Fernando D Martinez

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
  2. pmc Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing
    F D Martinez
    Respiratory Sciences Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Clin Invest 100:3184-8. 1997
  3. ncbi request reprint Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, PO Box 245030, 1501 N Campbell Avenue, Room 2349, Tucson, AZ 85764, USA
    Pediatr Infect Dis J 22:S76-82. 2003
  4. pmc The coming-of-age of the hygiene hypothesis
    F D Martinez
    The Respiratory Sciences Center, University of Arizona, Tucson, Arizona, USA
    Respir Res 2:129-32. 2001
  5. ncbi request reprint Development of wheezing disorders and asthma in preschool children
    Fernando D Martinez
    University of Arizona, Tucson, Arizona, USA
    Pediatrics 109:362-7. 2002
  6. ncbi request reprint Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
  7. ncbi request reprint Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments
    Waltraud Eder
    Innate Immunity Program for Genomic Applications, Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    J Allergy Clin Immunol 116:601-7. 2005
  8. pmc Combined effects of parental and active smoking on early lung function deficits: a prospective study from birth to age 26 years
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
    Thorax 68:1021-8. 2013
  9. pmc The course of persistent airflow limitation in subjects with and without asthma
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    Respir Med 102:1473-82. 2008
  10. pmc Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724 5030, USA
    Thorax 65:499-504. 2010

Detail Information

Publications72

  1. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
    ..We sought to determine whether common genetic variants were associated with AHR severity...
  2. pmc Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing
    F D Martinez
    Respiratory Sciences Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Clin Invest 100:3184-8. 1997
    ..No association was found between the beta2AR-27 polymorphism and response to albuterol. These results may explain some of the variability in response to therapeutic doses of albuterol in children...
  3. ncbi request reprint Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, PO Box 245030, 1501 N Campbell Avenue, Room 2349, Tucson, AZ 85764, USA
    Pediatr Infect Dis J 22:S76-82. 2003
    ..It is likely, however, that strategies for the prevention of RSV infection may play a role in the prevention of the subsequent development of persistent wheezing and asthma-like symptoms in childhood...
  4. pmc The coming-of-age of the hygiene hypothesis
    F D Martinez
    The Respiratory Sciences Center, University of Arizona, Tucson, Arizona, USA
    Respir Res 2:129-32. 2001
    ..The latter interact with a sensitive and complex receptor system, and genetic variations in this receptor system may be an important determinant of inherited susceptibility to asthma and allergies...
  5. ncbi request reprint Development of wheezing disorders and asthma in preschool children
    Fernando D Martinez
    University of Arizona, Tucson, Arizona, USA
    Pediatrics 109:362-7. 2002
    ..Defining which children are at risk for persistent asthma could allow for better management and, potentially, for reduced morbidity and mortality...
  6. ncbi request reprint Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
    ..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
  7. ncbi request reprint Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments
    Waltraud Eder
    Innate Immunity Program for Genomic Applications, Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    J Allergy Clin Immunol 116:601-7. 2005
    ..Most complex diseases are the result of interactions between polymorphisms in the genome and environmental exposures...
  8. pmc Combined effects of parental and active smoking on early lung function deficits: a prospective study from birth to age 26 years
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
    Thorax 68:1021-8. 2013
    ..We assessed prospectively whether parental smoking enhances the effects of active smoking on early deficits of lung function in young adults...
  9. pmc The course of persistent airflow limitation in subjects with and without asthma
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    Respir Med 102:1473-82. 2008
    ..We sought to compare the natural course of lung function associated with persistent airflow limitation in subjects with and without asthma from early to late adult life...
  10. pmc Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724 5030, USA
    Thorax 65:499-504. 2010
    ..This study was undertaken to determine demographic, clinical and mortality profiles of subjects with either a recurrent or an inconsistent restrictive spirometric pattern assessed prospectively...
  11. pmc Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial
    Fernando D Martinez
    Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ, USA
    Lancet 377:650-7. 2011
    ..We assessed the effectiveness of an inhaled corticosteroid (beclomethasone dipropionate) used as rescue treatment...
  12. ncbi request reprint Polymorphisms in the CD14 gene associated with pulmonary function in farmers
    Tricia D LeVan
    Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona, USA
    Am J Respir Crit Care Med 171:773-9. 2005
    ..Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin...
  13. ncbi request reprint Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33
    Penelope E Graves
    Arizona Respiratory Center, University of Arizona, Tuscon, AZ 85724 5030, USA
    J Allergy Clin Immunol 116:650-6. 2005
    ....
  14. ncbi request reprint Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age
    Stefano Guerra
    Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724 5030, USA
    Am J Respir Crit Care Med 169:70-6. 2004
    ..031). Our findings from a longitudinal cohort suggest that impaired IFNgamma production at 3 months and reduced plasma-sCD14 levels at birth significantly increase the risk of developing recurrent wheezing in the first year of life...
  15. ncbi request reprint Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma
    Theresa W Guilbert
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 114:1282-7. 2004
    ....
  16. pmc Familial aggregation of allergen-specific sensitization and asthma
    Margaret Kurzius-Spencer
    Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    Pediatr Allergy Immunol 23:21-7. 2012
    ..Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts...
  17. pmc Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence
    Wayne J Morgan
    Arizona Respiratory Center, P O Box 245030, Tucson, Arizona 85724, USA
    Am J Respir Crit Care Med 172:1253-8. 2005
    ....
  18. pmc Relation of early childhood growth and wheezing phenotypes to adult lung function
    Duane L Sherrill
    Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA
    Pediatr Pulmonol 46:956-63. 2011
    ....
  19. pmc Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media
    Paloma I Beamer
    Asthma and Airways Disease Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Int J Environ Res Public Health 13:. 2016
    ..Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities. ..
  20. pmc Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA Centre for Research in Environmental Epidemiology CREAL, Universitat Pompeu Fabra, and CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain Electronic address
    Lancet Respir Med 3:613-20. 2015
    ..We investigated whether low circulating CC16 concentrations precede lung function deficits and incidence of COPD in the general population...
  21. pmc Effect of breastfeeding on lung function in childhood and modulation by maternal asthma and atopy
    Theresa W Guilbert
    Arizona Respiratory Center, Department of Pediatrics, University of Arizona, Tucson, Arizona, USA
    Am J Respir Crit Care Med 176:843-8. 2007
    ..The protective effect of breastfeeding on early respiratory infections is well established, but its relationship to the development of subsequent asthma remains controversial...
  22. ncbi request reprint Relation of beta2-adrenoceptor polymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of puberty
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, PO Box 245030, Tucson, AZ 85724 5030, USA
    Chest 128:609-17. 2005
    ..It has long been recognized that many children with asthma outgrow the disease after the onset of puberty, but little is known about genetic factors influencing this outcome...
  23. ncbi request reprint Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation
    Tricia D LeVan
    Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, Arizona, USA
    J Allergy Clin Immunol 121:434-440.e1. 2008
    ..A prerequisite for activation of the innate immune response by endotoxin is its binding to CD14...
  24. pmc Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study
    Debra A Stern
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    Lancet 372:1058-64. 2008
    ..Incidence of asthma increases during early adulthood. We aimed to estimate the contributions of sex and early life factors to asthma diagnosed in young adults...
  25. pmc CD14, endotoxin, and asthma risk: actions and interactions
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, Ste 2349, P O Box 245030, Tucson, AZ 85724, USA
    Proc Am Thorac Soc 4:221-5. 2007
    ..These results suggest that the often encountered, limited replicability of genetic associations may, at least in part, be due to complex interactions between genes and environment in determining asthma-related outcomes...
  26. ncbi request reprint Factors influencing gender differences in the diagnosis and treatment of asthma in childhood: the Tucson Children's Respiratory Study
    Anne L Wright
    Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Pediatr Pulmonol 41:318-25. 2006
    ..8 vs. 1.6 years, P < 0.005). These findings indicate that gender differences in the diagnosis and treatment of asthma cannot be explained completely by differences in symptom prevalence and frequency...
  27. ncbi request reprint The relation of rhinitis to recurrent cough and wheezing: a longitudinal study
    Duane L Sherrill
    Mel and Enid Zuckerman College of Public Health, University of Arizona, Arizona, USA
    Respir Med 99:1377-85. 2005
    ..Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma...
  28. pmc Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study
    Debra A Stern
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
    Lancet 370:758-64. 2007
    ..We aimed to investigate whether lung function in early adulthood is, in turn, affected by airway function measured shortly after birth...
  29. doi request reprint Effects of parental smoking on interferon gamma production in children
    Gina Tebow
    Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, PO Box 245030, Tucson, AZ 85724 5030, USA
    Pediatrics 121:e1563-9. 2008
    ..In a population-based birth cohort, we sought to determine the relation of parental smoking, as assessed prospectively since pregnancy, to the child's interferon gamma and interleukin 4 production at 11 years of age...
  30. doi request reprint Asthma
    Fernando D Martinez
    Arizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, AZ, USA Electronic address
    Lancet 382:1360-72. 2013
    ....
  31. ncbi request reprint The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
    Control Clin Trials 25:286-310. 2004
    ..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
  32. ncbi request reprint Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, 1501 North Campbell Avenue, P O Box 245030, Tucson, AZ 85724 5030, USA
    Am J Respir Crit Care Med 170:78-85. 2004
    ..Our findings from a population-based longitudinal cohort challenge the commonly held view that asthma usually remits during adolescence...
  33. ncbi request reprint Prenatal factors associated with the development of eczema in the first year of life
    Margaret Kurzius-Spencer
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724 5030, USA
    Pediatr Allergy Immunol 16:19-26. 2005
    ..32, CI 0.16-0.63, p <0.001). Our findings from this cohort study suggest that in utero factors, including maternal IgE, colds, and eczema, may influence the risk of infant eczema...
  34. pmc Gene-environment interactions in asthma: with apologies to William of Ockham
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724, USA
    Proc Am Thorac Soc 4:26-31. 2007
    ..More likely, the most important gene variants for asthma are polymorphisms that exert their influence on the network system controlling biological responses to asthma-related exposures...
  35. ncbi request reprint Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood
    Debra A Stern
    The Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 120:835-41. 2007
    ..Diminished cytokine production in infancy has been associated with an increased risk for allergen sensitization and early-life wheeze...
  36. doi request reprint Spatial clusters of child lower respiratory illnesses associated with community-level risk factors
    Paloma I Beamer
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona
    Pediatr Pulmonol 51:633-42. 2016
    ..To reduce LRI incidence, multifaceted interventions should be developed at the community level. Pediatr Pulmonol. 2016;51:633-642. © 2015 Wiley Periodicals, Inc. ..
  37. pmc Asthma-associated differences in microbial composition of induced sputum
    Pradeep Reddy Marri
    BIO5 Institute, University of Arizona, Tucson, Ariz, USA
    J Allergy Clin Immunol 131:346-52.e1-3. 2013
    ..It is increasingly evident that microbial colonization of the respiratory tract might have a role in the pathogenesis of asthma...
  38. pmc Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
    Anthony Bosco
    Arizona Respiratory Center, University of Arizona, Tucson, Ariz, USA
    J Allergy Clin Immunol 129:88-94. 2012
    ..Most asthma exacerbations are triggered by viral infections; however, the underlying mechanisms have not been systematically investigated...
  39. pmc Managing childhood asthma: challenge of preventing exacerbations
    Fernando D Martinez
    Department of Pediatrics and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
    Pediatrics 123:S146-50. 2009
    ..This strategy is currently being tested in a large clinical trial involving children with mild persistent asthma...
  40. ncbi request reprint Parental asthma as a risk factor for the development of early skin test sensitization in children
    Elena Crestani
    Arizona Respiratory Center, Health Sciences Center, Tucson, Ariz, USA
    J Allergy Clin Immunol 113:284-90. 2004
    ..Recent epidemiologic evidence has challenged the paradigm suggesting a direct causal relationship between allergic sensitization and asthma...
  41. ncbi request reprint Toll-like receptor 2 as a major gene for asthma in children of European farmers
    Waltraud Eder
    Arizona Respiratory Center, University of Arizona, Tucson 85724, USA
    J Allergy Clin Immunol 113:482-8. 2004
    ..The toll-like receptors (TLRs) represent an evolutionarily conserved family of innate immunity receptors with microbial molecules as ligands...
  42. ncbi request reprint Rhinitis as an independent risk factor for adult-onset asthma
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson 85724 5030, USA
    J Allergy Clin Immunol 109:419-25. 2002
    ..Recently, it has been suggested that asthma and rhinitis are associated in the absence of atopy. The nature of this association is not well known...
  43. pmc Response to García-Nieto et al. Comments on Beamer et al. Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media. Int. J. Environ. Res. Public Health 2016, 13, 521
    Paloma I Beamer
    Asthma and Airway Disease Research Center, 1501 N Campbell Ave, University of Arizona, Tucson, AZ 85724, USA
    Int J Environ Res Public Health 13:. 2016
    ..We would like to thank the editors for providing us with the opportunity to respond to the points raised by Dr. García Nieto.[...]...
  44. pmc Persistent insomnia is associated with mortality risk
    Sairam Parthasarathy
    Department of Medicine, University of Arizona, Tucson Arizona Respiratory Center, University of Arizona, Tucson Electronic address
    Am J Med 128:268-75.e2. 2015
    ..Insomnia has been associated with mortality risk, but whether this association is different in subjects with persistent vs intermittent insomnia is unclear. Additionally, the role of systemic inflammation in such an association is unknown...
  45. pmc Pneumonia in childhood and impaired lung function in adults: a longitudinal study
    Johnny Y C Chan
    Department of Pediatrics, Kwong Wah Hospital, Hospital Authority, Kowloon, Hong Kong and Arizona Respiratory Center, University of Arizona, Tucson, Arizona
    Pediatrics 135:607-16. 2015
    ..Whether these associations persist up to adulthood has not been established...
  46. pmc Serum concentrations of club cell secretory protein (Clara) and cancer mortality in adults: a population-based, prospective cohort study
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA Centre for Research in Environmental Epidemiology CREAL, CIBER Epidemiologia y Salud Pública CIBERESP, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain Electronic address
    Lancet Respir Med 1:779-85. 2013
    ..The goal of this study was to establish whether serum CC16 concentrations predict all-cause and cancer-specific mortality in adults...
  47. pmc Environmental determinants of and impact on childhood asthma by the bacterial community in household dust
    Raina M Maier
    Department of Soil, Water and Environmental Science, University of Arizona, 429 Shantz Building 38, Tucson, AZ 85721, USA
    Appl Environ Microbiol 76:2663-7. 2010
    ..0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma...
  48. pmc Epidemiology of the origins of airflow limitation in asthma
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724 5030, USA
    Proc Am Thorac Soc 6:707-11. 2009
    ....
  49. ncbi request reprint Inhaled corticosteroids and asthma prevention
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    Lancet 368:708-10. 2006
  50. ncbi request reprint The differential effect of genetic variation on soluble CD14 levels in human plasma and milk
    Stefano Guerra
    Arizona Respiratory Center, College of Medicine, University of Arizona, Tuscon, AZ 85724 5030, USA
    Am J Reprod Immunol 52:204-11. 2004
    ..The protein CD14 is a pattern recognition receptor for bacterial lipopolysaccharide (LPS). Whether genetic variation has the same influence on soluble CD14 (sCD14) levels in human plasma and milk remains to be determined...
  51. ncbi request reprint The relation of body mass index to asthma, chronic bronchitis, and emphysema
    Stefano Guerra
    Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5030, USA
    Chest 122:1256-63. 2002
    ..Recent studies have suggested a relationship between asthma and obesity. Despite these reports, the effect of being underweight or overweight as a risk factor for airway obstructive diseases (AODs) is not clear...
  52. ncbi request reprint Asthma genetics: from linear to multifactorial approaches
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724, USA
    Annu Rev Med 59:327-41. 2008
    ....
  53. ncbi request reprint Gene-environment interaction in complex diseases: asthma as an illustrative case
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona, 1501 N Cambpbell Ave, Rm 2349, PO Box 245030, Tucson, AZ 85724 5030, USA
    Novartis Found Symp 293:184-92; discussion 192-7. 2008
    ..A better understanding of the genetics of asthma is thus inseparable from a better understanding of the mechanisms by which environmental factors increase the risk for asthma or protect against it...
  54. ncbi request reprint Asthma treatment and asthma prevention: a tale of 2 parallel pathways
    Fernando D Martinez
    Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 119:30-3. 2007
    ....
  55. ncbi request reprint Serious adverse events and death associated with treatment using long-acting beta-agonists
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ
    Clin Rev Allergy Immunol 31:269-78. 2006
    ..Until the biological mechanisms involved are better understood, efforts should be made to confine the use of LABAs to those patients who really need them...
  56. ncbi request reprint Phenotypic and genotypic heterogeneity in familial Milroy lymphedema
    M H Witte
    Department of Surgery, University of Arizona College of Medicine, Tucson, USA
    Lymphology 31:145-55. 1998
    ..The findings provide evidence for a spectrum of ML clinical and LAS phenotypes and also suggest ML locus heterogeneity...
  57. ncbi request reprint Influence of attendance at day care on the common cold from birth through 13 years of age
    Thomas M Ball
    Department of Pediatrics, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
    Arch Pediatr Adolesc Med 156:121-6. 2002
    ..To describe trends in the occurrence of the common cold during the first 13 years of life among children who attended different childcare settings early in life...
  58. ncbi request reprint Is there a common cold constitution?
    Thomas M Ball
    Department of Pediatrics and the Steele Memorial Children s Research Center, University of Arizona College of Medicine, Tucson 85724 5073, USA
    Ambul Pediatr 2:261-7. 2002
    ..Constitutional factors might play a role in the susceptibility to clinical illness during the common cold. This study seeks to determine if the likelihood of developing frequent common colds persists during childhood...
  59. pmc eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs
    Haiquan Li
    Department of Medicine, University of Arizona, Tucson, AZ, USA Bio5 Institute, University of Arizona, Tucson, AZ, USA
    J Biomed Inform 58:226-34. 2015
    ..Our findings provide novel insights into the pleiotropy of mRNAs targeted by complex disease polymorphisms and the architecture of the information flow between the genetic polymorphisms and transcriptomes of complex diseases. ..
  60. pmc Asthma, airflow limitation and mortality risk in the general population
    Shuang Huang
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA
    Eur Respir J 45:338-46. 2015
    ..In a population-based cohort, subjects with concomitant airflow limitation and asthma had an increased risk of dying, which was mainly related to their baseline lung function deficits...
  61. pmc The relation of circulating YKL-40 to levels and decline of lung function in adult life
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain IMIM Hospital del Mar Research Institute, Barcelona, Spain CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain Electronic address
    Respir Med 107:1923-30. 2013
    ..YKL-40 is a chitinase-like protein that, in cross-sectional clinical studies, has been associated with severe asthma and COPD in smokers...
  62. ncbi request reprint Safety of long-acting beta-agonists--an urgent need to clear the air
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, USA
    N Engl J Med 353:2637-9. 2005
  63. ncbi request reprint Trends in asthma prevalence, admission rates, and asthma deaths
    Fernando D Martinez
    Arizona Respiratory Center, 1501 N Campbell Avenue, Tucson AZ 85724 5030, USA
    Respir Care 53:561-5; discussion 565-7. 2008
    ..A better understanding of what determines the stable asthma death rate is urgently needed, especially since inhaled corticosteroids have been shown to prevent asthma deaths in persons who take them regularly...
  64. ncbi request reprint Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causation
    Fernando D Martinez
    Arizona Respiratory Center, College of Medicine, The University of Arizona, 1501 N Campbell Avenue, 2349, Tucson, AZ 85724 5030, USA
    Immunol Allergy Clin North Am 25:709-21. 2005
    ..Discrepancies between well-designed genetic studies of asthma and allergies, therefore, may be suggesting something fundamental about how these diseases develop and how it will be possible to abolish them in the future...
  65. pmc The origins of asthma and chronic obstructive pulmonary disease in early life
    Fernando D Martinez
    Arizona Respiratory Center, University of Arizona College of Medicine, 1501 N Campbell Avenue, PO Box 245030, Tucson, AZ 85724 5030, USA
    Proc Am Thorac Soc 6:272-7. 2009
    ..Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions...
  66. doi request reprint Self-Reported Stressful Life Events During Adolescence and Subsequent Asthma: A Longitudinal Study
    Eyal Oren
    Department of Epidemiology and Biostatistics, College of Public Health, University of Arizona Health Sciences Center, Tucson, Ariz Asthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz Electronic address
    J Allergy Clin Immunol Pract . 2016
    ....
  67. pmc Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes
    Vincent Gardeux
    Department of Medicine, University of Arizona, Tucson, AZ, USA
    J Biomed Inform 55:94-103. 2015
    ..Unsurprisingly, in vivo human experimentation to understand individualized dynamic response of the transcriptome to viruses are rarely studied because of the obvious limitations stemming from ethical considerations of the clinical risk...
  68. ncbi request reprint What have we learned from the Tucson Children's Respiratory Study?
    Fernando D Martinez
    Arizona Respiratory Center, The University of Arizona, Tucson, AZ, USA
    Paediatr Respir Rev 3:193-7. 2002
    ..Understanding the different asthma phenotypes of childhood will provide new clues for strategies for the primary prevention of the disease...
  69. ncbi request reprint Automated high-throughput sex-typing assay
    Lizhi Yu
    Arizona Respiratory Center, Tucson, Arizona 85641, USA
    Biotechniques 37:662-4. 2004
  70. pmc New insights into the natural history of asthma: primary prevention on the horizon
    Fernando D Martinez
    Arizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, Ariz 85712, USA
    J Allergy Clin Immunol 128:939-45. 2011
    ..It is thus plausible to hypothesize that primary prevention of asthma could be attained through surrogate therapeutic interventions that activate similar mechanisms in young children at high risk for asthma...
  71. ncbi request reprint Heterogeneity of the association between lower respiratory illness in infancy and subsequent asthma
    Fernando D Martinez
    Swift McNear Professor of Pediatrics, Director, Arizona Respiratory Center, The University of Arizona, 1501 N Campbell Avenue, Suite 2349 Tucson, AZ 85724 5030, USA
    Proc Am Thorac Soc 2:157-61. 2005
    ..Future preventive and therapeutic strategies will need to address the specific mechanisms that explain this association in different groups of subjects...