Genomes and Genes
Affiliation: University of California
- [Cancer stem cells in pediatric brain tumors]Ichiro Nakano
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
No Shinkei Geka 32:827-34. 2004..In this review, we discuss the difference as well as the similarity between tumor and normal stem cells, and also the possible clinical implication of cancer stem cells...
- Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferationIchiro Nakano
Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
J Cell Biol 170:413-27. 2005..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain...
- Methods for analysis of brain tumor stem cell and neural stem cell self-renewalIchiro Nakano
Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Methods Mol Biol 568:37-56. 2009..Utilizing our studies with MELK as an example, this chapter describes methods to culture NSC and BT stem cells, and to analyze the pathways, which regulate self-renewal of those cells...
- Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferationIchiro Nakano
Department of Neurological Surgery, UCLA, Los Angeles, CA 90095 1769, USA
Stem Cells 25:1975-84. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytesTetsuya Imura
Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
Glia 53:277-93. 2006..The findings provide evidence that GFAP-expressing NSCs are phenotypically and functionally distinct from non-neurogenic astrocytes...
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cellsIchiro Nakano
Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurosci Res 86:48-60. 2008..These results demonstrate a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors...
- BMPing off glioma stem cellsIchiro Nakano
Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
Cancer Cell 13:3-4. 2008..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
- A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cellsKoppany Visnyei
Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Mol Cancer Ther 10:1818-28. 2011..These studies show that our screening strategy provides potential candidates and a blueprint for lead compound identification in larger scale screens or screens involving other cancer types...
- Cancer stem cells in pediatric brain tumorsJoseph L Lasky
Department of Neurosurgery, David Geffen School of Medicine at UCLA, USA
Curr Stem Cell Res Ther 4:298-305. 2009....
- Brain tumor stem cellsIchiro Nakano
Departments of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, 90095, USA
Pediatr Res 59:54R-8R. 2006..In this review, we discuss the cellular and molecular relationships between brain tumor stem cells and normal neural stem cells, and also the possible clinical implications of brain tumor stem cells...
- Cancerous stem cells can arise from pediatric brain tumorsHouman D Hemmati
Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 100:15178-83. 2003..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...