Robert Mak

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease
    Wai W Cheung
    Pediatric Nephrology, University of California, San Diego, California, USA
    Am J Physiol Renal Physiol 303:F1315-24. 2012
  2. pmc The impact of inflammation on bone mass in children
    Wai W Cheung
    Division of Pediatric Nephrology, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, Mail Code 0634, La Jolla, CA 92093 0634, USA
    Pediatr Nephrol 26:1937-46. 2011
  3. pmc The growth hormone-insulin-like growth factor-I axis in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, Division of Pediatric Nephrology, University of California at San Diego, La Jolla, CA 92093 0634, USA
    Growth Horm IGF Res 18:17-25. 2008
  4. ncbi request reprint Adipokines and gut hormones in end-stage renal disease
    Robert H Mak
    Division of Pediatric Nephrology, Oregon Health and Science University, Portland, Oregon, USA
    Perit Dial Int 27:S298-302. 2007
  5. ncbi request reprint Insulin and its role in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, University of California at San Diego, 9500 Gilman Drive, MC0634, La Jolla, CA, 92093 0634, USA
    Pediatr Nephrol 23:355-62. 2008
  6. pmc Cachexia and protein-energy wasting in children with chronic kidney disease
    Robert H Mak
    Division of Nephrology, Department of Pediatrics, Rady Children s Hospital, University of California San Diego, San Diego, CA, USA
    Pediatr Nephrol 27:173-81. 2012
  7. doi request reprint Is ghrelin a biomarker for mortality in end-stage renal disease?
    Robert H Mak
    Division of Pediatric Nephrology, University of California, San Diego, La Jolla, California 92093 0634, USA
    Kidney Int 79:697-9. 2011
  8. ncbi request reprint Therapeutic strategy for cachexia in chronic kidney disease
    Robert H Mak
    Division of Pediatric Nephrology, University of California at San Diego, La Jolla, California 92093 0634, USA
    Curr Opin Nephrol Hypertens 16:542-6. 2007
  9. ncbi request reprint Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Clin Pract Nephrol 2:527-34. 2006
  10. ncbi request reprint Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC5, Portland, OR, 97239, USA
    Pediatr Nephrol 20:427-31. 2005

Research Grants

  1. GROWTH RETARDATION IN CHRONIC RENAL FAILURE
    Robert Mak; Fiscal Year: 2001

Collaborators

Detail Information

Publications29

  1. pmc Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease
    Wai W Cheung
    Pediatric Nephrology, University of California, San Diego, California, USA
    Am J Physiol Renal Physiol 303:F1315-24. 2012
    ..Our results suggest that these aberrant pathological pathways leading to muscle wasting in CKD mice were ameliorated by central administration of AgRP...
  2. pmc The impact of inflammation on bone mass in children
    Wai W Cheung
    Division of Pediatric Nephrology, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, Mail Code 0634, La Jolla, CA 92093 0634, USA
    Pediatr Nephrol 26:1937-46. 2011
    ..Growing research on the molecular mechanisms involved in inflammation-induced bone loss may lead to more selective therapeutic targeting of these pathological signaling pathways...
  3. pmc The growth hormone-insulin-like growth factor-I axis in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, Division of Pediatric Nephrology, University of California at San Diego, La Jolla, CA 92093 0634, USA
    Growth Horm IGF Res 18:17-25. 2008
    ..Further understanding of GH/IGF pathophysiology in CKD may lead to the development of therapeutic strategies for these devastating complications, which are associated with high rates of mortality and morbidity...
  4. ncbi request reprint Adipokines and gut hormones in end-stage renal disease
    Robert H Mak
    Division of Pediatric Nephrology, Oregon Health and Science University, Portland, Oregon, USA
    Perit Dial Int 27:S298-302. 2007
    ..Understanding the molecular pathophysiology of these novel hormones in ESRD may lead to novel therapeutic strategies...
  5. ncbi request reprint Insulin and its role in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, University of California at San Diego, 9500 Gilman Drive, MC0634, La Jolla, CA, 92093 0634, USA
    Pediatr Nephrol 23:355-62. 2008
    ..The goal of this review was to provide an update of the literature on insulin pathophysiology in CKD, current understanding of its mechanisms, and epidemiological association of insulin resistance and CKD...
  6. pmc Cachexia and protein-energy wasting in children with chronic kidney disease
    Robert H Mak
    Division of Nephrology, Department of Pediatrics, Rady Children s Hospital, University of California San Diego, San Diego, CA, USA
    Pediatr Nephrol 27:173-81. 2012
    ..Further research into the causes and consequences of wasting and growth retardation is needed in order to improve the survival and quality of life for children with CKD...
  7. doi request reprint Is ghrelin a biomarker for mortality in end-stage renal disease?
    Robert H Mak
    Division of Pediatric Nephrology, University of California, San Diego, La Jolla, California 92093 0634, USA
    Kidney Int 79:697-9. 2011
    ..ESRD patients with PEW, systemic inflammation, and low ghrelin and high leptin concentrations have the highest mortality risk and may benefit the most from ghrelin therapy...
  8. ncbi request reprint Therapeutic strategy for cachexia in chronic kidney disease
    Robert H Mak
    Division of Pediatric Nephrology, University of California at San Diego, La Jolla, California 92093 0634, USA
    Curr Opin Nephrol Hypertens 16:542-6. 2007
    ..This review will provide an update on advances in the understanding of the pathophysiology and novel therapeutic approach to cachexia in chronic kidney disease...
  9. ncbi request reprint Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Clin Pract Nephrol 2:527-34. 2006
    ..These findings could form the basis of a novel therapeutic strategy for uremic cachexia...
  10. ncbi request reprint Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease
    Robert H Mak
    Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC5, Portland, OR, 97239, USA
    Pediatr Nephrol 20:427-31. 2005
    ..Understanding the molecular mechanism of cachexia in CKD may lead to novel therapeutic strategies...
  11. doi request reprint Inflammation and cachexia in chronic kidney disease
    Wai W Cheung
    Division of Pediatrics Nephrology, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0634, USA
    Pediatr Nephrol 25:711-24. 2010
    ..Further research into the molecular pathways leading to inflammation and cachexia may lead to novel therapeutic therapies for this devastating and potentially fatal complication of chronic disease...
  12. ncbi request reprint Cachexia in chronic kidney disease: role of inflammation and neuropeptide signaling
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Opin Nephrol Hypertens 16:27-31. 2007
    ..Recent studies that examine the role of cytokines and hypothalamic neuropeptides are emphasized...
  13. pmc Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study
    Susan L Furth
    Department of Pediatrics, Johns Hopkins Children s Center, Baltimore MD, USA
    Clin J Am Soc Nephrol 1:1006-15. 2006
    ..The primary outcome is the rate of decline of GFR. The CKiD study will be the largest North American multicenter study of pediatric CKD...
  14. doi request reprint Modulation of melanocortin signaling ameliorates uremic cachexia
    Wai W Cheung
    Department of Pediatrics, Division of Pediatric Nephrology, University of California at San Diego, La Jolla, California 92093 0634, USA
    Kidney Int 74:180-6. 2008
    ..We suggest that AgRP improves uremic cachexia and muscle wasting by a peripheral mechanism involving the balance between myostatin and IGF-I...
  15. ncbi request reprint Energy homeostasis and cachexia in chronic kidney disease
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Pediatr Nephrol 21:1807-14. 2006
    ..Further research into the molecular pathways leading to cachexia may lead to novel therapeutic therapy for this devastating and potentially fatal complication of CKD...
  16. pmc C/EBPα regulates macrophage activation and systemic metabolism
    Bonggi Lee
    Department of Pediatrics, University of California San Diego, La Jolla, California
    Am J Physiol Endocrinol Metab 306:E1144-54. 2014
    ..Together, these results imply that C/EBPα is required for macrophage activation, which plays an important role in maintaining skeletal muscle energy metabolism. ..
  17. ncbi request reprint Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease
    Ihab M Wahba
    Department of Medicine, Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
    Clin J Am Soc Nephrol 2:550-62. 2007
    ..Potential preventive and therapeutic modalities based on the limited evidence available are discussed...
  18. doi request reprint Ghrelin and its analogues as therapeutic agents for anorexia and cachexia in end-stage renal disease
    Wai W Cheung
    Division of Pediatric Nephrology, Department of Pediatrics, University of California, San Diego, California 92093 0634, USA
    Kidney Int 76:135-7. 2009
    ..However, the clinical utility of ghrelin will depend on long-term outcomes in improving appetite and lean body mass as well as morbidity and mortality...
  19. ncbi request reprint Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice
    Wai W Cheung
    Department of Pediatric, University of California at San Diego, 9500 Gilman Drive, MC 0634, La Jolla, CA 92093 0634, USA
    J Am Soc Nephrol 18:2517-24. 2007
    ..These data underscore the importance of melanocortin signaling in the pathogenesis of uremia-associated cachexia and demonstrate the potential of peripheral administration of MC4-R antagonists as a novel therapeutic approach...
  20. ncbi request reprint Ghrelin in chronic kidney disease: too much or too little?
    Robert H Mak
    Department of Pediatrics, Center for the Study of Weight Regulation, Oregon Health and Science University, Portland, Oregon, USA
    Perit Dial Int 27:51-5. 2007
  21. ncbi request reprint Gene expression in uremic left ventricular hypertrophy: effects of hypertension and anemia
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University Portland, OR 97201, USA
    Exp Mol Med 36:251-8. 2004
    ..Thus, gene expression in uremic LVH is distinct from that in pressure-overload LVH, suggesting that other unidentified factor(s) might be involved in uremic LVH...
  22. pmc Role of leptin and melanocortin signaling in uremia-associated cachexia
    Wai Cheung
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 115:1659-65. 2005
    ..The results of this study suggest that elevated circulating levels of cytokines such as leptin may be an important cause of uremia-associated cachexia via signaling through the central melanocortin system...
  23. ncbi request reprint Pathogenesis of urinary tract infection: an update
    Robert H Mak
    Division of Pediatric Nephrology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Curr Opin Pediatr 18:148-52. 2006
    ..It may cause renal scarring leading to secondary hypertension and chronic kidney disease. Recent information has greatly improved our understanding of the pathogenesis of urinary tract infection and renal scarring...
  24. ncbi request reprint Animal models of obesity-associated chronic kidney disease
    Robert H Mak
    Division of Pediatric Nephrology, Oregon Health and Science University, Portland, OR 97239, USA
    Adv Chronic Kidney Dis 13:374-85. 2006
    ....
  25. ncbi request reprint Growth impairment of primary chondrocyte cells by serum of rats with chronic renal failure
    Robert H Mak
    Division of Pediatric Nephrology, Department of Pediatrics, Oregon Health and Science University Portland, OR 97201, USA
    Exp Mol Med 36:243-50. 2004
    ....
  26. ncbi request reprint Chronic kidney disease in children: state of the art
    Robert H Mak
    Pediatr Nephrol 22:1687-8. 2007

Research Grants1

  1. GROWTH RETARDATION IN CHRONIC RENAL FAILURE
    Robert Mak; Fiscal Year: 2001
    ....