Joseph P Neglia
Affiliation: University of Minnesota
- New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor StudyJoseph P Neglia
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA
J Natl Cancer Inst 98:1528-37. 2006..However, the details of the dose-response relationships, the expression of excess risk over time, and the modifying effects of other host and treatment factors have not been well defined...
- Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor StudyDebra L Friedman
Vanderbilt Ingram Cancer Center, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Natl Cancer Inst 102:1083-95. 2010..We have expanded our analysis of these events in the Childhood Cancer Survivor Study (CCSS) to better understand the occurrence of these events as the survivor population ages...
- Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyRajen Mody
Department of Pediatrics, University of Michigan, Ann Arbor, USA
Blood 111:5515-23. 2008..001). Long-term survivors of childhood ALL exhibit excess mortality and morbidity. Survivors who received radiation therapy as part of their treatment or had a leukemia relapse are at greatest risk for adverse outcomes...
- Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor studyRajaram Nagarajan
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer 97:2554-64. 2003..The authors described psychosocial outcomes (education, employment, health insurance, and marriage) for survivors of pediatric lower extremity bone tumors...
- Secondary sarcomas in childhood cancer survivors: a report from the Childhood Cancer Survivor StudyTara O Henderson
Department of Pediatrics, Section of Hematology Oncology, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Ave, MC 4060, Chicago, IL 60637, USA
J Natl Cancer Inst 99:300-8. 2007..We analyzed a large cohort of childhood cancer survivors to determine the true incidence of secondary sarcomas and to examine factors associated with the risk of developing secondary sarcomas...
- Risk factors associated with secondary sarcomas in childhood cancer survivors: a report from the childhood cancer survivor studyTara O Henderson
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
Int J Radiat Oncol Biol Phys 84:224-30. 2012..Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified...
- Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor StudyJames G Gurney
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Cancer 97:663-73. 2003....
- Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor studyJames G Gurney
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Endocrinol Metab 88:4731-9. 2003..We did not find a corresponding elevated risk for obesity...
- Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor StudyDaniel A Mulrooney
Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
Cancer 112:2071-9. 2008..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)...
- Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor studyJoanna L Perkins
Children s Hospitals and Clinics, 2525 Chicago Ave S, Ste 4150, Minneapolis, MN 55404, USA
J Clin Oncol 23:3733-41. 2005..This article reports on the occurrence of secondary NMSC as a long-term effect of cancer therapy in survivors of childhood cancer...
- Fatigue and sleep disturbance in adult survivors of childhood cancer: a report from the childhood cancer survivor study (CCSS)Daniel A Mulrooney
Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Sleep 31:271-81. 2008..To examine the prevalence of and risk factors for fatigue and sleep disturbance among adult survivors of childhood cancer...
- Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor StudyAnn C Mertens
Department of Pediatrics, Emory University, 2015 Uppergate Dr, Atlanta, GA 30322, USA
J Natl Cancer Inst 100:1368-79. 2008..The proportion of pediatric and adolescent cancer patients surviving 5 years has increased during the past four decades. This growing population of survivors remains at risk for disease- and treatment-associated late mortality...
- Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative projectLeslie L Robison
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
Med Pediatr Oncol 38:229-39. 2002..To facilitate such research, a multi-institutional consortium established the Childhood Cancer Survivor Study (CCSS), a large, diverse, and well-characterized cohort of 5-year survivors of childhood and adolescent cancer...
- Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)Shu Xiao Ou
Department of Pediatrics, University of Minnesota, Minneapolis, USA
Cancer Causes Control 13:15-25. 2002..To investigate the associations of birth characteristics and maternal reproductive factors with risk of childhood acute lymphoblastic leukemia (ALL) by immunophenotypic subtypes...
- XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin diseaseAnn C Mertens
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Cancer 101:1463-72. 2004..Survivors of Hodgkin disease (HD), in particular, have been shown to be at high risk of subsequent malignancy, the occurrence of which has been associated strongly with exposure to radiotherapy...
- Childhood cancer survivors' knowledge about their past diagnosis and treatment: Childhood Cancer Survivor StudyNina S Kadan-Lottick
Department of Pediatrics, 420 Delaware St SE, Mayo Mail Code 715, Minneapolis, MN 55455, USA
JAMA 287:1832-9. 2002..This knowledge is necessary to motivate them to seek medical follow-up and to report essential history to health care professionals...
- Assessment of physical performance using the 6-minute walk test in children receiving treatment for cancerMary C Hooke
School of Nursing, University of Minnesota, Minneapolis, MN, USA
Cancer Nurs 36:E9-E16. 2013..Studies have shown that children with cancer experience deficits in physical performance during treatment that may be present years after therapy...
- Pilot study of vascular health in survivors of Hodgkin lymphomaDaniel A Mulrooney
School of Public Health, Masonic Cancer Center, and University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 59:285-9. 2012..Vascular-related toxicities have been reported among survivors of Hodgkin lymphoma (HL), but their genesis is not well understood...
- Second neoplasms after megavoltage radiation for pediatric tumorsDouglas G Gold
University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Cancer 97:2588-96. 2003..The authors updated an earlier study on the nature and risk of second neoplasms (SN) in patients treated with megavoltage radiotherapy as children...
- Transplacental and other routes of cancer transmission between individualsJakub Tolar
Department of Pediatrics, Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Pediatr Hematol Oncol 25:430-4. 2003..As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional guidelines are given for the screening of infants born to women with cancer...
- Reversible Fanconi syndrome in a pediatric patient on deferasiroxMichelle N Rheault
Department of Pediatrics, University of Minnesota Amplatz Children s Hospital, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 56:674-6. 2011..Kidney and proximal tubular function should be periodically monitored in patients receiving deferasirox throughout their course of therapy...
- Sleep in children with neoplasms of the central nervous system: case review of 14 childrenGerald M Rosen
Minnesota Regional Sleep Disorder Center, University of Minnesota Minneapolis, Minnesota 55403, USA
Pediatrics 112:e46-54. 2003..The objective of this study was to characterize the sleep problems seen in children with neoplasms of the CNS through a comprehensive clinical and objective sleep evaluation...
- Caring for adult survivors of childhood cancerDaniel A Mulrooney
Department of Pediatrics, University of Minnesota Cancer Center, Mayo Mail Code 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Curr Treat Options Oncol 9:51-66. 2008....
- Evaluation of traditional and novel measures of cardiac function to detect anthracycline-induced cardiotoxicity in survivors of childhood cancerAndrew C Dietz
Division of Hematology Oncology BMT, Department of Pediatrics, University of California San Diego and Rady Children s Hospital, 3020 Children s Way, MC5035, San Diego, CA, 92123, USA
J Cancer Surviv 8:183-9. 2014..This study aimed to evaluate these modalities in detection of anthracycline-induced cardiac toxicity...
- Splenomegaly unresponsive to standard and salvage chemotherapy in Langerhans cell histiocytosis: a case of extramedullary hematopoiesisEllen C Christiansen
University of Minnesota Medical School, Minneapolis, MN, USA
Pediatr Blood Cancer 58:998-9. 2012..These findings thus challenge our understanding of splenomegaly as a marker of disease...
- Autoimmune haemolytic anaemia complicating haematopoietic cell transplantation in paediatric patients: high incidence and significant mortality in unrelated donor transplants for non-malignant diseasesTracey A O'Brien
Pediatric Hematology Oncology and Blood and Marrow Transplant Program, Medical School, University of Minnesota, Minneapolis, MN, USA
Br J Haematol 127:67-75. 2004..Alternative treatment strategies were employed, with the majority of patients demonstrating disease refractory to traditional steroid therapy...
- Diagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotypeXiao Ou Shu
University of Minnesota, Minneapolis, Minnesota, USA
Cancer Epidemiol Biomarkers Prev 11:177-85. 2002....
- A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group studyBrenda J Weigel
University of Minnesota Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Clin Cancer Res 13:1789-93. 2007..To determine the recommended phase 2 dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and pharmacodynamics of the heat shock protein (Hsp) 90 inhibitor, 17-allylaminogeldanamycin (17-AAG)...
- New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factorsK Scott Baker
Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
J Clin Oncol 21:1352-8. 2003..To determine the incidence and risk factors for the development of new malignancies occurring after stem-cell transplantation (SCT)...
- Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications?Rajaram Nagarajan
Department of Pediatrics, Division of Hematology Oncology Blood and Marrow Transplant, University of Minnesota, Minneapolis 55455, USA
J Clin Oncol 20:4493-501. 2002....
- Breast cancer after chest radiation therapy for childhood cancerChaya S Moskowitz
Chaya S Moskowitz, Joanne F Chou, Suzanne L Wolden, Jonine L Bernstein, Danielle Novetsky Friedman, Nidha Z Mubdi, Colin B Begg, and Kevin C Oeffinger, Memorial Sloan Kettering Cancer Center Jyoti Malhotra, Mount Sinai Medical Center, New York, NY Wendy M Leisenring, Fred Hutchinson Cancer Research Center, Seattle, WA Marilyn Stovall and Susan A Smith, University of Texas MD Anderson Cancer Center, Houston, TX Sue Hammond, Nationwide Children s Hospital, Columbus, OH Tara O Henderson, University of Chicago Medicine Comer Children s Hospital, Chicago, IL John D Boice, Vanderbilt Ingram Cancer Center, Nashville Melissa M Hudson and Leslie L Robison, St Jude Children s Research Hospital, Memphis, TN Lisa R Diller and Lisa B Kenney, Dana Farber Cancer Institute, Boston, MA Smita Bhatia, City of Hope National Medical Center, Duarte, CA and Joseph P Neglia, University of Minnesota Masonic Cancer Center, Minneapolis, MN
J Clin Oncol 32:2217-23. 2014..The risk of breast cancer is high in women treated for a childhood cancer with chest irradiation. We sought to examine variations in risk resulting from irradiation field and radiation dose...
- The contribution of neurocognitive functioning to quality of life after childhood acute lymphoblastic leukemiaAlicia Kunin-Batson
HealthPartners Institute for Education and Research, Minneapolis, MN, USA University of Minnesota Medical School, Minneapolis, MN, USA
Psychooncology 23:692-9. 2014..In this multi-site study, we examined the relative influence of neurocognitive functioning, steroid randomization (prednisone vs. dexamethasone), and demographic characteristics on QOL in first-remission survivors of childhood ALL...
- Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusionMichelle Dolan
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 59:194-6. 2012..This patient's atypical presentation highlights the importance of obtaining cytogenetic analysis at the time of bone marrow sampling and considering this uncommon entity in the differential diagnosis of hematologic disorders...
- Characteristics of patients with TEL-AML1-positive acute lymphoblastic leukemia with single or multiple fusionsSuleimman A Al-Sweedan
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 48:510-4. 2007..Some TEL-AML1+ ALL patients present at diagnosis with extra copies of the fusion, enumerated by FISH. The aim of the study was to determine whether additional copies of TEL-AML1 have clinical significance...
- Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemiaKris Ann P Schultz
Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Pediatr Blood Cancer 51:293-5. 2008..Further studies revealed absence of Bruton's tyrosine kinase (BTK) protein expression and a novel BTK mutation...
- Pediatric acute lymphoblastic leukemia: redefining outcomesNina Kadan-Lottick
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, USA
J Pediatr Hematol Oncol 24:88. 2002
- First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantationChristopher J Fraser
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 106:4377-80. 2005..This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients...
- Pediatric ovarian tumors: a review of 67 casesKris Ann P Schultz
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Pediatr Blood Cancer 44:167-73. 2005..Ovarian tumors are uncommon but important childhood neoplasms...
- Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor studyRoger J Packer
Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC, USA
J Clin Oncol 21:3255-61. 2003..To describe the neurologic and neurosensory deficits in children with brain tumors (BTs), compare incidence of these deficits with that of a sibling control group, and evaluate the factors associated with the development of these deficits...
- Cancer risk in nontransplanted and transplanted cystic fibrosis patients: a 10-year studyPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
J Natl Cancer Inst 95:381-7. 2003..However, more patients now reach adulthood, and more patients undergo organ transplantation-factors associated with an increased cancer risk. Our aim was to assess the risk of cancer in nontransplanted and transplanted CF patients...
- Second neoplasms following megavoltage radiation for pediatric tumorsDouglas G Gold
Cancer 100:212-3. 2004
- Day care, childhood infections, and risk of neuroblastomaFlorence Menegaux
INSERM U170 IFR69, 94800 Villejuif, France
Am J Epidemiol 159:843-51. 2004..This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection...
- Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor StudyLisa B Kenney
Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Intern Med 141:590-7. 2004..Survivors of childhood cancer are at risk for secondary breast cancer. Other than previous chest radiation therapy, risk factors for secondary breast cancer have not been established...
- Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control studyAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
Lancet 365:2014-23. 2005..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...
- Breast cancerCécile M Ronckers
Lancet 366:1605-6; author reply 1606. 2005
- Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor StudyMylène Bassal
Division of Pediatric Hematology Oncology BMT, University of Colorado Health Sciences Center, Denver, CO, USA
J Clin Oncol 24:476-83. 2006..To determine the risk of subsequent carcinomas other than breast, thyroid, and skin, and to identify factors that influence the risk among survivors of childhood cancer...
- Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiersCécile M Ronckers
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
Radiat Res 166:618-28. 2006..In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses...
- Prediction of second malignant neoplasm incidence in a large cohort of long-term survivors of childhood cancersIrina Dinu
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Pediatr Blood Cancer 50:1026-31. 2008..The ability to predict adverse-event occurrences accurately in long-term survivors of childhood cancer is of high importance in late effects research, both clinically and methodologically...
- Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor StudyElizabeth C Bluhm
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7238, Rockville, MD 20892 7238, USA
Blood 111:4014-21. 2008..1), mediastinal NHL disease (RR = 5.2), and breast irradiation (RR = 4.3). Survivors of childhood NHL, particularly those treated with chest RT, are at continued increased risk of early mortality and solid tumor SMNs...
- Parental exposure to medical radiation and neuroblastoma in offspringTara Patton
Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA
Paediatr Perinat Epidemiol 18:178-85. 2004..The data presented here, coupled with the lower radiation doses currently used, indicate that any further study of this question will require larger studies with improved exposure assessment...
- Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing DisciplineWendy Landier
Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
J Clin Oncol 22:4979-90. 2004..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org...
- Comparison of results of a pilot study of alternating vincristine/doxorubicin/cyclophosphamide and etoposide/ifosfamide with IRS-IV in intermediate risk rhabdomyosarcoma: a report from the Children's Oncology GroupCarola A S Arndt
Mayo Clinic and Foundation, Rochester, Minnesota, USA
Pediatr Blood Cancer 50:33-6. 2008..Treatment with alternating cycles of non-cross-resistant chemotherapy has been used in a number of diseases with good results...
- Case 4-2008: A pregnant woman with a swollen left breast and dyspneaJakub Tolar
N Engl J Med 358:2848; author reply 2848-9. 2008
- Maternal vitamin use and reduced risk of neuroblastomaAndrew F Olshan
Department of Epidemiology, School of Public Health University of North Carolina, Chapel Hill, NC, USA
Epidemiology 13:575-80. 2002..Using data from a large North American study, we conducted an analysis to investigate maternal vitamin use and neuroblastoma in offspring...
- Transplacental transfer of small-cell carcinoma of the lungJakub Tolar
N Engl J Med 346:1501-2. 2002
- A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancersYutaka Yasui
Cancer Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 158:1108-13. 2003..These showed appreciable differences in the analytical results by not accounting for the natural age-associated increase of risk, illustrating a significant impact of this methodological issue on study conclusions...