R J O'Keefe

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction
    R J O'Keefe
    Department of Pathology, University of Rochester, NY, USA
    Iowa Orthop J 18:26-34. 1998
  2. doi request reprint Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
    R A Eliseev
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 27:3605-14. 2008
  3. pmc Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance
    Z Liu
    Department of Orthopaedics and Rehabilitation, The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA Department of Biology, University of Rochester, Rochester, NY 14642, USA
    Osteoarthritis Cartilage 24:740-51. 2016
  4. ncbi request reprint Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    H Ito
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Gene Ther 11:34-41. 2004
  5. ncbi request reprint Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues
    S D Reynolds
    Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Gene 248:233-43. 2000

Collaborators

Detail Information

Publications5

  1. pmc Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction
    R J O'Keefe
    Department of Pathology, University of Rochester, NY, USA
    Iowa Orthop J 18:26-34. 1998
    ..The role of cytokine secretion and regulation of MMP production in PVNS has not been investigated...
  2. doi request reprint Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
    R A Eliseev
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 27:3605-14. 2008
    ..Our study provides the first evidence for Bax as a direct target of Runx2, suggesting that Runx2 may act as a proapoptotic factor in osteosarcoma cells...
  3. pmc Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance
    Z Liu
    Department of Orthopaedics and Rehabilitation, The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA Department of Biology, University of Rochester, Rochester, NY 14642, USA
    Osteoarthritis Cartilage 24:740-51. 2016
    ..This study investigated the targeted cell population within the knee joint in which Notch signaling is required for normal cartilage and joint integrity...
  4. ncbi request reprint Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    H Ito
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Gene Ther 11:34-41. 2004
    ..These results demonstrate that LAGT combined with rAAV is a promising procedure to facilitate gene induction in HuMSCs for human gene therapy...
  5. ncbi request reprint Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues
    S D Reynolds
    Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Gene 248:233-43. 2000
    ..The Chordin gene is also expressed in chondrocytes and osteoblasts, suggesting that BMP1 and Tolloid influence BMP signaling as well as matrix maturation during skeletogenesis...