loss and the aggregation of A beta peptide...
  5. ncbi request reprint 31P-MRS study of acetyl-L-carnitine treatment in geriatric depression: preliminary results
    Jay W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 4:61-6. 2002
    ....
  6. ncbi request reprint Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B 28, 4201 St Antoine Street, Detroit, MI 48201, USA
    Psychiatry Res 148:217-21. 2006
    ..No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD...
  7. ncbi request reprint Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies
    Pravat K Mandal
    Neurophysics Laboratory, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neurochem Res 29:2267-72. 2004
    ....
  8. ncbi request reprint Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats
    Joseph Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Int J Neuropsychopharmacol 8:65-74. 2005
    ..The precise mechanism by which ALCAR decreases anxiety-like behaviour after peripheral administration remains to be determined...
  9. ncbi request reprint Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment
    Pravat K Mandal
    Laboratory of Neurophysics, Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA
    Neurochem Res 29:447-53. 2004
    ..but that ganglioside GT1b does not bind Abeta. Plausible pathways for the involvement of gangliosides in amyloidogenesis are discussed...
  10. ncbi request reprint Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Biol Psychiatry 52:823-30. 2002
    ..To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects...
  11. ncbi request reprint Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
    Robert A Sweet
    Department of Psychiatry, Division of Geriatrics, Neuropsychiatry, University of Pittsburgh School of Medicine, PA, USA
    Neurobiol Aging 23:547-53. 2002
    ..Although AD+P has been inconsistently associated with more severe neuropathology, no prior studies have examined measures of neuronal and synaptic integrity...
  12. pmc Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy study
    Jeffrey A Stanley
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
    Schizophr Res 93:23-32. 2007
    ....

Research Grants4

  1. IN VIVO 31P-1H MRSI/MRI OF CHRONIC SCHIZOPHRENIA
    JAY PETTEGREW; Fiscal Year: 2003
    ....
  2. IN VIVO 31P-1H MRSI AND MRI BRAIN STUDIES OF NICOTINE
    JAY PETTEGREW; Fiscal Year: 2004
    ..We propose to investigate these aspects of brain metabolism in humans using 31P-1H MRSI. ..
  3. Molecular Neurodevelopment: An In Vivo 31P-1H MRSI Study
    JAY PETTEGREW; Fiscal Year: 2006
    ..Longitudinal 31P-1H MRSI and single voxel 1H MRS follow-up of the subjects yearly for 4 years after entry into study will be used to generate neurodevelopmental curves for brain/metabolic measures. ..
  4. Molecular Studies of Cognition in Chronic Alcoholism
    Jay W Pettegrew; Fiscal Year: 2010
    ..abstract_text> ..