William E Lowry

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma
    William E Lowry
    Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA Electronic address
    J Invest Dermatol 136:1543-8. 2016
  2. pmc let-7 miRNAs can act through notch to regulate human gliogenesis
    M Patterson
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Box 957357, Los Angeles, CA 90095, USA Department of Molecular, Cell and Developmental Biology, UCLA, 621 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Stem Cell Reports 3:758-73. 2014
  3. pmc -Oh no! hiPSCs misplace their 5hmCs
    William E Lowry
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 13:10-1. 2013
  4. pmc Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?
    William E Lowry
    Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA, United States
    Curr Opin Genet Dev 22:429-34. 2012
  5. pmc Generation of human induced pluripotent stem cells from dermal fibroblasts
    W E Lowry
    Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, 615 Charles E Young Drive South, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:2883-8. 2008
  6. doi request reprint Roadblocks en route to the clinical application of induced pluripotent stem cells
    William E Lowry
    Department of Molecular, Cell and Developmental Biology, 621 Charles Young Drive South, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Cell Sci 123:643-51. 2010
  7. pmc Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
  8. pmc Defining the nature of human pluripotent stem cell progeny
    Michaela Patterson
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Res 22:178-93. 2012
  9. pmc Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach
    Lina R Nih
    Department of Chemical and Biomolecular Engineering, University of California, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Data Brief 10:202-209. 2017
  10. pmc Dynamic distribution of linker histone H1.5 in cellular differentiation
    Jing Yu Li
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 8:e1002879. 2012

Collaborators

Detail Information

Publications29

  1. doi request reprint Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma
    William E Lowry
    Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA Electronic address
    J Invest Dermatol 136:1543-8. 2016
    ..A synthesis of these studies potentially could provide unique insights into the process by which Ras can initiate squamous cell carcinoma in human patients and could eventually inform treatment strategies. ..
  2. pmc let-7 miRNAs can act through notch to regulate human gliogenesis
    M Patterson
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Box 957357, Los Angeles, CA 90095, USA Department of Molecular, Cell and Developmental Biology, UCLA, 621 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Stem Cell Reports 3:758-73. 2014
    ..These data link the let-7 circuit to NOTCH signaling and suggest that this interaction serves to regulate human developmental progression. ..
  3. pmc -Oh no! hiPSCs misplace their 5hmCs
    William E Lowry
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 13:10-1. 2013
    ..2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs. ..
  4. pmc Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?
    William E Lowry
    Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA, United States
    Curr Opin Genet Dev 22:429-34. 2012
    ..In this review, I will attempt to summarize the data that serve to distinguish these types of pluripotent stem cells and speculate on the ramifications of any differences...
  5. pmc Generation of human induced pluripotent stem cells from dermal fibroblasts
    W E Lowry
    Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, 615 Charles E Young Drive South, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:2883-8. 2008
    ..In the future, the use of defined factors to change cell fate may be the key to routine nuclear reprogramming of human somatic cells...
  6. doi request reprint Roadblocks en route to the clinical application of induced pluripotent stem cells
    William E Lowry
    Department of Molecular, Cell and Developmental Biology, 621 Charles Young Drive South, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Cell Sci 123:643-51. 2010
    ..In this Essay, we discuss what we believe are important issues that should be considered when attempting to bring hiPSC-based technology to the clinic...
  7. pmc Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
    ....
  8. pmc Defining the nature of human pluripotent stem cell progeny
    Michaela Patterson
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Res 22:178-93. 2012
    ..These findings provide support for the idea that hPSCs can serve as useful in vitro models of early human development, but also raise important issues for disease modeling and the clinical application of hPSC derivatives...
  9. pmc Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach
    Lina R Nih
    Department of Chemical and Biomolecular Engineering, University of California, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Data Brief 10:202-209. 2017
    ..W. 2 Weible and T. Chan-Ling, 2007) [2] to select multi-factorial experimental conditions, and (3) Inflammatory response and cell survival after transplantation...
  10. pmc Dynamic distribution of linker histone H1.5 in cellular differentiation
    Jing Yu Li
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 8:e1002879. 2012
    ..Our data reveal for the first time a specific and novel function for linker histone subtype H1.5 in maintenance of condensed chromatin at defined gene families in differentiated human cells...
  11. pmc PTK7 marks the first human developmental EMT in vitro
    David N Chan
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e50432. 2012
    ..We also find that cells that undergo this developmental EMT retain developmental plasticity as sorting, dissociation and re-plating reestablishes an epithelial phenotype...
  12. pmc Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
    ..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases...
  13. pmc Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo
    Karina Palomares
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    J Virol 87:2094-108. 2013
    ..Bypassing the liver sink is a critical barrier for targeted gene therapy. The extraordinary specificity of NiV-G for ephrinB2 holds promise for targeting specific ephrinB2(+) populations in vivo or in vitro...
  14. pmc Progress in understanding reprogramming to the induced pluripotent state
    Kathrin Plath
    David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
    Nat Rev Genet 12:253-65. 2011
    ..To inform the next phase in understanding reprogramming, we review the latest findings, highlight ongoing debates and outline future challenges...
  15. ncbi request reprint Signaling in adult stem cells
    William E Lowry
    Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095, USA
    Front Biosci 12:3911-27. 2007
    ....
  16. pmc Defining the origins of Ras/p53-mediated squamous cell carcinoma
    Andrew C White
    Department of Molecular, Cell, and Developmental Biology, David Geffen School of Medicine, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:7425-30. 2011
    ..Furthermore, we provide insights into the inability of hair follicle TA cells to respond to tumorigenic stimuli...
  17. pmc Defining Transcriptional Regulatory Mechanisms for Primary let-7 miRNAs
    Xavier Gaeta
    Broad Stem Cell Center, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 12:e0169237. 2017
    ....
  18. doi request reprint SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
    Peiyee Lee
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, California 90095, USA
    Nat Commun 4:1824. 2013
    ..This platform allows for efficient screening of novel compounds, identification of target and off-target effects, and preclinical testing on relevant cell types for the pathogenic dissection and treatment of ataxia telangiectasia...
  19. pmc The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
    Apriliana E R Kartikasari
    Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095 7073, USA
    EMBO J 32:1393-408. 2013
    ..Our results demonstrate that Jmjd3 sequentially associates with two T-box factors, Tbx3 and Eomes to drive stem cell differentiation towards the definitive endoderm lineage...
  20. pmc Molecular analyses of human induced pluripotent stem cells and embryonic stem cells
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 7:263-9. 2010
    ....
  21. pmc Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State
    Wen Gu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 19:476-490. 2016
    ..They may also suggest methods for regulating self-renewal and initial cell fate specification of hESCs...
  22. pmc Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
    Tae Sub Park
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
    Stem Cells 27:783-95. 2009
    ....
  23. pmc Refining the role for adult stem cells as cancer cells of origin
    Andrew C White
    Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, LA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, LA, USA Molecular Biology Institute, UCLA, Los Angeles, LA, USA Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, LA, USA
    Trends Cell Biol 25:11-20. 2015
    ..In this review, we summarize some of the recent findings regarding CCOs and solid tumor initiation and highlight its relation with bona fide human cancer. ..
  24. pmc Hmga2 is dispensable for cutaneous squamous cell carcinoma
    Andrew White
    Department of Molecular Cell and Developmental Biology, UCLA, Los Angeles, CA, USA
    Exp Dermatol 25:409-12. 2016
    ..Tumors lacking the ability to induce Hmga2 proceeded to initiate cutaneous spindle cell and squamous cell carcinomas with all the typical pathological and molecular hallmarks of these cancers. ..
  25. pmc Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain
    Pouria Moshayedi
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 635 Charles Young Drive, CA 90095, USA
    Biomaterials 105:145-55. 2016
    ..This HA hydrogel can be tracked in vivo with MRI. A hydrogel can serve as a therapeutic adjunct in a stem cell therapy through selective control of stem cell survival and differentiation in vivo. ..
  26. pmc Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
    Roger Lee
    Department of Medicine, David Geffen School of Medicine, University of California, LA, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:1603-17. 2010
    ..Like Fntb-deficient keratinocytes, Pggt1b-deficient keratinocytes did not proliferate in culture. Thus, both FTase and GGTase-I are required for the homeostasis of skin keratinocytes...
  27. pmc Defining the role of oxygen tension in human neural progenitor fate
    Yuan Xie
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA Eli and Edythe Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Stem Cell Reports 3:743-57. 2014
    ..We also identify key small molecules that can take advantage of this pathway to quickly and efficiently promote the development of mature cell types...
  28. pmc Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
    ..Together, these data suggest that iPSCs should be considered a unique subtype of pluripotent cell...