Robert A Lustig

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Imaging response in malignant glioma, RTOG 90-06
    Robert A Lustig
    Hospital of the University of Pennsylvania, Department of Radiation Oncology, Philadelphia, PA 19104, USA
    Am J Clin Oncol 30:32-7. 2007
  2. ncbi request reprint Long term responses with cetuximab therapy in glioblastoma multiforme
    Robert Lustig
    Department of Radiation Oncology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1242-3. 2006
  3. ncbi request reprint Does stereotactic eligibility for the treatment of glioblastoma cause selection bias in randomized studies?
    Robert A Lustig
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Clin Oncol 27:516-21. 2004
  4. pmc The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study
    Sydney M Evans
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Transl Oncol 3:160-9. 2010
  5. pmc Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay
    Kelly M MacArthur
    Authors Affiliations Departments of Radiation Oncology and Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Cancer Res 74:2152-9. 2014
  6. pmc Headache as a risk factor for neurovascular events in pediatric brain tumor patients
    Sarah M Kranick
    Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Neurology 80:1452-6. 2013
  7. ncbi request reprint Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement
    Paul C McGovern
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 36:759-65. 2003
  8. ncbi request reprint Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
    Ulas Sunar
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 11:064021. 2006
  9. ncbi request reprint Treatment of pediatric intracranial arteriovenous malformations with linear-accelerator-based stereotactic radiosurgery: the University of Pennsylvania experience
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Neurosurg 40:207-14. 2004
  10. ncbi request reprint A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Imaging response in malignant glioma, RTOG 90-06
    Robert A Lustig
    Hospital of the University of Pennsylvania, Department of Radiation Oncology, Philadelphia, PA 19104, USA
    Am J Clin Oncol 30:32-7. 2007
    ..This study compared patients treated with hyperfractionated radiation and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) to standard fractionation and BCNU...
  2. ncbi request reprint Long term responses with cetuximab therapy in glioblastoma multiforme
    Robert Lustig
    Department of Radiation Oncology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1242-3. 2006
  3. ncbi request reprint Does stereotactic eligibility for the treatment of glioblastoma cause selection bias in randomized studies?
    Robert A Lustig
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Clin Oncol 27:516-21. 2004
    ....
  4. pmc The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study
    Sydney M Evans
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Transl Oncol 3:160-9. 2010
    ..0291). In summary, patients had a worse prognosis if the [EF5/Ki-67(Binding)]/[Tumor(binding)] ratio was high. A hypothesis for the mechanisms and translational significance of these findings is discussed...
  5. pmc Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay
    Kelly M MacArthur
    Authors Affiliations Departments of Radiation Oncology and Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Cancer Res 74:2152-9. 2014
    ..These results support further development of this assay as a generalized method to detect CTC in patients with cancer...
  6. pmc Headache as a risk factor for neurovascular events in pediatric brain tumor patients
    Sarah M Kranick
    Department of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Neurology 80:1452-6. 2013
    ..To determine whether severe recurrent headache is a risk factor for neurovascular events in children who received radiation for brain tumors...
  7. ncbi request reprint Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement
    Paul C McGovern
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 36:759-65. 2003
    ..Patients who received a Gliadel wafer had a higher incidence of infection than previously has been reported, and additional studies are required to better quantify this risk and describe the epidemiology of such infections...
  8. ncbi request reprint Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
    Ulas Sunar
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 11:064021. 2006
    ..0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise...
  9. ncbi request reprint Treatment of pediatric intracranial arteriovenous malformations with linear-accelerator-based stereotactic radiosurgery: the University of Pennsylvania experience
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Neurosurg 40:207-14. 2004
    ..Linear-accelerator-based SRS is effective in obliterating most AVMs in children; however, the potential for late effects exists, especially for those patients with larger target volumes...
  10. ncbi request reprint A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004
    ..This phase Ib study was designed to evaluate the safety and side effect profile of topical Tempol in patients with brain metastases being treated with whole brain radiotherapy...
  11. doi request reprint Acute toxicity of proton beam radiation for pediatric central nervous system malignancies
    Gita Suneja
    Department of Radiation Oncology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 60:1431-6. 2013
    ..Proton beam therapy (PBT) for pediatric CNS malignancies may reduce late toxicity, but acute toxicity is not well defined. We examined acute toxicity for children with CNS malignancies treated with PBT...
  12. ncbi request reprint A critical review of the clinical effects of therapeutic irradiation damage to the brain: the roots of controversy
    Carol L Armstrong
    Department of Neurology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Neuropsychol Rev 14:65-86. 2004
    ..Furthermore, radiation effects appear severe only in a minority of patients. Risk is related to direct and indirect effects of cancer type, concurrent clinical factors, and premorbid risk factors...
  13. ncbi request reprint Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 59:72-7. 2004
    ..We designed a prospective protocol to determine the feasibility, toxicity, and preliminary efficacy of a regimen of postoperative reirradiation, chemotherapy and the radioprotector amifostine after salvage head-and-neck surgery...
  14. pmc Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease
    Robert Lustig
    Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Neuro Oncol 10:1004-9. 2008
    ..R115777 administered prior to radiation therapy is not recommended for patients with newly diagnosed GBM...
  15. doi request reprint Factors associated with event reporting in the pediatric radiation oncology population using an electronic incident reporting system
    Christine E Hill-Kayser
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Pract Radiat Oncol 5:e417-22. 2015
    ..Pediatric patients may receive complex treatment. In our department, an electronic incident reporting system (condition reporting system [CRS]) was developed and made available to all members...
  16. ncbi request reprint Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer
    Sarina B Elmariah
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Breast J 12:470-4. 2006
    ..We briefly discuss the incidence of BRCA-1 mutations in breast cancer as well as other primary neoplasms and consider potential mechanisms shared in the pathogenesis of breast and glial tumors...
  17. ncbi request reprint Radiation Therapy Oncology Group (RTOG) 9413: Randomized trial comparing whole pelvic radiotherapy (WPRT) to prostate only (PORT) and neoadjuvant hormone therapy (NHT) to adjuvant hormone therapy (AHT)
    Mack Roach
    University of California, San Francisco, San Francisco, CA Radiation Therapy Oncology Group, Philadelphia, PA Medical College of Wisconsin, Milwaukee, WI Hospital of the University of Pennsylvania, Philadelphia, PA Radiological Associates of Sacramento, Sacramento, CA SUNY Health Science Center, Brooklyn, NY Albert Einstein Medical Center, Philadelphia, PA Thomas Jefferson University Hospital, Philadelphia, PA Karmanos Cancer Institute, Wayne State University, Detroit, MI Oregon Health and Science University Knight Cancer Institute, Portland, OR Massachusetts General Hospital, Boston, MA Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA
    J Clin Oncol 30:96. 2012
    ..We update primary and secondary endpoints (SE): biochemical failure (BF), time to metastasis (Mets), prostate specific survival (PSS) and overall survival (OS)...
  18. doi request reprint Patterns of Failure for Pediatric Glioblastoma Multiforme Following Radiation Therapy
    Jacob E Shabason
    Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Pediatr Blood Cancer 63:1465-7. 2016
    ..2%) were in-field, three (23.1%) were marginal, and one (7.7%) was distant. The majority of patients treated with adjuvant radiation failed in the region of high-dose RT, indicating the need for improvements in local therapy. ..
  19. doi request reprint Impact of image guidance during whole-brain radiation therapy
    Eric Ojerholm
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Pract Radiat Oncol 6:e345-e351. 2016
    ..Radiation oncologists are rapidly adopting image-guided radiation therapy (IGRT), warranting further evaluation of its role and value. We analyzed the impact of IGRT for one of the most common radiation treatments...
  20. pmc Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients
    Sydney M Evans
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Neurooncol 127:391-400. 2016
    ..Further studies will be needed to verify and further investigate the association between these two entities...
  21. doi request reprint Acute toxicity profile of patients with low-grade gliomas and meningiomas receiving proton therapy
    Genevieve Maquilan
    Department of Radiation Oncology, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA
    Am J Clin Oncol 37:438-43. 2014
    ..Proton therapy is an emerging treatment modality. We studied its acute side effects on patients with low-grade gliomas and meningiomas...
  22. pmc A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme
    Michelle Alonso-Basanta
    Department of Radiation Oncology, Smilow Center for Translational Research 8 135, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA, 19104, USA
    J Neurooncol 116:365-72. 2014
    ..NFV (1,250 mg bid) concurrent with temozolomide and radiotherapy is tolerated in most patients with glioblastoma. At the 1,250 mg bid dose level, patients should be monitored for hepatotoxicity and GI side effects...
  23. pmc Phase measurement of cognitive impairment specific to radiotherapy
    Carol L Armstrong
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 83:e319-24. 2012
    ..The study design investigated semantic vs. perceptual and visual vs. verbal memory to determine the most disease-specific measure of RT-related changes and understanding of the neurotoxicity from RT to the brain...
  24. ncbi request reprint Recurrent late cerebral necrosis with aggressive characteristics after radiosurgical treatment of an arteriovenous malformation. Case report
    H Isaac Chen
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurosurg 105:455-60. 2006
    ....
  25. ncbi request reprint Hypoxia is important in the biology and aggression of human glial brain tumors
    Sydney M Evans
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 10:8177-84. 2004
    ..1% oxygen) was present in 5 of 12 grade 4 tumors. A correlation between more rapid tumor recurrence and hypoxia was demonstrated with EF5 binding, but this relationship was not predicted by Eppendorf measurements...
  26. ncbi request reprint GliaSite brachytherapy boost as part of initial treatment of glioblastoma multiforme: a retrospective multi-institutional pilot study
    James Welsh
    Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
    Int J Radiat Oncol Biol Phys 68:159-65. 2007
    ..To report on a retrospective analysis of the cumulative experience from eight institutions using the GliaSite Radiotherapy System as a brachytherapy boost in the initial management of glioblastoma multiforme...
  27. ncbi request reprint In vivo light dosimetry for motexafin lutetium-mediated PDT of recurrent breast cancer
    Andreea Dimofte
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Lasers Surg Med 31:305-12. 2002
    ..To measure the fluence at tissue surface for patients in our Phase II clinical trial of motexafin lutetium (MLu)-mediated chest wall photodynamic therapy for recurrent breast carcinoma and to compare it to the calculated irradiance...
  28. doi request reprint Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fraction
    Emerson L Gasparetto
    Division of Neuroradiology, Department of Radiology, Division of Neuro Oncology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Radiology 250:887-96. 2009
    ....
  29. ncbi request reprint GliaSite brachytherapy for treatment of recurrent malignant gliomas: a retrospective multi-institutional analysis
    Arash J Gabayan
    Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Neurosurgery 58:701-9; discussion 701-9. 2006
    ..To review the cumulative experience of 10 institutions in treating recurrent malignant gliomas with the brachytherapy device, GliaSite Radiation Therapy System...
  30. pmc Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome
    Sydney M Evans
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Int J Radiat Oncol Biol Phys 69:1024-31. 2007
    ..EF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels, and prognostic significance of hypoxia in primary head and neck squamous cell tumors...