E L Murphy
Affiliation: University of California
- Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United StatesE L Murphy
Department of Laboratory Medicine, UCSF Box 0884, San Francisco, CA 94143, USA
J Infect Dis 180:1777-83. 1999..These data are consistent with a 30-year-old epidemic of HTLV-II in the United States due to injection drug use and secondary sexual transmission and with an apparent West Coast focus...
- Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aOE L Murphy
Department of Laboratory Medicine, University of California San Francisco 94143, USA
Virology 242:425-34. 1998..This finding could be explained by an epidemic of non-aO HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type aO among older Black and White persons...
- Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study InvestigatorsE L Murphy
University of California San Francisco 94143 0884, USA
J Acquir Immune Defic Syndr Hum Retrovirol 17:332-8. 1998..Lower eosinophil counts may be related to the increased susceptibility of HTLV-I-infected subjects to parasitic diseases...
- A prospective study of the risk of transfusion-acquired viral infectionsE L Murphy
Department of Laboratory Medicine, University of California San Francisco 94143 0884, USA
Transfus Med 8:173-8. 1998..04 x 10(3) per allogeneic unit transfused, based upon the upper 95% confidence interval of the zero incidence in this study...
- Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor StudyE L Murphy
Department of Laboratory Medicine, University of California, San Francisco, 94143 0084, USA
Arch Intern Med 159:1485-91. 1999....
- Risk factors for hepatitis C virus infection in United States blood donors. NHLBI Retrovirus Epidemiology Donor Study (REDS)E L Murphy
University of California San Francisco, San Francisco, CA 94143 0884, USA
Hepatology 31:756-62. 2000..Weaker associations with incarceration, religious scarification, being stuck or cut with a bloody object, pierced ears or body parts, and immunoglobulin injection must be interpreted with caution...
- Determinants of antimicrobial prophylaxis use and treatment for wasting among patients with advanced human immunodeficiency virus disease in the United States, 1995-1998E L Murphy
Depts of Laboratory Medicine, Medicine and Epidemiology Biostatistics, University of California San Francisco, San Francisco, CA 94143 0884, USA
Clin Infect Dis 32:116-23. 2001..Treatment of wasting was more common in white than nonwhite patients and in patients with HIV disease who lived in the region west of the Mississippi River of the United States versus those whose lived in the eastern region...
- Human T-lymphotropic virus type II RFLP subtypes a0 and b4/b5 are associated with different demographic and geographic characteristics in the United StatesH Liu
University of California San Francisco, San Francisco, California, 94143
Virology 279:90-6. 2001....
- Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV diseaseE L Murphy
Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143 0884, USA
Ann Intern Med 135:17-26. 2001..Mortality and morbidity related to AIDS have decreased among HIV-infected patients taking highly active anti-retroviral therapy (HAART), but previous studies may have been confounded by other changes in treatment...
- Neurologic abnormalities in HTLV-I- and HTLV-II-infected individuals without overt myelopathyH H Biswas
Blood Systems Research Institute, San Francisco, CA, USA
Neurology 73:781-9. 2009..However, despite some reports, it is unclear whether HTLV-I or -II infection is associated with other neurologic manifestations...
- Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cellsM P Busch
Department of Laboratory Medicine, University of California, San Francisco 94143 0134
N Engl J Med 325:1-5. 1991..Previous estimates of the risk of HIV-1 range from 1 in 38,000 to 1 in 300,000 per unit of blood but are based on either epidemiologic models or the demonstration of seroconversion in recipients...
- Risk factors for skin and soft-tissue abscesses among injection drug users: a case-control studyE L Murphy
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0884, USA
Clin Infect Dis 33:35-40. 2001..Cleaning the skin with alcohol before injection was found to have a protective effect. Neither human immunodeficiency virus nor human T-lymphotropic virus type II seropositivity was significantly associated with abscess...
- Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass indexEdward L Murphy
University of California, San Francisco, CA, USA
J Infect Dis 202:576-84. 2010..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking...
- Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoffDanielle M Carrick
Blood Systems Research Institute and Blood Centers of the Pacific, San Francisco, California 94118, USA
Transfusion 51:1105-16. 2011..HLA antibody detection methods include ELISA, flow cytometry, and multiplex bead-based assays, as well as the older lymphocytotoxicity assay, and it is not obvious how to compare results across platforms...
- Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes StudyJ R Orland
University of California San Francisco, Blood Centers of the Pacific, 94118, USA
Neurology 61:1588-94. 2003..Whereas the causative association of HTLV-I and HAM/TSP is generally recognized, controversy still surrounds the relationship between HTLV-II and HAM/TSP...
- Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological diseaseL C Ndhlovu
Division of Experimental Medicine, Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
Clin Exp Immunol 158:294-9. 2009..These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression...
- A pilot external quality assurance study of transfusion screening for HIV, HCV and HBsAG in 12 African countriesE M Bloch
Blood Systems Research Institute BSRI, San Francisco, CA, USA University of California, San Francisco, San Francisco, CA, USA
Vox Sang 107:333-42. 2014..However, actual performance as measured by proficiency testing has not been well studied in sub-Saharan Africa. Therefore, we conducted an external quality assessment of laboratories engaged in transfusion screening in the region...
- Does prevalence of transfusion-transmissible viral infection reflect corresponding incidence in United States blood donors?Baoguang Wang
Westat, Rockville, Maryland 20850, USA
Transfusion 45:1089-96. 2005..Prevalence, however, is readily available. Understanding whether prevalence reflects corresponding incidence may help blood centers monitor disease risks...
- The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusionS H Kleinman
Westat, Rockville, Maryland, USA
Transfusion 45:1073-83. 2005..An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor-recipient repository...
- Prevalence of transfusion-transmissible viral infections in first-time US blood donors by donation siteB Wang
Westat, Rockville, Maryland 20850, USA
Transfusion 43:705-12. 2003..Understanding the donor base, infectious disease prevalence, and donation loss at various blood donation sites will help maximize blood collection efforts and blood availability...
- Delayed hypersensitivity skin testing to mumps and Candida albicans antigens is normal in middle-aged HTLV-I- and-II-infected U.S. cohortsE L Murphy
University of California San Francisco, 94143, USA. murphy.itsa.ucsf.edu
AIDS Res Hum Retroviruses 17:1273-7. 2001..60, 95% CI 0.20-1.78), and 19% of HTLV-II (OR = 0.56, 95% CI 0.22-1.44). HTLV-I- and -II-infected persons appear to have intact delayed hypersensitivity skin test responses to mumps and Candida albicans antigens...