Affiliation: University of California
- Abnormal N400 word repetition effects in fragile X-associated tremor/ataxia syndromeJohn M Olichney
Department of Neurology, University of California Davis, Davis, CA 95618, USA
Brain 133:1438-50. 2010..Their more severe reduction in N400 repetition effect, than P600, is in contrast to the reverse pattern reported in amnestic mild cognitive impairment and incipient Alzheimer's disease (Olichney et al., 2008)...
- fMRI congruous word repetition effects reflect memory variability in normal elderlyJohn M Olichney
Department of Neurology, University of California, Davis, 4860 Y St Sacramento, CA 95817, USA
Neurobiol Aging 31:1975-90. 2010..A neural circuit of left-hemisphere brain regions, many identified as P600 generators by invasive electrophysiological studies, was activated by New>Old congruous words, likely mediating successful verbal encoding...
- fMRI responses to words repeated in a congruous semantic context are abnormal in mild Alzheimer's diseaseJohn M Olichney
Department of Neurology, University of California, Davis, Davis, CA 95618 5412, USA
Neuropsychologia 48:2476-87. 2010..We hypothesized that AD would be associated with reduced differential response to New/Old congruous words...
- Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementiaJ M Olichney
Department of Neurology, University of California, Davis, CA, USA
Neurology 70:1763-70. 2008..We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI)...
- Cognitive event-related potentials: biomarkers of synaptic dysfunction across the stages of Alzheimer's diseaseJohn M Olichney
Department of Neurology, University of California, Davis, CA, USA
J Alzheimers Dis 26:215-28. 2011..Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of "presymptomatic AD"...
- MRI predictors of cognitive change in a diverse and carefully characterized elderly populationOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, USA
Neurobiol Aging 33:83-95. 2012..Trajectories of cognitive decline among elderly individuals are heterogeneous, and markers that have high reliability for predicting cognitive trajectories across a broad spectrum of the elderly population have yet to be identified...
- Maximal brain size remains an important predictor of cognition in old age, independent of current brain pathologySarah Tomaszewski Farias
Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA
Neurobiol Aging 33:1758-68. 2012..Results suggest maximal brain development and measures of brain injury/atrophy jointly contribute to cognitive function in older people...
- Heterogeneity of cognitive trajectories in diverse older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Sacramento, CA 95817, USA
Psychol Aging 25:606-19. 2010....
- Neurophysiological evidence for a recollection impairment in amnesia patients that leaves familiarity intactRichard James Addante
University of California, Davis, Center for Neuroscience, 1544 Newton Ct Davis, CA 95616, USA
Neuropsychologia 50:3004-14. 2012....
- Conversion disorder in women with the FMR1 premutationAndreea L Seritan
Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, California, USA
Am J Med Genet A 149:2501-6. 2009..The FMR1 premutation with its associated mRNA toxicity is postulated as an underlying neurobiological mechanism of conversion symptoms, through functional and structural neural dysconnectivity...
- From amnesia to dementia: ERP studies of memory and languageJason R Taylor
Department of Neurosciences, University of California, San Diego, USA
Clin EEG Neurosci 38:8-17. 2007..ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD...
- Absent event-related potential (ERP) word repetition effects in mild Alzheimer's diseaseJohn M Olichney
Department of Neurosciences, University of California, San Diego, CA 92161, USA
Clin Neurophysiol 117:1319-30. 2006..The P600 (a late positive component, or 'LPC'), and the N400, are sensitive indices of memory encoding and semantic processing, respectively...
- Clinical applications of cognitive event-related potentials in Alzheimer's diseaseJohn M Olichney
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0662, USA
Phys Med Rehabil Clin N Am 15:205-33. 2004..This horizon and many others remain wide open for well-planned explorations...
- Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problemsRandi J Hagerman
MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
Clin Interv Aging 3:251-62. 2008..The current review summarizes what is currently known regarding the symptomatic treatment, or potential for treatment, of FXTAS...
- Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010....
- Alzheimer abnormalities of the amygdala with Klüver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer diseaseShawn J Kile
Department of Neurology, University of California at Davis, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
Arch Neurol 66:125-9. 2009..Neurofibrillary tangles and beta-amyloid plaques have been observed in the amygdala in Alzheimer disease. A disproportionate abundance of this abnormality in the amygdala may cause behavioral symptoms similar to Klüver-Bucy syndrome...
- Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCIClifford R Jack
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Neurobiol Aging 29:1285-95. 2008..000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI...
- Neurodegenerative disorders with diffuse cortical Lewy bodiesAdam S Fleisher
Department of Neuroscience, UCSD Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
Adv Neurol 96:148-65. 2005
- Reduced sensitivity of the N400 and late positive component to semantic congruity and word repetition in left temporal lobe epilepsyJohn M Olichney
Neurology Service 9127, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Clin Electroencephalogr 33:111-8. 2002..Further studies are ongoing to determine if these ERP abnormalities predict hippocampal sclerosis on histopathology, or outcome after anterior temporal lobectomy...
- Memory in Aging, Mild Cognitive impairment and ADJohn Olichney; Fiscal Year: 2005..Event-related FMRI BOLD response patterns will be used to constrain source dipole models for the neural generations of the N400 and LPC. ..