Genomes and Genes
Ruth G Perez
Affiliation: University of Pittsburgh
- Could a loss of alpha-synuclein function put dopaminergic neurons at risk?Ruth G Perez
Department of Neurology, University of Pittsburgh, BST South S 510, Pittsburgh, PA 15213, USA
J Neurochem 89:1318-24. 2004..This review focuses on how a loss of normal alpha-synuclein function may contribute to the dopamine-related loss of substantia nigra neurons during Parkinson's disease pathogenesis...
- Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout miceTshianda N M Alerte
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
Neurosci Lett 435:24-9. 2008..These findings have implications not only for normal alpha-Syn function in TH regulation, but also for measuring cell loss that is associated with synucleinopathy...
- Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cellsEva Lin
Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosci Res 86:108-17. 2008....
- A role for alpha-synuclein in the regulation of dopamine biosynthesisRuth G Perez
Department of Neurology and Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 22:3090-9. 2002..If so, a loss of soluble alpha-synuclein, by reduced expression or aggregation, could increase dopamine synthesis with an accompanying increase in reactive dopamine metabolites...
- Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivoHaiyan Lou
Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 285:17648-61. 2010..These findings extend our understanding of normal a-Syn biology and have implications for the dopamine dysfunction of Parkinson disease...
- Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cellsXiangmin Peng
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Cell Sci 118:3523-30. 2005..Together the data reveal a functional interaction between alpha-synuclein and PP2A that leads to PP2A activation and underscores a key role for alpha-synuclein in protein phosphorylation...
- Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cellsRoya Tehranian
Department of Neurology, University of Pittsburgh, School of Medicine, Pitttsburgh, Pennsylvania 15213, USA
J Neurochem 99:1188-96. 2006..These novel findings further support a role for alpha-synuclein in dopamine homeostasis and may explain, at least in part, the selective vulnerability of dopamine neurons that occurs in PD...
- Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEKSusana D Ugarte
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci Res 73:105-12. 2003..These studies suggest that GDNF can protect dopaminergic cells against some but not all aspects of 6-OHDA-induced toxicity by acting through both PI3K and MAPK signaling pathways...
- Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic functionKaitlin F Farrell
Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Neurochem 128:536-46. 2014..Collectively, the data identify an excellent model in which to screen compounds for their ability to block the spread of α-synuclein pathology associated with pre-motor stages of PD...
- 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expressionQinghua Liang
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci Res 77:747-61. 2004....
- Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?Michael J Zigmond
Department of Neurology, University of Pittsburgh, 5517 Biomedical Science Tower, Pittsburgh, PA 15213, USA
Parkinsonism Relat Disord 8:389-93. 2002..We suggest that PD is associated with an increase in dopamine turnover, which may not only reduce the immediate symptoms of the disease but also contribute to its progression...
- α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretionXuehui Geng
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
Am J Physiol Endocrinol Metab 300:E276-86. 2011..Synuclein might play similar roles in diabetes as it does in other degenerative diseases, including Alzheimer's and Parkinson's diseases...
- The endocytotic pathway is required for increased A beta 42 secretion during apoptosisChhinder P Sodhi
Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Brain Res Mol Brain Res 128:201-11. 2004..We demonstrate additionally that more A beta 40 apparently is generated in secretory compartments during apoptosis when APP processing by the endocytotic pathway is impaired...
- Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosisChhinder P Sodhi
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Brain Res 1198:204-12. 2008..These results are consistent with APP cytoplasmic-tail phosphorylation at T668 during apoptosis as contributory to increased Abeta42 secretion originating from the endocytotic pathway, likely with cell-line restriction...