K L Otipoby
Affiliation: University of Washington
- B cells with the guts to switchE A Clark
Departments of Immunology and Microbiology, University of Washington, Seattle, WA 98195, USA
Nat Immunol 2:581-2. 2001..Expression of mIgM was thought to be esential for the differentiation of B cells expressing antibodies of other classes. New evidence suggests isotype class switching to IgA can occur in the absence of mIgM...
- CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1K L Otipoby
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 276:44315-22. 2001..We propose that the cytoplasmic tail of CD22 contains two domains that regulate signal transduction pathways initiated by the BCR and B cell fate...
- Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selectionR J Cornall
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Palo Alto, California 94305, USA
Immunity 8:497-508. 1998..The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex...
- CD22 regulates thymus-independent responses and the lifespan of B cellsK L Otipoby
Department of Immunology, University of Washington Medical Center, Seattle 98195, USA
Nature 384:634-7. 1996..To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells...