Richard C McEachin

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    BioData Min 1:2. 2008
  2. pmc Convergence of genetic influences in comorbidity
    Richard C McEachin
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48105, USA
    BMC Bioinformatics 13:S8. 2012
  3. pmc Identifying hypothetical genetic influences on complex disease phenotypes
    Benjamin J Keller
    Eastern Michigan University, Computer Science Department, Ypsilanti, MI 48197, USA
    BMC Bioinformatics 10:S13. 2009
  4. pmc A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    BMC Syst Biol 4:158. 2010
  5. pmc Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 11:14. 2010
  6. pmc A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression
    Hernan Roca
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
    BMC Syst Biol 8:29. 2014
  7. ncbi request reprint SAGA: a subgraph matching tool for biological graphs
    Yuanyuan Tian
    Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 23:232-9. 2007
  8. ncbi request reprint SNP Function Portal: a web database for exploring the function implication of SNP alleles
    Pinglang Wang
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 22:e523-9. 2006
  9. pmc Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer
    Hernan Roca
    Department of Urology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e76773. 2013
  10. ncbi request reprint Profiles of growth hormone (GH)-regulated genes reveal time-dependent responses and identify a mechanism for regulation of activating transcription factor 3 by GH
    Jeffrey S Huo
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 281:4132-41. 2006

Collaborators

Detail Information

Publications12

  1. pmc Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    BioData Min 1:2. 2008
    ..We used an integrated bioinformatics approach, mining available data in multiple databases, to develop and refine a model of gene-by-environment interaction consistent with this comorbidity...
  2. pmc Convergence of genetic influences in comorbidity
    Richard C McEachin
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48105, USA
    BMC Bioinformatics 13:S8. 2012
    ..The Rank Product (RP) method overcomes limitations posed by Fisher assumptions, though RP was not designed for GWA data...
  3. pmc Identifying hypothetical genetic influences on complex disease phenotypes
    Benjamin J Keller
    Eastern Michigan University, Computer Science Department, Ypsilanti, MI 48197, USA
    BMC Bioinformatics 10:S13. 2009
    ..The computational problem we address is to discover relationships among genes from these interacting regions that may explain the observed statistical interaction and the role of these genes in the disease phenotype...
  4. pmc A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    BMC Syst Biol 4:158. 2010
    ..We initially hypothesized a gene-by-environment interaction where lithium, acting as an environmental influence, impacts signal transduction pathways leading to differential expression of genes important in the etiology of BD mania...
  5. pmc Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 11:14. 2010
    ..Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD...
  6. pmc A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression
    Hernan Roca
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
    BMC Syst Biol 8:29. 2014
    ..We now test this hypothesis by developing a model, OVOL Induced MET (OI-MET), and sub-model (OI-MET-TF), to characterize differential gene expression in MET common to prostate cancer (PC) and breast cancer (BC)...
  7. ncbi request reprint SAGA: a subgraph matching tool for biological graphs
    Yuanyuan Tian
    Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 23:232-9. 2007
    ..SAGA employs an indexing technique that allows it to efficiently evaluate queries even against large graph datasets...
  8. ncbi request reprint SNP Function Portal: a web database for exploring the function implication of SNP alleles
    Pinglang Wang
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 22:e523-9. 2006
    ....
  9. pmc Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer
    Hernan Roca
    Department of Urology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e76773. 2013
    ..The role of OVOL-TFs as inducers of MET is further supported by expression analyses in 917 cancer cell lines, suggesting their role as crucial regulators of epithelial-mesenchymal cell plasticity in cancer...
  10. ncbi request reprint Profiles of growth hormone (GH)-regulated genes reveal time-dependent responses and identify a mechanism for regulation of activating transcription factor 3 by GH
    Jeffrey S Huo
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, 48109, USA
    J Biol Chem 281:4132-41. 2006
    ..These findings suggest that GH regulates transcription of Atf3 through a mechanism utilizing factors, such as C/EBPbeta, which bind to a novel C/EBP site...
  11. pmc Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver
    Christopher Faulk
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA 48109 Department of Animal Science, University of Minnesota, Minneapolis, MN, USA 55108
    Environ Epigenet 1:. 2015
    ..Future longitudinal studies are needed to link these changes with altered health risks...
  12. pmc Computationally identifying novel NF-kappa B-regulated immune genes in the human genome
    Rongxiang Liu
    Bioinformatics Program and the Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genome Res 13:654-61. 2003
    ..Our method of predicting gene function, based on characteristic patterns of transcription factor binding, evolutionary conservation, and expression studies, would be applicable to finding genes with other functions...