Affiliation: University of Colorado Health Sciences Center
- Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to menAnn Olincy
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Biochem Pharmacol 74:1192-201. 2007..These data suggest that therapeutic agents selected for alpha7 nicotinic activity may have utility in treating certain symptoms of schizophrenia...
- Proof-of-concept trial of an alpha7 nicotinic agonist in schizophreniaAnn Olincy
Department of Veterans Affairs Schizophrenia Research Center, Denver, Colorado, USA
Arch Gen Psychiatry 63:630-8. 2006....
- Effects of an alpha 7-nicotinic agonist on default network activity in schizophreniaJason R Tregellas
Department of Psychiatry, Denver VA Medical Center, VISN19 MIRECC, Colorado, USA
Biol Psychiatry 69:7-11. 2011..This study examined the effects of DMXB-A on default network activity as a biomarker for drug effects on pathologic brain function associated with schizophrenia...
- Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
Am J Psychiatry 170:521-32. 2013..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
- Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
- Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010....
- Physiology of schizophrenia, bipolar disorder, and schizoaffective disorderLaura F Martin
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Am J Psychiatry 164:1900-6. 2007..A second aim was to determine whether subjects with schizoaffective disorder, bipolar type, were neurophysiologically more similar to subjects with schizophrenia or subjects with bipolar disorder...
- Initial phase 2 trial of a nicotinic agonist in schizophreniaRobert Freedman
Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
Am J Psychiatry 165:1040-7. 2008..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia...
- Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
- Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
- Sex differences in familiality effects on neurocognitive performance in schizophreniaMonica E Calkins
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Biol Psychiatry 73:976-84. 2013..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
- Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjectsJudith Gault
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 123:39-49. 2003..Twenty-one variants were found in the exons, but non-synonymous changes were rare. Although the expression of CHRNA7 is decreased in schizophrenia, the general structure of the remaining receptors is likely to be normal...
- Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measuresBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 33:69-94. 2007..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates...
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
Am J Psychiatry 168:930-46. 2011....
- Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophreniaJason R Tregellas
Department of Psychiatry, Denver VA Medical Center VISN19 MIRECC and University of Colorado Denver, Aurora, CO 80045, USA
Neuropsychopharmacology 35:938-42. 2010..Imaging of drug response is useful in planning future clinical tests of this compound and other nicotinic agonists for schizophrenia...
- Improved p50 auditory gating with ondansetron in medicated schizophrenia patientsLawrence E Adler
Denver VA Medical Center, 1055 Clermont St, Denver, CO 80220, USA
Am J Psychiatry 162:386-8. 2005..This study examined the effects of ondansetron, a highly selective 5-HT3 antagonist, on the P50 auditory evoked potential...
- Multiple genes in the 15q13-q14 chromosomal region are associated with schizophreniaSarah H Stephens
Department of Psychiatry, University of Colorado Denver, Colorado 80045, USA
Psychiatr Genet 22:1-14. 2012..This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7...
- Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar typeLaura F Martin
Department of Psychiatry, Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 144:611-4. 2007..The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type...
- The genetics of sensory gating deficits in schizophreniaRobert Freedman
Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C 268 71, Denver, CO 80262, USA
Curr Psychiatry Rep 5:155-61. 2003..Polymorphisms in the core promoter of the gene are associated with schizophrenia and also with diminished inhibition of the P50 response. These genetic data may identify a new pathophysiologic target for drug discovery...
- Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblingsJames Schmeidler
Department of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L Levy Place, Box 1230, New York, NY, USA
Psychiatry Res 219:67-71. 2014..A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes. ..
- Early sensory processing deficits predict sensitivity to distraction in schizophreniaJason Smucny
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Schizophr Res 147:196-200. 2013..The observed relationship between noise effects on reaction time and P50 auditory gating supports the hypothesis that early inhibitory processing deficits may contribute to susceptibility to distraction in the illness...
- Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patientsLawrence E Adler
Box C268 26, Psychiatry, University of Colorado Health Science Ctr, 4200 East 9th Ave, Denver, CO 80262, USA
Am J Psychiatry 161:1822-8. 2004..This study sought to determine whether other atypical neuroleptics improve P50 ratios...
- Sensory gating impairment associated with schizophrenia persists into REM sleepMichael A Kisley
Department of Psychiatry, University of Colorado Health Sciences Center and Denver Veteran s Affairs Medical Center, Denver, Colorado, USA
Psychophysiology 40:29-38. 2003..These results suggest that REM sleep is an appropriate state during which to assess P50 gating in order to disentangle the effects of state and trait on sensory gating impairment in other clinical populations...
- Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophreniaAnn Olincy
Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C 268 71, Denver, CO 80262, USA
Psychiatry Res 117:223-36. 2003..However, premature saccades and large anticipatory saccades, although measures of inhibitory dysfunction in schizophrenia, appear to be unrelated to the nicotinic system...
- Early biomarkers of psychosisRobert Freedman
Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Dialogues Clin Neurosci 7:17-29. 2005..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
- Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophreniaSherry Leonard
Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
Arch Gen Psychiatry 59:1085-96. 2002..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
- Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI studyJason R Tregellas
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Psychiatry 161:315-21. 2004..The investigators used functional magnetic resonance imaging (fMRI) to compare brain hemodynamic response during a smooth pursuit eye movement task in patients with schizophrenia and healthy comparison subjects...
- Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum DisorderAnn Olincy
Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA
J Autism Dev Disord 46:3812-3817. 2016..Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder...
- The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
- Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypesRandal G Ross
Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
Psychophysiology 39:809-19. 2002..Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia...
- Neuronal effects of nicotine during auditory selective attentionJason Smucny
Research Service, Denver VA Medical Center, Denver, CO, USA
Psychopharmacology (Berl) 232:2017-28. 2015..Although the attention-enhancing effects of nicotine have been behaviorally and neurophysiologically well-documented, its localized functional effects during selective attention are poorly understood...
- Input dysfunction, schizotypy, and genetic models of schizophreniaRobert Freedman
Department of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, Campus Box C 268 71, 4200 E Ninth Avenue, Denver, CO 80262, USA
Schizophr Res 54:25-32. 2002..Thus, as predicted by Venables, the substrates of schizotypy and schizophrenia may arise from variants in normal brain function...
- Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the α7 nicotinic receptorAnn Olincy
Department of Psychiatry, University of Colorado, Denver, Aurora, CO 80045, USA
Handb Exp Pharmacol . 2012..There are multiple other nicotinic agents, including positive allosteric modulators, in the preclinical stages of development. Finally, the effects of varenicline and clozapine and their relation to smoking cessation are discussed...
- Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosisAnn Olincy
Department of Veterans Affairs and University of Colorado Health Sciences Center, Denver 80262, USA
Am J Psychiatry 162:43-9. 2005..This study addresses whether diminished P50 auditory evoked potential suppression represents a phenotype associated with psychosis in bipolar illness...
- Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sampleBrian K Suarez
Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
Am J Hum Genet 78:315-33. 2006..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
- Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
- No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008....
- Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008....
- The Genetics of Endophenotypes and SchizophreniaAnn Olincy; Fiscal Year: 2007..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..