John P McCutcheon

Summary

Affiliation: University of Montana
Country: USA

Publications

  1. doi request reprint From microbiology to cell biology: when an intracellular bacterium becomes part of its host cell
    John P McCutcheon
    Division of Biological Sciences, University of Montana, Missoula, MT 59801, USA Electronic address
    Curr Opin Cell Biol 41:132-6. 2016
  2. doi request reprint Endosymbiosis: protein targeting further erodes the organelle/symbiont distinction
    John P McCutcheon
    Division of Biological Sciences, University of Montana, Missoula, MT 59801, USA Electronic address
    Curr Biol 24:R654-5. 2014
  3. doi request reprint Genome evolution: a bacterium with a Napoleon complex
    John P McCutcheon
    Division of Biological Sciences, University of Montana, 32 Campus Dr, HS104, Missoula, MT 59801, USA
    Curr Biol 23:R657-9. 2013
  4. doi request reprint Extreme genome reduction in symbiotic bacteria
    John P McCutcheon
    University of Montana, Division of Biological Sciences, 32 Campus Drive, HS104, Missoula, Montana 59812, USA
    Nat Rev Microbiol 10:13-26. 2011
  5. pmc An interdependent metabolic patchwork in the nested symbiosis of mealybugs
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Curr Biol 21:1366-72. 2011
  6. pmc Functional convergence in reduced genomes of bacterial symbionts spanning 200 My of evolution
    John P McCutcheon
    Center for Insect Science, University of Arizona, Arizona, USA
    Genome Biol Evol 2:708-18. 2010
  7. pmc The bacterial essence of tiny symbiont genomes
    John P McCutcheon
    Center for Insect Science, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Curr Opin Microbiol 13:73-8. 2010
  8. pmc Convergent evolution of metabolic roles in bacterial co-symbionts of insects
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 106:15394-9. 2009
  9. pmc Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ, USA
    PLoS Genet 5:e1000565. 2009
  10. doi request reprint Genomics and evolution of heritable bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Genet 42:165-90. 2008

Collaborators

Detail Information

Publications15

  1. doi request reprint From microbiology to cell biology: when an intracellular bacterium becomes part of its host cell
    John P McCutcheon
    Division of Biological Sciences, University of Montana, Missoula, MT 59801, USA Electronic address
    Curr Opin Cell Biol 41:132-6. 2016
    ..Understanding these bacteria will require inspiration from eukaryotic cell biology, because a traditional microbiological framework is insufficient for understanding how they work. ..
  2. doi request reprint Endosymbiosis: protein targeting further erodes the organelle/symbiont distinction
    John P McCutcheon
    Division of Biological Sciences, University of Montana, Missoula, MT 59801, USA Electronic address
    Curr Biol 24:R654-5. 2014
    ..New work in aphids shows that a nuclear-encoded protein resulting from a horizontal gene transfer is targeted to a bacterial symbiont, further blurring the distinction between organelle and symbiont. ..
  3. doi request reprint Genome evolution: a bacterium with a Napoleon complex
    John P McCutcheon
    Division of Biological Sciences, University of Montana, 32 Campus Dr, HS104, Missoula, MT 59801, USA
    Curr Biol 23:R657-9. 2013
    ..Surprisingly, the symbiont's genome is highly reduced, with genes devoted to polyketide synthesis making up a large fraction of its coding capacity. ..
  4. doi request reprint Extreme genome reduction in symbiotic bacteria
    John P McCutcheon
    University of Montana, Division of Biological Sciences, 32 Campus Drive, HS104, Missoula, Montana 59812, USA
    Nat Rev Microbiol 10:13-26. 2011
    ..These discoveries have implications for the concept of minimal genomes, the origins of cellular organelles, and studies of symbiosis and host-associated microbiota...
  5. pmc An interdependent metabolic patchwork in the nested symbiosis of mealybugs
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Curr Biol 21:1366-72. 2011
    ....
  6. pmc Functional convergence in reduced genomes of bacterial symbionts spanning 200 My of evolution
    John P McCutcheon
    Center for Insect Science, University of Arizona, Arizona, USA
    Genome Biol Evol 2:708-18. 2010
    ....
  7. pmc The bacterial essence of tiny symbiont genomes
    John P McCutcheon
    Center for Insect Science, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Curr Opin Microbiol 13:73-8. 2010
    ..New data from various systems with symbiotic bacterial or archaeal partners have begun to shed light on how these bacteria may function with such small gene sets, but major mechanistic questions remain...
  8. pmc Convergent evolution of metabolic roles in bacterial co-symbionts of insects
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 106:15394-9. 2009
    ....
  9. pmc Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ, USA
    PLoS Genet 5:e1000565. 2009
    ..Although it is not clear why this tiny genome lacks the low GC content typical of other small bacterial genomes, these observations support a role of genome reduction rather than base composition as a driver of codon reassignment...
  10. doi request reprint Genomics and evolution of heritable bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Genet 42:165-90. 2008
    ..In addition, insect symbionts provide some of the extremes of cellular genomes, including the smallest and the fastest evolving, raising new questions about the limits of evolution of life...
  11. pmc Genome expansion via lineage splitting and genome reduction in the cicada endosymbiont Hodgkinia
    Matthew A Campbell
    Division of Biological Sciences, University of Montana, Missoula, MT 59812
    Proc Natl Acad Sci U S A 112:10192-9. 2015
    ..These results parallel some examples of genome fragmentation and expansion in organelles, although the mechanisms that give rise to these extreme genome instabilities are likely different. ..
  12. pmc An AT mutational bias in the tiny GC-rich endosymbiont genome of Hodgkinia
    James T Van Leuven
    Division of Biological Sciences, University of Montana, USA
    Genome Biol Evol 4:24-7. 2012
    ..These results provide further evidence that an AT mutational bias is universal in bacteria, even in strict endosymbionts with elevated genomic GC contents...
  13. pmc Parallel genomic evolution and metabolic interdependence in an ancient symbiosis
    John P McCutcheon
    Center for Insect Science and Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Proc Natl Acad Sci U S A 104:19392-7. 2007
    ..Analysis of the coding capacities of Sulcia and Baumannia reveals striking complementarity in metabolic capabilities...
  14. doi request reprint Population genomics of a symbiont in the early stages of a pest invasion
    Amanda M V Brown
    Division of Biological Sciences, University of Montana, 32 Campus Drive, HS104, Missoula, MT, 59812, USA
    Mol Ecol 23:1516-30. 2014
    ..Our data reveal the evolutionary trajectory of an important insect-bacteria symbiosis in the early stages of an invasion, highlighting the role microbial symbionts may play in the spread of invasive species...
  15. doi request reprint Sympatric speciation in a bacterial endosymbiont results in two genomes with the functionality of one
    James T Van Leuven
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Cell 158:1270-80. 2014
    ..We suggest that our results highlight the potential power of nonadaptive forces in shaping organismal complexity...