Richard A Perugini
Affiliation: University of Massachusetts Medical School
- Metabolic characterization of nondiabetic severely obese patients undergoing Roux-en-Y gastric bypass: preoperative classification predicts the effects of gastric bypass on insulin-glucose homeostasisRichard A Perugini
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gastrointest Surg 11:1083-90. 2007..Whereas gastric bypass cures insulin resistance and diabetes mellitus, its effects on normal physiology have not been described. We studied insulin resistance and beta-cell function for patients undergoing gastric bypass...
- Predictors of complication and suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass: a series of 188 patientsRichard A Perugini
Department of Surgery and the Informatics Unit, University of Massachusetts Medical School, Worcester 01655, USA
Arch Surg 138:541-5; discussion 545-6. 2003..An analysis of patients undergoing laparoscopic Roux-en-Y gastric bypass (RYGB) may identify factors predictive of complication and of suboptimal weight loss...
- Remission of type 2 diabetes mellitus following bariatric surgery: review of mechanisms and presentation of the concept of 'reversibility'Richard A Perugini
Department of Surgery, University of Massachusetts Medical Center, Worcester, Massachusetts 01655 0333, USA
Curr Opin Endocrinol Diabetes Obes 18:119-28. 2011..Roux-en-Y gastric bypass (RYGB) leads to remission of type 2 diabetes mellitus (T2DM) in a majority of patients. This is prompting investigation of RYGB, and other bariatric operations as interventional therapies for T2DM...
- Reduced heart rate variability correlates with insulin resistance but not with measures of obesity in population undergoing laparoscopic Roux-en-Y gastric bypassRichard A Perugini
University of Massachusetts Memorial Health Care, Worcester, Massachusetts, USA
Surg Obes Relat Dis 6:237-41. 2010..We sought to identify the factors predictive of HRV in a severely obese population of undergoing GB at a university hospital in the United States...
- Predictors of weight status following laparoscopic gastric bypassYunsheng Ma
Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Obes Surg 16:1227-31. 2006..Weight loss after bariatric surgery varies and depends on many factors, such as time elapsed since surgery, baseline weight, and co-morbidities...
- Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesityOlga T Hardy
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Surg Obes Relat Dis 7:60-7. 2011..We sought to identify the molecular pathways that might cause obesity-associated insulin resistance in humans by studying the morbidly obese who were insulin sensitive versus insulin resistant, thereby eliminating obesity as a variable...
- Small-bowel obstruction after laparoscopic Roux-en-Y gastric bypass surgeryGowthaman Gunabushanam
Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA
J Comput Assist Tomogr 33:369-75. 2009..The purpose of this study was to review the etiology and computed tomography (CT) findings of small-bowel obstruction (SBO) in patients who have undergone bariatric laparoscopic Roux-en-Y gastric bypass (LGBP) surgery...
- Use of laparoscopy in evaluation and treatment of penetrating and blunt abdominal injuriesGordie K Kaban
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Surg Innov 15:26-31. 2008..Use of laparoscopy in selected patients with blunt and penetrating abdominal trauma is safe, minimizes nontherapeutic laparotomies, and allows for minimal invasive management of selected intra-abdominal injuries...
- Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesityOlga Gealekman
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01615, USA
Circulation 123:186-94. 2011..The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish whether there is a relationship between obesity, metabolic status, and the angiogenic properties of these depots...
- Feasibility of laparoscopic adrenalectomy for large adrenal massesYuri W Novitsky
Department of Surgery, University of Massachusetts Medical School, Worcester, USA
Surg Laparosc Endosc Percutan Tech 13:106-10. 2003..Both right and left large adrenal masses can be approached laparoscopically with equal success. The role of minimally invasive approaches to adrenal malignancies necessitates further investigation...
- Immunologic effects of hand-assisted surgery on peritoneal macrophages: comparison to open and standard laparoscopic approachesYuri W Novitsky
Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Ste H1 760, Worcester, MA 01655, USA
Surgery 139:39-45. 2006..Although laparoscopy (L) is known to elicit a smaller attenuation of peritoneal host defenses, compared with open (O) surgery, effects of the hand-assisted (HA) approach have not been investigated to date...
- The presence of Helicobacter pylori is not associated with long-term anastomotic complications in gastric bypass patientsJohn J Kelly
Division of General, Minimally Invasive, and Bariatric Surgery, Department of Surgery, University of Massachusetts Medical Center, 55 Lake Ave N, H1 760, Worcester, MA, 01655, USA
Surg Endosc 29:2885-90. 2015..However, evidence to support a causal relationship between preoperative H. pylori status and postoperative anastomotic ulceration is weak...
- Cidea is associated with lipid droplets and insulin sensitivity in humansVishwajeet Puri
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 105:7833-8. 2008..The data support a model whereby failure of this pathway results in ectopic lipid accumulation, insulin resistance, and its associated comorbidities in humans...
- Activated Kupffer cells inhibit insulin sensitivity in obese miceMichaela Tencerova
Program in Molecular Medicine, Department of Surgery, and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
FASEB J 29:2959-69. 2015..Importantly, GeRPs had no detectable toxic effect. Thus, KCs are key contributors to hepatic insulin resistance in obesity and a potential therapeutic target for metabolic disease...