C David Pauza

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Attenuated disease in SIV-infected macaques treated with a monoclonal antibody against FasL
    Maria S Salvato
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Clin Dev Immunol 2007:93462. 2007
  2. pmc Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells
    David J Riedel
    Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    AIDS 23:1955-64. 2009
  3. ncbi request reprint Effects of virus burden and chemokine expression on immunity to SHIV in nonhuman primates
    Paul M Waterman
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA
    Viral Immunol 17:545-57. 2004
  4. pmc Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cells
    Elizabeth M Urban
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Immunol 10:50. 2009
  5. pmc Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement
    Amudhan Maniar
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, USA
    Blood 116:1726-33. 2010
  6. pmc Innate-like gammadelta T cell responses to mycobacterium Bacille Calmette-Guerin using the public V gamma 2 repertoire in Macaca fascicularis
    Cristiana Cairo
    University of Maryland School of Medicine, Institute of Human Virology, 725 W Lombard St, Baltimore, MD 21201, USA
    Tuberculosis (Edinb) 87:373-83. 2007
  7. pmc Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS
    Jean Saville Cummings
    Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St, N546, Baltimore, MD 21201, USA
    J Leukoc Biol 84:371-9. 2008
  8. pmc Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Clin Immunol 128:349-57. 2008
  9. pmc Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus
    Bhawna Poonia
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 114:1196-204. 2009
  10. pmc Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Antiviral Res 92:125-38. 2011

Collaborators

Detail Information

Publications47

  1. pmc Attenuated disease in SIV-infected macaques treated with a monoclonal antibody against FasL
    Maria S Salvato
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Clin Dev Immunol 2007:93462. 2007
    ..By blocking FasL during only the first few weeks after infection, we attenuated SIVmac disease and increased the life span for infected and treated macaques...
  2. pmc Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells
    David J Riedel
    Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    AIDS 23:1955-64. 2009
    ..To evaluate Vgamma2Vdelta2 T cells in a group of HIV-infected patients who suppress HIV replication without antiretroviral therapy (natural viral suppressors, NVSs)...
  3. ncbi request reprint Effects of virus burden and chemokine expression on immunity to SHIV in nonhuman primates
    Paul M Waterman
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA
    Viral Immunol 17:545-57. 2004
    ..6) nef-deleted vaccination, likely reflects differences in replication capacity. The protective effect of nef-deleted virus was partly restored by expressing Type 1 chemokines to augment viral immunity...
  4. pmc Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cells
    Elizabeth M Urban
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Immunol 10:50. 2009
    ..Our goal was to show whether CD56 expression was regulated stochastically, similar to conventional activation antigens, or whether CD56 defined a lineage of cells committed to the cytotoxic phenotype...
  5. pmc Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement
    Amudhan Maniar
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, USA
    Blood 116:1726-33. 2010
    ..Our data reveal a novel function of human γδ T lymphocytes in the regulation of NK cell-mediated cytotoxicity and provide rationale for the use of strategies to manipulate the CD137 pathway to augment innate antitumor immunity...
  6. pmc Innate-like gammadelta T cell responses to mycobacterium Bacille Calmette-Guerin using the public V gamma 2 repertoire in Macaca fascicularis
    Cristiana Cairo
    University of Maryland School of Medicine, Institute of Human Virology, 725 W Lombard St, Baltimore, MD 21201, USA
    Tuberculosis (Edinb) 87:373-83. 2007
    ..The unusual composition of a normal V gamma 2 repertoire helps to explain the powerful gammadelta T cell responses to BCG immunization...
  7. pmc Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS
    Jean Saville Cummings
    Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St, N546, Baltimore, MD 21201, USA
    J Leukoc Biol 84:371-9. 2008
    ..Changes in Vgamma2Vdelta2 T cells, along with concomitant effects on NK and NKT cells that also contribute to tumor surveillance, may be important factors for elevating the risk of malignancy during AIDS...
  8. pmc Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Clin Immunol 128:349-57. 2008
    ..2Vdelta2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV...
  9. pmc Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus
    Bhawna Poonia
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 114:1196-204. 2009
    ..Anti-FasL treatment during the initial stages of acute SIV infection preserved the T-cell compartment and sustained cell-mediated immunity to SIV...
  10. pmc Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Antiviral Res 92:125-38. 2011
    ..By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets...
  11. pmc Sequence variation within the dominant amino terminus epitope affects antibody binding and neutralization of human immunodeficiency virus type 1 Tat protein
    Tracy J Ruckwardt
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 W Lombard St, Room N546, Baltimore, MD 21201, USA
    J Virol 78:13190-6. 2004
    ..Tat-neutralizing antibodies to the dominant amino terminus epitope are affected by HIV clade variation...
  12. pmc Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever
    Juan D Rodas
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Med Virol 72:424-35. 2004
    ..Cross protection between the two strains was observed. The three out of seven monkeys that experienced protection were also the three with the strongest cell-mediated immunity...
  13. pmc High cancer-related mortality in an urban, predominantly African-American, HIV-infected population
    David J Riedel
    Institute of Human Virology and Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    AIDS 27:1109-17. 2013
    ..To determine mortality associated with a new cancer diagnosis in an urban, predominantly African-American, HIV-infected population...
  14. pmc An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
    Virol J 10:52. 2013
    ..However, since the LHF endemic area of West Africa also has high HIV seroprevalence, it is important to determine whether vaccination could be safe in the context of HIV infection...
  15. pmc Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells
    Elizabeth M Urban
    Institute of Human Virology, University of Maryland, School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Clin Dev Immunol 2010:732893. 2010
    ..Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy...
  16. pmc Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells
    Haishan Li
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    J Infect Dis 195:37-45. 2007
    ..Increased VV replication or expression in the absence of gammadelta T cell responses might contribute to its potency as a vaccine against poxvirus and recombinant antigens...
  17. doi request reprint Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity
    Bhawna Poonia
    Division of Basic Science and Vaccine Research, Institute of Human Virology, Baltimore, Maryland, USA
    Cytotherapy 14:173-81. 2012
    ..We investigated whether zoledronate/interleukin (IL)-2 could expand cytotoxic Vδ2 cells from HIV+ donors and whether these cells functioned in ADCC...
  18. pmc Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    Cancer Immunol Immunother 56:819-29. 2007
    ..Our studies further justify efforts to stimulate tumor immunity by administering low molecular weight phosphoantigens and boosting the frequency and tumor effector functions of circulating Vgamma2Vdelta2 T cells...
  19. pmc Role of the Fas/FasL pathway in HIV or SIV disease
    Bhawna Poonia
    Institute of Human Virology, University of Maryland, School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, USA
    Retrovirology 6:91. 2009
    ..This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease...
  20. pmc Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15
    Cristiana Cairo
    Institute of Human Virology, University of Maryland Baltimore, Baltimore, MD, USA
    Immunology 138:346-60. 2013
    ..Selection was similar using IL-2 or myeloid-derived IL-15. The Vγ2Vδ2 T cells present in neonates are capable of generating potent immune responses even when relying on IL-15...
  21. pmc TNF-alpha is a positive regulatory factor for human Vgamma2 Vdelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:7131-7. 2008
    ..Our studies demonstrate that TNF-alpha plays a critical role in regulating human Vgamma2 Vdelta2 T cell immune responses...
  22. pmc Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma
    Alan A Z Alexander
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, MD 21201, USA
    Clin Cancer Res 14:4232-40. 2008
    ..CD56 is also expressed on a subset of gammadelta T cells. However, antitumor effector functions of CD56(+) gammadelta T cells are poorly characterized...
  23. pmc Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells
    Sarah Boudová
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 205:1448-55. 2012
    ..By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia...
  24. pmc Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Retrovirology 10:60. 2013
    ..The outcomes of Env binding are analyzed in terms of signal transduction and the effects on cell activation or cell death pathways...
  25. pmc HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 118:5824-31. 2011
    ..Cell death was increased by antigen stimulation after exposure to envelope glycoprotein. Direct signaling by envelope glycoprotein killed CD4-negative γδ T cells and reproduced a defect observed in all patients with HIV disease...
  26. pmc Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e7726. 2009
    ..Their effects on gammadelta T cells, which are involved in animal model and human and animal autoimmune diseases, are unknown...
  27. pmc Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys
    Carl O Deetz
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Infect Immun 74:4505-11. 2006
    ..A functional TLR2 that requires coincident TCR stimulation may increase the initial potency of Vgamma2Vdelta2 T-cell responses at the site of infection and promote the rapid development of subsequent acquired antipathogen immunity...
  28. pmc Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism
    Yida Yang
    Institute of Human Virology, University of Maryland Biotechnology Center, Baltimore, Maryland 21201, USA
    J Virol 77:6700-8. 2003
    ..Remarkably, uninfected T cells are more susceptible to TRAIL than are HIV-infected T cells. The production of TRAIL by Tat-stimulated monocytes provides a mechanism by which HIV infection can destroy uninfected bystander cells...
  29. pmc Vdelta2 T-lymphocyte responses in cord blood samples from Italy and Côte d'Ivoire
    Cristiana Cairo
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunology 124:380-7. 2008
    ..Neonatal Vdelta2 T lymphocytes may be important participants in responses to microbial infections early in life...
  30. pmc Impact of age, gender, and race on circulating γδ T cells
    Cristiana Cairo
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Immunol 71:968-75. 2010
    ....
  31. pmc The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus
    Mahmoud Djavani
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard St, Baltimore, MD 21201, USA
    J Virol 79:2461-73. 2005
    ..The interaction of an arenavirus with a homeodomain protein suggests a mechanism for viral teratogenic effects and for the tissue-specific manifestations of arenavirus disease...
  32. pmc Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
    Haishan Li
    Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St Rm N546, Baltimore, MD 21201, USA
    Cancer Immunol Immunother 60:361-70. 2011
    ..Rapamycin treatment during antigen-stimulation of Vγ2Vδ2 T cells may be a strategy for overcoming current obstacles in tumor immunotherapy...
  33. pmc Early blood profiles of virus infection in a monkey model for Lassa fever
    Mahmoud M Djavani
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard St, Baltimore, MD 21201, USA
    J Virol 81:7960-73. 2007
    ..Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease...
  34. pmc Altered cord blood gammadelta T cell repertoire in Nigeria: possible impacts of environmental factors on neonatal immunity
    Cristiana Cairo
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Mol Immunol 45:3190-7. 2008
    ..Fetal gammadelta T cell depletion might be a mechanism for impaired neonatal immunity and lowered responses to pediatric vaccines...
  35. ncbi request reprint Simian/human immunodeficiency virus(89.6) expressing the chemokine genes MIP-1alpha, RANTES, or lymphotactin
    Paul M Waterman
    Institute of Human Virology, University of Maryland, Biotechnology Institute, Baltimore, Maryland, USA
    Viral Immunol 16:35-44. 2003
    ..SHIV expressing the chemokine genes MIP-1alpha, RANTES, or LTN may help determine the in vivo roles for these chemokines in modulating virus replication and disease...
  36. pmc Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Mol Immunol 10:42-9. 2013
    ..This field is moving toward immune therapies based on targeting Vδ2 cells and we now have clear goals and expectations to guide interventional clinical trials...
  37. pmc High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression
    Bhawna Poonia
    Division of Basic Science and Vaccine Research, Institute of Human Virology, Baltimore, Maryland, United States of America
    PLoS ONE 5:e15562. 2010
    ..Thus, Fc receptors may be important for virus immunity but might also promote immune hyperactivation that would enhance infection...
  38. pmc The γδ T-cell receptor repertoire is reconstituted in HIV patients after prolonged antiretroviral therapy
    Suchita Chaudhry
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    AIDS 27:1557-62. 2013
    ..Determine whether reconstitution of Vγ2Vδ2 T cells in patients with HIV is due to new cell synthesis with recovery of the T-cell receptor repertoire or proliferative expansion of residual cells from the time of treatment initiation...
  39. pmc The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset
    Cristiana Cairo
    Institute of Human Virology, Baltimore, MD 21201, USA
    Immunology 115:197-205. 2005
    ....
  40. ncbi request reprint Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
    Lin Li
    Department of Pathology, Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    Cell Res 15:923-34. 2005
    ....
  41. ncbi request reprint Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment
    Bruce L Gilliam
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    AIDS 21:2108-10. 2007
    ..These results support further clinical evaluation of G1 cytostatic agents such as rapamycin targeting the downregulation of CCR5 expression as a strategy for both the prevention and treatment of HIV infection...
  42. pmc Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation
    Haoting Hsu
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201
    J Immunol 197:1884-92. 2016
    ..PD1 expression by neonatal Vδ2 cells is inversely associated with promoter DNA methylation. Prolonged PD1 expression may be part of a functional program to control Vδ2 cell inflammatory responses during fetal life. ..
  43. ncbi request reprint Association between longer duration of HIV-suppressive therapy and partial recovery of the V gamma 2 T cell receptor repertoire
    Jose Bordon
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Infect Dis 189:1482-6. 2004
    ..Changes in the V gamma 2 TCR repertoire are sensitive measures for the effects of HAART and of residual HIV replication...
  44. pmc Tat-neutralizing antibodies in vaccinated macaques
    Ilia Tikhonov
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Virol 77:3157-66. 2003
    ..Macaques immunized with Tat or Tat toxoid proteins varied in their responses to minor epitopes, but all developed a strong response to the amino terminus, and antisera were capable of neutralizing Tat in a transactivation assay...
  45. pmc CD25(+) Bcl6(low) T follicular helper cells provide help to maturing B cells in germinal centers of human tonsil
    Haishan Li
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Eur J Immunol 45:298-308. 2015
    ..CD25 expression on Tfh cells and local production of IL-2 in tonsil or lymph node may support B helper T-cell function during later stages of B-cell maturation and the development of immune memory. ..
  46. pmc Evolution and function of the TCR Vgamma9 chain repertoire: It's good to be public
    C David Pauza
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA Electronic address
    Cell Immunol 296:22-30. 2015
    ..Cell clones expressing public TCR can accelerate the kinetics of response to pathogens and impact host survival. ..
  47. pmc Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy
    Bhawna Poonia
    Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 9:e88884. 2014
    ..Our initial studies indicate that IL-15 treatment partly reverses the CD56 defect, implying that myeloid cell defects could be targeted for immune therapy during chronic HIV disease. ..