M A Perera
Affiliation: University of Chicago
- The missing linkage: what pharmacogenetic associations are left to find in CYP3A?Minoli A Perera
University of Chicago, Section of Genetic Medicine and Committee on Clinical Pharmacology and Pharmacogenomics, Division of Biological Sciences, Department of Medicine, Chicago, IL 60637, USA
Expert Opin Drug Metab Toxicol 6:17-28. 2010....
- Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitutionAshraf G Madian
Committee of Clinical Pharmacology and Pharmacogenomics, The University of Chicago, Chicago, IL, USA
BMC Pharmacol Toxicol 15:69. 2014..We report the case of a pediatric patient having an inability to achieve a therapeutic trough level for tacrolimus after conversion from brand name to the generic formulation...
- Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African AmericansM A Perera
Committee on Clinical Pharmacology and Pharmacogenomics, Division of Biological Sciences, University of Chicago, Chicago, IL, USA
Pharmacogenomics J 9:49-60. 2009..This study marks the first systematic evaluation of coding and noncoding variation that may contribute to CYP3A phenotypic variability...
- The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African AmericansM A Perera
Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, Illinois, USA
Clin Pharmacol Ther 89:408-15. 2011..Our regression model, encompassing both genetic and clinical variables, explained 40% of the variability in warfarin dose in African-American subjects, significantly more than any model thus far...
- Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?Minoli A Perera
Sections of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
Pharmacotherapy 28:755-68. 2008..In addition, ethical and logistic implications of pharmacogenetic testing exist...
- African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunityJames P Lodolce
Department of Medicine, University of Chicago, Chicago, IL 60612, USA
J Immunol 184:7001-9. 2010..This is the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americans...