Jaume Padilla

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. doi Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, Ind, USA
    J Vasc Res 46:592-600. 2009
  2. pmc Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns
    Jaume Padilla
    Dept of Biomedical Sciences Univ of Missouri, Columbia, 65211, USA
    Am J Physiol Heart Circ Physiol 298:H1128-35. 2010
  3. pmc Identification of genes whose expression is altered by obesity throughout the arterial tree
    Jaume Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri Child Health, University of Missouri, Columbia, Missouri Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
    Physiol Genomics 46:821-32. 2014
  4. pmc Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Eur J Appl Physiol 114:531-44. 2014
  5. ncbi Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1
    J Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    J Physiol Pharmacol 64:557-64. 2013
  6. pmc Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 45:434-46. 2013
  7. pmc Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Regul Integr Comp Physiol 304:R543-52. 2013
  8. pmc Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 98:337-47. 2013
  9. pmc Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis
    Jaume Padilla
    Dept of Biomedical Sciences, E102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 301:H555-64. 2011
  10. pmc Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 96:1019-27. 2011

Collaborators

Detail Information

Publications67

  1. doi Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, Ind, USA
    J Vasc Res 46:592-600. 2009
    ....
  2. pmc Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns
    Jaume Padilla
    Dept of Biomedical Sciences Univ of Missouri, Columbia, 65211, USA
    Am J Physiol Heart Circ Physiol 298:H1128-35. 2010
    ..Future studies should examine the complex interaction between MSNA, arterial blood pressure, and other potential modulatory factors of shear rate patterns...
  3. pmc Identification of genes whose expression is altered by obesity throughout the arterial tree
    Jaume Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri Child Health, University of Missouri, Columbia, Missouri Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
    Physiol Genomics 46:821-32. 2014
    ..These data may serve as an important resource for identifying novel therapeutic targets against obesity-related vascular complications. ..
  4. pmc Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Eur J Appl Physiol 114:531-44. 2014
    ..Indeed, a vast amount of evidence supports the notion that excessive blood pressure and oscillatory shear stress are potent pro-atherogenic signals to the endothelium. ..
  5. ncbi Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1
    J Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    J Physiol Pharmacol 64:557-64. 2013
    ..Together, these findings support the hypothesis that vascular ER stress-mediated activation of ET-1 may be an underlying cause of impaired vasomotor responsiveness to insulin and endothelial dysfunction. ..
  6. pmc Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 45:434-46. 2013
    ..In particular, our results suggest that the oxidized LDL/LOX-1/NF-κB signaling axis may be involved in the early initiation of a juvenile obesity-induced proatherogenic coronary artery phenotype...
  7. pmc Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Regul Integr Comp Physiol 304:R543-52. 2013
    ..Phenotypic differences in PVAT between regions of the aorta may be relevant in light of the evidence in large animals and humans that the abdominal aorta is more vulnerable to atherosclerosis than the thoracic aorta...
  8. pmc Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 98:337-47. 2013
    ..This heterogeneous influence of short-term physical inactivity could be attributed to the distinct alteration in haemodynamic forces between arteries...
  9. pmc Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis
    Jaume Padilla
    Dept of Biomedical Sciences, E102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 301:H555-64. 2011
    ....
  10. pmc Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 96:1019-27. 2011
    ..These results are consistent with the hypothesis that shear stress plays a key role in signalling brachial artery vasodilatation during dynamic leg exercise...
  11. pmc Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Hypertension 57:484-9. 2011
    ....
  12. pmc Long-term exercise training does not alter brachial and femoral artery vasomotor function and endothelial phenotype in healthy pigs
    Jaume Padilla
    Dept of Biomedical Sciences, W102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 299:H379-85. 2010
    ....
  13. pmc Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 6:44. 2008
    ..The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability...
  14. pmc Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats
    Jacqueline M Crissey
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 306:R596-606. 2014
    ..Collectively, we show in OLETF rats that lower adiposity leads to less AT and aortic inflammation, as well as an exercise-specific improvement in insulin-stimulated vasorelaxation...
  15. pmc Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats
    Michael D Roberts
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
    Metabolism 62:1052-6. 2013
    ..We hypothesized that FNDC5 expression would be greater in obese (OLETF) versus lean (LETO) animals...
  16. doi Peripheral circulation
    M Harold Laughlin
    Department of Medical Pharmacology and Physiology, and the Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
    Compr Physiol 2:321-447. 2012
    ....
  17. doi The flow-mediated dilation response to acute exercise in overweight active and inactive men
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, School of Health, Physical Education and Recreation, Indiana University, Bloomington, IN, USA
    Obesity (Silver Spring) 16:578-84. 2008
    ..The aim of this study was to investigate the interaction of IL-6 and TNF-alpha on endothelial function in response to acute exercise in overweight men exhibiting different physical activity profiles...
  18. pmc Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat
    Jeffrey S Martin
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    J Appl Physiol (1985) 113:1223-32. 2012
    ....
  19. pmc Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation
    Grant H Simmons
    E102 Veterinary Medicine Bldg, Univ of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 110:389-97. 2011
    ..9 ± 12.5 s(-1)). We conclude that increased brachial artery retrograde SR at the onset of leg cycling subsequently returns toward baseline values due in part to thermoregulatory cutaneous vasodilation during prolonged exercise...
  20. ncbi The effect of acute exercise on endothelial function following a high-fat meal
    Jaume Padilla
    Department of Kinesiology, Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, IN 47405, USA
    Eur J Appl Physiol 98:256-62. 2006
    ....
  21. ncbi Reproducibility of the flow-mediated dilation response to acute exercise in overweight men
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, School of Health, Physical Education and Recreation, Department of Kinesiology, Indiana University, Bloomington, IN 47404, USA
    Ultrasound Med Biol 33:1579-85. 2007
    ..The findings of the present study support the use of FMD as an outcome variable in response to acute exercise...
  22. pmc Relationship between brachial and femoral artery endothelial vasomotor function/phenotype in pigs
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Exp Biol Med (Maywood) 235:1287-91. 2010
    ....
  23. pmc Ovariectomized Highly Fit Rats Are Protected against Diet-Induced Insulin Resistance
    Young Min Park
    1Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 2Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 3Department of Molecular Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 4Biomedical Sciences, University of Missouri, Columbia, MO 5Child Health, University of Missouri, Columbia, MO 6Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO
    Med Sci Sports Exerc 48:1259-69. 2016
    ....
  24. ncbi Variability of flow-mediated dilation measurements with repetitive reactive hyperemia
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, Indiana 47404, USA
    Vasc Med 11:1-6. 2006
    ..In addition, this study found no time trends for FMD measurements during the 2-h morning period to allow for pre/post intervention FMD measurements...
  25. pmc Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats
    Young Min Park
    1Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 2Child Health, University of Missouri, Columbia, MO 3Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 4Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 5Department of Molecular Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 6Biomedical Sciences, University of Missouri, Columbia, MO
    Med Sci Sports Exerc . 2016
    ..Exercise training mitigates metabolic abnormalities induced by low aerobic fitness, but whether the protective effect is maintained following ovariectomy and HFD is unknown...
  26. pmc Effects of ovariectomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity
    Young Min Park
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Endocrinol Metab 310:E190-9. 2016
    ..HCR rats have greater skeletal muscle, BAT, and WAT insulin-mediated glucose uptake, which may aid in protection against OVX-associated insulin resistance...
  27. pmc Influence of spontaneously occurring bursts of muscle sympathetic nerve activity on conduit artery diameter
    Seth T Fairfax
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Am J Physiol Heart Circ Physiol 305:H867-74. 2013
    ....
  28. pmc Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats
    Nathan T Jenkins
    Department of 1Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 113:1873-83. 2012
    ..Overall, this study indicates that exercise training and metformin have additive influences on adipose tissue secretion and plasma concentrations of leptin and IL-10...
  29. pmc Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans
    Seth T Fairfax
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65212, USA
    Am J Physiol Heart Circ Physiol 304:H759-66. 2013
    ....
  30. doi Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
    Am J Physiol Heart Circ Physiol 297:H1103-8. 2009
    ..Further efforts are needed to determine if this apparent protection of the leg vasculature against an acute hydrostatic challenge is attributable to posture-induced chronic adaptations...
  31. doi Characterization of the brachial artery shear stress following walking exercise
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Vasc Med 13:105-11. 2008
    ..0001) which was abolished after 2 hours. Thus, we found that brachial artery SS is greatest following high-intensity walking and that the rate of decline in SS is similar across all walking intensities...
  32. pmc Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression
    Young Min Park
    Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    Physiol Behav 164:383-9. 2016
    ..We recently demonstrated that HCR are not immune to ovariectomy (OVX)-associated reductions in spontaneous cage (i.e. locomotor) activity. Whether HCR and LCR rats differ in their OVX-mediated voluntary wheel running response is unknown...
  33. doi Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats
    Jaume Padilla
    1 Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA
    Exp Biol Med (Maywood) . 2017
    ..These findings support the notion that vascular gene regulation in response to oral pharmacological therapy, such as metformin, is vessel specific...
  34. pmc Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats
    M Harold Laughlin
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri Biomedical Sciences, University of Missouri, Columbia, Missouri Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    J Appl Physiol (1985) 119:604-16. 2015
    ..Finally, results indicate that the 2a arterioles of soleus muscle (S2a) from endurance-trained animals and the DFA of SPRINT animals exhibited the largest number of genes with altered expression. ..
  35. pmc Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs
    Victoria J Vieira-Potter
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
    Obesity (Silver Spring) 23:2421-9. 2015
    ..The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here...
  36. pmc Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity
    Ryan G Toedebusch
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Physiol Genomics 46:362-75. 2014
    ....
  37. doi Heterogeneity of endothelial cell phenotype within and amongst conduit vessels of the swine vasculature
    Grant H Simmons
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Exp Physiol 97:1074-82. 2012
    ..Importantly, even straight vessel segments from systemic conduit arteries (e.g. brachial and carotid arteries) exhibited regional phenotypic heterogeneity; a finding not expected on the basis of local haemodynamic forces alone...
  38. doi The exercise dose affects oxidative stress and brachial artery flow-mediated dilation in trained men
    Blair D Johnson
    Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Eur J Appl Physiol 112:33-42. 2012
    ..4 vs. 7.6 ± 2.7%). These data suggest that acute exercise-induced TBARS are exercise intensity-dependent whereas FMD appears to improve following energy expenditure equivalent to 30 min 50% VO(2peak), regardless of intensity or duration...
  39. pmc Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model?
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 5:45. 2007
    ....
  40. ncbi A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Clin Sci (Lond) 110:387-92. 2006
    ..18+/-1.13%) treatment. In conclusion, the measurement of brachial artery vasodilation in response to active hyperaemia did not detect a change in endothelial function following a single perturbation meal, whereas reactive hyperaemia did...
  41. pmc Ablation of eNOS does not promote adipose tissue inflammation
    Thomas J Jurrissen
    Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 310:R744-51. 2016
    ..Collectively, these findings do not support the hypothesis that reduced NO production from eNOS contributes to obesity-related AT inflammation. ..
  42. pmc Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats
    M Harold Laughlin
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri Biomedical Sciences, University of Missouri, Columbia, Missouri Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    J Appl Physiol (1985) 119:583-603. 2015
    ..We conclude that training-induced changes in arteriolar gene expression patterns differ by muscle fiber type composition and along the arteriolar tree. ..
  43. pmc Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity
    Jaume Padilla
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    J Appl Physiol (1985) 116:1033-47. 2014
    ....
  44. pmc Disturbed blood flow acutely induces activation and apoptosis of the human vascular endothelium
    Nathan T Jenkins
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Hypertension 61:615-21. 2013
    ..These data provide the first in vivo experimental evidence of disturbed blood flow-induced endothelial injury in humans...
  45. pmc Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats
    Rebecca J Welly
    1Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 2Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 3Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO and 4Department of Child Health, University of Missouri, Columbia, MO
    Med Sci Sports Exerc 48:1688-98. 2016
    ..Recent evidence has also associated the gut microbiome with cardiometabolic health...
  46. pmc Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting
    Takuma Morishima
    Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan Japan Society for the Promotion of Science, Chiyoda, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 311:H177-82. 2016
    ....
  47. pmc Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity
    Michael D Roberts
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, 65211, USA
    Am J Physiol Regul Integr Comp Physiol 303:R247-58. 2012
    ..The use of the juvenile rodent WL or other inactivity models will continue to provide a powerful clinical translational tool that can be used for primordial prevention of human childhood obesity...
  48. pmc Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via α-adrenergic receptors
    Shekhar H Deo
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 305:R1124-32. 2013
    ..These findings indicate for the first time that NE increases superoxide production in freshly isolated primary human PBMCs via NADPH oxidase through α-adrenergic receptors, an effect facilitating monocyte adhesion to the endothelium...
  49. pmc Vascular effects of exercise: endothelial adaptations beyond active muscle beds
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
    Physiology (Bethesda) 26:132-45. 2011
    ....
  50. doi Vascular consequences of a high-fat meal in physically active and inactive adults
    Blair D Johnson
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Appl Physiol Nutr Metab 36:368-75. 2011
    ..9% ± 3.7% vs. 9.3% ± 3.2%). In conclusion, the differential responses following an HFM support the concept that habitual physical activity can attenuate the negative postprandial alterations that affect vascular health...
  51. doi Increased monocyte derived reactive oxygen species in type 2 diabetes: Role of endoplasmic reticulum stress
    Robert M Restaino
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO
    Exp Physiol . 2016
    ..This article is protected by copyright. All rights reserved...
  52. pmc Impact of prolonged sitting on lower and upper limb micro- and macrovascular dilator function
    Robert M Restaino
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    Exp Physiol 100:829-38. 2015
    ..In contrast, upper arm microvascular reactivity is selectively impaired with prolonged sitting, and walking does not influence this effect...
  53. pmc Chronic NOS inhibition accelerates NAFLD progression in an obese rat model
    Ryan D Sheldon
    Research Service, Harry S Truman Memorial Veterans Affairs Hospital, Columbia, Missouri Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Gastrointest Liver Physiol 308:G540-9. 2015
    ..These findings suggest an important role for proper NO metabolism in the hepatic adaptation to obesity...
  54. pmc Characterizing rapid-onset vasodilation to single muscle contractions in the human leg
    Daniel P Credeur
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    J Appl Physiol (1985) 118:455-64. 2015
    ....
  55. pmc Myogenic responses occur on a beat-to-beat basis in the resting human limb
    Seth T Fairfax
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri
    Am J Physiol Heart Circ Physiol 308:H59-67. 2015
    ..Overall, these results suggest that myogenic responses are present and occur rapidly in human limbs during rest, overwhelm perfusion pressure gradient influences, and are primarily mediated by the distal limb circulation...
  56. pmc Metformin does not enhance insulin-stimulated vasodilation in skeletal muscle resistance arteries of the OLETF rat
    Jacqueline M Crissey
    Biomedical Sciences, University of Missouri, Columbia, Missouri, USA Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
    Microcirculation 20:764-75. 2013
    ..To test the hypothesis that chronic metformin treatment enhances insulin-induced vasodilation in skeletal muscle resistance arteries and arterioles...
  57. doi Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load
    Lauren K Walsh
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, U S A
    Clin Sci (Lond) 130:1881-8. 2016
    ....
  58. pmc Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity
    Katherine S Wainright
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 309:R594-602. 2015
    ..059). Collectively, these findings suggest that intermittent physical activity over a prolonged period of time may lead to a reduction in adiposity but with retention of a sedentary obese white AT and metabolic phenotype. ..
  59. pmc Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction
    Victoria J Vieira-Potter
    Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 308:R530-42. 2015
    ..001). In conclusion, despite reduced SPA following OVX, high intrinsic aerobic fitness protects against OVX-associated increases in adiposity and insulin resistance. The mechanism may involve preservation of resting energy expenditure...
  60. pmc Loss of Nlrp3 Does Not Protect Mice from Western Diet-Induced Adipose Tissue Inflammation and Glucose Intolerance
    Rebecca E Ringling
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 11:e0161939. 2016
    ....
  61. pmc Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice
    Camila Manrique
    Division of Endocrinology, Diabetes and Metabolism V G D, G L, G J, A R A, C M, J R S, D H, D C, B J B, M G, Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212 Department of Medical Pharmacology and Physiology 65212 V G D, F I R P, L A M L, J R S and Research Service V G D, J R S, Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201 Dalton Cardiovascular Research Center F I R P, L A M L, J P, University of Missouri, Columbia, Missouri 65201 Department of Nutrition and Exercise Physiology J P, University of Missouri, Columbia, Missouri 65211 and Departments of Child Health 65201 J P and Biological Engineering L A M L, F I R P, University of Missouri, Columbia, Missouri 65211
    Endocrinology 157:1590-600. 2016
    ..In the setting of a WD, endothelial ERα signaling contributes to vascular stiffening in females. The precise mechanisms underlying the detrimental effects of endothelial ERα in the setting of a WD remain to be elucidated. ..
  62. pmc Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress
    Robert M Restaino
    Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Heart Circ Physiol 310:H648-53. 2016
    ..Thus these findings are consistent with the hypothesis that sitting-induced leg endothelial dysfunction is mediated by a reduction in shear stress. ..
  63. pmc Role of habitual physical activity in modulating vascular actions of insulin
    Jaume Padilla
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    Exp Physiol 100:759-71. 2015
    ..Ultimately, we propose that targeting vascular insulin resistance may represent a viable strategy for improving glycaemic control and reducing cardiovascular risk in patients with type 2 diabetes...
  64. pmc Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction
    Shawn B Bender
    From the Research Service, Harry S Truman Memorial Veterans Hospital, Columbia, MO S B B, V G D M, J H, M G, L P, A R A, J R S Department of Biomedical Sciences S B B, Dalton Cardiovascular Research Center S B B, J P, J R S, and Department of Nutrition and Exercise Physiology J P, University of Missouri, Columbia Division of Endocrinology, Diabetes and Metabolism V G D M, J H, M G, A R A, J R S and Division of Cardiovascular Medicine L P, Department of Medicine, Department of Medical Pharmacology and Physiology V G D M, L P, J R S, and Department of Child Health J P, University of Missouri School of Medicine, Columbia Department of Kinesiology, University of Georgia, Athens, GA N T J and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA I Z J
    Hypertension 65:1082-8. 2015
    ..These findings help identify a particular population with DD that might benefit from MR antagonist therapy, specifically patients with obesity and insulin resistance...
  65. ncbi Accumulation of physical activity reduces blood pressure in pre- and hypertension
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 37:1264-75. 2005
    ....
  66. pmc Exercise and Estrogen Make Fat Cells "Fit"
    Victoria J Vieira-Potter
    1Departments of Nutrition and Exercise Physiology, and 2Child Health, and 3Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO
    Exerc Sport Sci Rev 43:172-8. 2015
    ..Explicitly, exercise may improve adipose tissue "immunometabolism" by improving mitochondrial function and reducing inflammation. ..