Patrizia Luppi

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Monocytes are progressively activated in the circulation of pregnant women
    Patrizia Luppi
    Division of Immunogenetics Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    J Leukoc Biol 72:874-84. 2002
  2. ncbi request reprint Normal pregnancy is associated with peripheral leukocyte activation
    P Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Am J Reprod Immunol 47:72-81. 2002
  3. ncbi request reprint How immune mechanisms are affected by pregnancy
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh and University of Pittsburgh, School of Medicine, Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA15213, USA
    Vaccine 21:3352-7. 2003
  4. ncbi request reprint Preeclampsia activates circulating immune cells with engagement of the NF-kappaB pathway
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, PA 15213, USA
    Am J Reprod Immunol 56:135-44. 2006
  5. ncbi request reprint The effects of cigarette smoking on circulating maternal leukocytes during pregnancy
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Clin Immunol 122:214-9. 2007
  6. pmc FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival
    Vincenza Cifarelli
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Mol Endocrinol 26:1213-24. 2012
  7. doi request reprint C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia
    Jaime Haidet
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Inflamm Res 61:27-35. 2012
  8. ncbi request reprint Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Clin Immunol 118:268-75. 2006
  9. doi request reprint Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells
    Vincenza Cifarelli
    Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Atherosclerosis 201:248-57. 2008
  10. doi request reprint C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes
    P Luppi
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Rangos Research Center, PA 15201, USA
    Diabetologia 52:2218-28. 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Monocytes are progressively activated in the circulation of pregnant women
    Patrizia Luppi
    Division of Immunogenetics Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    J Leukoc Biol 72:874-84. 2002
    ....
  2. ncbi request reprint Normal pregnancy is associated with peripheral leukocyte activation
    P Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Am J Reprod Immunol 47:72-81. 2002
    ..This study was designed to analyse further the phenotype of subpopulations of peripheral blood leukocytes in normal pregnant women...
  3. ncbi request reprint How immune mechanisms are affected by pregnancy
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh and University of Pittsburgh, School of Medicine, Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA15213, USA
    Vaccine 21:3352-7. 2003
    ..This unique dysregulation between different components of the immune system plays a central role in the maternal adaptation to pregnancy...
  4. ncbi request reprint Preeclampsia activates circulating immune cells with engagement of the NF-kappaB pathway
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, PA 15213, USA
    Am J Reprod Immunol 56:135-44. 2006
    ..Here, we investigated activation in additional leukocyte populations among women with preeclampsia...
  5. ncbi request reprint The effects of cigarette smoking on circulating maternal leukocytes during pregnancy
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, PA 15213, USA
    Clin Immunol 122:214-9. 2007
    ..Our data demonstrate that smoking affects several immune parameters, especially early in pregnancy. These perturbations may play a role in pregnancy loss in women who smoke...
  6. pmc FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival
    Vincenza Cifarelli
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Mol Endocrinol 26:1213-24. 2012
    ..FOXO1 deregulation, resulting from an impaired ability of ET-1 to control FOXO1 activity in endothelium, may contribute to hyperglycemia-induced endothelial lesion in diabetes...
  7. doi request reprint C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia
    Jaime Haidet
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Inflamm Res 61:27-35. 2012
    ..We investigated C-peptide effects on inflammatory cytokine release and adhesion of monocytes exposed to high glucose and lipopolysaccharide (LPS) in vitro...
  8. ncbi request reprint Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Clin Immunol 118:268-75. 2006
    ..5% +/- 1.4 SEM) (P = 0.04) suggesting that monocytes from preeclamptic patients cannot be further stimulated. These results indicate that maternal circulating monocytes represent a source of inflammatory cytokines during preeclampsia...
  9. doi request reprint Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells
    Vincenza Cifarelli
    Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Atherosclerosis 201:248-57. 2008
    ..In patients with T1D, physiological C-peptide levels may exert beneficial effects on the vasculature that, under high glucose conditions, is subject to progressive dysfunction...
  10. doi request reprint C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes
    P Luppi
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Rangos Research Center, PA 15201, USA
    Diabetologia 52:2218-28. 2009
    ..In this study, we investigated the hypothesis that C-peptide is internalised via an endocytic pathway and traffics to classic endocytic organelles, such as endosomes and lysosomes...
  11. doi request reprint Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-kappaB pathway
    P Luppi
    Division of Immunogenetics, Department of Pediatrics, Rangos Research Center, Children s Hospital of Pittsburgh, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetologia 51:1534-43. 2008
    ....
  12. ncbi request reprint Intracellular adhesion molecule concentrations in women who smoke during pregnancy
    Kristine Y Lain
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 107:588-94. 2006
    ..Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources...
  13. ncbi request reprint CD11b Expression on circulating leukocytes increases in preparation for parturition
    Patrizia Luppi
    Department of Pediatrics, Division of Immunogenetics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Reprod Immunol 52:323-9. 2004
    ..ICAM-1 binds to the beta(2) integrin CD11b on the leukocytes. In this study, we wanted to investigate whether complementary changes occur in expression of adhesion molecules on maternal leukocytes in preparation for parturition...
  14. ncbi request reprint Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection
    Patrizia Luppi
    Department of Pediatrics, Division of Immunogenetics, University of Pittsburgh School of Medicine, PA, USA
    Hum Immunol 64:194-210. 2003
    ..This immune response may play a critical role in modulating disease progression after viral infections...
  15. doi request reprint Can C-peptide mediated anti-inflammatory effects retard the development of microvascular complications of type 1 diabetes?
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Rangos Research Center, Pittsburgh, PA 15201, USA
    Diabetes Metab Res Rev 29:357-62. 2013
    ..Further clinical trials in patients with microvascular complications including measurements of inflammatory markers are warranted to explore the clinical significance of the aforementioned, previously unrecognized, C-peptide effects...
  16. pmc Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children
    Vincenza Cifarelli
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Rev Diabet Stud 4:112-7. 2007
    ..The potential effects of glycemic control and body mass index (BMI) on monocyte phenotype were also investigated...
  17. pmc Anti-inflammatory properties of C-Peptide
    Jaime Haidet
    Division of Endocrinology, Metabolism, and Diabetes Mellitus, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Rev Diabet Stud 6:168-79. 2009
    ....
  18. pmc Maternal circulating CD34+VEGFR-2+ and CD133+VEGFR-2+ progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia
    Patrizia Luppi
    Department of Pediatrics, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Reprod Sci 17:643-52. 2010
    ..Circulating EPCs appear to increase during normal pregnancy, and comparatively reduced numbers of these cells exist during preeclampsia...
  19. doi request reprint C-peptide and long-term complications of diabetes
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201 USA Department of Molecular Medicine and Surgery, Karolinska Institutet, S 171 77 Stockholm Sweden
    Pediatr Diabetes 12:276-92. 2011
    ..Luppi P, Cifarelli V, Wahren J. C-peptide and long-term complications of diabetes...
  20. ncbi request reprint Analysis of TCR Vbeta repertoire and cytokine gene expression in patients with idiopathic dilated cardiomyopathy
    P Luppi
    Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Autoimmun 16:3-13. 2001
    ..IL-1beta, IL-2, IL-6 and IFN-gamma were expressed in the myocardium while others, like IL-4 were not. In conclusion, an orchestrated complex of immune mechanisms seems to be the basis of IDC etiopathogenesis...
  21. ncbi request reprint Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells
    Matthew J Loza
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, BLSB 750, 233 South, 10th Street, Philadelphia, PA 19107, USA
    Int Immunol 17:1213-25. 2005
    ....