David K Ornstein

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Proteomics for the identification of new prostate cancer biomarkers
    David K Ornstein
    Department of Urology, The University of California Irvine, Orange, CA 92868, USA
    Urol Oncol 24:231-6. 2006
  2. ncbi request reprint Proteomics to diagnose human tumors and provide prognostic information
    David K Ornstein
    Department of Urology, University of California, Irvine UCI Medical Center, Orange, California 92868, USA
    Oncology (Williston Park) 18:521-9; discussion 529-32. 2004
  3. doi request reprint Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells
    Junichi Inokuchi
    Department of Urology, University of California Irvine, Orange, CA, USA
    Int J Cancer 124:68-74. 2009
  4. doi request reprint Histological evaluation of cold versus hot cutting: clinical impact on margin status for laparoscopic partial nephrectomy
    Jason M Phillips
    Department of Urology, University of California Irvine, Irvine, California, USA
    J Urol 180:2348-52. 2008
  5. pmc Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling
    Junichi Inokuchi
    Department of Urology, University of California, Irvine, Orange, CA 92868, USA
    Carcinogenesis 30:1082-8. 2009
  6. doi request reprint Robotic versus standard laparoscopic partial/wedge nephrectomy: a comparison of intraoperative and perioperative results from a single institution
    Leslie A Deane
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Endourol 22:947-52. 2008
  7. doi request reprint Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness
    David S Finley
    Department of Urology, University of California Irvine, Orange, California, USA
    J Urol 182:1621-7. 2009
  8. doi request reprint Robotic radical anterior pelvic exenteration: the UCI experience
    Oskar G Kaufmann
    University of California, Irvine, California, USA
    Minim Invasive Ther Allied Technol 20:240-6. 2011
  9. ncbi request reprint Proteomics of cancer of hormone-dependent tissues
    Darren R Tyson
    Department of Urology and Physiology University of California Irvine Medical Center, Orange, CA 92868, USA
    Adv Exp Med Biol 630:133-47. 2008
  10. ncbi request reprint Comparative analysis of laparoscopic and robot-assisted radical cystectomy with ileal conduit urinary diversion
    Jose Benito A Abraham
    Department of Urology, University of California at Irvine, Orange, California 92868, USA
    J Endourol 21:1473-80. 2007

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Proteomics for the identification of new prostate cancer biomarkers
    David K Ornstein
    Department of Urology, The University of California Irvine, Orange, CA 92868, USA
    Urol Oncol 24:231-6. 2006
    ..If several technologic hurdles can be overcome, it is possible that methodology will improve the specificity and sensitivity of prostate cancer detection...
  2. ncbi request reprint Proteomics to diagnose human tumors and provide prognostic information
    David K Ornstein
    Department of Urology, University of California, Irvine UCI Medical Center, Orange, California 92868, USA
    Oncology (Williston Park) 18:521-9; discussion 529-32. 2004
    ..It is likely that mass spectroscopy-based serum proteomics will evolve into useful clinical tools for the detection and treatment of human cancers...
  3. doi request reprint Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells
    Junichi Inokuchi
    Department of Urology, University of California Irvine, Orange, CA, USA
    Int J Cancer 124:68-74. 2009
    ..Finally, this is the first description of a role for ANXA2 in IL-6 expression, and ANXA2 represents a new therapeutic target for reducing IL-6 in high-grade prostate cancer...
  4. doi request reprint Histological evaluation of cold versus hot cutting: clinical impact on margin status for laparoscopic partial nephrectomy
    Jason M Phillips
    Department of Urology, University of California Irvine, Irvine, California, USA
    J Urol 180:2348-52. 2008
    ..We clinically characterized the histological appearance of tumor margins excised with cold scissors, and bipolar and ultrasonic shears...
  5. pmc Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling
    Junichi Inokuchi
    Department of Urology, University of California, Irvine, Orange, CA 92868, USA
    Carcinogenesis 30:1082-8. 2009
    ..Taken together, these data support a direct role for decreased ANXA1 expression in prostate carcinogenesis and enhancing tumor aggressiveness via the upregulation of IL-6 expression and activity...
  6. doi request reprint Robotic versus standard laparoscopic partial/wedge nephrectomy: a comparison of intraoperative and perioperative results from a single institution
    Leslie A Deane
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Endourol 22:947-52. 2008
    ....
  7. doi request reprint Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness
    David S Finley
    Department of Urology, University of California Irvine, Orange, California, USA
    J Urol 182:1621-7. 2009
    ..We investigated the association of cytokines and growth factors secreted by periprostatic adipose tissue with pathological features of aggressive prostate cancer...
  8. doi request reprint Robotic radical anterior pelvic exenteration: the UCI experience
    Oskar G Kaufmann
    University of California, Irvine, California, USA
    Minim Invasive Ther Allied Technol 20:240-6. 2011
    ..According to the UCI experience, robotic anterior exenteration appears to achieve the clinical and oncologic goals for the surgical treatment of bladder cancer...
  9. ncbi request reprint Proteomics of cancer of hormone-dependent tissues
    Darren R Tyson
    Department of Urology and Physiology University of California Irvine Medical Center, Orange, CA 92868, USA
    Adv Exp Med Biol 630:133-47. 2008
    ..This chapter not only reviews the clinical need and potential impact of proteomic studies of hormone-sensitive cancers, but details specific technologies and discusses the issues surrounding tissue/biofluid procurement...
  10. ncbi request reprint Comparative analysis of laparoscopic and robot-assisted radical cystectomy with ileal conduit urinary diversion
    Jose Benito A Abraham
    Department of Urology, University of California at Irvine, Orange, California 92868, USA
    J Endourol 21:1473-80. 2007
    ..To compare our experience with laparoscopic radical cystectomy (LACIC) and robot-assisted laparoscopic radical cystectomy (RACIC) with ileal conduit urinary diversion...
  11. ncbi request reprint Anatomic excision of anterior prostatic fat at radical prostatectomy: implications for pathologic upstaging
    David S Finley
    Department of Urology, University of California, Irvine, School of Medicine, Orange, California 92868, USA
    Urology 70:1000-3. 2007
    ..In this study, we describe a technique to dissect and remove the anterior prostatic fat pad (APF) and its anatomic and pathologic significance...
  12. pmc PCA3 molecular urine assay for prostate cancer: association with pathologic features and impact of collection protocols
    Michael A Liss
    Department of Urology, University of California Irvine, 333 City Blvd Suit 2100, Orange, CA 92868, USA
    World J Urol 29:683-8. 2011
    ..The purpose of this study is to evaluate the utility of the PCA3 molecular urine test scores to predict adverse pathologic features and catheterized specimen collection...
  13. doi request reprint Long-term impact of a robot assisted laparoscopic prostatectomy mini fellowship training program on postgraduate urological practice patterns
    Aldrin Joseph R Gamboa
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    J Urol 181:778-82. 2009
    ..We evaluated whether a mini fellowship for robot assisted laparoscopic prostatectomy would enable postgraduate urologists to incorporate this new procedure into clinical practice...
  14. doi request reprint Repair of rectal injury during robotic-assisted laparoscopic prostatectomy
    David S Yee
    Department of Urology, University of California, Irvine, School of Medicine, Orange, California 92868, USA
    Urology 72:428-31. 2008
    ..Of the first 251 robotic-assisted laparoscopic radical prostatectomies performed, 2 (0.8%) were complicated by rectal injury...
  15. doi request reprint Robot-assisted radical cystectomy: an expert panel review of the current status and future direction
    John W Davis
    Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Urol Oncol 28:480-6. 2010
    ..At the 9th Annual Meeting of the Society of Urologic Oncology (SUO), an expert panel discussed the current status of robot-assisted radical cystectomy (RARC)...
  16. ncbi request reprint Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate specific antigen levels between 2.5 and 15.0 ng/ml
    David K Ornstein
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Urol 172:1302-5. 2004
    ....
  17. pmc Robotic-assisted repair of iatrogenic ureteral ligation following robotic-assisted hysterectomy
    Jonathan F Kalisvaart
    Department of Urology, University of California Irvine Medical Center, Orange, California, USA
    JSLS 12:414-6. 2008
    ..We present, to our knowledge, the first case of delayed robotic-assisted ureteral deligation and ureterolysis following iatrogenic ureteral injury occurring during a robotic abdominal hysterectomy...
  18. ncbi request reprint Combined robot-assisted laparoscopic nephroureterectomy and radical prostatectomy
    David S Finley
    Department of Urology, University of California Irvine, Orange, California, USA
    J Endourol 21:411-4. 2007
    ..We describe the initial report of this combined operation and the novel use of the da Vinci robot for extravesical bladder-cuff excision and repair...
  19. ncbi request reprint Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium
    Darren R Tyson
    Department of Urology, University of California Irvine, Irvine Medical Center, Irvine, CA 92868 2656, USA
    Prostate 67:1601-13. 2007
    ..The present studies examine the culture conditions important for prostatic acinar morphogenesis in vitro and the role of extracellular calcium in this process...
  20. pmc Robotic-assisted laparoscopic cystoprostatectomy for prostatic carcinosarcoma
    Jennifer L Young
    Department of Urology, University of California at Irvine, Orange, California 90803, USA
    JSLS 11:109-12. 2007
    ..Robotic-assisted radical cystoprostatectomy is also discussed as a new procedure in minimally invasive surgery and as the first reported use for prostatic carcinosarcoma...
  21. ncbi request reprint Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer
    David S Yee
    Department of Urology, University of California Irvine Medical Center, Orange, CA 92868, USA
    Arch Pathol Lab Med 131:902-8. 2007
    ..Although commonly underexpressed in prostate cancer, the association of reduced expression with pathologic grade and stage is unknown...
  22. ncbi request reprint Robot-assisted laparoscopic radical cystoprostatectomy and totally intracorporeal ileal neobladder
    Leandro G Sala
    Department of Urology, UCI Medical Center, University of California, Irvine, Orange 92868, USA
    J Endourol 20:233-5; discussion 236. 2006
    ..To describe robot-assisted laparoscopic radical cystoprostatectomy and intracorporeal orthotopic ileal neobladder construction...
  23. ncbi request reprint The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells
    Chin Hui Hsiang
    Department of Urology, University of California, Irvine, California, USA
    Prostate 66:1413-24. 2006
    ..Although reduced expression levels of annexin I (ANX I) protein is a common finding in all stages of prostate cancer a causative relationship between ANX I dysregulation and prostate cancer development has yet to be established...
  24. ncbi request reprint Serum proteomic patterns for detection of prostate cancer
    Emanuel F Petricoin
    Food and Drug Administration FDA National Cancer Institute NCI Clinical Proteomics Program, Department of Therapeutic Proteins Center for Biologics Evaluation and Research CBER, Bethesda, MD, USA
    J Natl Cancer Inst 94:1576-8. 2002
    ..If validated in future series, serum proteomic pattern diagnostics may be of value in deciding whether to perform a biopsy on a man with an elevated PSA level...
  25. ncbi request reprint Evaluation of ethanol-fixed, paraffin-embedded tissues for proteomic applications
    Mamoun Ahram
    Pathogenetics Unit, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Proteomics 3:413-21. 2003
    ..In light of these results, we conclude that ethanol-fixed tissues can be successfully utilized for proteomic analyses...
  26. ncbi request reprint Clinical proteomics: Applications for prostate cancer biomarker discovery and detection
    Emanuel F Petricoin
    FDA NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Urol Oncol 22:322-8. 2004
    ..These diagnostic fragments may one day be harvested by circulating nanoparticles, designed to absorb, enrich, and amplify the repertoire of diagnostic biomarkers generated-even at the critical, initial stages of carcinogenesis...
  27. ncbi request reprint Proteomic analysis of human prostate cancer
    Mamoun Ahram
    Pathogenetics Unit, Laboratory of Pathology and Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Carcinog 33:9-15. 2002
    ..The marked heterogeneity of the observed protein alterations may have significance with regard to tumor biology and research strategies for molecular profiling analyses of human prostate cancer...
  28. ncbi request reprint Pharmacotherapy for biochemical recurrences after therapy for localised prostate cancer
    Kris E Gaston
    University of North Carolina, Department of Surgery, Division of Urology, Chapel Hill, NC 27599 7235, USA
    Expert Opin Pharmacother 3:657-69. 2002
    ..Future advances in gene therapy and immunotherapy hold the greatest promise to provide effective treatments against recurrent CaP while minimising morbidity...
  29. ncbi request reprint A case of T1C, N3, M1 prostate cancer
    Raj S Pruthi
    Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA
    Urol Int 69:82-4. 2002
  30. ncbi request reprint Expression of annexin I, II and VII proteins in androgen stimulated and recurrent prostate cancer
    Andrew B Smitherman
    Lineburger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    J Urol 171:916-20. 2004
    ..We performed a comprehensive survey of annexin I, II and VII protein expression in patient matched benign prostatic epithelium (BPE), androgen stimulated prostate cancer (AS-CaP) and recurrent prostate cancer (R-CaP)...
  31. ncbi request reprint Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer
    John S Kang
    Department of Surgery, Divisions of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 8:117-23. 2002
    ..Real-time fluorescence quantitative PCR was used to measure expression levels of annexin I mRNA in patient-matched CaP and BPE from 14 snap-frozen, radical prostatectomy specimens...

Research Grants2

  1. THE ROLE OF ANNEXIN I DOWN-REGULATION IN PROSTATE CANCER
    David Ornstein; Fiscal Year: 2005
    ....
  2. Prostate Cancer Detection by Serum Proteomic Profiling
    David Ornstein; Fiscal Year: 2005
    ..5 to 10.0 ng/ml. Aim 4: Determine the biological variability of serum proteomic patterns by analyzing serum samples collected from the same patient on 3 consecutive days. ..