C Alex McMahan

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Mutation spectral changes in spermatogenic cells obtained from old mice
    Christi A Walter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    DNA Repair (Amst) 3:495-504. 2004
  2. ncbi request reprint Fostering dental student self-assessment of knowledge by confidence scoring of multiple-choice examinations
    C Alex McMahan
    Dr McMahan is Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio Dr Pinckard is Distinguished Teaching Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio Dr Jones is Distinguished Teaching Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio and Mr Hendricson is Assistant Dean for Education and Faculty Development, School of Dentistry, The University of Texas Health Science Center at San Antonio
    J Dent Educ 78:1643-54. 2014
  3. ncbi request reprint Improving multiple-choice questions to better assess dental student knowledge: distractor utilization in oral and maxillofacial pathology course examinations
    C Alex McMahan
    San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900
    J Dent Educ 77:1593-609. 2013
  4. pmc Association of Pathobiologic Determinants of Atherosclerosis in Youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study)
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Cardiol 100:1124-9. 2007
  5. ncbi request reprint Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Cardiovasc Pathol 16:151-8. 2007
  6. ncbi request reprint Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis
    C Alex McMahan
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Pediatrics 118:1447-55. 2006
  7. ncbi request reprint PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youth
    C Alex McMahan
    The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Atherosclerosis 190:370-7. 2007
  8. ncbi request reprint Risk scores predict atherosclerotic lesions in young people
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Intern Med 165:883-90. 2005
  9. ncbi request reprint Short-answer questions and formula scoring separately enhance dental student academic performance
    R Neal Pinckard
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Dent Educ 76:620-34. 2012
  10. ncbi request reprint Prospective implementation of correction for guessing in oral and maxillofacial pathology multiple-choice examinations: did student performance improve?
    Thomas J Prihoda
    San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Dent Educ 72:1149-59. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Mutation spectral changes in spermatogenic cells obtained from old mice
    Christi A Walter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    DNA Repair (Amst) 3:495-504. 2004
    ....
  2. ncbi request reprint Fostering dental student self-assessment of knowledge by confidence scoring of multiple-choice examinations
    C Alex McMahan
    Dr McMahan is Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio Dr Pinckard is Distinguished Teaching Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio Dr Jones is Distinguished Teaching Professor, Department of Pathology, The University of Texas Health Science Center at San Antonio and Mr Hendricson is Assistant Dean for Education and Faculty Development, School of Dentistry, The University of Texas Health Science Center at San Antonio
    J Dent Educ 78:1643-54. 2014
    ..This is a professional development competency that is emphasized in the educational standards of the Commission on Dental Accreditation (CODA). ..
  3. ncbi request reprint Improving multiple-choice questions to better assess dental student knowledge: distractor utilization in oral and maxillofacial pathology course examinations
    C Alex McMahan
    San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900
    J Dent Educ 77:1593-609. 2013
    ....
  4. pmc Association of Pathobiologic Determinants of Atherosclerosis in Youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study)
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Cardiol 100:1124-9. 2007
    ..997 for a 1-point decrease). In conclusion, the change in risk score over time (decrease or increase) during adolescence and young adulthood, as well as the risk score early in life, are important predictors of atherosclerosis...
  5. ncbi request reprint Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA study
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Cardiovasc Pathol 16:151-8. 2007
    ....
  6. ncbi request reprint Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis
    C Alex McMahan
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Pediatrics 118:1447-55. 2006
    ..In this study we investigated the relation of these risk scores to the early atherosclerotic lesions...
  7. ncbi request reprint PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youth
    C Alex McMahan
    The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Atherosclerosis 190:370-7. 2007
    ..These results support the proposal that early control of risk factors is likely to prevent or delay the onset of CHD...
  8. ncbi request reprint Risk scores predict atherosclerotic lesions in young people
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Intern Med 165:883-90. 2005
    ..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...
  9. ncbi request reprint Short-answer questions and formula scoring separately enhance dental student academic performance
    R Neal Pinckard
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Dent Educ 76:620-34. 2012
    ....
  10. ncbi request reprint Prospective implementation of correction for guessing in oral and maxillofacial pathology multiple-choice examinations: did student performance improve?
    Thomas J Prihoda
    San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Dent Educ 72:1149-59. 2008
    ..We interpret this improved performance as a response to a higher expectation imposed on the 2005-06 students by the prospective implementation of correction for guessing...
  11. ncbi request reprint Smoking is associated with advanced coronary atherosclerosis in youth
    Arthur W Zieske
    Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Atherosclerosis 180:87-92. 2005
    ..The difference in qualities of advanced lesions suggests that smoking possibly accelerates the transition from Grade 4 to Grade 5 lesions by promoting thrombosis and accretion on the intimal surface of the plaque...
  12. ncbi request reprint Correcting for guessing increases validity in multiple-choice examinations in an oral and maxillofacial pathology course
    Thomas J Prihoda
    Department of Pathology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Dent Educ 70:378-86. 2006
    ..015) higher than agreement of uncorrected multiple-choice scores with short-answer scores (intraclass correlation coefficient 0.71). The higher agreement indicated increased validity for the corrected multiple-choice examination...
  13. ncbi request reprint Short-answer examinations improve student performance in an oral and maxillofacial pathology course
    R Neal Pinckard
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Dent Educ 73:950-61. 2009
    ..Our interpretation of these results is that the utilization of examinations containing short-answer questions created a more challenging learning environment that motivated students to adopt more effective study regimens...
  14. pmc DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status
    Maryanne C S Herzig
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Cancer Prev Res (Phila) 9:245-52. 2016
    ..Together, these results suggest that targeting the repair of cytotoxic lesions may be a good preventative for patients at high risk of developing hepatocellular carcinoma...
  15. pmc Effects of calorie restriction on chromosomal stability in rhesus monkeys (Macaca mulatta)
    Charleen M Moore
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Age (Dordr) 29:15-28. 2007
    ..CR, implemented in adult rhesus monkeys, does not have a major effect on the reduction of numerical or structural aberrations related to aging...
  16. ncbi request reprint Programming of initial steps in bile acid synthesis by breast-feeding vs. formula-feeding in the baboon
    Glen E Motta
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Lipids 38:1213-20. 2003
    ..The present results suggest that this difference is most likely due to significantly higher CYP7A1 activity among formula-fed vs. breast-fed animals...
  17. ncbi request reprint Evaluation of a model to predict poor survival in patients undergoing elective TIPS procedures
    Hector Ferral
    Division of Cardiovascular and Special Interventions, Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Vasc Interv Radiol 13:1103-8. 2002
    ..The model is implemented with use of a nomogram or a formula...
  18. pmc Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice
    Jamila R Sanchez
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Mutat Res 779:124-33. 2015
    ....
  19. pmc Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice
    Kristine S Vogel
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Reprod Dev 78:906-19. 2011
    ..Thus, Apex1 heterozygosity results in accelerated damage to mtDNA and spontaneous mutagenesis, consistent with an essential role for APEN in maintaining nuclear and mtDNA integrity in spermatogenic cells throughout life...
  20. doi request reprint Human O6 -methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice
    Maryanne C S Herzig
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Carcinog 52:275-85. 2013
    ..These results provide evidence that residue C145 in hMGMT is required to reduce the prevalence of HCC in C3HeB/FeJ mice transgenic for hMGMT...
  21. pmc Early-life exposure to benzo[a]pyrene increases mutant frequency in spermatogenic cells in adulthood
    Guogang Xu
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 9:e87439. 2014
    ..The data demonstrate that exposure to environmental genotoxins at different life phases (e.g., pre-adult and adult) can have differential effects on reproductive health. ..
  22. pmc Enhanced genetic integrity in mouse germ cells
    Patricia Murphey
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Biol Reprod 88:6. 2013
    ....
  23. pmc Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice
    Guogang Xu
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mutat Res 744:135-9. 2012
    ..This study indicates that age modulates the mutagenic response to ionizing radiation in the male germline...
  24. doi request reprint Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study
    Henry C McGill
    University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
    Circulation 117:1216-27. 2008
  25. ncbi request reprint Coronary heart disease risk factors and atherosclerosis in young people
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Clin Lipidol 2:118-26. 2008
    ..Risk-factor control beginning in the late teenage years will retard development of the earliest stage of atherosclerosis and its progression, and will reduce or delay occurrence of CHD...
  26. ncbi request reprint Senescent terminal weight loss in the male F344 rat
    Bill J Black
    Departments of Medicine, Pathology and Physiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Regul Integr Comp Physiol 284:R336-42. 2003
    ..The duration of the period of terminal weight loss was similar for the AL and DR groups. Apparently, restricting calories delays the occurrence but does not affect the duration of senescent terminal weight loss...
  27. pmc Spontaneous mutagenesis is enhanced in Apex heterozygous mice
    Jessica Huamani
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Mol Cell Biol 24:8145-53. 2004
    ..These data indicate that diminution of AP endonuclease has a significant effect on spontaneous mutagenesis in somatic and germ line cells...
  28. doi request reprint Esthetic, clinical and patient-centered outcomes of immediately placed implants (Type 1) and early placed implants (Type 2): preliminary 3-month results of an ongoing randomized controlled clinical trial
    Guy Huynh-Ba
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Clin Oral Implants Res 27:241-52. 2016
    ..The objective of the study was to compare (i) esthetic, (ii) clinical and (iii) patient-centered outcomes following immediate (Type 1) and early implant placement (Type 2)...
  29. pmc High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice
    Neha Garg
    Department of Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 413:476-80. 2011
    ....
  30. pmc Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues
    Ana Maria Garcia
    University of Texas at San Antonio, San Antonio, TX, USA
    Mech Ageing Dev 129:528-33. 2008
    ..This could be responsible, at least in part, for the enhanced longevity associated with Ames dwarfism and CR...
  31. pmc Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice
    Diwi Allen
    Departments of Cellular and Structural Biology and Pathology, and The Barshop Center for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Biol Reprod 79:824-31. 2008
    ..Notably, spermatogenic cells respond differently than somatic cells to Polb haploinsufficiency...
  32. ncbi request reprint A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1
    Rene Garza
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Mutat Res 615:98-110. 2007
    ..We conclude that a mild mutator phenotype arises in the tumors and tissues of cisNf1+/-; p53+/- mice, and propose that genomic instability influences NF1 tumor progression and disease severity...
  33. pmc Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice
    Gabriel W Intano
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Cell Biol 22:2410-8. 2002
    ....
  34. pmc Epigenetic regulation of genetic integrity is reprogrammed during cloning
    Patricia Murphey
    Department of Biology, University of Texas, 1 UTSA Circle, San Antonio, TX 78249, USA
    Proc Natl Acad Sci U S A 106:4731-5. 2009
    ..These results also demonstrate that epigenetic mechanisms normally contribute to the regulation of genetic integrity in a tissue-specific manner, and that these mechanisms are subject to reprogramming during cloning...
  35. ncbi request reprint Age-related base excision repair activity in mouse brain and liver nuclear extracts
    Gabriel W Intano
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Gerontol A Biol Sci Med Sci 58:205-11. 2003
    ..Abundances of other tested base excision repair proteins did not change relative to age. The conclusion is that, during aging, a decline in DNA repair could contribute to increased levels of DNA damage and mutagenesis...
  36. pmc Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis
    Guogang Xu
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Mutat Res 654:150-7. 2008
    ..These findings provide evidence that there is a mechanism(s) to prevent spermatogenic cells with elevated mutant frequencies from progressing through spermatogenesis...
  37. ncbi request reprint Genetic mouse models of extended lifespan
    Hanyu Liang
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7762, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:1353-64. 2003
    ..However, these mouse models are already providing new information about the mechanism underlying mammalian aging...
  38. pmc Assisted reproductive technologies do not alter mutation frequency or spectrum
    Lee Caperton
    University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 104:5085-90. 2007
    ..These results, based on analyses of a transgenic mouse system, indicate that with respect to maintenance of genetic integrity, ARTs appear to be safe...
  39. ncbi request reprint Nucleotide excision repair activity varies among murine spermatogenic cell types
    Guogang Xu
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78229, USA
    Biol Reprod 73:123-30. 2005
    ..Overall, the data suggest cell type-specific NER activity during murine spermatogenesis, and our results have possible implications for germ cell aging...
  40. ncbi request reprint Elevated serum C-reactive protein levels and advanced atherosclerosis in youth
    Arthur W Zieske
    Louisiana State University Health Sciences Center, New Orleans 70112 1393, USA
    Arterioscler Thromb Vasc Biol 25:1237-43. 2005
    ..To determine the associations among serum C-reactive protein (CRP) concentration, age, sex, risk factors for coronary heart disease (CHD), and atherosclerosis in young people...
  41. ncbi request reprint Obesity accelerates the progression of coronary atherosclerosis in young men
    Henry C McGill
    University of Texas Health Science Center at San Antonio, USA
    Circulation 105:2712-8. 2002
    ..Results regarding the association of obesity with atherosclerosis are conflicting, particularly when analyses account for other risk factors...
  42. ncbi request reprint Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study
    Samuel S Gidding
    Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Arch Intern Med 166:2341-7. 2006
    ....
  43. ncbi request reprint Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score
    Hector Ferral
    Dept of Radiology, Div of Cardiovascular and Special Interventions, University of Texas Health Science Center at San Antonio, USA
    Radiology 231:231-6. 2004
    ....
  44. ncbi request reprint Starting earlier to prevent heart disease
    Henry C McGill
    JAMA 290:2320-2. 2003