JAMIE MILLIGAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Repair of guanyl radicals in plasmid DNA by electron transfer is coupled to proton transfer
    Jamie R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    J Am Chem Soc 126:1682-7. 2004
  2. ncbi request reprint Modification of ionizing radiation clustered damage: estimate of the migration distance of holes through DNA via guanyl radicals under physiological conditions
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 78:733-41. 2002
  3. ncbi request reprint One-electron oxidation of plasmid DNA by selenium(V) species
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093, USA
    Int J Radiat Biol 78:359-74. 2002
  4. ncbi request reprint Redox equilibrium between guanyl radicals and thiocyanate influences base damage yields in gamma irradiated plasmid DNA. Estimation of the reduction potential of guanyl radicals in plasmid DNA in aqueous solution at physiological ionic strength
    J R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 77:1195-205. 2001
  5. ncbi request reprint Reaction of guanyl radicals in plasmid DNA with biological reductants: chemical repair of DNA damage produced by the direct effect of ionizing radiation
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 77:1095-108. 2001
  6. pmc Repair of oxidative DNA damage by amino acids
    J R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Nucleic Acids Res 31:6258-63. 2003
  7. ncbi request reprint DNA strand break yields after post-high LET irradiation incubation with endonuclease-III and evidence for hydroxyl radical clustering
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla 92093 0610, USA
    Int J Radiat Biol 77:155-64. 2001
  8. ncbi request reprint DNA strand-break yields after post-irradiation incubation with base excision repair endonucleases implicate hydroxyl radical pairs in double-strand break formation
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, 92093 0610, USA
    Int J Radiat Biol 76:1475-83. 2000
  9. ncbi request reprint Mechanism of DNA damage by thiocyanate radicals
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla 92093 0610, USA
    Int J Radiat Biol 76:1305-14. 2000
  10. ncbi request reprint Peptide repair of oxidative DNA damage
    Jamie R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0610, USA
    Biochemistry 43:5102-8. 2004

Collaborators

  • Charles L Limoli
  • C C Wu
  • Shubhadeep Purkayastha
  • Anne Ly
  • William A Bernhard
  • Nancy Q Tran
  • Mandi Tsoi
  • Kiran Kumar K Sharma
  • Simona L Bandong
  • G L Newton
  • Trinh T Do
  • Vicky J Tang
  • Joseph A Aguilera
  • Ji Hae Won
  • Sam Bullick
  • Kathrina Sullivan
  • Kathrina J Sullivan
  • A Ly
  • N Q Tran
  • J F Ward
  • John F Ward

Detail Information

Publications25

  1. ncbi request reprint Repair of guanyl radicals in plasmid DNA by electron transfer is coupled to proton transfer
    Jamie R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    J Am Chem Soc 126:1682-7. 2004
    ..By comparing the expected energetics of the reaction with the observed rate constants, the electron transfer is found to be mechanistically coupled with the proton transfer...
  2. ncbi request reprint Modification of ionizing radiation clustered damage: estimate of the migration distance of holes through DNA via guanyl radicals under physiological conditions
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 78:733-41. 2002
    ..The migration distance is presumably a function of the lifetime of the intermediate guanyl radical, and we wished to quantify the relationship between them...
  3. ncbi request reprint One-electron oxidation of plasmid DNA by selenium(V) species
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093, USA
    Int J Radiat Biol 78:359-74. 2002
    ....
  4. ncbi request reprint Redox equilibrium between guanyl radicals and thiocyanate influences base damage yields in gamma irradiated plasmid DNA. Estimation of the reduction potential of guanyl radicals in plasmid DNA in aqueous solution at physiological ionic strength
    J R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 77:1195-205. 2001
    ....
  5. ncbi request reprint Reaction of guanyl radicals in plasmid DNA with biological reductants: chemical repair of DNA damage produced by the direct effect of ionizing radiation
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 77:1095-108. 2001
    ....
  6. pmc Repair of oxidative DNA damage by amino acids
    J R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Nucleic Acids Res 31:6258-63. 2003
    ....
  7. ncbi request reprint DNA strand break yields after post-high LET irradiation incubation with endonuclease-III and evidence for hydroxyl radical clustering
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla 92093 0610, USA
    Int J Radiat Biol 77:155-64. 2001
    ..To determine the increase in single- (SSB) and double-strand break (DSB) yields after post-high LET irradiation incubation of plasmid DNA with the endonuclease-III (endo-III) of Escherichia coli...
  8. ncbi request reprint DNA strand-break yields after post-irradiation incubation with base excision repair endonucleases implicate hydroxyl radical pairs in double-strand break formation
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, 92093 0610, USA
    Int J Radiat Biol 76:1475-83. 2000
    ....
  9. ncbi request reprint Mechanism of DNA damage by thiocyanate radicals
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla 92093 0610, USA
    Int J Radiat Biol 76:1305-14. 2000
    ..The authors wished to characterize the mechanism responsible for the production of these FPG-sensitive sites...
  10. ncbi request reprint Peptide repair of oxidative DNA damage
    Jamie R Milligan
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0610, USA
    Biochemistry 43:5102-8. 2004
    ..10-fold increase in reactivity. The results suggest that amino acid residues located close to DNA (for example, in DNA binding proteins such as histones) might participate in the repair of oxidative DNA damage...
  11. ncbi request reprint Redox reactivity of guanyl radicals in plasmid DNA
    J R Milligan
    Department of Radiology, University of California at San Diego, La Jolla, 92093-0610, USA
    Int J Radiat Biol 77:281-93. 2001
    ....
  12. ncbi request reprint Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution
    J R Milligan
    Department of Radiology, University of California, San Diego, La Jolla 92093 0610
    Radiat Res 133:151-7. 1993
    ..This is equivalent to 2 x 10(-10) SSB Gy-1 Da-1. Estimates of the efficiency of SSB induction per OH. radical interaction with DNA (0.32-0.44) reveal that all plasmids are essentially equal in reactivity...
  13. ncbi request reprint Variation of single-strand break yield with scavenger concentration for the SV40 minichromosome irradiated in aqueous solution
    J R Milligan
    Department of Radiology, University of California, San Diego, La Jolla 92093 0610
    Radiat Res 133:158-62. 1993
    ..At a DNA concentration of 50 micrograms ml-1, G(SSB) for the direct effect in the minichromosome is about 1 x 10(-5) mumol J-1 (2 x 10(-10) SSB Gy-1 Da-1), essentially equal to that for naked DNA...
  14. ncbi request reprint Radioprotection of plasmid DNA by oligolysines
    G L Newton
    Department of Chemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Int J Radiat Biol 80:643-51. 2004
    ..This will enable a reversible compaction model for plasmid DNA to be devised that models more closely mammalian chromatin than those based on polyamines...
  15. ncbi request reprint Photochemical production of uracil quantified in bromodeoxyuridine-substituted SV40 DNA by uracil DNA glycosylase and a lysyl-tyrosyl-lysine tripeptide
    C L Limoli
    Department of Radiology, University of California at San Diego, La Jolla 92093 0610, USA
    Mutagenesis 12:443-7. 1997
    ..Formation of uracil suggests a mechanism for the high cellular toxicity of the dye-BrdU-UVA treatment...
  16. doi request reprint Reduction of electron deficient guanine radical species in plasmid DNA by tyrosine derivatives
    Mandi Tsoi
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Org Biomol Chem 8:2553-9. 2010
    ..The experimental conditions used in this model system provide a reasonable approximation to those involved in the radioprotection of DNA by tightly bound proteins in chromatin...
  17. ncbi request reprint Involvement of proton transfer in the reductive repair of DNA guanyl radicals by aniline derivatives
    Anne Ly
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0610, USA
    Org Biomol Chem 3:917-23. 2005
    ....
  18. pmc The role of hydration in the distribution of free radical trapping in directly ionized DNA
    Shubhadeep Purkayastha
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, 14642, USA
    Radiat Res 166:1-8. 2006
    ..These results not only add to our understanding of how the holes redistribute after ionization but are also central to predicting the yield and location of strand breaks in DNA exposed to the direct effects of ionizing radiation...
  19. ncbi request reprint Repair of oxidative guanine damage in plasmid DNA by indoles involves proton transfer between complementary bases
    Anne Ly
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0610, USA
    Biochemistry 43:9098-104. 2004
    ..Comparison of the kinetic results with literature thermodynamic data suggests that the source of this proton is the complementary base-paired cytosine...
  20. ncbi request reprint Reactivity of DNA guanyl radicals with phenolate anions
    Anne Ly
    Department of Radiology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0610, USA
    J Phys Chem B 109:13368-74. 2005
    ..These results emphasize the potential importance of acidic tyrosine residues and the intimate involvement of protons in DNA repair...
  21. pmc Correlation of free radical yields with strand break yields produced in plasmid DNA by the direct effect of ionizing radiation
    Shubhadeep Purkayastha
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA
    J Phys Chem B 109:16967-73. 2005
    ..To explain this disparity, various mechanisms were considered, including one that entails two one-electron oxidations of a single deoxyribose carbon...
  22. pmc An investigation into the mechanisms of DNA strand breakage by direct ionization of variably hydrated plasmid DNA
    Shubhadeep Purkayastha
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA
    J Phys Chem B 110:26286-91. 2006
    ..To account for these nonradical precursors, we hypothesize that strand breaks are produced by two one-electron oxidations at a single deoxyribose residue within an ionization cluster...
  23. pmc On the chemical yield of base lesions, strand breaks, and clustered damage generated in plasmid DNA by the direct effect of X rays
    Shubhadeep Purkayastha
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    Radiat Res 168:357-66. 2007
    ..5 +/- 0.5 nmol/J for fully hydrated pUC18, comparable to the yield of 4.1 +/- 0.9 nmol/J for DSBs derived from opposed damages in which at least one of the sites is a damaged base...
  24. pmc Multiplicity of DNA single-strand breaks produced in pUC18 exposed to the direct effects of ionizing radiation
    Kiran Kumar K Sharma
    Department of Biochemistry and Biophysics, University of Rochester, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Radiat Res 170:156-62. 2008
    ..The lack of change between the two extremes of hydration is in keeping with the suggestion that non-radical species, such as doubly oxidized deoxyribose, are responsible for the shortfall...
  25. ncbi request reprint Cationic peptides containing tyrosine protect against radiation-induced oxidative DNA damage
    Anne Ly
    Department of Radiology, University of California at San Diego, La Jolla, California 92093 0610, USA
    Int J Radiat Biol 82:421-33. 2006
    ..To examine the effect of the amino acid tyrosine on oxidatively or direct-type damaged DNA damage when it is present in a DNA binding ligand...