Philip G Morgan
Affiliation: University of Washington
- Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegansErnst Bernhard Kayser
Department of Anesthesiology, University of Washington and Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
Anesth Analg 112:1321-9. 2011..We hypothesized that isoflurane inhibits electron transport by competing with ubiquinone for binding to complex I...
- Novel interactions between mitochondrial superoxide dismutases and the electron transport chainWichit Suthammarak
Department of Anesthesiology and Pain Medicine, Center for Developmental Therapeutics, University of Washington and Seattle Children s Research Institute, Seattle, WA, USA
Aging Cell 12:1132-40. 2013..The results call for a change in the usual paradigm for the interaction of electron transport chain function, ROS release, scavenging, and compensatory responses. ..
- mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndromeSimon C Johnson
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Science 342:1524-8. 2013..This therapeutic strategy may prove relevant for a broad range of mitochondrial diseases. ..
- A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transferJonathon L Burman
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Dis Model Mech 7:1165-74. 2014..Together, our findings support the model that diminished respiratory chain activity, and consequent energy deficiency, are responsible for the pathogenesis of complex-I-associated neurodegeneration. ..
- Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failureGeorgios Karamanlidis
Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, 98109, USA
Cell Metab 18:239-50. 2013..These findings describe a mechanism connecting mitochondrial dysfunction to the susceptibility to diseases and propose a potential therapeutic target...
- Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegansKatherine R Gentry
Department of Anesthesiology and Pain Medicine, Seattle Children s Hospital, M S W 9824, PO Box 5371, Seattle, WA 98105, USA
Anesth Analg 116:185-9. 2013..We hypothesized that exposing the nematode to volatile anesthetics early in life would induce neuron cell death, producing a behavioral defect that would be manifested in adulthood...
- Glutathione S-transferase mediates an ageing response to mitochondrial dysfunctionBeverley M Dancy
Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA Electronic address
Mech Ageing Dev 153:14-21. 2016..elegans. Thus, whereas HNE is typically considered damaging, our work is consistent with recent reports of its role in signaling, and that in this case, the signal is pro-longevity in a model of mitochondrial dysfunction. ..
- Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse BrainErnst Bernhard Kayser
Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, Washington, United States of America
PLoS ONE 11:e0148219. 2016..For the understanding of disease etiology and ultimately for the development of rationale treatments for LS, it appears important to uncover the mechanisms that govern focal neurodegeneration...
- Mitochondrial bioenergetics and disease in Caenorhabditis elegansBeverley M Dancy
Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Ave, Seattle, WA, USA, 2 Department of Anesthesiology and Pain Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA, USA
Front Biosci (Landmark Ed) 20:198-228. 2015..C. elegans will undoubtedly continue to provide a useful system in which to explore unanswered questions in mitochondrial biology and disease. ..
- Effects of the mitochondrial respiratory chain on longevity in C. elegansBeverley M Dancy
Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Avenue C9S 9, Seattle, WA 98199, USA Electronic address
Exp Gerontol 56:245-55. 2014..In this review, we discuss how findings with C. elegans genetics extend our understanding of the contributions of the mitochondrial respiratory chain and ROS to the process of aging. ..
- Genetics and the evolution of the anesthetic responseMargaret M Sedensky
Department of Anesthesiology, University Hospitals and Case School of Medicine, Cleveland, Ohio 44106 5007, USA
Anesth Analg 107:855-8. 2008
- MECHANISM OF ACTION OF VOLATILE ANESTHETICSPhilip G Morgan; Fiscal Year: 2010..Understanding how these anesthetics function may contribute to improvements in design of anesthetics and in the understanding of consciousness. ..
- Anesthetic effects in mitochondrial diseasePhilip Morgan; Fiscal Year: 2008..These translational studies have important implications for patient safety as well as for the understanding the mechanism of action of volatile anesthetics. . [unreadable] [unreadable] [unreadable]..
- Interaction of ubiquinone & complex I control longevityPhilip Morgan; Fiscal Year: 2009..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..