David E Misek

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Transforming properties of a Q18-->E mutation of the microtubule regulator Op18
    David E Misek
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 2:217-28. 2002
  2. ncbi An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer
    Su Hyung Hong
    Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Cancer Res 64:5504-10. 2004
  3. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002
  4. ncbi Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
  5. ncbi Proteomic analysis of eIF-5A in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
    Proteomics 3:496-504. 2003
  6. ncbi Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
  7. ncbi Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways
    Rong Wu
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 11:321-33. 2007
  8. ncbi RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
  9. ncbi Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
  10. ncbi Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    Donald R Schwartz
    Department of Pathology, College of Literature Science and the Arts, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 63:2913-22. 2003

Collaborators

Detail Information

Publications63

  1. ncbi Transforming properties of a Q18-->E mutation of the microtubule regulator Op18
    David E Misek
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 2:217-28. 2002
    ..These results suggest that the somatic mutation identified in Op18 has profound effects on cell homeostasis that may lead to tumorigenicity...
  2. ncbi An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer
    Su Hyung Hong
    Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Cancer Res 64:5504-10. 2004
    ..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer...
  3. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002
    ..Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas...
  4. ncbi Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  5. ncbi Proteomic analysis of eIF-5A in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
    Proteomics 3:496-504. 2003
    ..Moreover, the investigation on agents that inhibit eIF-5A function is encouraged...
  6. ncbi Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
    ..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers...
  7. ncbi Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways
    Rong Wu
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 11:321-33. 2007
    ..The biological behavior and gene expression patterns of the murine cancers resemble those of human OEAs with defects in the Wnt/beta-catenin and PI3K/Pten pathways...
  8. ncbi RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
    ..The purpose of this study was to identify differences in global gene expression profiles between stage I NSCLC tumors with ALR (ALR+) and those without ALR (ALR-)...
  9. ncbi Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
    ..Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas...
  10. ncbi Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    Donald R Schwartz
    Department of Pathology, College of Literature Science and the Arts, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 63:2913-22. 2003
    ....
  11. ncbi Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors
    Guoan Chen
    Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:2298-305. 2002
    ..The goal of this study was to identify potential protein markers in lung adenocarcinomas...
  12. pmc Protein profiles associated with survival in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:13537-42. 2003
    ..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer...
  13. pmc Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot
    Yinghua Qiu
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Proteome Res 7:1693-703. 2008
    ..These results demonstrate the utility of this strategy for the identification of N -linked glycan patterns as potential markers of CRC in human plasma, and may have the utility to distinguish different disease states...
  14. pmc Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
    Wei Min Gao
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Cancer 5:110. 2005
    ..We hypothesized that distinctive profiles may result from the differential expression of relatively abundant serum proteins associated with the host response...
  15. ncbi Genomic and proteomic analyses of vascular endothelial growth factor and insulin-like growth factor-binding protein 3 in lung adenocarcinomas
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor 48109, USA
    Clin Lung Cancer 5:307-12. 2004
    ..Among other highly correlated genes, several, including bradykinin receptor B2, suggest additional cellular processes that were not previously known to be associated with VEGF expression in lung adenocarcinoma...
  16. ncbi Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mapping
    Jia Zhao
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 6:987-99. 2007
    ..These differentially expressed proteins may have utility as useful candidate markers of esophageal adenocarcinoma...
  17. ncbi Histologic type, organ of origin, and Wnt pathway status: effect on gene expression in ovarian and uterine carcinomas
    Kerby A Shedden
    Department of Statistics, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 11:2123-31. 2005
    ..A widely accepted view is that the accumulation of specific gene defects and gene expression changes underlies phenotypic traits of cancers, including their response to treatment...
  18. ncbi Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses
    Sophie Girard
    Department of Microbiology, University of Michigan, Ann Arbor, MI, USA
    Hepatology 40:708-18. 2004
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  19. pmc Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
    Eduardo Vilar
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:2829-39. 2009
    ..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets...
  20. ncbi The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas
    Lin Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 62:5273-9. 2002
    ..Amplification of HNF3alpha in esophageal and lung tumors may suggest a potential oncogenic role for this gene in tumorigenesis...
  21. ncbi Discovery of cancer biomarkers through the use of mouse models
    Rork Kuick
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
    Cancer Lett 249:40-8. 2007
    ..Proteomic studies of mouse models of cancer allow assessment of the range of changes in plasma proteins that occur with tumor development and may lead to the identification of potential cancer markers applicable to humans...
  22. ncbi Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  23. pmc Comparative proteomic study of two closely related ovarian endometrioid adenocarcinoma cell lines using cIEF fractionation and pathway analysis
    Lan Dai
    Bioinformatics Program, University of Michigan Medical Center, Ann Arbor, MI 48109 0656, USA
    Electrophoresis 30:1119-31. 2009
    ....
  24. ncbi Integral protein microarrays for the identification of lung cancer antigens in sera that induce a humoral immune response
    Juan Madoz-Gurpide
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Mol Cell Proteomics 7:268-81. 2008
    ..Protein microarrays from tumor-derived fractions hold the diagnostic potential of uncovering antigens that induce an immune response in patients with certain types of cancers...
  25. ncbi Development of natural protein microarrays for diagnosing cancer based on an antibody response to tumor antigens
    Ji Qiu
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Proteome Res 3:261-7. 2004
    ..008). Microarrays of tumor-derived proteins provide the means for uncovering a repertoire of tumor antigens that have induced an antibody response in patients with specific cancers...
  26. ncbi Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    Craig D Logsdon
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:2649-57. 2003
    ..These data provide new insights into the molecular pathology of pancreatic cancer that may be useful for detection, diagnosis, and treatment...
  27. ncbi Aging is associated with increased T-cell chemokine expression in C57BL/6 mice
    Jun Chen
    Division of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    J Gerontol A Biol Sci Med Sci 58:975-83. 2003
    ....
  28. ncbi Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
    ....
  29. ncbi Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3
    Myeong J Nam
    Department of Pediatrics, University of Michigan Medical School, 1150 W Medical Drive, Ann Arbor, MI 48109 0656, USA
    Proteomics 3:2108-15. 2003
    ..Our findings indicate the occurrence of an immune response to a broad set of antigens in colon cancer and the feasibility of identifying the antigenic targets using a combination of protein microarrays and mass spectrometry...
  30. ncbi Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation
    Chad J Creighton
    Bioinformatics Program, Department of Pathology, University of Michigan, 4237 Med Sci I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Cancer Res 3:119-29. 2005
    ..Thus, analysis of tumor xenografts by gene expression profiling has the potential for identifying genes involved in tumor development that may not be expressed in cancer cells grown in vitro...
  31. ncbi A wide range of protein isoforms in serum and plasma uncovered by a quantitative intact protein analysis system
    David E Misek
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
    Proteomics 5:3343-52. 2005
    ..IPAS provides a high resolution, high sensitivity, and quantitative approach for the analysis of serum and plasma proteins, and allows assessment of PTMs as a potential source of biomarkers...
  32. ncbi Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays
    Tamotsu Ichiba
    Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, USA
    Blood 102:763-71. 2003
    ....
  33. ncbi Glycoprotein microarrays with multi-lectin detection: unique lectin binding patterns as a tool for classifying normal, chronic pancreatitis and pancreatic cancer sera
    Jia Zhao
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, Department of Statistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Proteome Res 6:1864-74. 2007
    ..These altered glycan structures may have utility for the differential diagnosis of pancreatic cancer and chronic pancreatitis and identify critical differences between biological samples from patients with different clinical conditions...
  34. pmc Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stage
    Yanfei Wang
    Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Proteome Res 8:1452-63. 2009
    ..To further confirm the stage-dependent protein identifications, Lamin A/C and Vimentin expression in ovarian serous carcinomas was assessed by immunohistochemistry using ovarian tumor tissue microarrays for 66 samples...
  35. ncbi Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 12:1983-93. 2006
    ..These results have implications for the neoplastic mechanism of these follicular carcinomas...
  36. pmc Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
    Kerby Shedden
    Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 14:822-7. 2008
    ..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas...
  37. pmc A biomarker panel for acute graft-versus-host disease
    Sophie Paczesny
    Department of Pediatrics, University of Michigan, Ann Arbor, USA
    Blood 113:273-8. 2009
    ..A panel of 4 biomarkers can confirm the diagnosis of GVHD in patients at onset of clinical symptoms of GVHD and provide prognostic information independent of GVHD severity...
  38. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  39. ncbi CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  40. ncbi Early detection and biomarkers in pancreatic cancer
    David E Misek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 0331, USA
    J Natl Compr Canc Netw 5:1034-41. 2007
    ..Thus, a great need exists for new biomarkers for pancreatic cancer. This article focuses on recent developments in the identification of new serum protein biomarkers that are useful in the early detection of PDAC...
  41. ncbi Inducible expression of macrophage receptor Marco by dendritic cells following phagocytic uptake of dead cells uncovered by oligonucleotide arrays
    Annabelle Grolleau
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 171:2879-88. 2003
    ..Therefore, we have identified a repertoire of genes that likely play a role in DC function...
  42. ncbi Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator
    Baoan Ji
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Physiol Genomics 14:59-72. 2003
    ..Thus this study identified EGR-1 and several other novel genes likely to be important in the development and severity of acute pancreatitis...
  43. ncbi Oligonucleotide-directed microarray gene profiling of pancreatic adenocarcinoma
    David E Misek
    Department of Pediatric Oncology, University of Michigan, Ann Arbor, USA
    Methods Mol Med 103:175-87. 2005
    ..The details of the approach we utilized are reported here, including information on experimental design, sample collection, expression level measurements, and data analysis for gene profiling...
  44. ncbi Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids
    Hong Wang
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 4:618-25. 2005
    ..IPAS provides a combination of comprehensive profiling and quantitative analysis, with a substantial dynamic range, for disease-related applications...
  45. ncbi Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
    Bong Kyung Shin
    Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan 48109 0656, USA
    J Biol Chem 278:7607-16. 2003
    ..Comprehensive profiling of the cell surface proteome provides an effective approach for the identification of commonly occurring proteins as well as proteins with restricted expression patterns in this compartment...
  46. ncbi Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    Donald R Schwartz
    Departments of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4722-9. 2002
    ..Moreover, these studies provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer...
  47. pmc Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice
    Chad Creighton
    Bioinformatics Program, Human Genetics, and Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Genome Biol 4:R46. 2003
    ..Global gene-expression profiles of the tumors were determined, based on analysis of expression of human genes, and compared with expression profiles of the cell lines grown in culture...
  48. ncbi Application of proteomic technologies to tumor analysis
    David E Misek
    Department of Pediatrics, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan, 48109 0656, USA
    Pharmacogenomics 5:1129-37. 2004
    ....
  49. ncbi Discordant protein and mRNA expression in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 1:304-13. 2002
    ..Using a quantitative analysis of mRNA and protein expression within the same lung adenocarcinomas, we showed that only a subset of the proteins exhibited a significant correlation with mRNA abundance...
  50. pmc Characterization of apolipoprotein and apolipoprotein precursors in pancreatic cancer serum samples via two-dimensional liquid chromatography and mass spectrometry
    Jianzhong Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    J Chromatogr A 1162:117-25. 2007
    ..The detection of differentially expressed proapolipoprotein C-II and apolipoprotein C-III(1) in the sera of pancreatic cancer patients may have utility for detection of this deadly malignancy...
  51. pmc Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
    Thomas J Giordano
    Departments of Pathology, Pediatrics, Surgery, and Biostatistics, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 162:521-31. 2003
    ..Moreover, we identified several genes that represent potential diagnostic markers and may play a role in the pathogenesis of ACC...
  52. pmc Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism
    Sarah E Ross
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 22:5989-99. 2002
    ..These findings demonstrate new metabolic roles for LXR alpha and increase our understanding of adipogenesis...
  53. ncbi T cell chemokine receptor expression in aging
    RuRan Mo
    Division of Geriatric Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    J Immunol 170:895-904. 2003
    ..We propose that the aging-associated changes in T cell chemokine receptor expression may contribute to the different clinical outcome in T cell chemokine receptor-dependent diseases in the elderly...
  54. ncbi Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma
    Cecelia E Schmalbach
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0656, USA
    Arch Otolaryngol Head Neck Surg 130:295-302. 2004
    ..To investigate differences in gene expression profiles between oral cavity/oropharynx squamous cell carcinoma (OC/OP SCC) primary tumors that have metastasized to cervical lymph nodes and nonmetastatic OC/OP SCC tumors...
  55. ncbi A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis
    Francois Le Naour
    Departments of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109 0666, USA
    Mol Cell Proteomics 1:197-203. 2002
    ..We conclude that a distinct repertoire of autoantibodies is associated with HCC that may have utility in early diagnosis of HCC among high risk subjects with chronic hepatitis...
  56. ncbi Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 16:2953-66. 2005
    ..Hypertrophy above a certain threshold was associated with podocyte stress and then failure, culminating in reduced podocyte numbers in sclerotic glomeruli. This process could be prevented by calorie restriction...
  57. ncbi Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis
    Ji Yao Li
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:9069-76. 2002
    ..This study identifies a novel gene induced by fasting and demonstrates the feasibility of using oligonucleotide microarrays for the study of complex neuronal processes...
  58. ncbi An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis
    Sophie Girard
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor 48109 0666, USA
    Virology 295:272-83. 2002
    ..Our findings provide a mechanism for NS5A-mediated interferon resistance...
  59. ncbi Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer
    Sandra R Pereira-Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 67:12000-6. 2007
    ..5 proteins previously identified as associated with autoantibodies in lung cancer, gave a sensitivity of 55% at 95% specificity (area under the curve, 0.838) in discriminating lung cancer at the preclinical stage from matched controls...
  60. pmc Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
    Jörg van den Boom
    Department of Neuropathology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Am J Pathol 163:1033-43. 2003
    ..Thus, we identified and validated a set of interesting candidate genes whose differential expression likely plays a role in astrocytoma progression...
  61. ncbi The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis
    Jose M Cuezva
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, E 28049 Madrid, Spain
    Carcinogenesis 25:1157-63. 2004
    ..We conclude that the bioenergetic signature of lung adenocarcinomas is altered, further providing a relevant marker for the diagnosis and classification of lung adenocarcinomas, and for the prognosis of lung cancer patients...
  62. ncbi Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays
    Kevin K Dobbin
    Cancer Diagnosis Program, National Cancer Institute NIH, Bethesda, MD 20894, USA
    Clin Cancer Res 11:565-72. 2005
    ..The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study...
  63. ncbi Long-term ethanol consumption alters pancreatic gene expression in rats: a possible connection to pancreatic injury
    Constanze H Kubisch
    Department of Cancer Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77230 1429, USA
    Pancreas 33:68-76. 2006
    ..The mechanisms responsible for this sensitization are unknown. To determine whether alterations in pancreatic gene expression might participate in ethanol-mediated sensitization, we performed gene-profiling analysis...