Affiliation: University of Maryland
- Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: clinical significanceJacek Mamczarz
Division of Translational Toxicology, Department Epidemiology and Public Health, University of Maryland School of Medicine, 10 S Pine St Suite 900, Baltimore, MD 21210, USA
Neurotoxicology 32:785-98. 2011..In conclusion, learning impairment develops months after a single exposure to 1xLD50 soman, and galantamine prevents both the acute toxicity and the delayed cognitive deficits triggered by this OP poison...
- Delayed hippocampal effects from a single exposure of prepubertal guinea pigs to sub-lethal dose of chlorpyrifos: a magnetic resonance imaging and spectroscopy studyRoger J Mullins
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Neurotoxicology 36:42-8. 2013....
- Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brainRoger J Mullins
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, United States Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Neurotoxicology 48:9-20. 2015..These findings reveal the lasting effect of prenatal exposure to CPF as well as the danger of mother to child transmission of CPF in the environment...
- An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: interactions with acute restraintJacek Mamczarz
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Neurotoxicology 31:77-84. 2010..It is concluded that a single exposure to sub-lethal doses of soman triggers long-lasting anxiogenesis and decreased locomotor activity and that acute restraint stress modifies the magnitude of these effects...
- Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacyTadanobu Utsuki
Drug Design and Development Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Pharmacol Exp Ther 321:353-61. 2007..Particular benefits over oral therapies might include avoiding first-pass metabolic effects and improved dosing compliance...