Kristen J Nadeau

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218, USA
    J Biol Chem 279:34380-7. 2004
  2. ncbi request reprint Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr Gastroenterol Nutr 41:94-8. 2005
  3. pmc Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity
    Kristen J Nadeau
    Division of Pediatric Endocrinology, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3687-95. 2009
  4. pmc Insulin resistance in type 2 diabetic youth
    Kara Mizokami-Stout
    Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children s Hospital Colorado, Denver, Colorado, USA
    Curr Opin Endocrinol Diabetes Obes 19:255-62. 2012
  5. doi request reprint Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 10:5-13. 2009
  6. ncbi request reprint Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty
    Megan Moriarty-Kelsey
    Department of Pediatrics, University of Colorado Denver The Children s Hospital, 13123 East 16th Avenue, Aurora, CO 80045, USA
    J Pediatr Endocrinol Metab 23:1281-7. 2010
  7. pmc Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance
    Melanie Cree-Green
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Obesity (Silver Spring) 24:2399-2406. 2016
  8. doi request reprint Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Pediatr Diabetes . 2016
  9. pmc The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Denver, Aurora
    Pediatr Diabetes . 2016
  10. doi request reprint Use of glycosylated hemoglobin increases diabetes screening for at-risk adolescents in primary care settings
    Kathryn A Love-Osborne
    Pediatrics Adolescent Medicine, Denver Health and Hospitals and University of Colorado School of Medicine, Denver, CO, 80205, USA
    Pediatr Diabetes 14:512-8. 2013

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218, USA
    J Biol Chem 279:34380-7. 2004
    ....
  2. ncbi request reprint Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr Gastroenterol Nutr 41:94-8. 2005
    ..The prevalence of nonalcoholic fatty liver disease in type 2 diabetes is unclear in adults and unknown in children...
  3. pmc Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity
    Kristen J Nadeau
    Division of Pediatric Endocrinology, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3687-95. 2009
    ..Cardiopulmonary fitness, a marker of morbidity and mortality, is abnormal in adults with T2D, yet the mechanisms are incompletely understood...
  4. pmc Insulin resistance in type 2 diabetic youth
    Kara Mizokami-Stout
    Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children s Hospital Colorado, Denver, Colorado, USA
    Curr Opin Endocrinol Diabetes Obes 19:255-62. 2012
    ..Insulin resistance is associated with a variety of cardiometabolic problems leading to increased morbidity and mortality across the lifespan...
  5. doi request reprint Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 10:5-13. 2009
    ..While metformin plus lifestyle intervention appears promising, defining NAFLD therapies capable of preventing fibrosis and cirrhosis requires further study...
  6. ncbi request reprint Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty
    Megan Moriarty-Kelsey
    Department of Pediatrics, University of Colorado Denver The Children s Hospital, 13123 East 16th Avenue, Aurora, CO 80045, USA
    J Pediatr Endocrinol Metab 23:1281-7. 2010
    ..To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys...
  7. pmc Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance
    Melanie Cree-Green
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Obesity (Silver Spring) 24:2399-2406. 2016
    ..The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS...
  8. doi request reprint Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Pediatr Diabetes . 2016
    ....
  9. pmc The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Denver, Aurora
    Pediatr Diabetes . 2016
    ..Glucose measures captured by continuous glucose monitoring (CGM) (eg, peak glucose, standard deviation, hypoglycemia) in youth have not been explored as predictors of insulin sensitivity (IS)...
  10. doi request reprint Use of glycosylated hemoglobin increases diabetes screening for at-risk adolescents in primary care settings
    Kathryn A Love-Osborne
    Pediatrics Adolescent Medicine, Denver Health and Hospitals and University of Colorado School of Medicine, Denver, CO, 80205, USA
    Pediatr Diabetes 14:512-8. 2013
    ..To examine rates of diabetes screening in obese adolescents in an ethnically diverse primary care health care system before and after an internal recommendation to use HbA1c-based screening...
  11. pmc Etiology of insulin resistance in youth with type 2 diabetes
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children s Hospital Colorado, Box 265, 13123 E Colfax Avenue, Aurora, CO 80045, USA
    Curr Diab Rep 13:81-8. 2013
    ..Further understanding of IR, the progression to T2DM in youth, and later outcomes as adults will help direct future therapies and interventions for youth at risk...
  12. pmc Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease
    Kathy A Love-Osborne
    Division of Adolescent Medicine, Department of Pediatrics, Denver Health and Hospitals, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80205, USA
    J Adolesc Health 42:543-8. 2008
    ..To evaluate whether the presence of metabolic syndrome (MS) in obese adolescents is associated with other comorbidities of obesity..
  13. ncbi request reprint Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle
    Kristen J Nadeau
    The Children s Hospital, Dept of Pediatric Endocrinology, Box 265, 1056 East 19th Ave, Denver, CO 80218, USA
    Am J Physiol Endocrinol Metab 291:E90-8. 2006
    ..CR and exercise-induced augmentation of SREBP-1 expression may be responsible for the increased IMTG seen in skeletal muscle of highly conditioned athletes...
  14. doi request reprint Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin
    Christine L Chan
    Department of Pediatrics, Section of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Denver, Aurora, CO, USA
    Pediatr Diabetes 17:206-11. 2016
    ..Whereas the usefulness of these markers for identifying prediabetes is limited, they may be useful in certain scenarios as second line screening tools for diabetes in overweight/obese youth...
  15. pmc Development and Validation of a Method to Estimate Insulin Sensitivity in Patients With and Without Type 1 Diabetes
    Lindsey M Duca
    Barbara Davis Center for Diabetes L M D, D M M, P B, M R, J K S B, School of Medicine, University of Colorado, Aurora, Colorado 80045 Colorado School of Public Health L M D, D M M, J K S B, University of Colorado, Aurora, Colorado 80045 Division of Endocrinology, Metabolism, and Diabetes I E S, B C B, Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado 80045 Division of Pediatric Endocrinology K J N, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045 and Denver VA Medical Center I E S, Denver, Colorado 80220
    J Clin Endocrinol Metab 101:686-95. 2016
    ..People with type 1 diabetes (T1D) have markedly reduced insulin sensitivity (IS) compared to their nondiabetic counterparts, and reduced IS is linked to higher cardiovascular risk...
  16. pmc Effects of low dose metformin in adolescents with type I diabetes mellitus: a randomized, double-blinded placebo-controlled study
    Kristen J Nadeau
    University of Colorado Denver School of Medicine, Children s Hospital Colorado, Division of Pediatric Endocrinology, Denver, CO, USA
    Pediatr Diabetes 16:196-203. 2015
    ..Metformin, typically used in type 2 diabetes mellitus (T2DM), is a possible adjunct therapy in T1DM to help improve glycemic control and insulin sensitivity...
  17. pmc Childhood obesity and cardiovascular disease: links and prevention strategies
    Kristen J Nadeau
    The Children s Hospital, Department of Pediatrics, University of Colorado School of Medicine, Building A, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Nat Rev Cardiol 8:513-25. 2011
    ..We also evaluate how obesity treatment strategies can improve risk factors and, ultimately, adverse clinical outcomes...

Research Grants1

  1. Insulin Control of Fat Regulation and Exercise in Teens
    Kristen Nadeau; Fiscal Year: 2008
    ..The K-23 application will help me reach my long-term goal of being an independent investigator in the field of pediatric insulin resistance and type 2 diabetes. ..