Nitin Patel

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem J 434:473-82. 2011
  2. pmc GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role
    Nitin Patel
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e57843. 2013
  3. pmc Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD)
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 285:16713-22. 2010
  4. pmc Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
  5. pmc Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 285:20570-9. 2010
  6. doi request reprint A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair
    Gabriel M Gordon
    USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California
    Wound Repair Regen 24:89-99. 2016
  7. pmc Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 112:856-65. 2008
  8. pmc Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression
    Nitin Patel
    Institute for Genetic Medicine, University of Southern California, Los Angeles, United States of America
    PLoS ONE 10:e0117758. 2015
  9. pmc Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Pathol 180:2028-39. 2012
  10. pmc Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, United States 2USC Eye Institute Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California
    Invest Ophthalmol Vis Sci 56:2737-48. 2015

Collaborators

  • Stephen G Schwartz
  • PABLO ARGUESO
  • Hooman Allayee
  • Jacek Pinski
  • Jose M Gonzalez
  • Catherine Madigan
  • ShinWu Jeong
  • Gabriel M Gordon
  • M Elizabeth Fini
  • Tatsuo Itakura
  • Adriana J LaGier
  • Aditi Bauskar
  • Corinne Ponchel
  • Janet L Davis
  • Hussein Wafapoor
  • Minako Hijikata
  • Naoto Keicho
  • Xiaoyi Gao
  • Carmen A Puliafito
  • Dennis J Hazelett
  • Alexander M Eaton
  • Gerhard A Coetzee
  • Pei Chang Wu
  • Christopher K Edlund
  • Mathew T Pletcher
  • Harry W Flynn
  • Robert L Avery
  • David V Conti
  • Geeta Lalwani
  • Jaana Hartiala
  • Aaron Martin
  • Dolena R Ledee

Detail Information

Publications10

  1. pmc Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem J 434:473-82. 2011
    ..Finally, plasma levels of miR-30c and miR-301a were significantly down-regulated in patients with SCA compared with normal controls. These results provide a post-transcriptional regulatory mechanism of PlGF-induced PAI-1 elevation...
  2. pmc GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role
    Nitin Patel
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e57843. 2013
    ..Regulated paracellular permeability controls aqueous outflow facility in vivo. Since GCs stimulate GPR158 expression, the result is consistent with a role for elevation of GPR158 expression in GC-induced ocular hypertension...
  3. pmc Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD)
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 285:16713-22. 2010
    ..In conclusion, we identify a novel mechanism of PAI-1 elevation in SCD...
  4. pmc Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
    ..Herein, we identify a mechanism of increased LT in SCD and show HIF-1alpha as a hypoxia-independent target of PlGF. These studies provide new avenues to ameliorate these complications...
  5. pmc Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 285:20570-9. 2010
    ..This study provides a new therapeutic target, namely Egr-1, for attenuation of elevated leukotriene levels in patients with sickle cell disease and other inflammatory diseases...
  6. doi request reprint A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair
    Gabriel M Gordon
    USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California
    Wound Repair Regen 24:89-99. 2016
    ..Anisomycin has not previously been characterized as antifibrotic, thus, this is a novel finding of the study. ..
  7. pmc Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 112:856-65. 2008
    ..PlGF levels are intrinsically elevated from the increased red cell turnover in SCD and in other chronic anemia (eg, thalassemia) and may contribute to inflammation and PHT seen in these diseases...
  8. pmc Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression
    Nitin Patel
    Institute for Genetic Medicine, University of Southern California, Los Angeles, United States of America
    PLoS ONE 10:e0117758. 2015
    ..Our findings strongly suggest that pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of CRPC. ..
  9. pmc Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Pathol 180:2028-39. 2012
    ....
  10. pmc Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, United States 2USC Eye Institute Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California
    Invest Ophthalmol Vis Sci 56:2737-48. 2015
    ..In this study, a pharmacogenomics approach was taken to discover candidate genes for this disorder...