R R Luedtke

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes
    R R Luedtke
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 76107, USA
    J Neuroimmunol 101:170-87. 1999
  2. ncbi request reprint Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors
    R R Luedtke
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76116, USA
    Synapse 38:438-49. 2000
  3. ncbi request reprint Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders
    Robert R Luedtkea
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Curr Pharm Des 9:643-71. 2003
  4. ncbi request reprint Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells
    M W Martin
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Eur J Pharmacol 420:73-82. 2001
  5. ncbi request reprint Genetic polymorphisms at the rat and murine loci coding for dopamine D2-like receptors
    A W Scott
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth 76107, USA
    Brain Res Mol Brain Res 29:347-57. 1995

Research Grants

  1. Mapping the D2/D3 Dopamine Receptor Binding Sites
    ROBERT LUEDTKE; Fiscal Year: 2004

Collaborators

  • S R Sesack
  • Robert R Luedtkea
  • M W Martin
  • A W Scott
  • Robert H Mach
  • S Griffin
  • D E Johnston
  • S A Griffin

Detail Information

Publications5

  1. ncbi request reprint Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes
    R R Luedtke
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 76107, USA
    J Neuroimmunol 101:170-87. 1999
    ..Immunoreactivity of the anti-(D1b receptor) antibody was also observed in layer V pyramidal neurons of the frontal sensorimotor cortex...
  2. ncbi request reprint Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors
    R R Luedtke
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76116, USA
    Synapse 38:438-49. 2000
    ..Finally, a unique property of the azabicyclononane benzamide (125)I-IABN compared to previously studied substituted benzamides is that the binding of this radioligand is not effected by variations in Na(+) concentration...
  3. ncbi request reprint Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders
    Robert R Luedtkea
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Curr Pharm Des 9:643-71. 2003
    ..A. survey of the literature, including a description of the medicinal chemistry approaches toward developing D3-selective ligands, is also presented in this review...
  4. ncbi request reprint Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells
    M W Martin
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Eur J Pharmacol 420:73-82. 2001
    ..Therefore, these nonselective dopamine receptor compounds displayed negative intrinsic or inverse agonist activity. None of the compounds tested were neutral antagonists...
  5. ncbi request reprint Genetic polymorphisms at the rat and murine loci coding for dopamine D2-like receptors
    A W Scott
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth 76107, USA
    Brain Res Mol Brain Res 29:347-57. 1995
    ..It is anticipated that these genetic polymorphisms will be useful in pharmacogenetic studies to determine the influence of the D2-like receptors in reward and addictive behaviors...

Research Grants1

  1. Mapping the D2/D3 Dopamine Receptor Binding Sites
    ROBERT LUEDTKE; Fiscal Year: 2004
    ..LB dopamine receptor selective compounds bind to the neumtransmitter binding sate and 2) provide additional structural information that will assist us in the design of novel compounds with increased selectivity for LB dopamine receptors ..