Mitchell B Max
Affiliation: University of Pittsburgh
- Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?Mark Lazarev
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Pain 4:58. 2008....
- The molecular epidemiology of pain: a new discipline for drug discoveryMitchell B Max
Center for Pain Research, Departments of Anesthesiology and Medicine, University of Pittsburgh, A 1305 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA
Nat Rev Drug Discov 7:647-58. 2008..This Perspective outlines how methods of molecular epidemiology, proved effective in the study of other diseases, can enhance the returns from human genomic studies and expedite the development of new drugs to prevent or treat pain...
- Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?Bikash K Mishra
Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 3:20. 2007..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...
- Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphismsJorn Lotsch
Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Clin Chem 53:1010-5. 2007..A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype...
- Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendationsDennis C Turk
University of Washington, Seattle, WA 98195, USA
Pain 125:208-15. 2006
- GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistenceIrmgard Tegeder
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
Nat Med 12:1269-77. 2006..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...
- Effects of chronic osteoarthritis pain on neuroendocrine function in menSuzan Khoromi
Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 1302, USA
J Clin Endocrinol Metab 91:4313-8. 2006..Most endocrine studies have been conducted in patients in whom the potentially confounding effects of depression, inflammatory disease, or coexistent medication use have not been controlled...
- Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuliLuda Diatchenko
Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
Pain 125:216-24. 2006..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
- Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandableJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Pain Symptom Manage 31:369-77. 2006..Whether as a primary or secondary approach to a clinical trial of pain therapy, the display of data in a CPRA format may be useful in the understanding of results and applicability to patient care...
- A clinical genetic method to identify mechanisms by which pain causes depression and anxietyMitchell B Max
Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 2:14. 2006..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year...
- Combination pharmacotherapy for neuropathic pain: current evidence and future directionsIan Gilron
Queen s University, Department of Anaesthesiology, c o Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
Expert Rev Neurother 5:823-30. 2005..Continued close integration of basic and clinical sciences is crucial in further harnessing the potential of combination pharmacotherapy in neuropathic pain...
- Genetic basis for individual variations in pain perception and the development of a chronic pain conditionLuda Diatchenko
Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hum Mol Genet 14:135-43. 2005..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
- Pain in Parkinson diseaseBeata Buzas
Neurology 62:2156-7. 2004
- Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample sizeInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Anesthesiology 100:1562-72. 2004
- Assessing pain candidate gene studiesMitchell B Max
Pain 109:1-3. 2004
- How to move pain and symptom research from the margin to the mainstreamMitchell B Max
J Pain 4:355-60. 2003..Academic health centers that develop the cross-disciplinary infrastructure to conduct this research will win major shares of this influx of funding and improve the diagnosis and management of many diseases...
- Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trialsChristine N Sang
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Anesthesiology 96:1053-61. 2002..The authors sought to evaluate two low-affinity N-methyl-d-aspartate antagonists using a novel two-stage design...