Kristen J Nadeau

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function
    Kristen J Nadeau
    AssistantUniversity of Colorado Health Sciences Center, The Children s Hospital, Department of Pediatric Endocrinology B265, 13123 East 16th Avenue, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:513-21. 2010
  2. pmc Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity
    Kristen J Nadeau
    Division of Pediatric Endocrinology, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3687-95. 2009
  3. doi request reprint Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Pediatr Diabetes . 2016
  4. pmc Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance
    Melanie Cree-Green
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Obesity (Silver Spring) 24:2399-2406. 2016
  5. doi request reprint Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction
    Melanie Cree-Green
    Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus and Children s Hospital Colorado, Aurora, CO, 80045 Center for Women s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045 Electronic address
    J Diabetes Complications . 2016
  6. doi request reprint Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 10:5-13. 2009
  7. doi request reprint Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin
    Christine L Chan
    Department of Pediatrics, Section of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Denver, Aurora, CO, USA
    Pediatr Diabetes 17:206-11. 2016
  8. pmc Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado Center for Women s Health Research, Anschutz Medical Campus, Aurora, Colorado
    Am J Physiol Endocrinol Metab 308:E726-33. 2015
  9. pmc Continuous glucose monitoring and its relationship to hemoglobin A1c and oral glucose tolerance testing in obese and prediabetic youth
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology C L C, L N, K J N, P S Z, M M K, and Department of Pediatrics, Administrative Division L P, University of Colorado Denver, Aurora, Colorado 80045
    J Clin Endocrinol Metab 100:902-10. 2015
  10. pmc Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO Center for Women s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO
    Diabetes 64:383-92. 2015

Detail Information

Publications28

  1. pmc Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function
    Kristen J Nadeau
    AssistantUniversity of Colorado Health Sciences Center, The Children s Hospital, Department of Pediatric Endocrinology B265, 13123 East 16th Avenue, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:513-21. 2010
    ..Although insulin resistance (IR) likely contributes to exercise and cardiovascular dysfunction in T2D, IR is not typically considered a contributor in T1D...
  2. pmc Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity
    Kristen J Nadeau
    Division of Pediatric Endocrinology, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3687-95. 2009
    ..Cardiopulmonary fitness, a marker of morbidity and mortality, is abnormal in adults with T2D, yet the mechanisms are incompletely understood...
  3. doi request reprint Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Pediatr Diabetes . 2016
    ....
  4. pmc Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance
    Melanie Cree-Green
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Obesity (Silver Spring) 24:2399-2406. 2016
    ..The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS...
  5. doi request reprint Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction
    Melanie Cree-Green
    Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus and Children s Hospital Colorado, Aurora, CO, 80045 Center for Women s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045 Electronic address
    J Diabetes Complications . 2016
    ..Insulin resistance (IR) correlates with mitochondrial dysfunction, free fatty acids (FFAs), and intramyocellular lipid (IMCL) in adults with type 2 diabetes (T2D). We hypothesized that muscle IR would relate to similar factors in T2D youth...
  6. doi request reprint Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 10:5-13. 2009
    ..While metformin plus lifestyle intervention appears promising, defining NAFLD therapies capable of preventing fibrosis and cirrhosis requires further study...
  7. doi request reprint Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin
    Christine L Chan
    Department of Pediatrics, Section of Pediatric Endocrinology, Children s Hospital Colorado and University of Colorado Denver, Aurora, CO, USA
    Pediatr Diabetes 17:206-11. 2016
    ..Whereas the usefulness of these markers for identifying prediabetes is limited, they may be useful in certain scenarios as second line screening tools for diabetes in overweight/obese youth...
  8. pmc Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado Center for Women s Health Research, Anschutz Medical Campus, Aurora, Colorado
    Am J Physiol Endocrinol Metab 308:E726-33. 2015
    ..These may provide future options as targets for therapeutic intervention...
  9. pmc Continuous glucose monitoring and its relationship to hemoglobin A1c and oral glucose tolerance testing in obese and prediabetic youth
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology C L C, L N, K J N, P S Z, M M K, and Department of Pediatrics, Administrative Division L P, University of Colorado Denver, Aurora, Colorado 80045
    J Clin Endocrinol Metab 100:902-10. 2015
    ..The optimal screening test for diabetes and prediabetes in obese youth is controversial...
  10. pmc Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO Center for Women s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO
    Diabetes 64:383-92. 2015
    ..The correlation between skeletal muscle mitochondrial dysfunction in type 1 diabetes and IR suggests a relationship between mitochondrial dysfunction and IR in type 1 diabetes. ..
  11. ncbi request reprint Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty
    Megan Moriarty-Kelsey
    Department of Pediatrics, University of Colorado Denver The Children s Hospital, 13123 East 16th Avenue, Aurora, CO 80045, USA
    J Pediatr Endocrinol Metab 23:1281-7. 2010
    ..To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys...
  12. pmc The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes
    Christine L Chan
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Denver, Aurora
    Pediatr Diabetes . 2016
    ..Glucose measures captured by continuous glucose monitoring (CGM) (eg, peak glucose, standard deviation, hypoglycemia) in youth have not been explored as predictors of insulin sensitivity (IS)...
  13. pmc Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes
    Melanie Cree-Green
    Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    Pediatr Diabetes 17:257-65. 2016
    ..We sought to determine if T1D youth have more atherogenic profile than controls via a cross-sectional study...
  14. pmc Method for controlled mitochondrial perturbation during phosphorus MRS in children
    Melanie Cree-Green
    1Division of Endocrinology, Department of Pediatrics, Children s Hospital Colorado, Anschutz Medical Campus, Aurora, CO 2Center for Women s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO 3Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL 4Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO and 5Department of Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
    Med Sci Sports Exerc 46:2030-6. 2014
    ..We therefore developed a method to predict MVC using maximal calf muscle cross-sectional area (MCSA) to assure controlled and reproducible muscle metabolic perturbations...
  15. pmc Psychological functioning in adolescents with obesity co-morbidities
    Natalie Walders-Abramson
    Department of Psychiatry and Behavioral Sciences, University of Colorado Denver and Children s Hospital Colorado, Aurora, CO, USA
    Child Obes 9:319-25. 2013
    ....
  16. ncbi request reprint Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle
    Kristen J Nadeau
    The Children s Hospital, Dept of Pediatric Endocrinology, Box 265, 1056 East 19th Ave, Denver, CO 80218, USA
    Am J Physiol Endocrinol Metab 291:E90-8. 2006
    ..CR and exercise-induced augmentation of SREBP-1 expression may be responsible for the increased IMTG seen in skeletal muscle of highly conditioned athletes...
  17. ncbi request reprint Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr Gastroenterol Nutr 41:94-8. 2005
    ..The prevalence of nonalcoholic fatty liver disease in type 2 diabetes is unclear in adults and unknown in children...
  18. pmc Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood
    Rebecca A Ohman-Hanson
    Pediatric Endocrinology R O H, M C G, M M K, K J N, University of Colorado School of Medicine, Anschutz Medical Campus and Children s Hospital Colorado, Aurora, Colorado 80045 Endocrinology D H B, R I P, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045 Colorado School of Public Health at the University of Northern Colorado T A S, Greeley, Colorado 80639 Department of Pediatrics L P, University of Colorado School of Medicine, Aurora, Colorado 80045 and Department of Biostatistics and Informatics L P, Colorado School of Public Health, Aurora, Colorado 80045
    J Clin Endocrinol Metab 101:4808-4815. 2016
    ..Adiponectin has a known role in IR, and therefore, understanding ethnic and sex-specific behavior of adiponectin across the lifespan is of clinical significance...
  19. pmc Development and Validation of a Method to Estimate Insulin Sensitivity in Patients With and Without Type 1 Diabetes
    Lindsey M Duca
    Barbara Davis Center for Diabetes L M D, D M M, P B, M R, J K S B, School of Medicine, University of Colorado, Aurora, Colorado 80045 Colorado School of Public Health L M D, D M M, J K S B, University of Colorado, Aurora, Colorado 80045 Division of Endocrinology, Metabolism, and Diabetes I E S, B C B, Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado 80045 Division of Pediatric Endocrinology K J N, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045 and Denver VA Medical Center I E S, Denver, Colorado 80220
    J Clin Endocrinol Metab 101:686-95. 2016
    ..People with type 1 diabetes (T1D) have markedly reduced insulin sensitivity (IS) compared to their nondiabetic counterparts, and reduced IS is linked to higher cardiovascular risk...
  20. pmc Estimated insulin sensitivity and cardiovascular disease risk factors in adolescents with and without type 1 diabetes
    Brian J Specht
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Pediatr 162:297-301. 2013
    ....
  21. doi request reprint Diabetic Kidney Disease in Adolescents With Type 2 Diabetes: New Insights and Potential Therapies
    Petter Bjornstad
    Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA
    Curr Diab Rep 16:11. 2016
    ..In this review, we focus on early DKD in T2D and summarize potential novel biomarkers and therapeutic targets. ..
  22. pmc Effects of low dose metformin in adolescents with type I diabetes mellitus: a randomized, double-blinded placebo-controlled study
    Kristen J Nadeau
    University of Colorado Denver School of Medicine, Children s Hospital Colorado, Division of Pediatric Endocrinology, Denver, CO, USA
    Pediatr Diabetes 16:196-203. 2015
    ..Metformin, typically used in type 2 diabetes mellitus (T2DM), is a possible adjunct therapy in T1DM to help improve glycemic control and insulin sensitivity...
  23. pmc Hemoglobin A1c assay variations and implications for diabetes screening in obese youth
    Christine L Chan
    Children s Hospital Colorado, Aurora, CO, USA
    Pediatr Diabetes 15:557-63. 2014
    ..However, significant A1c assay variability remains and has implications for clinical management...
  24. pmc Etiology of insulin resistance in youth with type 2 diabetes
    Melanie Cree-Green
    Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children s Hospital Colorado, Box 265, 13123 E Colfax Avenue, Aurora, CO 80045, USA
    Curr Diab Rep 13:81-8. 2013
    ..Further understanding of IR, the progression to T2DM in youth, and later outcomes as adults will help direct future therapies and interventions for youth at risk...
  25. pmc Childhood obesity and cardiovascular disease: links and prevention strategies
    Kristen J Nadeau
    The Children s Hospital, Department of Pediatrics, University of Colorado School of Medicine, Building A, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Nat Rev Cardiol 8:513-25. 2011
    ..We also evaluate how obesity treatment strategies can improve risk factors and, ultimately, adverse clinical outcomes...
  26. doi request reprint Cardiovascular function/dysfunction in adolescents with type 1 diabetes
    Kristen J Nadeau
    Pediatric Endocrinology, University of Colorado The Children s Hospital, 13123 East 16th Avenue, B265, Aurora, CO 80045, USA
    Curr Diab Rep 11:185-92. 2011
    ....
  27. doi request reprint Age-related consequences of childhood obesity
    Megan M Kelsey
    Division of Pediatric Endocrinology, University of Colorado Denver, Aurora, Colo, USA
    Gerontology 60:222-8. 2014
    ..This review outlines the evidence for childhood obesity as a predictor of adult obesity and obesity-related disorders, thereby emphasizing the importance of early intervention to prevent the onset of obesity in childhood...
  28. ncbi request reprint Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218, USA
    J Biol Chem 279:34380-7. 2004
    ....