O I Olopade

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Inherited predisposition to breast cancer among African American women
    Jane E Churpek
    Department of Medicine, Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 149:31-9. 2015
  2. pmc Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: a cross-sectional study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, RM, 7 E108, Bethesda 20892 9774, MD, USA
    Breast Cancer Res 16:424. 2014
  3. pmc Parity and breastfeeding are protective against breast cancer in Nigerian women
    D Huo
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Br J Cancer 98:992-6. 2008
  4. pmc Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e40494. 2012
  5. pmc The role of tumor-associated macrophages in breast cancer progression (review)
    Elias Obeid
    Section of Hematology Medical and Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 43:5-12. 2013
  6. pmc Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity
    Melissa B Davis
    The Institute for Genomics and Systems Biology, University of Chicago Biological Sciences Division, Chicago, IL 60637, USA
    Mol Cancer 12:40. 2013
  7. pmc Level of awareness of mammography among women attending outpatient clinics in a teaching hospital in Ibadan, South-West Nigeria
    Millicent O Obajimi
    Department of Radiology, University College Hospital, Ibadan, Nigeria
    BMC Public Health 13:40. 2013
  8. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  9. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  10. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006

Research Grants

  1. Genetics of Breast Cancer in Blacks
    Olufunmilayo Olopade; Fiscal Year: 2006

Detail Information

Publications110 found, 100 shown here

  1. pmc Inherited predisposition to breast cancer among African American women
    Jane E Churpek
    Department of Medicine, Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 149:31-9. 2015
    ..Each of these criteria defines patients who would benefit from genomic testing and novel therapies targeting DNA repair pathways...
  2. pmc Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: a cross-sectional study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, RM, 7 E108, Bethesda 20892 9774, MD, USA
    Breast Cancer Res 16:424. 2014
    ..It has been suggested that digitized mammographic images contain computer-extractable information within the parenchymal pattern, which may contribute to distinguishing between BRCA1/2 mutation carriers and non-carriers...
  3. pmc Parity and breastfeeding are protective against breast cancer in Nigerian women
    D Huo
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Br J Cancer 98:992-6. 2008
    ..Our findings also highlight the heterogeneity of breast cancer aetiology across populations, and indicate the need for further studies among indigenous sub-Saharan women...
  4. pmc Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women
    Yonglan Zheng
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e40494. 2012
    ....
  5. pmc The role of tumor-associated macrophages in breast cancer progression (review)
    Elias Obeid
    Section of Hematology Medical and Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 43:5-12. 2013
    ..Given the multiple roles of TAMS in breast cancer progression and metastasis, therapies targeting these cells are in development and demonstrate promising results...
  6. pmc Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity
    Melissa B Davis
    The Institute for Genomics and Systems Biology, University of Chicago Biological Sciences Division, Chicago, IL 60637, USA
    Mol Cancer 12:40. 2013
    ..We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry...
  7. pmc Level of awareness of mammography among women attending outpatient clinics in a teaching hospital in Ibadan, South-West Nigeria
    Millicent O Obajimi
    Department of Radiology, University College Hospital, Ibadan, Nigeria
    BMC Public Health 13:40. 2013
    ..This study examined the level of awareness of mammography and determined factors influencing the level of awareness...
  8. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  9. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  10. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  11. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  12. pmc Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay
    Laurent Perreard
    The ARUP Institute for Clinical and Experimental Pathology, SLC, Utah, USA
    Breast Cancer Res 8:R23. 2006
    ..In the current article, we use microarray analysis and a real-time quantitative reverse-transcription (qRT)-PCR assay to risk-stratify breast cancers based on biological 'intrinsic' subtypes and proliferation...
  13. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
    ..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies...
  14. pmc The molecular portraits of breast tumors are conserved across microarray platforms
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genomics 7:96. 2006
    ..To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list...
  15. ncbi request reprint Using genetic analysis to individualize preventive measures for breast and ovarian cancers
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics at the University of Chicago, Chicago, IL, USA
    Nat Clin Pract Oncol 3:182-3. 2006
  16. ncbi request reprint Cancer genetics in oncology practice
    O I Olopade
    University of Chicago Pritzker School of Medicine, Illinois, USA
    Ann Oncol 12:895-908. 2001
    ..This article reviews the current status of genetic testing and counseling for cancer risk assessment and will suggest a framework for integrating such counseling into oncology practice...
  17. ncbi request reprint FANCF methylation contributes to chemoselectivity in ovarian cancer
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
    Cancer Cell 3:417-20. 2003
    ..Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts...
  18. pmc Advances in breast cancer: pathways to personalized medicine
    Olufunmilayo I Olopade
    Department of Medicine, Section of Hematology Oncology, Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Clin Cancer Res 14:7988-99. 2008
    ..The five articles in this edition of CCR Focus highlight recent advances and future directions on the pathway to individualized approaches for the early detection, treatment, and prevention of breast cancer...
  19. ncbi request reprint Computerized analysis of digitized mammograms of BRCA1 and BRCA2 gene mutation carriers
    Zhimin Huo
    Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Radiology 225:519-26. 2002
    ..To evaluate, by using computer image analysis, the mammographic density patterns of women with germ-line mutations in BRCA1 and BRCA2 genes in comparison with those of women at low risk of developing breast cancer...
  20. ncbi request reprint Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
    James D Fackenthal
    Department of Medicine and Center for Clinical Cancer Genetics, University of Chicago, Box MC2115, 5841 S Maryland Avenue, Chicago, Illinois 60615, USA
    Nat Rev Cancer 7:937-48. 2007
    ..Although estimates of both mutation prevalence and mutation penetrance rates are inconsistent and occasionally controversial, understanding them is crucial for providing accurate risk information to each patient...
  21. ncbi request reprint Computerized analysis of mammographic parenchymal patterns for assessing breast cancer risk: effect of ROI size and location
    Hui Li
    Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
    Med Phys 31:549-55. 2004
    ..However, we failed to show a statistically significant decrease in the performance of the computerized texture features with decreasing ROI size for the range studied...
  22. ncbi request reprint Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Breast J 10:S5-9. 2004
    ....
  23. ncbi request reprint Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry
    Rita Nanda
    Center for Clinical Cancer Genetics, Section of Hematology Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, Ill 60637 1470, USA
    JAMA 294:1925-33. 2005
    ..Ten years after BRCA1 and BRCA2 were first identified as major breast cancer susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic minorities remain undefined...
  24. ncbi request reprint MYC is amplified in BRCA1-associated breast cancers
    Tatyana A Grushko
    Section of Hematology Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, Chicago, Illinois 60637 1463, USA
    Clin Cancer Res 10:499-507. 2004
    ....
  25. ncbi request reprint Disparities in genetic testing: thinking outside the BRCA box
    Michael J Hall
    Department of Medicine, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Clin Oncol 24:2197-203. 2006
    ..The importance of expanded testing in underserved populations is emphasized...
  26. ncbi request reprint Alterations of the 9p21 and 9q33 chromosomal bands in clinical bladder cancer specimens by fluorescence in situ hybridization
    W M Stadler
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Clin Cancer Res 7:1676-82. 2001
    ..To better define cytogenetic mechanisms of CDKN2 loss at 9p21 and of DBCCR1 loss at 9q33 in bladder cancer, and to determine correlation with p53 and pRb...
  27. ncbi request reprint Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Acad Radiol 14:513-21. 2007
    ..To evaluate fractal-based computerized image analyses of mammographic parenchymal patterns in the task of differentiating between women at high risk and women at low risk for developing breast cancer...
  28. doi request reprint Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry
    Bifeng Zhang
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, MC 2115, 5830 S Ellis Ave, Chicago, IL 60637, USA
    Fam Cancer 8:15-22. 2009
    ..Still, identifying such mutations could be important for designing genetic testing strategies for high-risk breast/ovarian cancer families in non-founder populations...
  29. ncbi request reprint Genetic susceptibility to breast cancer
    Angela R Bradbury
    Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    Rev Endocr Metab Disord 8:255-67. 2007
    ....
  30. pmc Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Digit Imaging 21:145-52. 2008
    ..The purpose of the study was to evaluate the usefulness of power law spectral analysis on mammographic parenchymal patterns in breast cancer risk assessment...
  31. pmc Translational integrity and continuity: personalized biomedical data integration
    Xiaoming Wang
    Biomedical Informatics Core, Computation Institute, University of Chicago, 950 E 61st Street, Room 334, Chicago, IL 60637, USA
    J Biomed Inform 42:100-12. 2009
    ..In its current stage, TraM relies on a semi-automated mechanism to standardize and restructure source data for data integration and thus does not support real-time data application...
  32. ncbi request reprint Colorectal cancer model of health disparities: understanding mortality differences in minority populations
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA
    J Clin Oncol 24:2179-87. 2006
    ..Finally, areas of ongoing and future research and policy initiatives aimed at reducing disparities are discussed...
  33. pmc MYC in breast tumor progression
    Yinghua Chen
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL 60637, USA
    Expert Rev Anticancer Ther 8:1689-98. 2008
    ..MYC amplification is emerging as an important predictor of response to HER2-targeted therapies and its role in BRCA1-associated breast cancer makes it an important target in basal-like/triple-negative breast cancers...
  34. pmc Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States
    Dezheng Huo
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    J Clin Oncol 27:1184-90. 2009
    ..We also assessed the clinical utility of mutation status of probands (the first individual tested in a family) in the recommendation of BRCA mutation testing for other at-risk family members...
  35. doi request reprint CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors
    Jinhua Xu
    Department of Medicine, Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL, 60637 1463, USA
    Breast Cancer Res Treat 120:593-601. 2010
    ..This indicates that reduced accessibility of transcription factors to the methylated promoter is one of the mechanisms for down-regulation of BRCA1 in heavily methylated cancer cells...
  36. ncbi request reprint BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy
    Minjie Wei
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago, Chicago, Illinois 60637 1463, USA
    Cancer Res 65:10692-9. 2005
    ..Our data support a model of carcinogenesis in which BRCA1 promoter methylation may serve as a "first hit," much like an inherited germ line mutation, and promote tumor progression down a restricted set of molecular pathways...
  37. ncbi request reprint The effect of varying spectral resolution on the quality of high spectral and spatial resolution magnetic resonance images of the breast
    Milica Medved
    Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Magn Reson Imaging 18:442-8. 2003
    ..To evaluate the effect of varying spectral resolution on image quality of high spectral and spatial resolution (HiSS) images...
  38. pmc Concordance in histological and biological parameters between first and second primary breast cancers
    Dezheng Huo
    Department of Health Studies, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer 117:907-15. 2011
    ..Women with breast cancer are more likely to have a second breast cancer than women in the general population are to have a primary cancer. However, the biological relationship between primary and second breast cancers is not clear...
  39. ncbi request reprint Breast cancer genetics in African Americans
    Olufunmilayo I Olopade
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Cancer 97:236-45. 2003
    ..An overview of the state of genetic testing for BRCA1 and BRCA2 genes was presented at the Summit Meeting on Breast Cancer Among African American women...
  40. pmc Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE)
    Milica Medved
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    Magn Reson Med 63:1557-63. 2010
    ..This is the first application of the sensitivity encoding algorithm to characterize the structure of the water resonance at high spatial resolution...
  41. pmc BRCA2 T2722R is a deleterious allele that causes exon skipping
    James D Fackenthal
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL, 60637, USA
    Am J Hum Genet 71:625-31. 2002
    ....
  42. ncbi request reprint Racial and ethnic disparities in breast cancer: a multilevel perspective
    Christopher M Masi
    Section of General Internal Medicine, University of Chicago, M C 2007, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Med Clin North Am 89:753-70. 2005
    ..Efforts to reduce breast cancer incidence and disparities must consider societal and individual factors and the important effects these factors can have on normal cell function...
  43. ncbi request reprint Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637 1470, USA
    Med Clin North Am 89:771-93. 2005
    ..The task now becomes to continue to understand the reasons for the disparities and ultimately to come up with workable solutions so that the amazing progress in CRC treatment benefits all groups in this country...
  44. ncbi request reprint Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms
    Hui Li
    Department of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637, USA
    Acad Radiol 12:863-73. 2005
    ..Thus, computerized texture analysis of breast parenchymal patterns on mammograms may be useful in assessing breast cancer risk...
  45. pmc Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer
    Ezra E W Cohen
    Department of Medicine, University of Chicago, Chicago, IL, USA
    J Clin Oncol 28:3336-43. 2010
    ....
  46. ncbi request reprint How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults
    Angela R Bradbury
    Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    J Clin Oncol 25:3705-11. 2007
    ..Yet, many BRCA mutation carriers discuss their results with their children. This study describes the prevalence and experiences of parental communication of BRCA results to children under the age of 25 years old...
  47. pmc Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer
    Nicholas W Choong
    Section of Hematology Oncology and Phase II Network, University of Chicago Medical Center, MC 2115, 5841, S Maryland Avenue, Chicago, Illinois, USA
    J Thorac Oncol 3:1003-11. 2008
    ..This Phase I trial aimed to determine the maximum-tolerated-dose of erlotinib administered with two standard chemoradiotherapy regimens for non-small cell lung cancer...
  48. pmc Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
    Dezheng Huo
    Department of Health Studies, University of Chicago, Chicago, IL, USA
    Breast Cancer Res Treat 110:367-76. 2008
    ....
  49. ncbi request reprint Racial differences in genetic factors associated with breast cancer
    Foluso O Ademuyiwa
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Metastasis Rev 22:47-53. 2003
    ....
  50. pmc Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
    Angela R Bradbury
    University of Chicago Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois, USA
    Genet Med 10:161-6. 2008
    ..To evaluate prophylactic salpingo-oophorectomy uptake and timing among BRCA1/2 mutation carriers in a cancer risk assessment program...
  51. ncbi request reprint Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons
    Xiaobing Fan
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    J Magn Reson Imaging 24:1311-5. 2006
    ..To compare conventional fat-suppressed MR images of the breast to images derived from high spectral and spatial resolution MR data. Image quality and the level of fat suppression are compared qualitatively and quantitatively...
  52. doi request reprint Risk assessment and genetic testing for ovarian cancer
    Cassandra Gulden
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, IL 60637, USA
    AJR Am J Roentgenol 194:309-10. 2010
    ..In this review, strategies for identifying high-risk individuals and the clinical utility of genetic testing for BRCA1 and BRCA2 will be discussed...
  53. ncbi request reprint Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    Susan M Domchek
    Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Lancet Oncol 7:223-9. 2006
    ..However, the reduction in mortality after this surgery is unclear. We aimed to assess whether BPSO improves overall mortality or cancer-specific mortality in BRCA1 and BRCA2 mutation carriers...
  54. ncbi request reprint High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience
    Milica Medved
    Department of Radiology, The University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
    AJR Am J Roentgenol 186:30-7. 2006
    ..To test HiSS in the clinical setting, we used HiSS MRI to image 30 women with suspicious breast lesions...
  55. ncbi request reprint Breast cancer and race: a rising tide does not lift all boats equally
    Blase N Polite
    Section of Hematology Oncology, Department of Medicine, University of Chicago, IL 60637, USA
    Perspect Biol Med 48:S166-75. 2005
    ..This paper discusses the factors that may contribute to differences in survival and differences in stage at diagnosis between African American and white women...
  56. pmc Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression
    Sujun Hua
    Joint Institute for Genomics and Systems Biology, The University of Chicago and Argonne National Laboratory, Chicago, IL, USA
    Mol Syst Biol 4:188. 2008
    ..This integrated approach has accelerated the identification of a molecule linked to breast cancer progression, has implications for diagnostic and therapeutic interventions, and can be applied to a wide range of cancers...
  57. pmc Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment
    Michael J Hall
    Department of Medicine, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY 10032, USA
    J Genet Couns 17:365-72. 2008
    ..In risk assessment for HBOS, identifying a family history of PC should strongly raise the suspicion of an unrecognized BRCA1/2 mutation...
  58. pmc Glucocorticoid receptor expression in breast cancer associates with older patient age
    Larissa Belova
    Department of Medicine, The University of Chicago, MC2115, Chicago, IL 60637, USA
    Breast Cancer Res Treat 116:441-7. 2009
    ..Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to long-term clinical outcome...
  59. pmc Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers
    Minjie Wei
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637 1463, USA
    Breast Cancer Res Treat 111:113-20. 2008
    ..These data suggest that unlike FANCF, both ER and BRCA1 are specifically targeted for methylation in sporadic breast cancers, a phenomenon that should be explored for development of novel diagnostic and therapeutic approaches...
  60. pmc Fourier component imaging of water resonance in the human breast provides markers for malignancy
    Milica Medved
    Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Phys Med Biol 54:5767-79. 2009
    ..83. In the human breast, an inhomogeneously broadened water resonance can serve as a correlate marker for malignancy and is likely to reflect the underlying anatomy or physiology...
  61. ncbi request reprint Should genetic testing for BRCA1/2 be permitted for minors? Opinions of parents who completed BRCA1/2 testing
    A R Bradbury
    Fox Chase Cancer Center, Philadelphia, PA The Cancer Institute of New Jersey, New Brunswick, NJ University of Chicago, Department of Medicine, Chicago, IL
    J Clin Oncol 26:1511. 2008
    ..To better understand the opinions of those most affected by these issues, we interviewed parents who had undergone BRCA1/2 testing and had children <25 years old at the time of BRCA testing...
  62. ncbi request reprint Results from a longitudinal breast MRI surveillance study: Psychological impact for high-risk women
    L J Patrick-Miller
    The MacLean Center for Clinical Medical Ethics, The Pritzker School of Medicine, The University of Chicago, Chicago, IL Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA Hematology Oncology, The Pritzker School of Medicine, The University of Chicago, Chicago, IL Health Studies, Pritzker School of Medicine, The University of Chicago, Chicago, IL Pritzker Medical School, University of Chicago, Chicago, IL Radiology, The Pritzker School of Medicine, The University of Chicago, Chicago, IL The University of Chicago Medical Center, Chicago, IL
    J Clin Oncol 29:1563. 2011
    ..The long term psychological impact of intensive (MRI) screening of women at high-risk of breast cancer (HRW) is unknown...
  63. pmc SNP discovery, expression and cis-regulatory variation in the UGT2B genes
    C Sun
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Pharmacogenomics J 12:287-96. 2012
    ..Our results provide insight into studying the role of UGT2B variation in hormone-dependent cancers and drug response...
  64. doi request reprint Characterizing early contrast uptake of ductal carcinoma in situ with high temporal resolution dynamic contrast-enhanced MRI of the breast: a pilot study
    S A Jansen
    Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637, USA
    Phys Med Biol 55:N473-85. 2010
    ..04). This pilot study demonstrates the feasibility of quantitative analysis of early contrast kinetics at high temporal resolution and points to the potential for such an analysis to improve the characterization of DCIS...
  65. ncbi request reprint Computerized analysis of mammographic parenchymal patterns for breast cancer risk assessment: feature selection
    Z Huo
    Department of Radiology, The University of Chicago, Illinois 60637, USA
    Med Phys 27:4-12. 2000
    ..Similar computer-extracted mammographic features were identified in the two approaches. Results show that women at high risk tend to have dense breasts and their mammographic patterns tend to be coarse and low in contrast...
  66. pmc Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21
    O I Olopade
    Department of Medicine, University of Chicago Pritzker School of Medicine, IL 60637, USA
    Proc Natl Acad Sci U S A 92:6489-93. 1995
    ..8-kDa protein in the pet gene (coding for cytochrome bc1 complex) region of Rhodospirillum rubrum. The location, expression pattern, and nucleotide sequence of this gene suggest that it codes for the MTAP enzyme...
  67. pmc Male breast cancer in Cowden syndrome patients with germline PTEN mutations
    J D Fackenthal
    Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
    J Med Genet 38:159-64. 2001
    ..These two cases of male breast cancer associated with germline PTEN mutations and the CS phenotype suggest that CS may be associated with an increased risk of early onset male as well as female breast cancer...
  68. doi request reprint Epidermal growth factor receptor in triple-negative and basal-like breast cancer: promising clinical target or only a marker?
    Monika L Burness
    Section of Hematology Oncology, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL 60637, USA
    Cancer J 16:23-32. 2010
    ....
  69. pmc Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays
    Maria Argos
    Department of Health Studies, University of Chicago, 5841 S Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Cancer Genet Cytogenet 182:69-74. 2008
    ..The present study demonstrates a feasible methodological approach for the assessment of LOH and copy number changes...
  70. pmc Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage
    Milica Medved
    Department of Radiology, The University of Chicago, Chicago, IL 60637, USA
    Magn Reson Imaging 28:16-21. 2010
    ..Thus, we show that volumetric HiSS imaging can conserve the advantages of single-slice HiSS imaging and that further technical development of volumetric HiSS is desirable...
  71. doi request reprint Parent opinions regarding the genetic testing of minors for BRCA1/2
    Angela R Bradbury
    University of Chicago, Chicago, IL, USA
    J Clin Oncol 28:3498-505. 2010
    ..Thus, we evaluated parent opinions regarding BRCA1/2 testing of minors, in general, and hypothetically, for parents' own minor child...
  72. ncbi request reprint Molecular-cytogenetic analysis of HER-2/neu gene in BRCA1-associated breast cancers
    Tatyana A Grushko
    Section of Hematology Oncology, Department of Medicine, Committee on Genetics, University of Chicago, Chicago, Illinois 60637 1463, USA
    Cancer Res 62:1481-8. 2002
    ....
  73. ncbi request reprint UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women
    Andrew L Hong
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    Drug Metab Dispos 35:1254-61. 2007
    ..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry...
  74. ncbi request reprint Disparities in cancer care: a worldwide perspective and roadmap for change
    Olufunmilayo I Olopade
    University of Chicago Medical Center, Chicago, IL, USA
    J Clin Oncol 24:2135-6. 2006
  75. ncbi request reprint Structure of the human type-I interferon gene cluster determined from a YAC clone contig
    M O Diaz
    Department of Medicine, University of Chicago, Illinois 60637
    Genomics 22:540-52. 1994
    ..Some of these events may be explained by unequal crossing over between adjacent tandem genes. The location of several breakpoints within the cluster, from deletions associated with leukemias and gliomas, was also determined...
  76. ncbi request reprint Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients
    A B Benson
    Department of Medicine, Northwestern University Medical School, and Robert H Lurie Comprehensive Cancer Center Chicago, Illinois 60611, USA
    Clin Cancer Res 6:3870-7. 2000
    ..Further investigation of dose/schedule and biological end points is ongoing...
  77. ncbi request reprint Identification of a 1.2 Kb cDNA fragment from a region on 9p21 commonly deleted in multiple tumor types
    S Gursky
    Department of Biochemistry and Molecular Biology, 5841 South Maryland Avenue, MC 2115, The University of Chicago, Chicago, IL 60637, USA
    Cancer Genet Cytogenet 129:93-101. 2001
    ..Further investigation will determine whether the difference in the expression pattern between the 7 Kb transcript compared with the other sized transcripts could be due to specific targeting for alteration in certain tumor types...
  78. ncbi request reprint Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
    O I Olopade
    Department of Medicine, University of Chicago, Illinois 60637
    Genomics 14:437-43. 1992
    ..Our current results map the shortest region of overlap of these deletions in the various tumors to the region between the centromeric end of the IFNA/IFNW gene cluster and the MTAP gene locus...
  79. pmc An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: a Gynecologic Oncology Group study
    T A Grushko
    University of Chicago Medical Center, Chicago, IL 60637, USA
    Gynecol Oncol 108:3-9. 2008
    ..To investigate the frequency and potential prognostic or predictive value of HER-2 amplification or overexpression in advanced and recurrent endometrial cancers...
  80. pmc Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer
    Dezheng Huo
    Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    J Clin Oncol 27:4515-21. 2009
    ..In the first study of its kind, we determined the distribution of molecular subtypes of invasive breast tumors in indigenous black women in West Africa...
  81. ncbi request reprint Primary structure-based function characterization of BRCT domain replicates in BRCA1
    Yinghua Chen
    Center for Clinical Cancer Genetics, University of Chicago Medical Center, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 345:188-96. 2006
    ..Based on sequence analysis, we predict five p53-binding sites. Our comparison of binding by wild-type and mutant domains indicates the sequence specificity of BRCA1-p53 interaction...
  82. pmc Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15
    Chang Sun
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Hum Mutat 31:99-107. 2010
    ..Our results provide a good example for how AI can be used to identify cis-regulatory variation and gain insights into the tissue specific regulation of gene expression...
  83. pmc Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  84. ncbi request reprint Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast
    Milica Medved
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    Magn Reson Med 52:193-6. 2004
    ..The synthesis of water Fourier component images from high spectral and spatial resolution data may provide a new form of contrast, and increase sensitivity to subvoxel physiology and anatomy...
  85. pmc "Why take it if you don't have anything?" breast cancer risk perceptions and prevention choices at a public hospital
    Talya Salant
    Pritzker Medical School and History of Culture, University of Chicago, Chicago, IL 60637, USA
    J Gen Intern Med 21:779-85. 2006
    ..Qualitative methods explore the complex meanings and logics of risk and prevention that quantitative approaches overlook...
  86. ncbi request reprint BRCA2 mutation and the risk of hematologic malignancy
    Michael J Hall
    Leuk Lymphoma 47:765-7. 2006
  87. pmc RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers
    Boning Gao
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:22-5. 2008
    ..Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers...
  88. ncbi request reprint Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
    Kelly Metcalfe
    Centre for Research on Women s Health, Women s College Hospital, Toronto, Ontario, Canada
    J Clin Oncol 22:2328-35. 2004
    ..To estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers after diagnosis and to determine which factors are predictive of the risk of a second primary breast cancer...
  89. ncbi request reprint Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type
    William D Foulkes
    Departments of Oncology, Sir M B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Clin Cancer Res 10:2029-34. 2004
    ..The relationship between ER status and other clinical features of hereditary breast cancers has not been well studied...
  90. ncbi request reprint Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, Abramson Family Cancer Research Institute, The University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 22:1055-62. 2004
    ..Thus, we estimated the degree of breast cancer risk reduction after surgery in women who carry these mutations...
  91. ncbi request reprint Direct-to-consumer marketing of genetic tests for cancer: buyer beware
    Stacy Gray
    J Clin Oncol 21:3191-3. 2003
  92. ncbi request reprint Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO
    David M Euhus
    The University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
    J Natl Cancer Inst 94:844-51. 2002
    ..We measured the performance of eight cancer risk counselors and of a computer model, BRCAPRO, at identifying families likely to carry a BRCA gene mutation...
  93. ncbi request reprint Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    N Engl J Med 346:1616-22. 2002
    ..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...
  94. ncbi request reprint Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 24:2437-43. 2006
    ..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
  95. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  96. doi request reprint Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring
    Angela R Bradbury
    Fox Chase Cancer, Division of Population Science, Philadelphia, PA 19111, USA
    Am J Med Genet C Semin Med Genet 148:70-7. 2008
    ....
  97. ncbi request reprint Confronting genetic testing disparities: knowledge is power
    Michael Hall
    JAMA 293:1783-5. 2005
  98. pmc Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
    Chad P Garner
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
    Hum Genet 123:247-55. 2008
    ..0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk...
  99. ncbi request reprint Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation
    Amy Finch
    Centre for Research in Women s Health, Toronto Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    JAMA 296:185-92. 2006
    ..Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this intervention has not been prospectively evaluated in a large cohort...
  100. ncbi request reprint Correlates of depressive symptoms among women seeking cancer genetic counseling and risk assessment at a high-risk cancer clinic
    Molly Middlecamp Kodl
    Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Genet Couns 15:267-76. 2006
    ..Given the known associations between depression, health behaviors such as cancer screening, and potential responses to the genetic testing process, assessment of mood disturbance remains an important consideration for genetic counselors...
  101. pmc A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    David S Shames
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 3:e486. 2006
    ....

Research Grants1

  1. Genetics of Breast Cancer in Blacks
    Olufunmilayo Olopade; Fiscal Year: 2006
    ..abstract_text> ..