David J Margolis

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Electronic address
    J Allergy Clin Immunol 133:784-9. 2014
  2. doi request reprint Epidemiology of foot ulceration and amputation: can global variation be explained?
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Med Clin North Am 97:791-805. 2013
  3. pmc Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis
    David J Margolis
    Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 2Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Dermatol 150:254-9. 2014
  4. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
  5. pmc Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 21:17-24. 2013
  6. ncbi request reprint Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
  7. doi request reprint Validity of subject self-report for acne
    Chandrakala Menon
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Dermatology 217:164-8. 2008
  8. ncbi request reprint The risk of mortality in patients with psoriasis: results from a population-based study
    Joel M Gelfand
    MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1493-9. 2007
  9. ncbi request reprint Validity of patient self-reported history of skin cancer
    Michael E Ming
    Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 140:730-5. 2004
  10. doi request reprint Immunosuppressant medications and mortality in inflammatory bowel disease
    James D Lewis
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 103:1428-35; quiz 1436. 2008

Detail Information

Publications73

  1. pmc Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Electronic address
    J Allergy Clin Immunol 133:784-9. 2014
    ..Atopic dermatitis (AD) is a common skin disease characterized by recurrent episodes of itching. Genetic variation associated with the persistence of AD has not been described for African American subjects...
  2. doi request reprint Epidemiology of foot ulceration and amputation: can global variation be explained?
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Med Clin North Am 97:791-805. 2013
    ..This area of study requires further investigation...
  3. pmc Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis
    David J Margolis
    Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 2Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Dermatol 150:254-9. 2014
    ..Atopic dermatitis (AD) is a common chronic illness of childhood...
  4. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  5. pmc Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 21:17-24. 2013
    ..97]) in whites and rs16849113 and rs6659759 (3.62 [1.11, 11.83] and 3.02 [0.82, 11.12], respectively) in African Americans. In conclusion, this is one of the first studies to show that NOS1AP gene variants are associated with DPN and LEA...
  6. ncbi request reprint Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  7. doi request reprint Validity of subject self-report for acne
    Chandrakala Menon
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Dermatology 217:164-8. 2008
    ..Acne prevalence studies often use subject self-report as data source. Our aim was to evaluate the validity of acne self-report...
  8. ncbi request reprint The risk of mortality in patients with psoriasis: results from a population-based study
    Joel M Gelfand
    MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1493-9. 2007
    ..To determine the risk of mortality in patients with psoriasis...
  9. ncbi request reprint Validity of patient self-reported history of skin cancer
    Michael E Ming
    Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 140:730-5. 2004
    ..To determine the validity of patient self-report of skin cancer history...
  10. doi request reprint Immunosuppressant medications and mortality in inflammatory bowel disease
    James D Lewis
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 103:1428-35; quiz 1436. 2008
    ..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies...
  11. pmc Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:1961-6. 2013
    ..The study goal was to compare the effectiveness of HBO with other conventional therapies administered in a wound care network for the treatment of a diabetic foot ulcer and prevention of lower-extremity amputation...
  12. pmc Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease
    David J Margolis
    Center for Clinical Epidemiology and Biostatistics, 815 Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Ther 17:1822-9. 2009
    ..In this phase I study, we demonstrate the initial safety, feasibility, and biologic plausibility of using H5.020CMV.PDGF-beta to treat venous leg ulcer disease...
  13. ncbi request reprint Effectiveness of recombinant human platelet-derived growth factor for the treatment of diabetic neuropathic foot ulcers
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 13:531-6. 2005
    ....
  14. pmc Extrinsic risk factors for pressure ulcers early in the hospital stay: a nested case-control study
    Mona Baumgarten
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Gerontol A Biol Sci Med Sci 63:408-13. 2008
    ....
  15. ncbi request reprint Prevalence of cardiovascular risk factors in patients with psoriasis
    Andrea L Neimann
    Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 55:829-35. 2006
    ..Limited population-based data exist on this association, and few studies have determined which factors are independently associated with psoriasis...
  16. pmc Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study
    David J Margolis
    Department of Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Dermatol 148:326-32. 2012
    ..To prospectively evaluate the association between antibiotics used to treat acne and pharyngitis...
  17. pmc The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 130:912-7. 2012
    ..Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have been associated with an increased risk of AD...
  18. ncbi request reprint Prevalence and treatment of psoriasis in the United Kingdom: a population-based study
    Joel M Gelfand
    Center for Clinical Epidemiology and Biostatistics, and Department of Dermatology, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA 19104, USA
    Arch Dermatol 141:1537-41. 2005
    ..To measure the prevalence and treatment of psoriasis in the United Kingdom...
  19. ncbi request reprint Diabetic neuropathic foot ulcers: predicting which ones will not heal
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med 115:627-31. 2003
    ..Neuropathic foot ulcers are a serious complication of diabetes. The purpose of this study was to develop a clinically useful prognostic model for identifying ulcers that are not likely to heal...
  20. pmc Geographic variation in Medicare spending and mortality for diabetic patients with foot ulcers and amputations
    Michael R Sargen
    Department of Biostatistics and Epidemiology of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Diabetes Complications 27:128-33. 2013
    ..The purpose of this study was to identify the presence or absence of geographic variation in Medicare spending and mortality rates for diabetic patients with foot ulcers (DFU) and lower extremity amputations (LEA)...
  21. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  22. pmc Five-year malignancy incidence in patients with chronic pruritus: a population-based cohort study aimed at limiting unnecessary screening practices
    Nicole Fett
    Philadelphia Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Acad Dermatol 70:651-8. 2014
    ..The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown...
  23. pmc Psoriasis severity and the prevalence of major medical comorbidity: a population-based study
    Howa Yeung
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Dermatol 149:1173-9. 2013
    ..Despite the growing literature on comorbidity risks in psoriasis, there remains a critical knowledge gap on the degree to which objectively measured psoriasis severity may affect the prevalence of major medical comorbidity...
  24. ncbi request reprint Represcription of penicillin after allergic-like events
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 113:764-70. 2004
    ..We sought to determine the frequency of represcription of penicillin to individuals with penicillin allergy and the risk of a second reaction in those who had a previous reaction...
  25. ncbi request reprint The accuracy of venous leg ulcer prognostic models in a wound care system
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 12:163-8. 2004
    ..Ultimately, these models can be applied by a clinician to help determine whom to continue to treat with standard care and perhaps whom to treat with adjuvant therapies. They may also aid in the design of clinical trials...
  26. pmc Evaluation of the use of prognostic information for the care of individuals with venous leg ulcers or diabetic neuropathic foot ulcers
    Shanu K Kurd
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 17:318-25. 2009
    ..This intervention was easy to administer and likely had low associated costs. This method of dispersing prognostic information to healthcare providers should be expanded to include recently published treatment algorithms...
  27. ncbi request reprint Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    N Engl J Med 349:1628-35. 2003
    ..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
  28. ncbi request reprint Surrogate end points for the treatment of diabetic neuropathic foot ulcers
    David J Margolis
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes Care 26:1696-700. 2003
    ....
  29. pmc Increased risk of diabetes mellitus and likelihood of receiving diabetes mellitus treatment in patients with psoriasis
    Rahat S Azfar
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 16104, USA
    Arch Dermatol 148:995-1000. 2012
    ..To assess the risk of incident diabetes mellitus (DM) in patients with psoriasis and to evaluate DM treatment patterns among patients with psoriasis and incident DM...
  30. ncbi request reprint Risk of myocardial infarction in patients with psoriasis
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 296:1735-41. 2006
    ..Psoriasis has been associated with cardiovascular diseases, but has only been investigated in hospital-based studies that did not control for major cardiovascular risk factors...
  31. pmc Effect of psoriasis severity on hypertension control: a population-based study in the United Kingdom
    Junko Takeshita
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Dermatol 151:161-9. 2015
    ..Hypertension is prevalent among patients with psoriasis. The effect of psoriasis and its severity on hypertension control is unknown...
  32. pmc Geographic variation in pharmacotherapy decisions for U.S. Medicare enrollees with diabetes
    Michael R Sargen
    Department of Biostatistics and Epidemiology of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Diabetes Complications 26:301-7. 2012
    ..The goal of this study was to determine if non-clinical factors (patient race, ethnicity, gender, income) are associated with regional variation in pharmacotherapy decisions for diabetic patients enrolled in Medicare...
  33. ncbi request reprint Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists
    Michael Shapiro
    Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Cutan Pathol 31:523-30. 2004
    ..A 1992 National Institutes of Health (NIH) Consensus Conference sought to unify nomenclature and suggested that the term "nevus with architectural disorder" be used along with a comment on melanocytic atypia...
  34. ncbi request reprint Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1275-80. 2007
    ..To explore an association between the use of beta-adrenergic receptor agonists or antagonists and the onset of venous leg ulcers (VLUs)...
  35. pmc Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in children
    Jackie P D Garrett
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Allergy Asthma Immunol 110:146-9. 2013
    ....
  36. ncbi request reprint Diabetic neuropathic foot ulcers and amputation
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 13:230-6. 2005
    ..In conclusion, about 7% of those with a diabetic neuropathic foot ulcer will have an amputation and in the past 10 years there has been a remarkable increase in the number of minor as compared to major amputations...
  37. doi request reprint Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 105:2610-6. 2010
    ..The majority of patients prescribed isotretinoin for their acne are previously on an extended course of antibiotics. Therefore, it is important to consider antibiotic use as a confounding variable for the development of IBD...
  38. pmc Association of HLA-DRB1 genetic variants with the persistence of atopic dermatitis
    David J Margolis
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Department of Dermatology, University of Pennsylvania, Philadelphia, PA, United States Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States Electronic address
    Hum Immunol 76:571-7. 2015
    ..In conclusion, amino acid variations at peptide-binding pockets of HLA-DRB1 were associated with the persistence of AD in African-American children. ..
  39. pmc Persistence of mild to moderate atopic dermatitis
    Jacob S Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Dermatol 150:593-600. 2014
    ..Atopic dermatitis (AD) is a common illness of childhood...
  40. doi request reprint 20-100 kHz, ultrasound assisted treatment of chronic wounds
    Peter A Lewin
    Biomed_7_701, Drexel Univ, 3145 Market St, Philadelphia, PA
    J Acoust Soc Am 134:4121. 2013
    ..05) and cell (fibroblasts) proliferation (p < 0.01) vs. a sham. The subsequent in vitro experiments will focus on collagen production, crucial to wound healing. [NIH 5R01EB009670.]. ..
  41. pmc The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes
    David J Margolis
    Department of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 18:445-51. 2010
    ..45 (0.22, 0.91) for the new onset of a LEA. In conclusion, among those with diabetes, exposure to ACEi as compared with ARB increases the risk of developing a DFU or LEA...
  42. pmc Inhibition of propionibacterium acnes by bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius
    Whitney P Bowe
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Drugs Dermatol 5:868-70. 2006
    ..These findings suggest that BLIS may potentially be used for its anti-P. acnes activity in the treatment of acne...
  43. ncbi request reprint The lack of a relationship between atopic dermatitis and nonmelanoma skin cancers
    Michael E Ming
    Department of Dermatology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 50:357-62. 2004
    ..Very little has been published on whether a relationship exists between atopic dermatitis (AD) and skin cancer...
  44. ncbi request reprint Lack of association between exposure to topical calcineurin inhibitors and skin cancer in adults
    David J Margolis
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dermatology 214:289-95. 2007
    ..Two topical calcineurin inhibitors (TCI) are available for the treatment of atopic dermatitis and there has been concern that their use could be associated with an increased risk of nonmelanoma skin cancer (NMSC)...
  45. ncbi request reprint Relative risks and confidence intervals were easily computed indirectly from multivariable logistic regression
    A Russell Localio
    Division of Biostatistics, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:874-82. 2007
    ..To assess alternative statistical methods for estimating relative risks and their confidence intervals from multivariable binary regression when outcomes are common...
  46. ncbi request reprint Clinical protocol. Phase I trial to evaluate the safety of H5.020CMV.PDGF-b and limb compression bandage for the treatment of venous leg ulcer: trial A
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19102, USA
    Hum Gene Ther 15:1003-19. 2004
  47. ncbi request reprint Upper respiratory tract infection in household contacts of acne patients
    Whitney P Bowe
    Department of Dermatology, University of Pennsylvania Center for Education and Research in Therapeutics, Philadelphia, PA, USA
    Dermatology 215:213-8. 2007
    ..Antibiotic use in acne patients has been associated with an increased risk of upper respiratory tract infection (URTI)...
  48. pmc Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 31:1331-6. 2008
    ..The physicians participated in The Health Information Network of the U.K...
  49. pmc Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study
    Alexis Ogdie
    Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 74:326-32. 2015
    ....
  50. ncbi request reprint Reducing the incidence of foot ulceration and amputation in diabetes
    Cynthia L Bartus
    Department of Dermatology, University of Pennsylvania, 815 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Curr Diab Rep 4:413-8. 2004
    ..To reduce these complications, several preventive strategies have been devised, from reducing risk factors to improving treatment and management...
  51. ncbi request reprint Antibiotic treatment of acne may be associated with upper respiratory tract infections
    David J Margolis
    Departments of Dermatology and Biostatistics and Epidemiology, Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Dermatol 141:1132-6. 2005
    ..To determine if the long-term use of antibiotics for the treatment of acne results in an increase in either of 2 common infectious illnesses: upper respiratory tract infections (URTIs) or urinary tract infections...
  52. ncbi request reprint Antibiotics, acne, and upper respiratory tract infections
    David J Margolis
    Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
    LDI Issue Brief 11:1-4. 2006
    ..This Issue Brief summarizes a large study that evaluates the risk for upper respiratory and urinary tract infections among adolescents and young adults treated with antibiotics for acne...
  53. ncbi request reprint The risk of lymphoma in patients with psoriasis
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics University of Pennsylvania, Philadelphia, 19104, USA
    J Invest Dermatol 126:2194-201. 2006
    ..Although patients with psoriasis have an increased relative risk of lymphoma, the absolute risk attributable to psoriasis is low given that lymphoma is a rare disease and the magnitude of association is modest...
  54. pmc Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012
    Michael R Sargen
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 134:51-7. 2014
    ..Higher humidity (OR=0.90, 95% CI: 0.812-0.997, P=0.04) was also associated with poorly controlled disease, but the statistical significance of this association was lost in our multivariate analysis (P=0.44). ..
  55. pmc Antibiotics, acne, and Staphylococcus aureus colonization
    Matthew Fanelli
    Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 147:917-21. 2011
    ..To determine the frequency of Staphylococcus aureus colonization among patients with acne and to compare the susceptibility patterns between the patients who are using antibiotics and those who are not using antibiotics...
  56. pmc Health literacy and diabetic foot ulcer healing
    David J Margolis
    Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Wound Repair Regen 23:299-301. 2015
    ..Other measures of literacy showed similar results. In conclusion, those with diminished health literacy were less likely to enroll in an investigational study and had wounds that were less likely to heal...
  57. pmc Association Between Malignancy and Topical Use of Pimecrolimus
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia2Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Dermatol 151:594-9. 2015
    ....
  58. ncbi request reprint Surrogate endpoints for the treatment of venous leg ulcers
    Joel M Gelfand
    Department of Dermatology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Invest Dermatol 119:1420-5. 2002
    ....
  59. ncbi request reprint Prevalence of erectile dysfunction and active depression: an analytic cross-sectional study of general medical patients
    Jonathan Kantor
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Epidemiol 156:1035-42. 2002
    ..3, 95% CI: 0.5, 3.1; p = 0.565). Concomitant erectile dysfunction and depression represent a significant public health problem...
  60. doi request reprint A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers
    Pamela A Morganroth
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 60:444-52. 2009
    ..We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery...
  61. pmc Association between serious ischemic cardiac outcomes and medications used to treat diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:753-9. 2008
    ..Data on cardiovascular outcomes among treated diabetics have been inconsistent. Our goal was to compare cardiovascular outcomes associated with different treatments for diabetes...
  62. ncbi request reprint Diabetic neuropathic foot ulcers: the association of wound size, wound duration, and wound grade on healing
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes Care 25:1835-9. 2002
    ..The goal of this study was to evaluate whether simple risk factors can be identified that successfully characterize who will heal and who will not heal among patients who have received standard therapy for diabetic neuropathic foot ulcers...
  63. pmc Low-frequency (<100 kHz), low-intensity (<100 mW/cm(2)) ultrasound to treat venous ulcers: a human study and in vitro experiments
    Joshua A Samuels
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Acoust Soc Am 134:1541-7. 2013
    ..01) after 24 h when compared to the control, non-treated cells. Although statistically limited, this work supports the notion that low-intensity, low-frequency ultrasound is beneficial for treating venous ulcers. ..
  64. ncbi request reprint Epidemiology of psoriatic arthritis in the population of the United States
    Joel M Gelfand
    Department of Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 53:573. 2005
    ..Estimates of the prevalence of psoriatic arthritis vary widely and are usually not determined by population-based studies...
  65. ncbi request reprint Management of leg ulcers
    Jonathan Kantor
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Semin Cutan Med Surg 22:212-21. 2003
    ..We discuss the evidence for using compression, vitamin and mineral supplementation, antibiotic use, growth factors, and other interventions in the management of these wounds...
  66. ncbi request reprint Use of photographs for the identification of pressure ulcers in elderly hospitalized patients: validity and reliability
    A Russell Localio
    Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Wound Repair Regen 14:506-13. 2006
    ..69 and 0.84, respectively. Trained research nurses can accurately classify pressure ulcers from photographs, even when patients are largely non-White and the photographs depict pressure ulcers spanning all pressure ulcer stages...
  67. doi request reprint Approach to diagnosing lower extremity ulcers
    Eri Fukaya
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dermatol Ther 26:181-6. 2013
    ..Like for most medical illnesses, the determination of the etiology of these wounds is based on history, physical examination, and testing...
  68. ncbi request reprint Prevalence and factors associated with use of placebo control groups in randomized controlled trials in psoriasis: a cross-sectional study
    Kenneth A Katz
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 55:814-22. 2006
    ..The ethics and science of using placebo control groups in clinical trials have been widely debated. Few studies, however, have examined factors associated with choice of control group...
  69. ncbi request reprint Effect of antibiotics on the oropharyngeal flora in patients with acne
    Ross M Levy
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Dermatol 139:467-71. 2003
    ..To estimate the prevalence and resistance patterns of Streptococcus pyogenes and Staphylococcus aureus in the oropharynx of individuals with acne who were using or not using antibiotic therapy...
  70. ncbi request reprint Evidence-based dermatology
    David J Margolis
    From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Cutis 75:8-12; discussion 33-6. 2005
    ..For the treatment of rosacea, oral tetracycline, topical metronidazole, topical azelaic acid, and topical sulfur/sodium sulfacetamide have been validated by more than one randomized controlled trial...
  71. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  72. pmc Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy
    Stephen R Thom
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6068, USA
    Wound Repair Regen 19:149-61. 2011
    ..We conclude that HBO(2) T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds...
  73. doi request reprint A randomized trial and the treatment of pemphigus vulgaris
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 130:1964-6. 2010
    ..Mycophenolate mofetil has not become the "wonder drug" that had been anticipated based on initial clinical reports. Studies like that reported by Beissert et al. in this issue are essential to improve dermatologic care...