R R Luedtke
Affiliation: University of North Texas
- Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypesR R Luedtke
Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 76107, USA
J Neuroimmunol 101:170-87. 1999..Immunoreactivity of the anti-(D1b receptor) antibody was also observed in layer V pyramidal neurons of the frontal sensorimotor cortex...
- Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptorsR R Luedtke
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76116, USA
Synapse 38:438-49. 2000..Finally, a unique property of the azabicyclononane benzamide (125)I-IABN compared to previously studied substituted benzamides is that the binding of this radioligand is not effected by variations in Na(+) concentration...
- Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disordersRobert R Luedtkea
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Curr Pharm Des 9:643-71. 2003..A. survey of the literature, including a description of the medicinal chemistry approaches toward developing D3-selective ligands, is also presented in this review...
- Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cellsM W Martin
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Eur J Pharmacol 420:73-82. 2001..Therefore, these nonselective dopamine receptor compounds displayed negative intrinsic or inverse agonist activity. None of the compounds tested were neutral antagonists...
- Genetic polymorphisms at the rat and murine loci coding for dopamine D2-like receptorsA W Scott
Department of Pharmacology, University of North Texas Health Science Center at Fort Worth 76107, USA
Brain Res Mol Brain Res 29:347-57. 1995..It is anticipated that these genetic polymorphisms will be useful in pharmacogenetic studies to determine the influence of the D2-like receptors in reward and addictive behaviors...
- Mapping the D2/D3 Dopamine Receptor Binding SitesROBERT LUEDTKE; Fiscal Year: 2004..LB dopamine receptor selective compounds bind to the neumtransmitter binding sate and 2) provide additional structural information that will assist us in the design of novel compounds with increased selectivity for LB dopamine receptors ..