Affiliation: University of Washington
- Cannabinoid receptor homo- and heterodimerizationKen Mackie
Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98195 6540, USA
Life Sci 77:1667-73. 2005..In this review, the evidence for CB1 multimerization will be presented, the implications for cannabinoid signaling discussed, and possible future directions for this research considered...
- Cannabinoid receptors as therapeutic targetsKen Mackie
Department of Anesthesiology and Physiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
Annu Rev Pharmacol Toxicol 46:101-22. 2006..This review considers the components of the endocannabinoid system and discusses some of the most promising endocannabinoid-based therapies...
- Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strengthK Mackie
Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
Int J Obes (Lond) 30:S19-23. 2006..The behavioral consequences of these changes are many, but some of the most striking and relevant to the current symposium are those associated with endogenous reward and consumptive behavior...
- Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M currentM S Shapiro
Department of Physiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Neurosci 20:1710-21. 2000..Our data further rule out Ca(2+) as the diffusible messenger. The reconstitution of muscarinic modulation of the M current that uses cloned components should facilitate the elucidation of the muscarinic signaling mechanism...
- Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptorD E Garcia
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
J Neurosci 18:2834-41. 1998..Mutating this serine to alanine did not affect the ability of CB1 to modulate currents, but it eliminated disruption by PMA, demonstrating that PKC can disrupt ion channel modulation by receptor phosphorylation...
- Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neuronsW Twitchell
Department of Anesthesiology, School of Medicine, University of Washington, Seattle 98195, USA
J Neurophysiol 78:43-50. 1997....