WILLIAM JAMES MURDOCH

Summary

Affiliation: University of Wyoming
Country: USA

Publications

  1. doi request reprint Ovulatory factor in ovarian carcinogenesis
    William J Murdoch
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    Adv Exp Med Biol 622:119-28. 2008
  2. ncbi request reprint Oestradiol inhibits spontaneous and cisplatin-induced apoptosis in epithelial ovarian cancer cells: relationship to DNA repair capacity
    W J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie 82071, USA
    Apoptosis 2:478-84. 1997
  3. pmc Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring
    Nathan M Long
    The Center for the Study of Fetal Programming, Laramie, WY 82071, USA
    Reprod Biol Endocrinol 11:34. 2013
  4. ncbi request reprint Oxidative damage to DNA of ovarian surface epithelial cells affected by ovulation: carcinogenic implication and chemoprevention
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 229:546-52. 2004
  5. ncbi request reprint DNA damages in ovarian surface epithelial cells of ovulatory hens
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, 1000 E University Avenue, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 230:429-33. 2005
  6. ncbi request reprint Carcinogenic potential of ovulatory genotoxicity
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, 82071, USA
    Biol Reprod 73:586-90. 2005
  7. ncbi request reprint Complement-inhibiting effect of ovarian cancer antigen CA-125
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Cancer Lett 236:54-7. 2006
  8. pmc Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, USA
    Gynecol Oncol 110:251-5. 2008
  9. doi request reprint Pathogenic reactions of the ovarian surface epithelium to ovulation, dimethylbenzanthracene, and estrogen are negated by vitamin E
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Reprod Sci 15:839-45. 2008
  10. ncbi request reprint Mechanisms and pathobiology of ovulation
    W J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Soc Reprod Fertil Suppl 67:189-201. 2010

Research Grants

Collaborators

Detail Information

Publications32

  1. doi request reprint Ovulatory factor in ovarian carcinogenesis
    William J Murdoch
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    Adv Exp Med Biol 622:119-28. 2008
  2. ncbi request reprint Oestradiol inhibits spontaneous and cisplatin-induced apoptosis in epithelial ovarian cancer cells: relationship to DNA repair capacity
    W J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie 82071, USA
    Apoptosis 2:478-84. 1997
    ..The ability of oestrogen-responsive ovarian cancer cells to efficiently repair DNA and thereby avoid apoptosis may be related to propensity for clonal expansion and drug resistance...
  3. pmc Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring
    Nathan M Long
    The Center for the Study of Fetal Programming, Laramie, WY 82071, USA
    Reprod Biol Endocrinol 11:34. 2013
    ..This study was designed to investigate if this reduction in progesterone persisted into old age, and if it did, what mechanisms are involved...
  4. ncbi request reprint Oxidative damage to DNA of ovarian surface epithelial cells affected by ovulation: carcinogenic implication and chemoprevention
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 229:546-52. 2004
    ..A prophylactic benefit of a supplemental antioxidant is suggested in "ovulating" individuals designated at risk (e.g., due to a tumor suppressor malfunction) for the development of ovarian cancer...
  5. ncbi request reprint DNA damages in ovarian surface epithelial cells of ovulatory hens
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, 1000 E University Avenue, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 230:429-33. 2005
    ....
  6. ncbi request reprint Carcinogenic potential of ovulatory genotoxicity
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, 82071, USA
    Biol Reprod 73:586-90. 2005
    ..Ovarian cancer of surface epithelial origin is a deadly insidious disease because it characteristically remains asymptomatic until it has metastasized throughout the abdominal cavity; therefore, prevention is a high priority...
  7. ncbi request reprint Complement-inhibiting effect of ovarian cancer antigen CA-125
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Cancer Lett 236:54-7. 2006
    ..It is conceivable that CA-125 entraps/sheds effectors of the complement cascade...
  8. pmc Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cells and xenografts
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, USA
    Gynecol Oncol 110:251-5. 2008
    ..That progesterone can affect susceptibility of ovarian adenocarcinoma cells and xenografts to cisplatin was tested...
  9. doi request reprint Pathogenic reactions of the ovarian surface epithelium to ovulation, dimethylbenzanthracene, and estrogen are negated by vitamin E
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Reprod Sci 15:839-45. 2008
    ..Acute effects of ovulation, the tumor suppressor disruptor dimethylbenzanthracene, the mitogen estradiol-17beta, and the antioxidant vitamin E on the ovarian epithelium were assessed in seasonally anestrous ewes...
  10. ncbi request reprint Mechanisms and pathobiology of ovulation
    W J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Soc Reprod Fertil Suppl 67:189-201. 2010
    ..Epithelial ovarian cancer is a deadly insidious disease because it typically remains asymptomatic until it has metastasized to vital abdominal organs...
  11. ncbi request reprint Proteolytic mechanisms in the ovulatory folliculo-luteal transformation
    William J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Connect Tissue Res 44:50-7. 2003
    ..It appears that TNFalpha, via MMP-2 induction, contributes to the reorganization of an ovulatory follicle into a fully competent corpus luteum...
  12. pmc Ovarian responses to undernutrition in pregnant ewes, USA
    William J Murdoch
    Department of Animal Science, University of Wyoming, Laramie 82071
    Reprod Biol Endocrinol 1:6. 2003
    ....
  13. ncbi request reprint Plasmin cleaves tumor necrosis factor alpha exodomain from sheep follicular endothelium: implication in the ovulatory process
    W J Murdoch
    Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
    Biol Reprod 60:1166-71. 1999
    ..We suggest that plasmin-mediated cleavage of TNFalpha exodomain from its membrane anchor along thecal endothelium is a determinant of tissue dissolution within the formative ovulatory rupture site of ewes...
  14. ncbi request reprint Prostaglandin-independent anovulatory mechanism of indomethacin action: inhibition of tumor necrosis factor alpha-induced sheep ovarian cell apoptosis
    W J Murdoch
    Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
    Biol Reprod 61:1655-9. 1999
    ..It is concluded that indomethacin inhibits ovulation by anti-apoptotic mechanisms that can be dissociated from the paradigm of prostanoid down-regulation...
  15. ncbi request reprint Aetiology of attenuated luteal development in prednisolone-induced eosinopenic ewes
    W J Murdoch
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    Reprod Fertil Dev 12:127-32. 2000
    ..Vascular endothelial growth factor (VEGF) was localized by immunofluorescence microscopy to luteal eosinophils. It is suggested that VEGF of eosinophilic origin contributes to the neovascularization mechanism of corpora lutea in sheep...
  16. ncbi request reprint Ovulation-induced DNA damage in ovarian surface epithelial cells of ewes: prospective regulatory mechanisms of repair/survival and apoptosis
    W J Murdoch
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Biol Reprod 65:1417-24. 2001
    ....
  17. ncbi request reprint Luteal dysfunction in ewes induced to ovulate early in the follicular phase
    W J Murdoch
    Department of Animal Science, University of Wyoming, Laramie, 82071, USA
    Endocrinology 139:3480-4. 1998
    ..We suggest that premature induction of ovulation compromises the estrogen-mediated succession of granulosal cell proliferative events that necessitate the formation of a fully competent corpus luteum...
  18. ncbi request reprint Steroid hormonal regulation of proliferative, p53 tumor suppressor, and apoptotic responses of sheep ovarian surface epithelial cells
    William J Murdoch
    Department of Animal Science, Reproductive Biology Program, University of Wyoming, PO Box 3684, Laramie, WY 82071, USA
    Mol Cell Endocrinol 186:61-7. 2002
    ..Thus, it is conceivable that perturbations to the steroid hormonal milieu of ovarian cycles could be a predisposing factor for cancerous transformation of an ovarian surface epithelial cell...
  19. ncbi request reprint Metaplastic potential of p53 down-regulation in ovarian surface epithelial cells affected by ovulation
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Cancer Lett 191:75-81. 2003
    ....
  20. ncbi request reprint Roles of the ovarian surface epithelium in ovulation and carcinogenesis
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Reproduction 123:743-50. 2002
    ..Ovarian cancer is a deadly insidious disease because typically it is asymptomatic until the malignancy has reached beyond the ovaries...
  21. ncbi request reprint Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta -aminoester)-graft-PEG for cancer chemotherapy
    Wei Jin
    Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, Wyoming, USA
    Drug Deliv 14:279-86. 2007
    ..The nanogels had significantly lower in vitro cytotoxicity to SKOV-3 ovarian cancer cells than free cisplatin, but similar anticancer activity toward SKOV-3 tumors xenografted to immunocompromised mice...
  22. pmc Ovarian morphometrics in TP53-deficient mice
    Brenda M Alexander
    Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071, USA
    Anat Rec (Hoboken) 290:59-64. 2007
    ..There was no indication of precursor lesions in any TP53 KO or WT mouse. TP53 status did not influence recruitment of follicles, but TP53 deficiency hindered the ability of human chorionic gonadotropin to cause ovulation...
  23. ncbi request reprint Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep
    Kimberly A Vonnahme
    Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071 3684, USA
    Biol Reprod 69:133-40. 2003
    ..While these alterations in fetal/placental development may be beneficial to early fetal survival in the face of a nutrient restriction, their effects later in gestation as well as in postnatal life need further investigation...
  24. ncbi request reprint Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy
    Peisheng Xu
    Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, WY 82071 3375, USA
    Colloids Surf B Biointerfaces 48:50-7. 2006
    ..The IC50 of the cisplatin encapsulated in PCL/PDMA SCNPs was as low as 0.01 microg/mL, lower than that of cisplatin in PCL/PEG SCNPs and free cisplatin...
  25. doi request reprint Curcumin polymers as anticancer conjugates
    Huadong Tang
    Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, WY 82071, USA
    Biomaterials 31:7139-49. 2010
    ..In vivo, intravenously (i.v.) injected PCurc 8 shows remarkable antitumor activity in SKOV-3 intraperitoneal (i.p.) xenograft tumor model...
  26. ncbi request reprint Effects of progesterone on ovarian tumorigenesis in xenografted mice
    Anna C McDonnel
    Departments of Animal Science and Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Cancer Lett 221:49-53. 2005
    ..There was no beneficial effect of administration of progesterone if initiated after ovarian tumors had become established on organ surfaces. Our findings implicate a role for progesterone in ovarian cancer prophylaxis...
  27. ncbi request reprint Targeted charge-reversal nanoparticles for nuclear drug delivery
    Peisheng Xu
    Department of Chemical and Petroleum Engineering, Soft Materials Laboratory, University of Wyoming, Laramie, WY 82071, USA
    Angew Chem Int Ed Engl 46:4999-5002. 2007
  28. ncbi request reprint Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells
    Anna C McDonnel
    Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 228:308-14. 2003
    ..Progestins could therefore be of benefit in the prevention and(or) treatment of early-stage ovarian carcinomatosis...
  29. ncbi request reprint Morphologic responses of the mouse ovarian surface epithelium to ovulation and steroid hormonal milieu
    Garry S Gotfredson
    Department of Animal Science and Reproductive Biology Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Exp Biol Med (Maywood) 232:277-80. 2007
    ..We conclude that the proliferative/procarcinogenic reaction of the ovarian surface epithelium to ovulation is exacerbated by estrogen and counteracted by progesterone...
  30. ncbi request reprint Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation
    Xiaoping Yang
    Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 3375, USA
    Arterioscler Thromb Vasc Biol 26:85-90. 2006
    ..The objective of this study was to investigate the ability of curcumin to inhibit PDGF-stimulated migration, proliferation, and collagen synthesis in cultured VSMCs and neointima formation after carotid artery injury in rats...
  31. pmc Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles
    Peisheng Xu
    Soft Materials Laboratory and Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, 82071, USA
    Biomacromolecules 7:829-35. 2006
    ..Incidences of cellular pyknosis (a morphological indicator of apoptosis) were most evident within intestinal/mesentery tumors of mice treated with cisplatin/PDEA-PEG; tumor burdens were correspondingly reduced...
  32. doi request reprint Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery
    Peisheng Xu
    School of Pharmacy, University of Wyoming, Laramie, WY 82071, USA
    Angew Chem Int Ed Engl 47:1260-4. 2008

Research Grants1

  1. Progestogen Inhibition of Ovarian Cancer Cell Metastasis
    William Murdoch; Fiscal Year: 2003
    ....