CHRISTOPHER MARK NORRIS
Affiliation: University of Kentucky
- Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injuryChristopher M Norris
Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, United States Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, United States Electronic address
Exp Neurol 276:5-12. 2016..The results show that PYC preserves synaptic function after CCI and provides further rationale for investigating the use of PYC as a therapeutic in humans suffering from neurotrauma...
- Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementiaDana M Niedowicz
Sanders Brown Center on Aging, University of Kentucky, 800 S, Limestone, Sanders Brown 211, Lexington, KY 40536 0230, USA
Acta Neuropathol Commun 2:64. 2014....
- Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged ratsDiana M Sama
Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky, United States of America
PLoS ONE 7:e38170. 2012..The results suggest that diverse functional changes associated with brain aging may arise, in part, from selective alterations in TNF signaling...
- Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's modelsChristopher M Norris
Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 25:4649-58. 2005..Thus, the data identify calcineurin upregulation in astrocytes as a novel candidate for an intracellular trigger of astrogliosis, particularly in aging and AD brain...
- Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with agingChristopher M Norris
Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
Neurobiol Aging 31:328-38. 2010..Thus, these studies point to altered CN function as a novel and potentially key factor in aging-dependent neuronal Ca(2+) dysregulation...
- Recovery of afferent function and synaptic strength in hippocampal CA1 following traumatic brain injuryChristopher M Norris
Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA
J Neurotrauma 26:2269-78. 2009..Although plasticity mechanisms appear to remain intact, synaptic strength deficits in CA1 could limit information throughput in the hippocampus, leading to persistent memory dysfunction...
- Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neuronsJohn C Gant
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
J Neurosci 31:1693-703. 2011..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging...
- Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activityMichelle A Sama
Department of Molecular and Biomedical Pharmacology, Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky 40536, USA
J Biol Chem 283:21953-64. 2008..Taken together, the results have potentially important implications for the propagation and maintenance of neuroinflammatory signaling processes associated with many neurodegenerative conditions and diseases...
- Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signalingHafiz Mohmmad Abdul
The Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 29:12957-69. 2009..The results suggest that NFAT signaling is selectively altered in AD and may play an important role in driving Abeta-mediated neurodegeneration...
- The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscleDusan M Jeftinija
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
Muscle Nerve 36:482-90. 2007..2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype...
- Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte culturesJennifer L Furman
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
Neurosci Lett 469:365-9. 2010..Together, the results demonstrate that the presence of serum and cell confluency have a major impact on CN/NFAT signaling in primary astrocyte cultures and therefore must be taken into consideration when using this model system...
- Calcineurin and Biobehavioral Markers of Brain AgingChristopher Norris; Fiscal Year: 2008..Furthermore, individual neurons and glia will be harvested from zipper slices to examine single cell gene expression profiles using gene microarray technology. ..