- The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cellsLuke Norton
Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
Nucleic Acids Res 42:13646-61. 2014..Our findings suggest TCF7L2 is an important regulator of the hepatic phenotype, and highlight novel mechanisms of gene regulation by TCF7L2 that involve interplay between multiple hepatic transcriptional pathways. ..
- Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolismL Norton
Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Diabetologia 54:3132-42. 2011..We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF7L2 in hepatocytes...
- Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levelsB Doiron
Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USA
Diabetologia 55:719-28. 2012..We hypothesised that GRB10 is involved in pancreatic apoptosis, as GRB10 binds with a family of cell-survival-related proteins implicated in apoptosis...