Michael J McCarthy

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients
    Michael J McCarthy
    Research and Psychiatry Service, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Dr, MC 116A, San Diego, CA 92161, USA Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, USA Electronic address
    Eur Neuropsychopharmacol 26:1310-9. 2016
  2. pmc Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms
    Michael J McCarthy
    Research and Psychiatry Service, Veterans Affairs, San Diego, USA Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, USA Electronic address
    Neuropharmacology 101:439-48. 2016
  3. pmc Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients
    M J McCarthy
    1 Psychiatry Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA 2 Department of Psychiatry, University of California, San Diego, CA, USA 3 Center for Chronobiology, University of California, San Diego, CA, USA
    Transl Psychiatry 3:e318. 2013
  4. pmc Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Alcohol Clin Exp Res 37:1304-10. 2013
  5. pmc A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
    PLoS ONE 7:e32091. 2012
  6. pmc Internet monitoring of suicide risk in the population
    Michael J McCarthy
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, United States of America
    J Affect Disord 122:277-9. 2010
  7. doi request reprint Pharmacogenetics of lithium response in bipolar disorder
    Michael J McCarthy
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Pharmacogenomics 11:1439-65. 2010
  8. doi request reprint Circadian clock and stress interactions in the molecular biology of psychiatric disorders
    Dominic Landgraf
    Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    Curr Psychiatry Rep 16:483. 2014
  9. doi request reprint The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms
    Dominic Landgraf
    VA San Diego Healthcare System, San Diego, CA, USA Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA Electronic address
    Neuropharmacology 107:262-70. 2016
  10. pmc Towards the clinical implementation of pharmacogenetics in bipolar disorder
    Naji C Salloum
    Department of Psychiatry 0603, University of California San Diego, La Jolla, CA 92093, USA
    BMC Med 12:90. 2014

Collaborators

Detail Information

Publications14

  1. doi request reprint Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients
    Michael J McCarthy
    Research and Psychiatry Service, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Dr, MC 116A, San Diego, CA 92161, USA Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, USA Electronic address
    Eur Neuropsychopharmacol 26:1310-9. 2016
    ..Protein analyses revealed low phospho-ERK1/2 (p-ERK) content in fibroblasts from BD patients vs...
  2. pmc Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms
    Michael J McCarthy
    Research and Psychiatry Service, Veterans Affairs, San Diego, USA Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, USA Electronic address
    Neuropharmacology 101:439-48. 2016
    ..In human fibroblasts, CACNA1C genotype predicted the amplitude response to lithium, and the expression profiles of CACNA1C, CACNA1D and CACNB3 were altered in BD vs...
  3. pmc Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients
    M J McCarthy
    1 Psychiatry Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA 2 Department of Psychiatry, University of California, San Diego, CA, USA 3 Center for Chronobiology, University of California, San Diego, CA, USA
    Transl Psychiatry 3:e318. 2013
    ..Finally, Li enhanced the resynchronization of damped rhythms, suggesting a mechanism by which Li could act therapeutically in BD. Our work suggests that the circadian clock's response to Li may be relevant to molecular pathology of BD...
  4. pmc Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Alcohol Clin Exp Res 37:1304-10. 2013
    ..However, with respect to function, the molecular clock remains largely uncharacterized in AUD patients...
  5. pmc A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
    PLoS ONE 7:e32091. 2012
    ..Our analysis reveals previously unrecognized associations between clock genes and BD-spectrum illnesses, partly reconciling previously discordant results from past GWAS and candidate gene studies...
  6. pmc Internet monitoring of suicide risk in the population
    Michael J McCarthy
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, United States of America
    J Affect Disord 122:277-9. 2010
    ..Public health statistics are often released too late to affect reversible societal factors affecting suicide. Increasingly, internet search volume is used in epidemiology, but this method has not yet been applied to suicide...
  7. doi request reprint Pharmacogenetics of lithium response in bipolar disorder
    Michael J McCarthy
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Pharmacogenomics 11:1439-65. 2010
    ..Finally, a framework is proposed by which future pharmacogenetic studies can incorporate advances in genetics, molecular biology and bioinformatics in a pathway-based approach to predicting lithium treatment response...
  8. doi request reprint Circadian clock and stress interactions in the molecular biology of psychiatric disorders
    Dominic Landgraf
    Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    Curr Psychiatry Rep 16:483. 2014
    ....
  9. doi request reprint The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms
    Dominic Landgraf
    VA San Diego Healthcare System, San Diego, CA, USA Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Center for Circadian Biology, University of California, San Diego, La Jolla, CA, USA Electronic address
    Neuropharmacology 107:262-70. 2016
    ..Hence, VPA may exert beneficial effects on mood by normalizing lengthened circadian rhythm period in subjects with elevated DA resulting from reduced DAT. ..
  10. pmc Towards the clinical implementation of pharmacogenetics in bipolar disorder
    Naji C Salloum
    Department of Psychiatry 0603, University of California San Diego, La Jolla, CA 92093, USA
    BMC Med 12:90. 2014
    ..Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients...
  11. pmc Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients
    Michael J McCarthy
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    J Psychiatr Res 44:201-8. 2010
    ..However, tissue-specific mechanisms by which the A-haplotype could affect ADRBK2 in the central nervous system cannot be excluded...
  12. ncbi request reprint Cellular circadian clocks in mood disorders
    Michael J McCarthy
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    J Biol Rhythms 27:339-52. 2012
    ..This approach, informed by the new insights and tools of modern chronobiology, will allow a more definitive test of the role of cellular circadian clocks in mood disorders...
  13. pmc Polymorphisms in melatonin synthesis pathways: possible influences on depression
    Daniel F Kripke
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    J Circadian Rhythms 9:8. 2011
    ..Additionally, arylalkylamine N-acetyltransferase (AANAT) polymorphisms have been reported associated with depression, perhaps through their influence upon N-acetylserotonin or melatonin synthesis...
  14. pmc Whole brain expression of bipolar disorder associated genes: structural and genetic analyses
    Michael J McCarthy
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 9:e100204. 2014
    ..Our results highlight the complex neuroanatomical basis of BD, and reinforce illness models that emphasize impaired brain connectivity...