Samuel A McLean

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants
    Samuel A McLean
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Pain 155:309-21. 2014
  2. pmc Acute severe pain is a common consequence of sexual assault
    Samuel A McLean
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, North Carolina 27599 7010, USA
    J Pain 13:736-41. 2012
  3. pmc The potential contribution of stress systems to the transition to chronic whiplash-associated disorders
    Samuel A McLean
    Department of Anesthesiology, N2201 UNC Hospitals, Chapel Hill, NC 27599 7010, USA
    Spine (Phila Pa 1976) 36:S226-32. 2011
  4. pmc Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision
    Samuel A McLean
    Department of Anesthesiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27599, USA
    J Pain 12:101-7. 2011
  5. doi request reprint μ-Opioid receptor gene A118G polymorphism predicts pain recovery after sexual assault
    Lauren E Ballina
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, North Carolina 27599 7010, USA
    J Pain 14:165-71. 2013
  6. pmc Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure
    Andrey V Bortsov
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA
    Pain 154:1419-26. 2013
  7. pmc Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients
    Danielle C Orrey
    Department of Anesthesiology and TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Burn Care Res 33:518-23. 2012
  8. pmc CRHBP polymorphisms predict chronic pain development following motor vehicle collision
    Sarah D Linnstaedt
    aTRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA bAnesthesiology, University of North Carolina, Chapel Hill, NC, USA cEmergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA dEmergency Medicine, Massachusetts General Hospital, Boston, MA, USA eEmergency Medicine, Spectrum Health System, Grand Rapids, MI, USA fEmergency Medicine, Baystate Medical Center, Springfield, MA, USA gEmergency Medicine, North Shore University Hospital, Manhasset, NY, USA hEmergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USA iEmergency Medicine, University of Florida College of Medicine, Jacksonville, FL, USA jEmergency Medicine, University of North Carolina, Chapel Hill, NC, USA
    Pain 157:273-9. 2016
  9. pmc Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study
    Junmei Hu
    aTRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USAbAnesthesiology, University of North Carolina, Chapel Hill, NC, USAcEmergency Medicine, William Beaumont Hospital, Royal Oak, MI, USAdEmergency Medicine, Massachusetts General Hospital, Boston, MA, USAeEmergency Medicine, Spectrum Health System, Grand Rapids, MI, USAfEmergency Medicine, Baystate Medical Center, Springfield, MA, USAgEmergency Medicine, North Shore University Hospital, Manhasset, NY, USAhEmergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USAiEmergency Medicine, University of Florida, Jacksonville, FL, USAjEmergency Medicine, University of North Carolina, Chapel Hill, NC, USA
    Pain 157:438-44. 2016
  10. pmc No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision
    Jacob C Ulirsch
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA
    Pain 155:2116-23. 2014

Collaborators

Detail Information

Publications31

  1. pmc Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants
    Samuel A McLean
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Pain 155:309-21. 2014
    ..These data demonstrate that persistent pain after MVC is common among those not engaged in litigation, and provide evidence for bidirectional influences between pain outcomes and litigation after MVC. ..
  2. pmc Acute severe pain is a common consequence of sexual assault
    Samuel A McLean
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, North Carolina 27599 7010, USA
    J Pain 13:736-41. 2012
    ..These findings suggest that pain is common in SA survivors in the early postassault period, but rarely treated...
  3. pmc The potential contribution of stress systems to the transition to chronic whiplash-associated disorders
    Samuel A McLean
    Department of Anesthesiology, N2201 UNC Hospitals, Chapel Hill, NC 27599 7010, USA
    Spine (Phila Pa 1976) 36:S226-32. 2011
    ..A narrative description highlighting preclinical and clinical evidence that physiologic stress systems contribute to whiplash-associated disorders (WAD) pathogenesis...
  4. pmc Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision
    Samuel A McLean
    Department of Anesthesiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27599, USA
    J Pain 12:101-7. 2011
    ..038). These findings suggest that genetic variations affecting stress response system function influence the somatic and psychological response to MVC, and provide the first evidence of genetic risk for clinical symptoms after MVC...
  5. doi request reprint μ-Opioid receptor gene A118G polymorphism predicts pain recovery after sexual assault
    Lauren E Ballina
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, North Carolina 27599 7010, USA
    J Pain 14:165-71. 2013
    ....
  6. pmc Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure
    Andrey V Bortsov
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA
    Pain 154:1419-26. 2013
    ..These results suggest that glucocorticoid pathways influence the development of persistent posttraumatic pain, and that such pathways may be a target of pharmacologic interventions aimed at improving recovery after trauma...
  7. pmc Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients
    Danielle C Orrey
    Department of Anesthesiology and TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Burn Care Res 33:518-23. 2012
    ..These findings suggest that genetic factors influencing stress system function may have an important influence on pain severity after burn injury. Further studies of genetic predictors of pain after burn injury are needed...
  8. pmc CRHBP polymorphisms predict chronic pain development following motor vehicle collision
    Sarah D Linnstaedt
    aTRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA bAnesthesiology, University of North Carolina, Chapel Hill, NC, USA cEmergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA dEmergency Medicine, Massachusetts General Hospital, Boston, MA, USA eEmergency Medicine, Spectrum Health System, Grand Rapids, MI, USA fEmergency Medicine, Baystate Medical Center, Springfield, MA, USA gEmergency Medicine, North Shore University Hospital, Manhasset, NY, USA hEmergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USA iEmergency Medicine, University of Florida College of Medicine, Jacksonville, FL, USA jEmergency Medicine, University of North Carolina, Chapel Hill, NC, USA
    Pain 157:273-9. 2016
    ..The results of this study indicate that genetic variants in 2 different HPA axis genes predict chronic MSP severity following MVC and support the hypothesis that the HPA axis is involved in chronic post-MVC MSP pathogenesis. ..
  9. pmc Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study
    Junmei Hu
    aTRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USAbAnesthesiology, University of North Carolina, Chapel Hill, NC, USAcEmergency Medicine, William Beaumont Hospital, Royal Oak, MI, USAdEmergency Medicine, Massachusetts General Hospital, Boston, MA, USAeEmergency Medicine, Spectrum Health System, Grand Rapids, MI, USAfEmergency Medicine, Baystate Medical Center, Springfield, MA, USAgEmergency Medicine, North Shore University Hospital, Manhasset, NY, USAhEmergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USAiEmergency Medicine, University of Florida, Jacksonville, FL, USAjEmergency Medicine, University of North Carolina, Chapel Hill, NC, USA
    Pain 157:438-44. 2016
    ..These data support the hypothesis that individuals who develop CWP after MVC develop widespread pain in the early aftermath of MVC, which does not remit. ..
  10. pmc No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision
    Jacob C Ulirsch
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA
    Pain 155:2116-23. 2014
    ....
  11. pmc Effect of pain location and duration on life function in the year after motor vehicle collision
    Andrey V Bortsov
    Department of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA
    Pain 155:1836-45. 2014
    ..Further, pain across all body regions accounted for nearly twice as much of the variance in pain interference as neck pain alone (60% vs 34%). These findings suggest that studies of post-MVC pain should not focus on neck pain alone. ..
  12. pmc Side effects from oral opioids in older adults during the first week of treatment for acute musculoskeletal pain
    Katherine M Hunold
    Department of Biostatistics, University of North Carolina Chapel Hill, Chapel Hill, NC
    Acad Emerg Med 20:872-9. 2013
    ..The authors sought to describe the frequency of short-term side effects experienced by older adults initiating treatment with opioid-containing analgesics for acute musculoskeletal pain...
  13. pmc Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision
    Lauriane Auvergne
    From the Departments of Anesthesiology Auvergne, Bortsov, Ulirsch, McLean and Emergency Medicine McLean, University of North Carolina, Chapel Hill, North Carolina TRYUMPH Research Program Bortsov, Ulirsch, McLean, Chapel Hill, North Carolina Department of Emergency Medicine Peak, Massachusetts General Hospital, Boston, Massachusetts Department of Emergency Medicine Jones, Spectrum Health Hospital Butterworth, Grand Rapids, Michigan Department of Emergency Medicine Swor, William Beaumont Hospital, Royal Oak, Michigan Department of Emergency Medicine Domeier, St Joseph Mercy Hospital, Ann Arbor, Michigan Department of Emergency Medicine Lee, North Shore University, Manhasset, New York Department of Emergency Medicine Rathlev, Baystate Medical Center, Springfield, Massachusetts and Department of Emergency Medicine Hendry, University of Florida Health Science Center, Jacksonville, Florida
    Psychosom Med 78:68-78. 2016
    ....
  14. pmc Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes after motor vehicle collision: methodology of the CRASH study
    Timothy F Platts-Mills
    Department of Anesthesiology, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Emerg Med 11:14. 2011
    ....
  15. pmc More educated emergency department patients are less likely to receive opioids for acute pain
    Timothy F Platts-Mills
    Department of Anesthesiology, University of North Carolina, Chapel Hill, NC 27599 7010, USA
    Pain 153:967-73. 2012
    ..01). In this sample of post-MVC ED patients, more educated patients were less likely to receive opioids. Further study is needed to assess the generalizability of these findings and to determine the reason for the difference...
  16. pmc Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC Department of Anesthesiology, University of North Carolina, Chapel Hill, NC Electronic address
    Ann Emerg Med 67:166-176.e1. 2016
    ..We seek to describe the incidence, risk factors, and consequences of persistent pain among older adults evaluated in the emergency department (ED) after a motor vehicle crash...
  17. pmc Pain treatment for older adults during prehospital emergency care: variations by patient gender and pain severity
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Pain 14:966-74. 2013
    ..Further research is needed to assess the generalizability of this interaction between age, gender, and pain severity on pain treatment...
  18. pmc Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Ann Emerg Med 60:199-206. 2012
    ..The purpose of this study is to determine whether older adults presenting to the emergency department (ED) with pain are less likely to receive pain medication than younger adults...
  19. pmc Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study
    Inna E Tchivileva
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pharmacogenet Genomics 20:239-48. 2010
    ..We hypothesized that the nonselective beta-adrenergic antagonist propranolol will reduce clinical and experimental pain in TMD patients in a manner dependent on the individuals' COMT diplotype...
  20. pmc Shared decision-making in the selection of outpatient analgesics for older individuals in the emergency department
    Cameron G Isaacs
    School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Am Geriatr Soc 61:793-8. 2013
    ....
  21. pmc Pain and interference of pain with function and mood in elderly adults involved in a motor vehicle collision: a pilot study
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 7594, USA
    Exp Aging Res 38:330-43. 2012
    ....
  22. doi request reprint Emergency medical services use by the elderly: analysis of a statewide database
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Prehosp Emerg Care 14:329-33. 2010
    ..To test the hypothesis that EMS use for emergency department (ED) transports increases across the life span and to estimate changes in the EMS volume in North Carolina (NC) during the next 20 years due to the aging of the population...
  23. pmc Modification of COMT-dependent pain sensitivity by psychological stress and sex
    Carolina B Meloto
    aThe Alan Edwards Centre for Research on Pain, McGill University, McGill University Genome Building, Montreal, QC, Canada bDepartment of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA cCenter for Pain Research and Innovation, University of North Carolina at Chapel Hill Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA dDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA eCenter for Translational Pain Medicine, Duke University, Durham, NC, USA fDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA Brotman Facial Pain Center, University of Maryland School of Dentistry, Baltimore, MD, USA gCenter for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA hDepartment of Community Dentistry and Behavioral Science, University of Florida, College of Dentistry, and Pain, Research and Intervention Center of Excellence, Gainesville, FL, USA iDepartment of Oral Diagnostic Sciences, University at Buffalo, UK
    Pain 157:858-67. 2016
    ..In summary, our findings indicate that stress and sex should be evaluated in association studies aiming to investigate the effect of COMT genetic variants on pain sensitivity. ..
  24. pmc Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision
    Andrey V Bortsov
    TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, 27599, USA
    Neuromolecular Med 16:83-93. 2014
    ..These results suggest that genetic variants in the distal promoter are important contributors to the development of persistent pain after MVC, directly and via the interaction with haplotypes in the coding region of the gene. ..
  25. pmc μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer
    Andrey V Bortsov
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7010, USA
    Anesthesiology 116:896-902. 2012
    ..In this study we assessed the association between six common polymorphisms in the μ-opioid receptor gene, including the well known A118G polymorphism, and breast cancer survival...
  26. pmc μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision
    Sarah D Linnstaedt
    TRYUMPH Research Program, Anesthesiology Department, University of North Carolina, Chapel Hill, North Carolina Department of Anesthesiology, University of North Carolina, Chapel Hill, North Carolina
    J Pain 16:637-44. 2015
    ..In contrast, men with an AG/GG genotype experienced increased MSP severity at 6 weeks (β = .827, P = .019). Further studies are needed to understand the biologic mechanisms mediating observed sex differences in A118 G effects...
  27. pmc Somatic symptoms among US adolescent females: associations with sexual and physical violence exposure
    Carolyn Tucker Halpern
    Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, CB 8120, Carolina Population Center, Chapel Hill, NC, 27599 8120, USA
    Matern Child Health J 17:1951-60. 2013
    ..Treating symptoms alone, without addressing the potential violence experienced, may not adequately improve adolescents' somatic complaints and well-being...
  28. pmc Motor vehicle collision-related emergency department visits by older adults in the United States
    Timothy F Platts-Mills
    Department of Emergency Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Acad Emerg Med 19:821-7. 2012
    ..The authors sought to determine these characteristics using information from two nationally representative data sets...
  29. doi request reprint Substantial postoperative pain is common among children undergoing laparoscopic appendectomy
    Maggie J Tomecka
    Department of Anesthesiology, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Paediatr Anaesth 22:130-5. 2012
    ..In this study, we assessed the postoperative pain experience of children undergoing laparoscopic appendectomy...
  30. pmc MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences
    Sarah D Linnstaedt
    TRYUMPH Research Program, Chapel Hill, NC, USA
    Mol Pain 11:66. 2015
    ..miRNA expression was determined using miRNA-sequencing; nonparametric analyses were used to compare miRNA expression levels among individuals with and without persistent pain...
  31. doi request reprint Health status, not head injury, predicts concussion symptoms after minor injury
    Samuel A McLean
    Department of Emergency Medicine and the TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    Am J Emerg Med 27:182-90. 2009
    ..Postconcussion (PC) syndrome etiology remains poorly understood. We sought to examine predictors of persistent PC symptoms after minor injury...