Matthew F Mescher

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Semin Cancer Biol 17:299-308. 2007
  2. ncbi request reprint Signals required for programming effector and memory development by CD8+ T cells
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunol Rev 211:81-92. 2006
  3. pmc Programming for CD8 T cell memory development requires IL-12 or type I IFN
    Zhengguo Xiao
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 182:2786-94. 2009
  4. ncbi request reprint Signal 3 availability limits the CD8 T cell response to a solid tumor
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:6752-60. 2007
  5. ncbi request reprint Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction
    Christopher D Hammerbeck
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    J Immunol 180:2107-16. 2008
  6. ncbi request reprint The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo
    Lisa A E Harmala
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 169:5622-9. 2002
  7. ncbi request reprint In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen)
    Jodi Goldberg
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 170:228-35. 2003
  8. ncbi request reprint CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 171:5165-71. 2003
  9. pmc Antigen processing and MHC-II presentation by dermal and tumor-infiltrating dendritic cells
    Michael Y Gerner
    Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 182:2726-37. 2009
  10. ncbi request reprint IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
    Kerry A Casey
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 178:7640-8. 2007

Collaborators

Detail Information

Publications33

  1. pmc Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Semin Cancer Biol 17:299-308. 2007
    ..AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion...
  2. ncbi request reprint Signals required for programming effector and memory development by CD8+ T cells
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunol Rev 211:81-92. 2006
    ..Thus, in addition to antigen and costimulation, CD8+ T cells require cytokine signals at distinct stages of the response to be programmed for optimal generation of effector and memory populations...
  3. pmc Programming for CD8 T cell memory development requires IL-12 or type I IFN
    Zhengguo Xiao
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 182:2786-94. 2009
    ..These data demonstrate that IL-12 and type I IFN play an essential early role in determining whether Ag encounter by naive CD8 T cells results in formation of a protective memory population...
  4. ncbi request reprint Signal 3 availability limits the CD8 T cell response to a solid tumor
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:6752-60. 2007
    ....
  5. ncbi request reprint Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction
    Christopher D Hammerbeck
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    J Immunol 180:2107-16. 2008
    ..Thus, Ag-dependent signals regulate IL-7Ralpha levels on responding CD8 T cells, and this occurs whether the responding cells become fully activated or are rendered tolerant by administration of peptide Ag alone...
  6. ncbi request reprint The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo
    Lisa A E Harmala
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 169:5622-9. 2002
    ..These studies demonstrate that the potent adjuvant effect of M. tuberculosis hsp70 results from the relatively complete, rapid, and durable activation of Ag-specific CD8(+) T cells...
  7. ncbi request reprint In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen)
    Jodi Goldberg
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 170:228-35. 2003
    ....
  8. ncbi request reprint CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 171:5165-71. 2003
    ....
  9. pmc Antigen processing and MHC-II presentation by dermal and tumor-infiltrating dendritic cells
    Michael Y Gerner
    Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 182:2726-37. 2009
    ..These results show that TIDC are functionally distinct from normal interstitial DC, thus indicating that neoplastic tissues can evade effector CD4 T cells through modification of DC competence...
  10. ncbi request reprint IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
    Kerry A Casey
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 178:7640-8. 2007
    ....
  11. pmc Defective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses
    Michael Y Gerner
    Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 181:155-64. 2008
    ....
  12. ncbi request reprint The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses
    Zhengguo Xiao
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Int Immunol 19:733-43. 2007
    ....
  13. pmc Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    Pujya Agarwal
    Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1695-704. 2009
    ....
  14. ncbi request reprint Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis
    Julie M Curtsinger
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 175:4392-9. 2005
    ..Thus, it appears that cells rendered tolerant as a result of stimulation in the absence of a third signal fail to lyse target cells because they are "shooting blanks."..
  15. ncbi request reprint CD4 T cell-dependent conditioning of dendritic cells to produce IL-12 results in CD8-mediated graft rejection and avoidance of tolerance
    Alexander A Filatenkov
    Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    J Immunol 174:6909-17. 2005
    ..Thus, CD4 T cells condition dendritic cells by inducing the production of IL-12, which is needed as the "third signal" for CD8 T cell differentiation and avoidance of tolerance...
  16. ncbi request reprint Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells
    Javier O Valenzuela
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 174:600-4. 2005
    ..The time courses of expression suggest that Bcl-2 and Bcl-x(L) promote survival early in the response, whereas Bcl-3 acts later in the response...
  17. ncbi request reprint Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 174:4465-9. 2005
    ..Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function...
  18. pmc Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function
    Julie M Curtsinger
    University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 189:659-68. 2012
    ..Thus, IFN-γ is not only an important CD8 T cell effector cytokine, it is an autocrine/paracrine factor whose contributions to differentiation vary depending on whether the response is supported by IL-12 or type I IFN...
  19. pmc Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation
    Zhengguo Xiao
    Center for Immunology and 2Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN 55455
    J Exp Med 204:2667-77. 2007
    ..g., infected cells), while limiting collateral damage to bystander cells...
  20. pmc Molecular basis for checkpoints in the CD8 T cell response: tolerance versus activation
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Semin Immunol 19:153-61. 2007
    ..These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants...
  21. ncbi request reprint Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12
    Clint S Schmidt
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 168:5521-9. 2002
    ..In contrast, memory CD8 T cells are effectively activated by peptide Ag in the absence of IL-12 or adjuvant...
  22. pmc Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control
    Michael Y Gerner
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 191:1011-5. 2013
    ..Thus, IL-12 and IFN-α differentially program CD8 T cells to re-express distinct levels of PD-1 upon re-encountering Ag, resulting in IL-12-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag. ..
  23. pmc ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation
    Nicholas A Zumwalde
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455
    J Immunol 191:3681-93. 2013
    ..These results suggest that T cell clustering represents a mechanism that allows continued proliferation but regulates T cell effector function and differentiation. ..
  24. ncbi request reprint Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis
    Protul Shrikant
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:1753-9. 2002
    ....
  25. ncbi request reprint The poststimulation program of CD4 versus CD8 T cells (death versus activation-induced nonresponsiveness)
    Ee Loon Tham
    Center for Immunology, Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:1822-8. 2002
    ....
  26. pmc Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, MN 55455, USA
    J Exp Med 197:1141-51. 2003
    ....
  27. pmc Inflammatory cytokines as a third signal for T cell activation
    Julie M Curtsinger
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Curr Opin Immunol 22:333-40. 2010
    ..Signal 3 cytokines can replace adjuvants in supporting in vivo T cell responses to peptide and protein antigens, and a better understanding of their activities and mechanisms should contribute to more rational design of vaccines...
  28. pmc Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer
    Ruud P M Dings
    Department of Biochemistry, The Masonic Cancer Center, University of Minnesota, Minnesota 55455, USA
    Clin Cancer Res 17:3134-45. 2011
    ..We hypothesized that overcoming EAM suppression with angiogenesis inhibitors would increase leukocyte extravasation and subsequently enhance the effectiveness of cellular immunotherapy...
  29. doi request reprint Autologous large multivalent immunogen vaccine in patients with metastatic melanoma and renal cell carcinoma
    Arkadiusz Z Dudek
    Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware St SE, MMC 480, Minneapolis, MN 55455, USA
    Am J Clin Oncol 31:173-81. 2008
    ..To evaluate the safety and activity of large multivalent immunogen (LMI), prepared by immobilizing autologous tumor cell plasma membrane on 5-microm diameter silica beads, in patients with melanoma and renal cell carcinoma (RCC)...
  30. ncbi request reprint Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response
    Ee Loon Tham
    Center for Immunology, Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 168:1190-7. 2002
    ..Once permission is given, in the form of IL-2, to pass this checkpoint, the CTL can make a prolonged response to persisting Ag in the absence of further CD4 T cell help...
  31. pmc The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity
    Yaya Wang
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 39:111-22. 2013
    ..The findings establish a candidate innate immune mechanism of action for a human autoimmunity "risk" gene in the regulation of host defense and inflammation. ..
  32. ncbi request reprint Phase I trial of large multivalent immunogen derived from melanoma lysates in patients with disseminated melanoma
    Malcolm S Mitchell
    Center for Biological Therapy and Melanoma Research, University of California, San Diego, La Jolla, California, USA
    Clin Cancer Res 10:76-83. 2004
    ..The purpose of this research was to determine the toxicity and immunological activity of large multivalent immunogen (LMI), a preparation of tumor cell membranes affixed to amorphous silica microbeads, in patients with melanoma...
  33. ncbi request reprint Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes
    Liesbeth E M Oosten
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Blood 104:224-6. 2004
    ..Thus, aAPCs coated with HLA/mHag complexes, CD80, and CD54 may serve as tools for in vitro enrichment of immunotherapeutic mHag-specific CTL lines...