Genomes and Genes
Luis A Ortiz
Affiliation: University of Pittsburgh
- Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effectsLuis A Ortiz
Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 100:8407-11. 2003..Collectively, these studies demonstrate that murine MSCs home to lung in response to injury, adopt an epithelium-like phenotype, and reduce inflammation and collagen deposition in lung tissue of mice challenged with BLM...
- TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosisFabrizio Fazzi
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219
J Immunol 192:3837-46. 2014..7 macrophage survival to silica. These results identify TNFR1/Phox interaction as a key event in the pathogenesis of silicosis that prevents mtROS formation and reduces macrophage apoptosis. ..
- Systemic inhibition of NF-kappaB activation protects from silicosisMichelangelo Di Giuseppe
Division of Occupational and Environmental Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 4:e5689. 2009..Therefore, inhibition of NF-kappaB activation represents a potential therapeutic strategy for silicosis...
- Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 miceCheryl L Fattman
University of Pittsburgh, Graduate School of Public Health, Department of Environmental and Occupational Health, Bridgeside Point, 100 Technology Dr, Suite 328, Pittsburgh, PA 15219 3130, USA
Am J Physiol Lung Cell Mol Physiol 294:L572-81. 2008..We conclude that although TIMP-1 expression is differentially regulated in fibrosis-sensitive and fibrosis-resistant strains, epithelial overexpression of TIMP-1 does not appear to substantially alter fibrotic lung disease in mice...
- Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosisFederica Gambelli
Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, A731 Crabtree Hall, 130 De Soto Street, Pittsburgh, PA 15261, USA
J Biol Chem 279:2020-9. 2004..7 macrophages. These data suggest that NF-kappaB activation and ERK-mediated phosphorylation of the p55 TNF receptor are important cell survival mechanisms in the macrophage response to silica exposure...
- Molecular and functional properties of lung SP cellsSusan D Reynolds
Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, USA
Am J Physiol Lung Cell Mol Physiol 292:L972-83. 2007..We conclude that the SP phenotype is common to clonogenic cells at multiple airway locations and suggest that Hoechst efflux is a property of cells expressing a wound-repair phenotype...
- A multi-cyclone sampling array for the collection of size-segregated occupational aerosolsSteven E Mischler
a National Institute for Occupational Safety and Health, Office of Mine Safety and Health Research, Pittsburgh, Pennsylvania
J Occup Environ Hyg 10:685-93. 2013....
- LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cellsKiflai Bein
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
Am J Respir Cell Mol Biol 49:306-15. 2013....
- Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injuryLuis A Ortiz
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 104:11002-7. 2007..Identification of IL1RN-expressing human MSC subpopulations may provide a novel cellular vector for treating chronic inflammatory diseases in humans...
- Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infectionDouglas S Reed
Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e24654. 2011..Animal models of pneumonic tularemia with a pathophysiology similar to the human disease are needed to evaluate the efficacy of these potential medical countermeasures...
- Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunctionSusan D Reynolds
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Am J Physiol Lung Cell Mol Physiol 287:L1256-65. 2004..On the basis of these data we conclude that selective airway injury can serve as the inciting injury in diseases characterized by severely compromised alveolar function...
- Lung pathology in platelet-derived growth factor transgenic mice: effects of genetic background and fibrogenic agentsJian Li
Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Department of Medicine and Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Exp Lung Res 28:507-22. 2002..These results demonstrate that the amount of PDGF-BB produced in wild-type mice is not a limiting factor in the development of bleomycin- or silica-induced pulmonary fibrosis...
- Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1Luis A Ortiz
Section of Pulmonary Diseases, Critical Care, and Environmental Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
Am J Physiol Lung Cell Mol Physiol 282:L1209-21. 2002..These results suggest that ACE inhibitor treatment decreases lung injury and the development of pulmonary hypertension in bleomycin-treated mice...
- Bleomycin sensitivity of mice expressing dominant-negative p53 in the lung epitheliumSushmita Ghosh
Program in Lung Biology, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane Xavier Center for Bioenvironmental Research and Tualne Cancer Center, New Orleans, LA 70118, USA
Am J Respir Crit Care Med 166:890-7. 2002..These observations suggest that compromising p53 function in the alveolar epithelium impairs recovery of the lung from bleomycin-induced injury...
- Loss of fibroblast Thy-1 expression correlates with lung fibrogenesisJames S Hagood
Department of Pediatrics, University of Alabama, Birmingham, USA
Am J Pathol 167:365-79. 2005..These results suggest that fibrogenic injury promotes loss of lung fibroblast Thy-1 expression, resulting in enhanced fibrogenesis...
- Stem cells in lung biologyBruce R Pitt
Am J Physiol Lung Cell Mol Physiol 286:L621-3. 2004
- Stem cells and cell therapies in lung biology and lung diseasesDaniel J Weiss
Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, HSRF 226, Burlington, VT 05405, USA
Proc Am Thorac Soc 5:637-67. 2008
- Mesenchymal Stem Cells in the Treatment of Lung FibrosisLuis Ortiz; Fiscal Year: 2008..3) To determine whether or not the systemic administration of MSCs can be used to ameliorate the fibroproliferative responses observed in the injured lung. ..