Genomes and Genes
Affiliation: University of Louisville
- Functional variant in the DRD2 receptor promoter region and subtypes of alcoholismA Parsian
Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, KY 40202, USA
Am J Med Genet 96:407-11. 2000..We conclude that the functional and structural variations in DRD2 gene do not play a major role in the development of alcoholism subtypes in our sample...
- Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's diseaseAbbas Parsian
Birth Defects Center, University of Louisville Health Sciences Center, Department of Molecular and Cellular Biology, 501 S Preston Street, Room 301, Louisville, KY 40202, USA
Parkinsonism Relat Disord 10:213-9. 2004..Our data indicate the possibility of linkage disequilibrium between the C270T variation and a mutation in coding region of the BDNF gene and suggest that this gene may play a role in the development of familial PD...
- Association of variations in monoamine oxidases A and B with Parkinson's disease subgroupsA Parsian
Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, 501 S Preston Street, Rm 301, Louisville, KY 40292, USA
Genomics 83:454-60. 2004..The frequency of common haplotypes from MAO-A and -B was different in PD and control group (p = 0.02). Our data indicate that MAO-A and -B may play a role in susceptibility to PD in our sample...
- Functional variation in promoter region of monoamine oxidase A and subtypes of alcoholism: haplotype analysisAbbas Parsian
Birth Defects Center, Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, Louisville, Kentucky, USA
Am J Med Genet B Neuropsychiatr Genet 117:46-50. 2003..After Bonferroni's correction for multiple tests none of the results remained significant at P < 0.05. Our results indicate that MAO-A may play a role in the development of alcoholism but the gene effect is very small...
- Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onsetAbbas Parsian
University of Louisville Birth Defects Center, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
Genomics 79:458-61. 2002..05 level. We conclude that APOE does not play an important role in susceptibility to PD or age at onset of PD, but may play a role in dementia associated with PD in our sample...
- Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholismRashmi Sinha
Birth Defects Center, Department of Molecular and Cellular Biology, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
Am J Med Genet B Neuropsychiatr Genet 121:83-8. 2003..The pattern of distribution of haplotypes was similar in patients and controls. It is concluded that these SNPs are not playing any direct role in the development of susceptibility to alcoholism in our patient sample...
- Prevalence of parkin gene mutations and variations in idiopathic Parkinson's diseaseRashmi Sinha
Department of Pediatrics, UMAS College of Medicine, Little Rock, AR, USA
Parkinsonism Relat Disord 11:341-7. 2005..We concluded that no new mutation, nor the previously described parkin polymorphisms or known mutations, are playing any direct role in the development of PD in this group of PD patients...
- Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD studyMei Sun
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Arch Neurol 63:826-32. 2006..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
- Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson diseaseDemetrius M Maraganore
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
JAMA 296:661-70. 2006..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking...
- The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholismAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Psychiatr Genet 12:1-16. 2002..We conclude that the FH/Wjd rat is a genetic animal model of depression and alcoholism, but that the two measures reflective of these states are under separate genetic controls...
- Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic controlDavid H Overstreet
Department of Psychiatry and Center for Alcohol Studies, University of North Carolina, CB 7178, Chapel Hill, NC 27599 7178, USA
Neurosci Biobehav Rev 31:103-14. 2007..These findings suggest that although depressive-like behavior and high alcohol intake co-occur in the FH/Wjd rat, they are independently regulated...
- Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differencesBiswanath Patra
Department of Pediatrics, University of Arkansas for Medical Sciences, ACHRI, 1120 Marshall Street, Slot 512 40B, Little Rock, AR 72202, USA
Behav Brain Res 177:37-44. 2007..0001) greater effect on forced alcohol intake than the FH father. It is concluded from these analyses that alcohol-related phenotypes are segregating independently and may be influenced by maternal and sex factors...
- Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholismAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychiatr Genet 17:77-83. 2007..Recent comparisons of the parental strains with F1 and F2 intercrosses revealed that the alcohol and saccharin intakes were positively correlated with each other but not with immobility...