Philip G Morgan

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans
    Ernst Bernhard Kayser
    Department of Anesthesiology, University of Washington and Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Anesth Analg 112:1321-9. 2011
  2. pmc Novel interactions between mitochondrial superoxide dismutases and the electron transport chain
    Wichit Suthammarak
    Department of Anesthesiology and Pain Medicine, Center for Developmental Therapeutics, University of Washington and Seattle Children s Research Institute, Seattle, WA, USA
    Aging Cell 12:1132-40. 2013
  3. pmc mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
    Simon C Johnson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 342:1524-8. 2013
  4. pmc A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer
    Jonathon L Burman
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Dis Model Mech 7:1165-74. 2014
  5. pmc Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure
    Georgios Karamanlidis
    Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, 98109, USA
    Cell Metab 18:239-50. 2013
  6. pmc Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans
    Katherine R Gentry
    Department of Anesthesiology and Pain Medicine, Seattle Children s Hospital, M S W 9824, PO Box 5371, Seattle, WA 98105, USA
    Anesth Analg 116:185-9. 2013
  7. doi request reprint Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA Electronic address
    Mech Ageing Dev 153:14-21. 2016
  8. pmc Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
    Ernst Bernhard Kayser
    Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, Washington, United States of America
    PLoS ONE 11:e0148219. 2016
  9. ncbi request reprint Mitochondrial bioenergetics and disease in Caenorhabditis elegans
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Ave, Seattle, WA, USA, 2 Department of Anesthesiology and Pain Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA, USA
    Front Biosci (Landmark Ed) 20:198-228. 2015
  10. doi request reprint Effects of the mitochondrial respiratory chain on longevity in C. elegans
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Avenue C9S 9, Seattle, WA 98199, USA Electronic address
    Exp Gerontol 56:245-55. 2014

Research Grants

  1. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip G Morgan; Fiscal Year: 2010
  2. Anesthetic effects in mitochondrial disease
    Philip Morgan; Fiscal Year: 2008
  3. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2009

Collaborators

  • Louise M Steele
  • Katherine R Gentry
  • Matt Kaeberlein
  • Margaret M Sedensky
  • Beverley M Dancy
  • Ernst Bernhard Kayser
  • Wichit Suthammarak
  • Jonathon L Burman
  • Georgios Karamanlidis
  • Simon C Johnson
  • Nicole Brockway
  • Yoing Yang
  • Renjini Ramadasan-Nair
  • Leo J Pallanck
  • Adrienne M Wang
  • Leslie S Itsara
  • Jessica Hui
  • Maya Sangesland
  • Peter S Rabinovitch
  • Benjamin H Somerlot
  • Lauren Uhde
  • Albert Quintana
  • Margaret Sedensky
  • Arni Gagnidze
  • Valerie Z Wall
  • Richard D Palmiter
  • Anthony Castanza
  • Melana E Yanos
  • Fresnida J Ramos
  • Lorena Garcia-Menendez
  • Rong Tian
  • Elyce Opheim
  • Chi Fung Lee
  • Brian M Wasko
  • Kelly Oh
  • Guohua Gong
  • Wang Wang
  • Stephen C Kolwicz

Detail Information

Publications12

  1. pmc Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans
    Ernst Bernhard Kayser
    Department of Anesthesiology, University of Washington and Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Anesth Analg 112:1321-9. 2011
    ..We hypothesized that isoflurane inhibits electron transport by competing with ubiquinone for binding to complex I...
  2. pmc Novel interactions between mitochondrial superoxide dismutases and the electron transport chain
    Wichit Suthammarak
    Department of Anesthesiology and Pain Medicine, Center for Developmental Therapeutics, University of Washington and Seattle Children s Research Institute, Seattle, WA, USA
    Aging Cell 12:1132-40. 2013
    ..The results call for a change in the usual paradigm for the interaction of electron transport chain function, ROS release, scavenging, and compensatory responses. ..
  3. pmc mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
    Simon C Johnson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 342:1524-8. 2013
    ..This therapeutic strategy may prove relevant for a broad range of mitochondrial diseases. ..
  4. pmc A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer
    Jonathon L Burman
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Dis Model Mech 7:1165-74. 2014
    ..Together, our findings support the model that diminished respiratory chain activity, and consequent energy deficiency, are responsible for the pathogenesis of complex-I-associated neurodegeneration. ..
  5. pmc Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure
    Georgios Karamanlidis
    Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, 98109, USA
    Cell Metab 18:239-50. 2013
    ..These findings describe a mechanism connecting mitochondrial dysfunction to the susceptibility to diseases and propose a potential therapeutic target...
  6. pmc Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans
    Katherine R Gentry
    Department of Anesthesiology and Pain Medicine, Seattle Children s Hospital, M S W 9824, PO Box 5371, Seattle, WA 98105, USA
    Anesth Analg 116:185-9. 2013
    ..We hypothesized that exposing the nematode to volatile anesthetics early in life would induce neuron cell death, producing a behavioral defect that would be manifested in adulthood...
  7. doi request reprint Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA Electronic address
    Mech Ageing Dev 153:14-21. 2016
    ..elegans. Thus, whereas HNE is typically considered damaging, our work is consistent with recent reports of its role in signaling, and that in this case, the signal is pro-longevity in a model of mitochondrial dysfunction. ..
  8. pmc Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
    Ernst Bernhard Kayser
    Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, Washington, United States of America
    PLoS ONE 11:e0148219. 2016
    ..For the understanding of disease etiology and ultimately for the development of rationale treatments for LS, it appears important to uncover the mechanisms that govern focal neurodegeneration...
  9. ncbi request reprint Mitochondrial bioenergetics and disease in Caenorhabditis elegans
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Ave, Seattle, WA, USA, 2 Department of Anesthesiology and Pain Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA, USA
    Front Biosci (Landmark Ed) 20:198-228. 2015
    ..C. elegans will undoubtedly continue to provide a useful system in which to explore unanswered questions in mitochondrial biology and disease. ..
  10. doi request reprint Effects of the mitochondrial respiratory chain on longevity in C. elegans
    Beverley M Dancy
    Center for Developmental Therapeutics, Seattle Children s Research Institute, 1900 Ninth Avenue C9S 9, Seattle, WA 98199, USA Electronic address
    Exp Gerontol 56:245-55. 2014
    ..In this review, we discuss how findings with C. elegans genetics extend our understanding of the contributions of the mitochondrial respiratory chain and ROS to the process of aging. ..
  11. doi request reprint Genetics and the evolution of the anesthetic response
    Margaret M Sedensky
    Department of Anesthesiology, University Hospitals and Case School of Medicine, Cleveland, Ohio 44106 5007, USA
    Anesth Analg 107:855-8. 2008

Research Grants3

  1. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip G Morgan; Fiscal Year: 2010
    ..Understanding how these anesthetics function may contribute to improvements in design of anesthetics and in the understanding of consciousness. ..
  2. Anesthetic effects in mitochondrial disease
    Philip Morgan; Fiscal Year: 2008
    ..These translational studies have important implications for patient safety as well as for the understanding the mechanism of action of volatile anesthetics. . [unreadable] [unreadable] [unreadable]..
  3. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2009
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..