- Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesisFariborz Mortazavi
Division of Hematology Oncology, West Los Angeles VA, Los Angeles, CA, USA
BMC Cancer 15:381. 2015..Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC)...
- p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cellsFariborz Mortazavi
Division of Hematology Oncology, Veterans Administration, Greater Los Angeles, West Los Angeles, California, USA
Mol Cancer Res 8:762-74. 2010..In summary, our data support the notion that FOXC2 mediates the transcriptional repression of p120ctn in NSCLC...
- c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cellsFariborz Mortazavi
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Clin Exp Metastasis 28:391-404. 2011..In summary, our data provide evidence for the role of c-Crk proto-oncogene in transcriptional repression of p120ctn that further clarifies the mechanism by which this biochemical signal promotes metastasis in NSCLC...
- PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cellsMatthew Rettig
Division of Hematology Oncology, West Los Angeles VA, Los Angeles, California, United States of America
PLoS ONE 7:e42012. 2012..In summary, these data provide evidence for the role of PAK1 in the promotion of cell motility, cell invasiveness and the down regulation of p120-catenin through CRK serine 41 phosphorylation in NSCLC cells...