Jerry L Nadler

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes
    Zandong Yang
    University of Virginia, Charlottesville, Virginia 22908, USA
    Ann N Y Acad Sci 1005:409-11. 2003
  2. pmc 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet
    Craig S Nunemaker
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Endocrinol Metab 295:E1065-75. 2008
  3. pmc Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways
    Melissa H Nagelin
    Department of Pharmacology, The Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:31303-14. 2009
  4. doi request reprint Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Heart Circ Physiol 294:H1933-8. 2008
  5. ncbi request reprint Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, 22908, USA
    Endocrinology 147:2518-25. 2006
  6. ncbi request reprint Inflammatory blockade improves human pancreatic islet function and viability
    Zandong Yang
    Department of Internal Medicine, Division of Endocrinology, Metabolism, University of Virginia, Charlottesville, VA 22908, USA
    Am J Transplant 5:475-83. 2005
  7. ncbi request reprint Autoimmune diabetes is blocked in Stat4-deficient mice
    Zandong Yang
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, P O Box 801413, Charlottesville, VA 22908, USA
    J Autoimmun 22:191-200. 2004
  8. ncbi request reprint Viral IL-10-mediated immune regulation in pancreatic islet transplantation
    Jeffrey D Carter
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Ther 12:360-8. 2005
  9. ncbi request reprint The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 148:1313-22. 2007
  10. ncbi request reprint The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
    Zandong Yang
    Department of Internal Medicine, P O Box 801413, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 107:30-5. 2003

Research Grants

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes
    Zandong Yang
    University of Virginia, Charlottesville, Virginia 22908, USA
    Ann N Y Acad Sci 1005:409-11. 2003
    ..Interruption of IL-12-mediated STAT4 activation prevented autoimmune diabetes in NOD mice...
  2. pmc 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet
    Craig S Nunemaker
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Endocrinol Metab 295:E1065-75. 2008
    ..Inhibiting 12-LO may provide a new therapeutic approach to prevent inflammation-mediated metabolic consequences of excess fat intake...
  3. pmc Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways
    Melissa H Nagelin
    Department of Pharmacology, The Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:31303-14. 2009
    ..These findings provide evidence that 12/15LO regulates ABCG1 expression and function through p38- and JNK2-dependent mechanisms, and that targeting these pathways may provide novel approaches for regulating cholesterol homeostasis...
  4. doi request reprint Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Heart Circ Physiol 294:H1933-8. 2008
    ..These results suggest a potentially important mechanism linking 12/15-LO activation to MCP-1 expression that induces inflammatory cell infiltration...
  5. ncbi request reprint Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, 22908, USA
    Endocrinology 147:2518-25. 2006
    ..These results provide evidence for a potentially important mechanism linking elevated glucose and diabetes to inflammation...
  6. ncbi request reprint Inflammatory blockade improves human pancreatic islet function and viability
    Zandong Yang
    Department of Internal Medicine, Division of Endocrinology, Metabolism, University of Virginia, Charlottesville, VA 22908, USA
    Am J Transplant 5:475-83. 2005
    ..These results demonstrate that LSF profoundly enhances beta-cell function, and suggest the potential of using inflammatory blockade, such as LSF, to improve beta-cell function for islet transplantation...
  7. ncbi request reprint Autoimmune diabetes is blocked in Stat4-deficient mice
    Zandong Yang
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, P O Box 801413, Charlottesville, VA 22908, USA
    J Autoimmun 22:191-200. 2004
    ..Significantly, disruption of Stat4 activation completely prevented the development of spontaneous diabetes in NOD mice. This study reveals the important role of STAT4 in autoimmune diabetes pathogenesis...
  8. ncbi request reprint Viral IL-10-mediated immune regulation in pancreatic islet transplantation
    Jeffrey D Carter
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Ther 12:360-8. 2005
    ..We conclude that vIL-10 can regulate autoimmune activity and that transfer of its gene may have potential for therapeutic islet transplantation...
  9. ncbi request reprint The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 148:1313-22. 2007
    ..These results suggest a potentially important mechanism linking 12/15-LO activation to chronic inflammation and atherosclerosis...
  10. ncbi request reprint The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
    Zandong Yang
    Department of Internal Medicine, P O Box 801413, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 107:30-5. 2003
    ..These results suggest that FTY720 may be effective in prevention of autoimmune diabetes or in slowing its progression...
  11. ncbi request reprint The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation
    Zandong Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Transplantation 77:55-60. 2004
    ..In this study, the authors investigated the potential of LSF in preventing autoimmune diabetes recurrence after islet transplantation...
  12. pmc Impact of lifestyle intervention on lost productivity and disability: improving control with activity and nutrition
    Anne M Wolf
    Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908 0717, USA
    J Occup Environ Med 51:139-45. 2009
    ..To evaluate the effectiveness of a lifestyle intervention (LI) in reducing work loss and disability days...
  13. ncbi request reprint Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome
    Hong Pei
    Division of Endocrinology, Department of Internal Medicine, University of Virginia, PO Box 801405, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 290:E92-E102. 2006
    ..These studies suggest both the presence of an exaggerated injury response in the insulin-resistant obese ZR model and that inflammation plays a major role in mediating neointimal growth...
  14. pmc AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets
    William S Crim
    Department of Medicine, University of Virginia, VA 22908, USA
    Mol Cell Endocrinol 323:246-55. 2010
    ..This is the first report of direct stimulatory and protective effects of a first-in-class potential anti-diabetic agent on pancreatic islets...
  15. ncbi request reprint The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice
    Zandong Yang
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Pancreas 26:e99-104. 2003
    ..Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action...
  16. pmc Insulin and glucose play a role in foam cell formation and function
    Pavel N Shashkin
    Cardiovascular Research Center, University of Virginia, 415 Lane Road, Charlottesville, VA 22903, USA
    Cardiovasc Diabetol 5:13. 2006
    ....
  17. ncbi request reprint Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition
    David T Bolick
    Division of Endocrinology and Metabolism, University of Virginia Medical Center, Charlottesville, Virginia 22908 1405, USA
    Endocrinology 144:5227-31. 2003
    ..These results suggest that LSF may provide therapeutic benefit for prevention or treatment of diabetic nephropathy...
  18. ncbi request reprint Suppression of autoimmune diabetes by viral IL-10 gene transfer
    Zandong Yang
    Division of Endocrinology and Metabolism, and Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 168:6479-85. 2002
    ..This study provides evidence to support the possibility of using vIL-10 gene therapy to prevent type 1 diabetes...
  19. pmc Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes
    Marcia McDuffie
    University of Virginia, P O Box 801405, Charlottesville, VA 22908, USA
    Diabetes 57:199-208. 2008
    ..Since the gene encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in NOD mice, we hypothesized that 12/15-LO is also a key regulator of diabetes susceptibility in the NOD mouse...
  20. pmc 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1
    Melissa H Nagelin
    Department of Pharmacology, The Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 28:1811-9. 2008
    ..The purpose of this study was to evaluate the effect of 12/15-lipoxygenase (12/15LO) in macrophage ABCG1 expression and function associated with cholesterol efflux...
  21. ncbi request reprint Effects of lifestyle intervention on health care costs: Improving Control with Activity and Nutrition (ICAN)
    Anne M Wolf
    Department of Public Health Sciences, 1710 Allied St, Suite 34, Charlottesville, VA 22903, USA
    J Am Diet Assoc 107:1365-73. 2007
    ..To evaluate program and health care costs of a lifestyle intervention in a high-risk obese population...
  22. pmc Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells
    Margaret A Morris
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, P O Box 801394, Charlottesville, VA 22908, USA
    Autoimmunity 44:115-28. 2011
    ..FTY20 treatment started after disease onset slowed disease progression. The inability to fully suppress memory and effector T-cell circulation may explain why FTY720 is only partially effective in the NOD adoptive transfer model of T1D...
  23. ncbi request reprint Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
    Zandong Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA
    Biochem Biophys Res Commun 344:1017-22. 2006
    ..It is possible that such combined therapy could become a new strategy to defeat T1DM in humans...
  24. pmc Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging
    Patrick F Antkowiak
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 296:E573-8. 2009
    ....
  25. ncbi request reprint Lisofylline: a potential lead for the treatment of diabetes
    Zandong Yang
    Department of Internal Medicine, Diabetes and Hormone Center of Excellence, Division of Endocrinology and Metabolism, University of Virginia, P O Box 801413, Charlottesville, VA 22908, USA
    Biochem Pharmacol 69:1-5. 2005
    ....
  26. ncbi request reprint Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes
    Peng Cui
    Department of Chemistry, University of Virginia, Charlottesville, 22904, USA
    Bioorg Med Chem Lett 16:3401-5. 2006
    ..The LSF analogs were evaluated in a pancreatic beta-cell line for the effects on apoptosis protection and insulin release. The metabolic stability of selected compounds was also tested...
  27. ncbi request reprint Elevated glucose activates protein synthesis in cultured cardiac myocytes
    Wen Yeshao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
    Metabolism 54:1453-60. 2005
    ..These results provide new evidence for a direct effect of glucose independent of insulin on cardiac myocyte growth...
  28. ncbi request reprint Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats
    John S Striffler
    Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Metabolism 53:290-6. 2004
    ..These results support the conclusion that agents, such as LSF, may have therapeutic benefits in type 2 diabetes...
  29. pmc The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth
    Angela M Taylor
    Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 25:2069-74. 2005
    ..Id3 has been shown to regulate growth in various cell types and is expressed in VSMCs within atherosclerotic and restenotic lesions. This study examines the role of Id3 in 12/15-LO-mediated VSMC proliferation...
  30. ncbi request reprint Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
    Meng Chen
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 143:2341-8. 2002
    ..LSF at concentrations achievable in vivo protected beta-cells from the cytokine effects. The mechanism of LSF-induced protection may be by promoting mitochondrial metabolism...
  31. ncbi request reprint Lifestyle intervention in obese patients with type 2 diabetes: impact of the patient's educational background
    Matthew J Gurka
    Department of Public Health Sciences, Division of Endocrinology and Metabolism, University of Virginia School of Medicine, Charlottesville, 22908, USA
    Obesity (Silver Spring) 14:1085-92. 2006
    ..To determine whether people with different educational backgrounds respond differently to a lifestyle intervention program for obese patients with type 2 diabetes...
  32. ncbi request reprint 12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells
    Jiali Gu
    Division of Endocrinology, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 144:534-43. 2003
    ..These results suggest that 12-LO stimulation leads to aldosterone production in H295R cells in part through activation of CREB/ATF-1 and p38 MAPK pathway...
  33. ncbi request reprint Inflammatory mechanisms of diabetic complications
    Michael D Williams
    Division of Endocrinology and Metabolism, University of Virginia, P O Box 801405, 450 Ray C Hunt Drive, Room 1220, Charlottesville, VA 22908 1405, USA
    Curr Diab Rep 7:242-8. 2007
    ..Future approaches to the treatment of diabetic complications may involve regulation of inflammatory processes, specifically targeting factors that contribute to vascular damage...
  34. ncbi request reprint Magnesium deficiency is associated with insulin resistance in obese children
    Milagros G Huerta
    University of Virginia, Department of Pediatrics, Box 800386, Charlottesville, VA 22908, USA
    Diabetes Care 28:1175-81. 2005
    ..This study was designed to determine whether obese children exhibit serum or dietary magnesium deficiency and its potential association with IR...
  35. ncbi request reprint Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice
    Yuqing Huo
    University of Virginia, Charlottesville, VA, USA
    Circulation 110:2024-31. 2004
    ..12/15-LO is expressed in a variety of cells, including vascular cells, adipocytes, macrophages, and cardiomyocytes. The purpose of this study was to determine which cellular source of 12/15-LO is important for atherosclerosis...
  36. ncbi request reprint Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes
    Milagros G Huerta
    Division of Endocrinology and Metabolism, University of Virginia, P O Box 801405, Fontaine Research Park, 450 Ray C Hunt Drive, Fontaine Medical Research Building, 1st Floor Room 1220, Charlottesville, VA 22908 1405, USA
    Curr Diab Rep 2:396-402. 2002
    ..Prospective, randomized clinical trials are currently underway to confirm these initial findings and define indications for treatment of patients at risk...
  37. ncbi request reprint High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 56:2598-608. 2007
    ..This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity...
  38. ncbi request reprint Lipid inflammatory mediators in diabetic vascular disease
    Rama Natarajan
    Gonda Diabetes Research Center, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Arterioscler Thromb Vasc Biol 24:1542-8. 2004
    ..This review evaluates these inflammatory and proatherogenic pathways in the pathogenesis of diabetic vascular disease...
  39. ncbi request reprint Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability
    Konkal Matt R Prasad
    Division of Endocrinology and Metabolism, University of Virginia Health Science Center, Charlottesville 22908 2980, USA
    Biochem Biophys Res Commun 308:427-32. 2003
    ....
  40. ncbi request reprint The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II
    Marpadga A Reddy
    Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 277:9920-8. 2002
    ....
  41. ncbi request reprint 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo
    Kelly B Reilly
    Department of Diabetes, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    J Biol Chem 279:9440-50. 2004
    ..Thus, 12/15-LO mediates monocyte/EC interactions in the vessel wall in atherogenesis at least in part through molecular regulation of expression of endothelial adhesion molecules...
  42. ncbi request reprint Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls
    Tie Hua Sun
    Insmed Incorporated, 4851 Lake Brooke Dr, Glen Allen, VA 23060, USA
    Biochem Biophys Res Commun 293:1092-8. 2002
    ..Further it may also possibly play a role in the underlying insulin resistance...
  43. ncbi request reprint Lipoxygenases and lipid signaling in vascular cells in diabetes
    Rama Natarajan
    Gonda Diabetes Research Center, Beckman Research Institute of City of Hope, Duarte CA 91010, USA
    Front Biosci 8:s783-95. 2003
    ....
  44. ncbi request reprint Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells
    Marpadga A Reddy
    Department of Diabetes, Beckman Research Institute of the City of Hope, Duarte California 91010, USA
    Am J Physiol Renal Physiol 283:F985-94. 2002
    ..ANG II effects may be mediated by the LO pathway. These results suggest a novel interaction between LO and p38(MAPK) activation in MC matrix synthesis associated with renal complications...
  45. ncbi request reprint Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid
    Xiao Han
    Leslie and Susan Gonda Goldschmied Diabetes and Genetics Research Center, Department of Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, California 91010, USA
    Mol Endocrinol 16:2145-54. 2002
    ..These data demonstrate that 12-HETE mediates cytokine-induced COX-2 gene transcription and resultant PGE2 production in pancreatic beta-cells...
  46. pmc 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
    Rose A Gubitosi-Klug
    Department of Pediatrics, Case Western Reserve University Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Diabetes 57:1387-93. 2008
    ..Lipoxygenases are regulators of chronic inflammation and oxidative stress generation. We evaluated the role of 5- and 12-lipoxygenases in the development of diabetic retinopathy...
  47. ncbi request reprint A new dietary approach to reduce the risk of type 2 diabetes?
    Jerry L Nadler
    Diabetes Care 27:270-1. 2004

Research Grants1

  1. New Antiinflammatory Agents to Prevent Damage to Islets
    Jerry Nadler; Fiscal Year: 2003
    ..This same compound(s) should also provide benefit to maintain beta cell function after islet cell transplantation. ..