Carla M Nester

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Eculizumab in the treatment of atypical haemolytic uraemic syndrome and other complement-mediated renal diseases
    Carla M Nester
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Pediatr 25:225-31. 2013
  2. pmc Treatment options for C3 glomerulopathy
    Carla M Nester
    Departments of Internal Medicine and Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Curr Opin Nephrol Hypertens 22:231-7. 2013
  3. doi request reprint Multifaceted hemolytic uremic syndrome in pediatrics
    Carla M Nester
    Departments of Internal Medicine and Pediatrics, Rare Renal Disease Clinic, University of Iowa, Iowa City, IA 52242 1081, USA
    Blood Purif 35:86-92. 2013
  4. doi request reprint Atypical hemolytic uremic syndrome: what is it, how is it diagnosed, and how is it treated?
    Carla M Nester
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Hematology Am Soc Hematol Educ Program 2012:617-25. 2012
  5. pmc Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury
    Carla M Nester
    Department of Internal Medicine and Pediatrics, Divisions of Nephrology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242 1081, USA
    Am J Kidney Dis 53:866-70. 2009
  6. pmc Pre-emptive eculizumab and plasmapheresis for renal transplant in atypical hemolytic uremic syndrome
    Carla Nester
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Clin J Am Soc Nephrol 6:1488-94. 2011
  7. pmc Soluble CR1 therapy improves complement regulation in C3 glomerulopathy
    Yuzhou Zhang
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, Iowa
    J Am Soc Nephrol 24:1820-9. 2013
  8. doi request reprint Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene
    Xue Xiao
    Molecular Otolaryngology and Renal Research Laboratories, Caver College of Medicine, University of Iowa, Iowa City, IA, USA Interdepartmental PhD Program in Genetics, Caver College of Medicine, University of Iowa, Iowa City, IA, USA
    Mol Immunol 77:89-96. 2016
  9. pmc Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy
    Yuzhou Zhang
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Immunobiology 220:993-8. 2015
  10. pmc A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome
    Stephen J Eyler
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, 5270 CBRB Building, Iowa City, IA, 52242, USA
    Pediatr Nephrol 28:2221-5. 2013

Collaborators

Detail Information

Publications11

  1. doi request reprint Eculizumab in the treatment of atypical haemolytic uraemic syndrome and other complement-mediated renal diseases
    Carla M Nester
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Pediatr 25:225-31. 2013
    ....
  2. pmc Treatment options for C3 glomerulopathy
    Carla M Nester
    Departments of Internal Medicine and Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Curr Opin Nephrol Hypertens 22:231-7. 2013
    ..The purpose of this review is to discuss emerging nomenclature, review the salient clinicopathological features and describe the therapeutic options available for the treatment of C3 glomerulopathy (C3G)...
  3. doi request reprint Multifaceted hemolytic uremic syndrome in pediatrics
    Carla M Nester
    Departments of Internal Medicine and Pediatrics, Rare Renal Disease Clinic, University of Iowa, Iowa City, IA 52242 1081, USA
    Blood Purif 35:86-92. 2013
    ....
  4. doi request reprint Atypical hemolytic uremic syndrome: what is it, how is it diagnosed, and how is it treated?
    Carla M Nester
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Hematology Am Soc Hematol Educ Program 2012:617-25. 2012
    ..Further studies to identify additional genetic loci for aHUS and more robust biomarkers of both active and quiescent disease are required. Advances in these areas will undoubtedly improve the care of patients with aHUS...
  5. pmc Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury
    Carla M Nester
    Department of Internal Medicine and Pediatrics, Divisions of Nephrology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242 1081, USA
    Am J Kidney Dis 53:866-70. 2009
    ..The patient's course is consistent with cryoglobulinemia-associated kidney injury, which supports the inclusion of essential cryoglobulinemia in the differential diagnosis of pediatric patients with hypocomplementemic glomerulonephritis...
  6. pmc Pre-emptive eculizumab and plasmapheresis for renal transplant in atypical hemolytic uremic syndrome
    Carla Nester
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Clin J Am Soc Nephrol 6:1488-94. 2011
    ..S. transplant to open the door to this type of definitive care for this devastating disease...
  7. pmc Soluble CR1 therapy improves complement regulation in C3 glomerulopathy
    Yuzhou Zhang
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, Iowa
    J Am Soc Nephrol 24:1820-9. 2013
    ..Overall, these data indicate that soluble CR1 re-establishes regulation of the alternative complement pathway and provide support for a limited trial to evaluate soluble CR1 as a treatment for DDD and C3GN. ..
  8. doi request reprint Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene
    Xue Xiao
    Molecular Otolaryngology and Renal Research Laboratories, Caver College of Medicine, University of Iowa, Iowa City, IA, USA Interdepartmental PhD Program in Genetics, Caver College of Medicine, University of Iowa, Iowa City, IA, USA
    Mol Immunol 77:89-96. 2016
    ..These data highlight the role of factor H related proteins in the control of complement activity and illustrate how perturbation of that control leads to C3G. ..
  9. pmc Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy
    Yuzhou Zhang
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Immunobiology 220:993-8. 2015
    ..In aggregate, these data suggest that Cp40 may offer a novel and promising therapeutic option to C3G patients as a disease-specific, targeted therapy. As such, Cp40 could represent a major advance in the treatment of this disease. ..
  10. pmc A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome
    Stephen J Eyler
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, 5270 CBRB Building, Iowa City, IA, 52242, USA
    Pediatr Nephrol 28:2221-5. 2013
    ..This high degree of sequence identity renders this area susceptible to nonallelic homologous recombination (NAHR) events, resulting in large-scale deletions, duplications, and the generation of hybrid CFH genes...
  11. doi request reprint Complement inhibition in C3 glomerulopathy
    Carla M Nester
    Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Divisions of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Semin Immunol 28:241-9. 2016
    ..Research advances are laying the foundation for complement inhibition as a targeted approach to treatment of C3G. ..