Jonathan B McHugh

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint The clinical significance of focally enhanced gastritis in children
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 37:295-9. 2013
  2. ncbi request reprint Atypical compound nevus arising in mature cystic ovarian teratoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Med Sci Monit 12:CS34-7. 2006
  3. doi request reprint Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1798-803. 2009
  4. doi request reprint Update on selected salivary gland neoplasms
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1763-74. 2009
  5. doi request reprint Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 133:1587-93. 2009
  6. pmc p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Head Neck Pathol 1:123-31. 2007
  7. pmc High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 139:1320-7. 2013
  8. pmc Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis
    Matthew H Stenmark
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan Electronic address
    Int J Radiat Oncol Biol Phys 88:580-8. 2014
  9. pmc HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
  10. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013

Detail Information

Publications78

  1. doi request reprint The clinical significance of focally enhanced gastritis in children
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 37:295-9. 2013
    ..The presence of FEG is highly associated with IBD in pediatric patients. The presence of FEG does not reliably distinguish between patients with CD and those with UC...
  2. ncbi request reprint Atypical compound nevus arising in mature cystic ovarian teratoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Med Sci Monit 12:CS34-7. 2006
    ..Mature cystic ovarian teratoma (MCOT) is the most common primary ovarian tumor. Rarely, MCOT may undergo malignant transformation. Melanoma arising primarily in MCOT is a rare event. Melanocytic nevi have also rarely been reported in MCOT...
  3. doi request reprint Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1798-803. 2009
    ..Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis...
  4. doi request reprint Update on selected salivary gland neoplasms
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1763-74. 2009
    ..3% of all malignancies. In addition to their rarity, diagnosing these tumors can be challenging given the histologic overlap among various subtypes, their morphologic heterogeneity, and the recent recognition of new entities...
  5. doi request reprint Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 133:1587-93. 2009
    ..Osteomas may have osteoblastoma-like areas and distinguishing it from true osteoblastoma can be challenging. Some believe osteomas with osteoblastoma-like features behave more aggressively...
  6. pmc p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Head Neck Pathol 1:123-31. 2007
    ..While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives...
  7. pmc High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 139:1320-7. 2013
    ....
  8. pmc Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis
    Matthew H Stenmark
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan Electronic address
    Int J Radiat Oncol Biol Phys 88:580-8. 2014
    ..To investigate the relationship between human papillomavirus (HPV) and Epstein-Barr virus (EBV) in nonendemic nasopharyngeal carcinoma (NPC) and assess the prognostic implications of viral status...
  9. pmc HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
    ..The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC...
  10. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013
    ..These findings provide insight into the epigenetic regulation of viral vs. chemical carcinogenesis and could provide novel targets for development of individualized therapeutic and prevention regimens based on environmental exposures...
  11. pmc Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:893-9. 2013
    ..In the absence of these high-risk features, our objective was to determine if perineural invasion (PNI) is an independent risk factor and if adjuvant radiation (XRT) improves disease control rates...
  12. pmc Head and neck squamous cell carcinoma in pregnant women
    Anna M Eliassen
    Department of Otolaryngology Head and Neck Surgery, The University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 35:335-42. 2013
    ..The aim of this study was to investigate oral cancer in pregnant women, a rare but therapeutically challenging patient subset...
  13. pmc Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor, Michigan Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Mol Cancer Res 14:941-952. 2016
    ....
  14. pmc Exploration for an Algorithm for Deintensification to Exclude the Retropharyngeal Site From Advanced Oropharyngeal Squamous Cell Carcinoma Treatment
    Matthew E Spector
    Department of Otolaryngology, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 142:313-8. 2016
    ..Prediction of these drainage patterns could not only help minimize treatment morbidity but also prevent failures in at-risk patients as deintensification trials are under way for this disease...
  15. pmc Matted nodes: High distant-metastasis risk and a potential indication for intensification of systemic therapy in human papillomavirus-related oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 38:E805-14. 2016
    ....
  16. pmc Matted nodes as a predictor of distant metastasis in advanced-stage III/IV oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    Head Neck 38:184-90. 2016
    ..The purpose of this study was to determine if matted nodes are a predictive marker for distant metastasis...
  17. pmc Matted nodes: poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status
    Matthew E Spector
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Head Neck 34:1727-33. 2012
    ..Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis...
  18. pmc Human papillomavirus-related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor
    Jeffrey Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 37:8-11. 2015
    ..We postulated that a minor HPV-negative tumor subfraction may be responsible for recurrences of HPV+ oropharyngeal cancer...
  19. pmc Patterns of nodal metastasis and prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    Head Neck 36:1233-40. 2014
    ..The purpose of this study was to develop a system that more precisely predicts survival...
  20. pmc Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
    Oral Oncol 50:513-9. 2014
    ....
  21. doi request reprint The Utility of ETV1, ETV4, and ETV5 RNA In Situ Hybridization in the Diagnosis of CIC-DUX4 Sarcomas
    Steven C Smith
    Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA
    Histopathology . 2016
    ..To test the utility of an ancillary diagnostic technique for these tumors, we evaluated chromogenic RNA in situ hybridization assays for ETV1, ETV4, and ETV5, as diagnostic adjuncts for this emerging group of highly malignant sarcomas...
  22. pmc Classification of TP53 mutations and HPV predict survival in advanced larynx cancer
    Adam Scheel
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, U S A
    Laryngoscope 126:E292-9. 2016
    ..Assess tumor suppressor p53 (TP53) functional mutations in the context of other biomarkers in advanced larynx cancer...
  23. pmc NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas
    Shama Virani
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    BMC Cancer 15:825. 2015
    ..Here, we test the hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC, p16, GADD45A) are associated with tumor recurrence and survival, in a well-characterized, prospective, cohort of 346 HNSCC patients...
  24. pmc Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Head Neck 37:317-26. 2015
    ..Cancer stem cells (CSCs) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain...
  25. doi request reprint Undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: a novel highly aggressive soft tissue tumor with distinctive histopathology
    Eun Young Karen Choi
    Departments of Pathology Internal Medicine Orthopedic Surgery, University of Michigan, Ann Arbor, MI
    Am J Surg Pathol 37:1379-86. 2013
    ..8 months. CIC-DUX4 sarcoma represents a novel translocation-associated sarcoma with distinctive histopathologic features and rapid disease progression. ..
  26. pmc Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma
    Serena A Byrd
    Departments of Otolaryngology Head and Neck Surgery, Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:402-8. 2013
    ..To describe the epidemiology and determine the clinicopathologic predictors of recurrence and survival in patients with head and neck mucoepidermoid carcinoma (MEC)...
  27. pmc Tumor Biomarkers in Spindle Cell Variant Squamous Cell Carcinoma of the Head and Neck
    Andrew J Rosko
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 155:106-12. 2016
    ..To determine biomarkers of recurrence and survival in patients with spindle cell variant squamous cell carcinoma (SpSCC) of the head and neck...
  28. pmc Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms
    Adam Scheel
    Department of Otolaryngology, University of Michigan Health Systems, Ann Arbor, MI
    Int Forum Allergy Rhinol 5:701-7. 2015
    ..Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs...
  29. doi request reprint CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall
    Steven C Smith
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    J Cutan Pathol 40:639-45. 2013
    ..Case series have not assessed prevalence of CD34 reactivity among cutaneous examples of MFS...
  30. pmc Head and neck squamous cell carcinoma of unknown primary: neck dissection and radiotherapy or definitive radiotherapy
    Candan Demiroz
    Department of Radiation Oncology, Uludag University Faculty of Medicine, Bursa, Turkey Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 36:1589-95. 2014
    ..The purpose of this study was to characterize HNCUP and retrospectively compare outcomes for patients treated with neck dissection + RT versus definitive RT...
  31. pmc Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States Electronic address
    Oral Oncol 50:234-9. 2014
    ..We assessed the predictive value of 3-month PET/CT response for LRF in this population...
  32. pmc Weekly chemotherapy with radiation versus high-dose cisplatin with radiation as organ preservation for patients with HPV-positive and HPV-negative locally advanced squamous cell carcinoma of the oropharynx
    Irina Y Dobrosotskaya
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI
    Head Neck 36:617-23. 2014
    ..Optimal treatment for locally advanced squamous cell carcinoma of the oropharynx (SCCOP) is not well defined. Here we retrospectively compare survival and toxicities from 2 different organ preservation protocols...
  33. doi request reprint MRI diffusion-weighted imaging (DWI) in pediatric small bowel Crohn disease: correlation with MRI findings of active bowel wall inflammation
    Justin M Ream
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA
    Pediatr Radiol 43:1077-85. 2013
    ..However, the exact meaning of this finding, particularly within the pediatric Crohn disease population, is poorly understood...
  34. doi request reprint CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma
    Ryan T Downey
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Pediatr Radiol 42:410-7; quiz 513-4. 2012
    ..There is a paucity of published data regarding the CT/MRI appearances and accuracy of pretreatment radiologic staging of this form of cancer in children...
  35. doi request reprint p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
    Histopathology 60:597-608. 2012
    ..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ...
  36. doi request reprint Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma
    Aaron M Udager
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA
    J Pathol 239:394-8. 2016
    ..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  37. pmc Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures
    Yanxiao Zhang
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan
    Clin Cancer Res 22:4735-45. 2016
    ....
  38. pmc Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 154:473-9. 2016
    ..Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage laryngectomy cohort...
  39. doi request reprint A subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfall
    ANDREW S MCDANIEL
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Histol Histopathol 31:223-30. 2016
    ..This presents a diagnostic pitfall when evaluating possible metastases from the kidney, particularly when primary tumors show sarcomatoid or spindle cell morphologies. ..
  40. pmc Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma
    Giant C Lin
    Department of Otolaryngology, University of Michigan Health Systems, Ann Arbor, MI
    Int Forum Allergy Rhinol 3:885-9. 2013
    ....
  41. doi request reprint Esthesioneuroblastoma: updating histologic grading as it relates to prognosis
    Kelly K Gallagher
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Ann Otol Rhinol Laryngol 123:353-8. 2014
    ....
  42. pmc Sinonasal lobular capillary hemangioma: a clinicopathologic study of 34 cases characterizing potential for local recurrence
    Steven C Smith
    Department of Pathology, University of Michigan Health System, 2G332 UH, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Head Neck Pathol 7:129-34. 2013
    ..Awareness of this may aid in avoiding misdiagnosis of these lesions as more aggressive entities such as angiofibroma and angiosarcoma...
  43. doi request reprint Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma
    Stephen Y Kang
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Laryngoscope 123:1121-4. 2013
    ..While rare, this report highlights the possibility of encountering a distinct tumor type in the posttreatment surveillance of patients with anterior cranial base malignancies...
  44. doi request reprint Fine-needle aspiration cytology of Rosai-Dorfman disease of bone
    Xin Jing
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Diagn Cytopathol 36:516-8. 2008
    ..The diagnosis was confirmed by concurrent biopsy with immunhistochemical study. Our case highlighted the role of fine-needle aspiration with ThinPrep technique in the diagnosis of Rosai-Dorfman disease...
  45. doi request reprint Cross-sectional imaging of primary thoracic sarcomas with histopathologic correlation: a review for the radiologist
    Jonathan R Dillman
    Department of Radiology, University of Michigan Health System, C S Mott Children s Hospital, Section of Pediatric Radiology, Ann Arbor, MI 48109 0252, USA
    Curr Probl Diagn Radiol 39:17-29. 2010
    ..The purpose of this article is to review the various forms of primary sarcoma that may affect the thorax as well as illustrate pertinent cross-sectional radiologic findings with histopathologic correlation...
  46. pmc Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss
    Lorena Lazo de la Vega
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109
    Hum Pathol 58:161-170. 2016
    ..Additional functional work and assessment of larger cohorts are needed to determine the biological and clinical significance of the alterations identified herein...
  47. doi request reprint MYC immunohistochemistry in angiosarcoma and atypical vascular lesions: practical considerations based on a single institutional experience
    Aaron M Udager
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI, United States
    Pathology 48:697-704. 2016
    ..Increased MYC expression in high-grade de novo AS suggests that MYC overexpression may play a role in the pathogenesis of these tumours, and MYC IHC may be a prognostic and/or therapeutic biomarker in a subset of these tumours...
  48. doi request reprint CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression
    Steven Christopher Smith
    1 Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA 2 Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Mod Pathol 28:57-68. 2015
    ..These findings are cautionary regarding use of these immunostains in prospective case workup, whereas the prevalent MYC amplification may represent a therapeutically targetable oncogenic pathway in CIC-DUX sarcomas. ..
  49. doi request reprint Synchronous ipsilateral sebaceous lymphadenoma and membranous basal cell adenoma of the parotid
    Erica L Scheller
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:e41-6. 2013
    ..In this report, we present the case with its management, followed by a discussion of the histopathologic nature of each tumor including the possible overlap between these two entities...
  50. doi request reprint Napsin A is differentially expressed in sclerosing hemangiomas of the lung
    Lindsay A Schmidt
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 136:1580-4. 2012
    ....
  51. doi request reprint Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26
    Jerad M Gardner
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 36:1047-51. 2012
    ..The low incidence of MDM2 gene amplification in our series indicates that most superficial PLs are unrelated to WDL/DL. PL likely evolves by way of more than 1 molecular pathway...
  52. pmc Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence
    Jessica H Maxwell
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:1226-35. 2010
    ....
  53. pmc Tracheobronchial amyloidosis: A case report and review of the literature
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    J Case Rep Med 3:. 2014
    ..This is a case report on tracheobronchial amyloidosis. This disease may provide a diagnostic challenge for otolaryngologists due to its rarity and relative lack of literature. Our case highlights presentation and workup of this disease...
  54. pmc Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation
    Lester D Thompson
    Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA
    Head Neck Pathol 10:152-60. 2016
    ..Recognition of AiCC with high-grade transformation is imperative as more aggressive clinical management is warranted...
  55. pmc Head and Neck Schwannomas: 20-Year Experience of a Single Institution Excluding Cutaneous and Acoustic Sites
    Randall T Butler
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Head Neck Pathol 10:286-91. 2016
    ..Non-acoustic, non-cutaneous schwannomas of the head and neck appear to have clinicopathologic features similar to their soft tissue counterparts with some subsite variation in presentation and/or microscopic features. ..
  56. pmc Maxilla Osteonecrosis: a differential diagnosis in patients with metastatic cancer on bisphosphonates
    Joshua Smith
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Case Rep Med 5:. 2016
    ..As bisphosphonates are often prescribed for patients with metastatic disease, it is important to recognize that bisphosphonate-induced osteonecrosis may present similarly to bony metastases...
  57. pmc High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma
    Aaron M Udager
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan
    Cancer Res 75:2600-6. 2015
    ..These findings implicate a prominent role for activating EGFR mutations in the pathogenesis of ISP and associated SNSCC and rationalize consideration of irreversible EGFR inhibitors in the therapy of these tumors...
  58. pmc Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature
    Lester D R Thompson
    Woodland Hills Medical Center, Department of Pathology, Southern California Permanente Medical Group, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA
    Head Neck Pathol 9:181-95. 2015
    ..S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal squamous balls highlighted by CK5/6 or p16. ..
  59. doi request reprint Ewing sarcoma
    Eun Young K Choi
    Department of Pathology, University of Michigan, 3261G Medical Science I, 1301 Catherine St, SPC 5602, Ann Arbor, Michigan 48109
    Semin Diagn Pathol 31:39-47. 2014
    ..The purpose of this article is to review the clinical, radiological, histologic, and molecular features of Ewing sarcoma and to provide a discussion of the differential diagnosis of small round cell tumors of bone. ..
  60. pmc Pilomatrixoma of the forearm: a case report
    Michael V Birman
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor 48109 5328, USA
    Iowa Orthop J 29:121-3. 2009
    ..We present the case of a 52-year-old woman with a pilomatrixoma of the forearm, and we review the literature regarding pilomatrixomas in the upper extremity...
  61. pmc Effect of abrupt substitution of gadobenate dimeglumine for gadopentetate dimeglumine on rate of allergic-like reactions
    Matthew S Davenport
    Department of Radiology, B2 A209P, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, MI 48103, USA
    Radiology 266:773-82. 2013
    ..To evaluate the effect of abruptly substituting gadobenate dimeglumine for gadopentetate dimeglumine on allergic-like reactions...
  62. doi request reprint Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis
    Monisha Dandekar
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 134:1444-9. 2010
    ..We report the case of a 48-year-old woman with epistaxis and nasal obstruction who was diagnosed with glomangiopericytoma and discuss the histologic differential diagnosis...
  63. pmc Receptor-type Protein tyrosine phosphatase β regulates met phosphorylation and function in head and neck squamous cell carcinoma
    Yiru Xu
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 5609, USA
    Neoplasia 14:1015-22. 2012
    ..Reduced RPTP-β levels, with or without Met overexpression, could promote Met activation in HNSCC tumors...
  64. pmc UM-SCC-104: a new human papillomavirus-16-positive cancer stem cell-containing head and neck squamous cell carcinoma cell line
    Alice L Tang
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 34:1480-91. 2012
    ..We established University of Michigan-squamous cell carcinoma-104 (UM-SCC-104), a new HPV(+) HNSCC cell line from a recurrent oral cavity tumor, and characterized it for the presence of cancer stem cells (CSCs)...
  65. doi request reprint Pathology quiz case. Nasal hamartoma, fibroglandular type
    Jonathan G Thomas
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Arch Otolaryngol Head Neck Surg 134:783-5. 2008
  66. pmc Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Epigenetics 7:883-91. 2012
    ..These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression...
  67. doi request reprint Complete devascularization of a juvenile angiofibroma by direct percutaneous embolization with only ethylene vinyl alcohol copolymer (Onyx) through a single needle placement
    Joseph J Gemmete
    Department of Interventional Neuroradiology, University of Michigan Hospitals, Ann Arbor, MI, USA
    J Neurointerv Surg 3:191-3. 2011
    ..A midfacial degloving and medial maxillectomy/maxillotomy was then performed and the tumor extirpated with blunt finger dissection and the assistance of an endoscope, with 200 ml of blood loss...
  68. doi request reprint Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 34:844-51. 2010
    ..Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm...
  69. doi request reprint Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy
    Lindsay A Schmidt
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Surg Pathol 34:1205-10. 2010
    ..When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section...
  70. doi request reprint Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas
    Cohra C Mankey
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Histopathology 56:364-71. 2010
    ..The aim was to investigate further lymphatic antigen expression, and to explore the relation of immunohistochemistry to morphological and clinical findings...
  71. ncbi request reprint Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
    ..Although most are sporadic, some tumors occur in association with prior radiation therapy. The purpose of the current study was to compare clinicopathologic and prognostic features of primary and radiation-associated osteosarcoma...
  72. pmc Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms
    Randall T Butler
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Head Neck Pathol 9:47-50. 2015
    ..These results indicate that evaluation of PAX2 and/or PAX8 expression would be valuable in differentiating primary salivary gland tumors from metastases known to express PAX2 and/or PAX8...
  73. pmc An immunohistochemical panel for reliable differentiation of salivary duct carcinoma and mucoepidermoid carcinoma
    Randall T Butler
    Department of Pathology, University of Michigan, 1500 E Medical Center Drive, Room 2G332 UH, Ann Arbor, MI, 48109, USA
    Head Neck Pathol 8:133-40. 2014
    ..Utilization of this set of immunohistochemical markers allows reliable differentiation of salivary duct and mucoepidermoid carcinoma, a distinction with important prognostic and therapeutic implications. ..
  74. pmc Recurrent orbital schwannomas: clinical course and histopathologic correlation
    Michelle Kron
    University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Ophthalmol 12:44. 2012
    ..The presence of multiple schwannomas in a single patient suggests possible association with neurofibromatosis type 2 (NF2) or schwannomatosis...
  75. doi request reprint Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease
    Jonathan R Dillman
    Department of Radiology, CS Mott Children s Hospital, Section of Pediatric Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Pediatr Radiol 41:1552-8. 2011
    ..While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice...
  76. ncbi request reprint The diagnostic value of endoscopic terminal ileum biopsies
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Gastroenterol 102:1084-9. 2007
    ..We see many such biopsies in our gastrointestinal pathology service and have been impressed by the subjectively low yield of TI biopsies. Therefore, we studied this to obtain objective data...
  77. ncbi request reprint Expression of polycomb group protein EZH2 in nevi and melanoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Cutan Pathol 34:597-600. 2007
    ..We sought to determine the pattern of EZH2 expression in benign and malignant melanocytic tumors to see if EZH2 might play a role in melanoma pathogenesis and progression...
  78. pmc Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 145:242-7. 2011
    ..To determine clinicopathologic predictors of recurrence and survival in patients with spindle cell squamous cell carcinoma (SpSCC)...