Andrea G Nackley

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders
    Andrea G Nackley
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 617:375-93. 2010
  2. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
  3. ncbi Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
  4. pmc Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes
    Inna E Tchivileva
    The Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Immunol 46:2256-66. 2009
  5. pmc Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs
    Andrea G Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5237. 2009
  6. pmc MicroRNA expression profiles differentiate chronic pain condition subtypes
    Brittney P Ciszek
    Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC
    Transl Res 166:706-720.e11. 2015
  7. pmc Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness
    Gary D Slade
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 152:2802-12. 2011
  8. pmc Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation
    Jane E Hartung
    Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Brain Behav Immun 50:196-202. 2015
  9. pmc Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain
    Shad B Smith
    Center for Pain Research and Innovation, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    Pain 155:2390-9. 2014
  10. pmc Excess risk of temporomandibular disorder associated with cigarette smoking in young adults
    Anne E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7450, USA
    J Pain 13:21-31. 2012

Collaborators

Detail Information

Publications23

  1. doi Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders
    Andrea G Nackley
    Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 617:375-93. 2010
    ..The protocols applied to the study of these molecular genetic mechanisms are detailed herein...
  2. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
    ....
  3. ncbi Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
    ..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
  4. pmc Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes
    Inna E Tchivileva
    The Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Immunol 46:2256-66. 2009
    ....
  5. pmc Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs
    Andrea G Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5237. 2009
    ..Thus, both minor synonymous and nonsynonymous SNPs in the coding region are markers of functional APS and HPS haplotypes rather than independent contributors to COMT activity...
  6. pmc MicroRNA expression profiles differentiate chronic pain condition subtypes
    Brittney P Ciszek
    Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC
    Transl Res 166:706-720.e11. 2015
    ....
  7. pmc Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness
    Gary D Slade
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 152:2802-12. 2011
    ..Furthermore, they identify MCP-1, IL-1ra, IL-8, and TGFβ1 as potential diagnostic markers and therapeutic targets for pain in patients with TMD...
  8. pmc Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation
    Jane E Hartung
    Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Brain Behav Immun 50:196-202. 2015
    ..Collectively, these results demonstrate that systemic and astrocytic NF-κB activity drive inflammatory pain and regulate the expression of COMT in forebrain and midbrain structures. ..
  9. pmc Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain
    Shad B Smith
    Center for Pain Research and Innovation, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    Pain 155:2390-9. 2014
    ..Furthermore, these data suggest that the ability to predict the downstream effects of genetic variation on COMT activity is critically important to understanding the molecular basis of chronic pain conditions. ..
  10. pmc Excess risk of temporomandibular disorder associated with cigarette smoking in young adults
    Anne E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7450, USA
    J Pain 13:21-31. 2012
    ..The main finding was reproduced with secondary analyses of 2 nationally representative surveys of adults conducted in the US and Australia...
  11. ncbi Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    ..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
  12. pmc A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism
    Pavel Gris
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Pain 6:33. 2010
    ..Several hypotheses have been advanced to explain these phenomena, yet the molecular mechanisms underlying tolerance and OIH remain poorly understood...
  13. pmc Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Mol Pain 5:13. 2009
    ..Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents...
  14. ncbi Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats
    Karamarie Fecho
    Department of Anesthesiology, Division of Pain Medicine, School of Medicine, The University of North Carolina at Chapel Hill, CB 7010, 451 MacNider Hall, Chapel Hill, North Carolina 27599 7010, USA
    Physiol Behav 85:177-86. 2005
    ..The results further demonstrate that basal pain sensitivity can be predictive of inflammatory pain sensitivity, with the direction of the effect dependent upon the pain measure...
  15. ncbi Idiopathic pain disorders--pathways of vulnerability
    Luda Diatchenko
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27514 7455, USA
    Pain 123:226-30. 2006
  16. ncbi Genetic architecture of human pain perception
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina, 2190 Old Dental Building, Chapel Hill, NC 27599, USA
    Trends Genet 23:605-13. 2007
    ..We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes...
  17. pmc Novel intrathecal and subcutaneous catheter delivery systems in the mouse
    Folabomi A Oladosu
    Curriculum of Neurobiology, University of North Carolina, Chapel Hill, 27599 NC, USA Electronic address
    J Neurosci Methods 264:119-28. 2016
    ..The development of new sustained catheter delivery systems to spinal and peripheral sites will reduce the need for repeated injections, while ensuring constant levels of drug in plasma and tissues...
  18. pmc Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia
    Folabomi A Oladosu
    Center of Pain Research and Innovation, University of North Carolina Chapel Hill, Chapel Hill, NC, United States of America
    PLoS ONE 10:e0135711. 2015
    ..Here, we conducted the first study to directly test the role of MOR-1K in opioid-induced hyperalgesia...
  19. ncbi Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms
    Kai Soo Tan
    The Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Signal 19:251-60. 2007
    ....
  20. pmc Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors
    Brittney P Ciszek
    From the Dental Research Department, Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, North Carolina Current affiliation Center for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina A G N
    Anesthesiology 124:1122-35. 2016
    ..The contribution of distinct βAR populations to the development of persistent pain linked to abnormalities in catecholamine signaling requires further investigation...
  21. pmc Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients
    Elizabeth Applebaum
    Private Practice, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina
    J Endod 41:1214-8. 2015
    ..The present study extends this work by examining the potential contribution of the 2 COX isoforms to pain after endodontic treatment...
  22. pmc β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines
    Jane E Hartung
    Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pain 155:1346-55. 2014
    ..Furthermore, they identify β2- and β3ARs, NO, and proinflammatory cytokines as potential therapeutic targets for pain patients with abnormalities in COMT physiology...
  23. pmc Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management
    Folabomi A Oladosu
    Center for Pain Research and Innovation, University of North Carolina, Chapel Hill
    Mayo Clin Proc 90:1135-51. 2015
    ..We review the importance of GPCRs and their known splice variants to the management of pain. ..