Parmender P Mehta

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
    Pallavi Chaturvedi
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Res 68:2065-70. 2008
  2. ncbi request reprint Introduction: a tribute to cell-to-cell channels
    Parmender P Mehta
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Membr Biol 217:5-12. 2007
  3. pmc Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells
    Kristen E Johnson
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 24:715-33. 2013
  4. pmc Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 21:4089-107. 2010
  5. ncbi request reprint Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 277:50087-97. 2002
  6. pmc Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32846. 2012
  7. pmc The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells
    Parul Katoch
    From the Department of Biochemistry and Molecular Biology, Department of Oral Biology, Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198
    J Biol Chem 290:4647-62. 2015
  8. pmc Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 9:e106437. 2014
  9. pmc E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells
    Souvik Chakraborty
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:10761-76. 2010
  10. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
    Pallavi Chaturvedi
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Res 68:2065-70. 2008
    ..Our findings add a new dimension to MUC4 function as a modulator of cell signaling and provide mechanistic evidence for its role in pancreatic cancer progression...
  2. ncbi request reprint Introduction: a tribute to cell-to-cell channels
    Parmender P Mehta
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Membr Biol 217:5-12. 2007
  3. pmc Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells
    Kristen E Johnson
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 24:715-33. 2013
    ..Thus the differential phosphorylation of Cx43 on Ser-279 and Ser-282 is fine-tuned to control Cx43's endocytosis and assembly into gap junctions...
  4. pmc Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 21:4089-107. 2010
    ....
  5. ncbi request reprint Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 277:50087-97. 2002
    ..Our results suggest that impaired trafficking, and not the inability to form gap junctions, is the major cause of communication deficiency in human prostate cancer cell lines...
  6. pmc Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32846. 2012
    ..Thus, the effects of retinoids and androgens on growth and the formation and degradation of gap junctions and their function might be related to their ability to modulate prostate growth and cancer...
  7. pmc The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells
    Parul Katoch
    From the Department of Biochemistry and Molecular Biology, Department of Oral Biology, Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198
    J Biol Chem 290:4647-62. 2015
    ..Our findings suggest that the cytoplasmic tail of Cx32 may be involved in regulating the permeability of gap junctions by regulating their size. ..
  8. pmc Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 9:e106437. 2014
    ..These findings suggest that the growth-inhibitory effects of 1-25D in LNCaP cells may be related to its ability to modulate the assembly of Cx32 into gap junctions. ..
  9. pmc E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells
    Souvik Chakraborty
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:10761-76. 2010
    ....
  10. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007
    ....
  11. pmc ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells
    Sakthivel Muniyan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Cell Signal 27:2261-71. 2015
    ..These results suggest that ErbB-2 is a prominent player in mediating the ligand-dependent and -independent activation of AR in AS and AI/CR PCa cells respectively for PCa progression and survival. ..
  12. pmc Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies
    Murielle Mimeault
    and Surinder K Batra, Ph D, Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Endocr Rev 29:234-52. 2008
    ....
  13. pmc Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Shalini Mitra
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 17:5400-16. 2006
    ....

Research Grants2

  1. GAP JUNCTIONS AND CELL INTERACTIONS IN PROSTATE CANCER
    Parmender Mehta; Fiscal Year: 2002
    ..Such experiments should enhance our knowledge about the pathobiology of prostate cancer. ..
  2. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..abstract_text> ..